Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Pre+Pro 60B Ingredients & Drug Interactions

by Hyperbiotics

Pre+Pro 60B label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pre+Pro 60B against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pre+Pro 60B is a dietary supplement by Hyperbiotics with 6 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L. acidophilus SD-5212. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pre+Pro 60B by Hyperbiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with Pre+Pro 60B by Hyperbiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pre+Pro 60B by Hyperbiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (190 mg) without saying how much of each component you get.

Pre+Pro 60B contains 6 active ingredients: a proprietary probiotic blend (made up of five Lactobacillus species), plus fructooligosaccharides, a type of prebiotic fiber. The probiotics are live microorganisms — strains like L. acidophilus and L. plantarum — meant to support your gut bacteria.

The fructooligosaccharides act as food for those bacteria, helping them thrive. The capsule also contains inactive ingredients (microcrystalline cellulose, hydroxypropyl methylcellulose, water, and a few other stabilizers and binders).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Gut health and beneficial bacteria support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Helicobacter pylori — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation.

L. acidophilus in this formula is rated possibly effective for irritable bowel syndrome (IBS), possibly effective for Helicobacter pylori infection, possibly effective for antibiotic-associated diarrhea, and possibly effective for bacterial vaginosis. The evidence base for fructooligosaccharides is less established — we hold insufficient evidence to rate it for osteoporosis, constipation, diabetes, travelers' diarrhea, or high cholesterol.

We don't have effectiveness data on file for the other Lactobacillus strains in the blend.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Fructo-oligosaccharides (fos)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. acidophilus is generally well tolerated in healthy adults and children. The probiotics (including L. acidophilus with other strains) may cause mild gastrointestinal side effects — abdominal pain, bloating, flatulence, diarrhea, or burping — but these are uncommon.

Fructooligosaccharides can cause gas, bloating, abdominal pain, and flatulence, especially at higher doses, though clinical trials at doses under 10 grams daily didn't consistently show a higher rate of these effects. Because supplement-level doses of fructooligosaccharides aren't well studied, check with your doctor before use.

L. acidophilus has been isolated in rare cases of serious infections (bacteremia, sepsis, abscess, endocarditis), though most occurred in people with underlying conditions allowing bacterial translocation; cases in healthy people are extremely rare.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Fructo-oligosaccharides (fos)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main medication type to double-check is antibiotic drugs. Antibiotics can reduce how well the L. acidophilus in this product works by killing the live organisms.

Separate your antibiotic doses from this supplement by several hours — your pharmacist can help with exact timing.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic-and-prebiotic combo may help with certain gut conditions like IBS or antibiotic-related diarrhea, especially if you're taking L. acidophilus for those reasons. If you're on antibiotics, space out your doses — antibiotics will kill the live organisms in the probiotic.

Talk to your pharmacist before starting, particularly if you have a weakened immune system or planned antibiotic use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pre+Pro 60B, straight from the product label.

Brand Hyperbiotics
Barcode (UPC) 9504000252212
Net contents 30 Acid-Resistant Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 306762
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pre+Pro 60B by Hyperbiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
9504000252212
IngredientAmount% DV
Proprietary Probiotic Blend190 mg--
Fructooligosaccharides100 mg--
L. plantarum DSM-65950 NP--
L. rhamnosus DSM-65940 NP--
L. casei SD-58420 NP--
L. paracasei DSM-134340 NP--
L. acidophilus SD-52120 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water, Hypromellose Acetate Succinate, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For more information on gut health and to reorder, visit hyperbiotics.com

Please recycle

Suggested/Recommended/Usage/Directions

Daily maintenance: Take 1 capsule per day on an empty stomach.

Storage

No refrigeration necessary: Store in a cool, dry place.

Formula

With an acid-resistant capsule, the beneficial bacteria in PRE+PRO are exposed to stomach acids for less time, allowing more bacteria to make it into your small intestine where they are needed most. This formula is designed with five targeted Lactobacillus probiotic strains and 100mg of prebiotic FOS to support gut and immune system health on a daily basis. When taken regularly as part of a balanced diet and healthy lifestyle.

Prebiotic + Probiotic 60 Billion CFU At the time of manufacture. Minimum of 15 billion CFU at expiration. 5 Strains

Precautions

Note: As with any dietary supplement, consult your healthcare professional. Do not use if tamper-evident seal is broken or missing.

Keep out of reach of children.

Formulation

Vegetarian; Non-GMO; Yeast free; No dairy, no soy, no gluten, no wheat, no nuts, no preservatives, no sugar, no artificial colors or flavors.

Vegetarian; Non-GMO; Yeast free; No dairy, no soy, no gluten, no wheat, no nuts, no preservatives, no sugar, no artificial colors or flavors.

Enhanced support for bloating and gas

Vegan

Dairy free Gluten free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Premium Probiotic Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pre+Pro 60B by Hyperbiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pre+Pro 60B label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pre+Pro 60B by Hyperbiotics

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

190 mg per serving
  • › L. plantarum DSM-6595
  • › L. rhamnosus DSM-6594
  • › L. casei SD-5842
  • › L. paracasei DSM-13434
  • › L. acidophilus SD-5212

Fructooligosaccharides

No known
interactions
100 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water, Hypromellose Acetate Succinate, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pre+Pro 60B by Hyperbiotics Drug Interactions

Want to check YOUR meds against Pre+Pro 60B?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

L. acidophilus SD-5212 182

Individual Drug Interactions

The ingredients in Pre+Pro 60B interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Pre+Pro 60B interact with drugs. Each result below shows which ingredient is responsible. L. acidophilus SD-5212

Each ingredient & the kinds of drugs it affects

For each ingredient in Pre+Pro 60B with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L. acidophilus SD-52121 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus SD-5212 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pre+Pro 60B, from the product label.

Hyperbiotics

See all Hyperbiotics products
Name
Hyperbiotics
Street Address
45 Kenneth Dooley Drive
City
Middletown
State
CT
ZipCode
06457
Web Address
hyperbiotics.com
Pharmacist Counseling Corner

Pre+Pro 60B by Hyperbiotics: Common Questions

Does Pre+Pro 60B by Hyperbiotics interact with any medications?
Yes. Based on its ingredients, Pre+Pro 60B has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pre+Pro 60B contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Not at the same time. The antibiotic will kill the live probiotic organisms in this supplement, making it less effective. Space your doses a few hours apart — your pharmacist can suggest the best schedule for your specific antibiotic.
What side effects should I expect?
You might notice gas, bloating, abdominal pain, or flatulence, especially when you first start. These are usually mild and uncommon. If they're severe or don't settle down, stop and talk to your doctor.
Is this safe during pregnancy or breastfeeding?
We don't have safety data on file for L. acidophilus during pregnancy or lactation, and the fructooligosaccharides entry doesn't include pregnancy information either. Talk to your doctor or pharmacist to see if it's right for you at that stage.
Does this actually work for IBS or diarrhea?
L. acidophilus in this blend is rated possibly effective for IBS, antibiotic-related diarrhea, and bacterial vaginosis. That means some evidence supports it, but more research is needed to be certain. Your results may vary.
What's the prebiotic (fructooligosaccharides) for?
It's a type of fiber that feeds the live probiotics in the formula, helping them survive and grow in your gut. However, we don't have strong evidence yet that it improves specific conditions like constipation or high cholesterol.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pre+Pro 60B is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pre+Pro 60B label
Go deeper

The Full Monographs Behind Pre+Pro 60B’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph →
Sources

Sources & How We Checked

Pre+Pro 60B's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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