Prebiotic Ingredients & Drug Interactions
by Hyperbiotics
What is this page for?
First and foremost: checking Prebiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Prebiotic is a dietary supplement by Hyperbiotics with 4 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,026 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, organic Green Banana Flour. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Prebiotic by Hyperbiotics
Ask about any prescription or over-the-counter medication and we check it for interactions with Prebiotic by Hyperbiotics — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Prebiotic by Hyperbiotics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This powder contains 4 active ingredients: Soluble Fiber, organic Jerusalem Artichoke Fiber, organic Acacia Fiber, and organic Green Banana Flour. These are prebiotic fibers — carbohydrates that feed the beneficial bacteria already living in your gut, rather than adding new bacteria the way probiotics do.
The product has no inactive fillers or binders listed.
Does it work?
Strong evidence
The green banana flour in this product is possibly effective for diarrhea — the evidence supports its use for that purpose. For allergic rhinitis (hay fever), athletic performance, burns, and headache, there isn't enough reliable evidence in our data to say whether it works.
We hold no effectiveness data for the other fiber ingredients in this product.
How safe is it?
Well-documented data
Green banana flour is generally well tolerated when consumed as food. The most common side effects are bloating, cramping, and gas — exactly what you might expect from a prebiotic fiber product working in your gut.
Rarely, more serious effects like allergic reaction or intestinal obstruction have been reported. Some people may experience fullness or bloating during exercise if they take it beforehand, and children have reported nausea, vomiting, or belly swelling in treatment studies.
In pregnancy, bananas as a food are considered safe; concentrated banana supplements are less studied, so there isn't enough data to know either way — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant. Bananas as a food are considered safe while breastfeeding.
Meds to double-check
Moderate interaction found
If you take levodopa (a Parkinson's disease medication), check with your doctor or pharmacist before using this product — green banana may reduce how well it works. We could not check the interaction potential of the other three fiber ingredients in this product, so review your exact medications with your pharmacist.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This prebiotic powder may help with diarrhea and is generally well tolerated as a source of gut-feeding fiber. If you take levodopa for Parkinson's disease, check with your doctor or pharmacist before starting — this product may interfere with how that medication works.
For any other medications you take, use the interaction checker on this page to be sure, then talk it over with your own healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Prebiotic, straight from the product label.
| Brand | Hyperbiotics |
|---|---|
| Barcode (UPC) | 9506000116839 |
| Net contents | 375 Gram(s); 13.23 oz. |
| Market status | On market |
| Date entered into DSLD | Sep 22, 2022 |
| DSLD ID | 270231 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Prebiotic by Hyperbiotics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Carbohydrates | 6 Gram(s) | 2% |
| Dietary Fiber | 5 Gram(s) | 18% |
| Soluble Fiber | 5 Gram(s) | -- |
| organic Jerusalem Artichoke Fiber | 0 NP | -- |
| organic Acacia Fiber | 0 NP | -- |
| organic Green Banana Flour | 0 NP | -- |
| Organic Prebiotic Fiber Blend | 7 Gram(s) | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
For more information on gut health and to reorder, visit hyperbiotics.com
The problem? Incorporating enough of these critical foods into your diet can be extremely difficult.
Packaged in a GMP facility that may handle these ingredients.
Please Recycle
Formula
Prebiotics are to probiotics what fertilizer is to a garden; they are the specific fibers that supports your healthy bacteria and help them "set up shop" and thrive within your digestive tract. Nurturing the right balance of microbes in your digestive tract through Prebiotic foods supports digestion and immune system health, energy levels, metabolism, weight management, blood sugar levels already withing a normal range, brain function, and mental clarity.
That's why we've combined powerful food-based Prebiotic fibers from acacia, jerusalem artichoke and green bananas into a simple, daily spoonful of goodness.
Hyperbiotics organic Prebiotic blend is the ideal mix of inulin, FOS, resistant starch and soluble dietary fiber designed to support your gut barrier and beneficial bacteria, and reducing benefiting nearly every aspect of your health.
100% food based Organic proprietary blend Promotes the maintenance of good bacteria while supporting healthy digestion, weight management, and metabolism.
Precautions
Note: As with any dietary supplement, consult your healthcare professional. Do not use if tamper-evident seal is broken or missing.
Keep out of reach of children.
Prebiotics support many facets of overall health when taken regularly as part of a balanced diet and healthy lifestyle.
Please note: The introduction of prebiotic fibers into a fiber-deficient diet may temporarily cause mild gas, bloating or discomfort. These possible side effects are rare and vary from one person to another.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Gluten free Psyllium free Soy free Dairy free
Certified organic by QAI.
Not manufactured with gluten, wheat, soy, dairy, nuts, eggs or shellfish.
With US and worldwide ingredients
Organic, vegan & non-GMO; free of gluten, soy, wheat, psyllium and dairy. No preservatives, artificial colors or flavors.
Organic, vegan & non-GMO; free of gluten, soy, wheat, psyllium and dairy. No preservatives, artificial colors or flavors.
FDA Statement of Identity
Organic Prebiotic Fiber Supplement
Seals/Symbols
USDA Organic
Made in the USA
Suggested/Recommended/Usage/Directions
Recommended Daily: Mix one scoop into your favorite food or smoothie.
We recommend you start with only one scoop per day, and if you experience any digestive upset, reduce to a half a scoop until your body acclimates.
Storage
No Refrigeration Necessary: Once opened, store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Prebiotic by Hyperbiotics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Prebiotic by Hyperbiotics
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size7 Gram(s) Dosage formPowder Servings per container54 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactions- › Soluble Fiber
Organic Prebiotic Fiber Blend
- › Organic Jerusalem Artichoke Fiber
- › Organic Acacia Fiber
- › Organic Green Banana Flour
Prebiotic by Hyperbiotics Drug Interactions
HelloPharmacist Interaction Report
Hyperbiotics Prebiotic Powder interacts with medications through its organic Green Banana Flour content.
The most serious documented interaction is Moderate severity: green banana may reduce how well levodopa (a Parkinson's disease medication) works in your body. A case report describes a patient whose Parkinson symptoms worsened after eating banana daily; the symptoms improved once dietary bananas were removed.
Read the full breakdown — every affected drug type, severity by severity
We couldn't check three other ingredients in this product — Soluble Fiber, organic Jerusalem Artichoke Fiber, and organic Acacia Fiber — because we hold no interaction data for them. The Organic Prebiotic Fiber Blend is a group ingredient, so its component fibers are covered individually above.
Altogether, these interactions span 5 individual medications. If you take levodopa or any other prescription medication, run your exact drugs through the interaction checker on this page before adding this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Prebiotic?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Prebiotic interact with 2,026 drugs. Click any drug to see the details.
2 of the 4 ingredients in Prebiotic interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber organic Green Banana Flour
Alogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Alogliptin, Metformin interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Prebiotic — through 2 ingredients. Tap an ingredient for the detail:
Organic Green Banana FlourLevodopa Moderate
Interaction Summary
Taking banana may reduce the effectiveness of levodopa.
Read the full Organic Green Banana Flour + Benserazide, Levodopa interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Benserazide, Levodopa interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Canagliflozin, Metformin Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Carbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbamazepine interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Prebiotic — through 2 ingredients. Tap an ingredient for the detail:
Organic Green Banana FlourLevodopa Moderate
Interaction Summary
Taking banana may reduce the effectiveness of levodopa.
Read the full Organic Green Banana Flour + Carbidopa, Levodopa interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Prebiotic — through 2 ingredients. Tap an ingredient for the detail:
Organic Green Banana FlourLevodopa Moderate
Interaction Summary
Taking banana may reduce the effectiveness of levodopa.
Read the full Organic Green Banana Flour + Carbidopa, Levodopa, Entacapone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbidopa, Levodopa, Entacapone interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Dapagliflozin Propanediol, Metformin interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Empagliflozin, Metformin Hydrochloride interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ertugliflozin, Metformin Hydrochloride interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glipizide, Metformin interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glyburide, Metformin interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Prebiotic — through 2 ingredients. Tap an ingredient for the detail:
Organic Green Banana FlourLevodopa Moderate
Interaction Summary
Taking banana may reduce the effectiveness of levodopa.
Read the full Organic Green Banana Flour + Levodopa interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Organic Green Banana FlourLevodopa Moderate
Interaction Summary
Taking banana may reduce the effectiveness of levodopa.
Read the full Organic Green Banana Flour + Levodopa, Carbidopa interactionLinagliptin, Metformin HydrochlorideJentadueto XR
How Linagliptin, Metformin Hydrochloride interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Linagliptin, Metformin Hydrochloride interactionLithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Lithium Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Lithium Carbonate (prescription Drug) interactionMetforminGlucophage, Metformin
How Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Metformin interactionMetformin HydrochlorideRiomet ER
How Metformin Hydrochloride interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Metformin Hydrochloride interactionMetformin, LinagliptinJentadueto
How Metformin, Linagliptin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
How Metformin, Sitagliptin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Metformin, Sitagliptin interactionOlanzapineZyprexa
How Olanzapine interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Olanzapine (zyprexa) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Olanzapine interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Saxagliptin, Metformin Xr interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Sitagliptin, Metformin interactionPioglitazone, MetforminActoPlus Met
How Pioglitazone, Metformin interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Pioglitazone, Metformin interaction"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + "phentolamine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Prebiotic — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + 6-mercaptopurine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Prebiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
organic Green Banana Flour
Levodopa
Taking banana may reduce the effectiveness of levodopa.
A case report describes apparent wearing off in a patient with Parkinson disease after eating a banana every day. The wearing off subsided after removing dietary bananas.
Brand information
Manufacturer and brand details for Prebiotic, from the product label.
Hyperbiotics
See all Hyperbiotics products- Name
- Hyperbiotics
- Street Address
- 170 S. Green Valley Pkwy, Suite 300
- City
- Henderson
- State
- NV
- ZipCode
- 89012
- Phone Number
- (800) 711-5958
- Web Address
- hyperbiotics.com
Prebiotic by Hyperbiotics: Common Questions
Does Prebiotic by Hyperbiotics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help my digestive symptoms?
What side effects should I expect?
Is it safe to use during pregnancy?
Can I use it while breastfeeding?
What exactly is in this powder?
Why can't you check the other fibers for interactions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Prebiotic is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Prebiotic’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographBanana
Interacts with 5 drugsBananas are a nutritious, widely eaten fruit that provide potassium, fiber, vitamin B6, and quick energy, and they are part of a healthy diet. While some traditional uses (like easing diarrh...
Read the full Banana monograph →Sources & How We Checked
Prebiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 29 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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