Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

PRO-IBS Support+ Ingredients & Drug Interactions

by Hyperbiotics

PRO-IBS Support+ label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PRO-IBS Support+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PRO-IBS Support+ is a dietary supplement by Hyperbiotics with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Indian Frankincense Phytosome. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PRO-IBS Support+ by Hyperbiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with PRO-IBS Support+ by Hyperbiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PRO-IBS Support+ by Hyperbiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PRO-IBS Support+ contains 2 active ingredients: Lactobacillus plantarum Lp299v, a probiotic strain, and Indian Frankincense Phytosome (Boswellia serrata extract), a botanical resin complex traditionally used for digestive and joint support. The remaining ingredients—microcrystalline cellulose, hydroxypropyl methylcellulose, lecithin, magnesium stearate, and silicon dioxide—are inactive fillers and binders that form the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Boswellia Serrata's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Support for irritable bowel syndrome symptoms.
  • We looked for evidence on: Irritable bowel syndrome (IBS), Diarrhea, Bowel regularity, Digestive comfort, Gut health.
  • The closest evidence on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Irritable bowel syndrome (IBS).

Boswellia serrata is possibly effective for osteoarthritis based on available evidence. For other uses in this product—hay fever, Alzheimer disease, asthma, and cluster headache—the evidence is insufficient to rate whether it works.

The Lactobacillus plantarum effectiveness data isn't on file in our records, so we can't tell you whether the probiotic dose and strain in this product has established benefits.

The evidence, ingredient by ingredient Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boswellia serrata is generally well tolerated when taken by mouth short-term, though quality and strength vary widely between brands. The most common side effects are abdominal pain, diarrhea, headache, heartburn, itching, and nausea.

Dizziness and vertigo have been reported in some trial participants. A rare serious side effect—bezoar formation (a mass in the stomach)—has occurred with very large amounts of gum resin.

The safety data advises against use during pregnancy and while breastfeeding, since there isn't enough data to know it's safe. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PRO-IBS Support+, check whether you're on any medications broken down by the liver enzymes CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4—Boswellia may raise their levels and boost side effects. Also flag if you take immunosuppressant drugs, since Boswellia might affect how they work.

Use the medication checker on this page to see your exact drugs, and have your doctor or pharmacist review the results before you begin.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

PRO-IBS Support+ is a two-ingredient supplement mixing a probiotic and Boswellia, which is possibly effective for osteoarthritis but has moderate interactions with many common medications through liver enzyme changes. If you take any prescription drugs—especially antidepressants, heart or blood-pressure medications, or blood thinners—check them against this product's interaction tool and confirm with your doctor or pharmacist before starting.

Avoid it if you're pregnant or breastfeeding unless your doctor advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PRO-IBS Support+, straight from the product label.

Brand Hyperbiotics
Barcode (UPC) 9504000252298
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328454
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PRO-IBS Support+ by Hyperbiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
9504000252298
IngredientAmount% DV
Lactobacillus plantarum Lp299v85 mg--
Indian Frankincense Phytosome125 mg--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Lecithin, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule per day on an empty stomach.

Storage

No refrigeration necessary. Store in a cool, dry place.

Precautions

Keep out of reach of children.

Use only if safety seal is intact.

Warning: If you are pregnant, lactating, taking any medications, or have any medical condition, consult your healthcare practitioner before use.

Formulation

Free of dairy, gluten, soy, peanut, tree nut, sesame, egg, fish, shellfish, active yeast, preservatives, artificial flavors and colors, and added sugar, and is non-GMO.

Supports occasional gastrointestinal discomfort

Vegan

Dairy free Gluten free

Brand IP Statement(s)

LP299V is a registered trademark of Probi AB.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

PRO-IBS Support Featuring LP299V 30 Billion CFU 30 Billion CFU at time of manufacture. 10 Billion CFU at time of expiration date.

FDA Statement of Identity

Premium Probiotic Supplement

General Statements

Lactiplantibacillus plantarum, formerly classified as lactobacillus plantarum.

For more information on gut health and to reorder, visit hyperbiotics.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PRO-IBS Support+ by Hyperbiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PRO-IBS Support+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PRO-IBS Support+ by Hyperbiotics

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactobacillus plantarum Lp299v

85 mg per serving

Indian Frankincense Phytosome

Interacts with
952 drugs
125 mg per serving Form: Boswellia serrata Oleo-gum Resin Extract

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

Indian Frankincense Phytosome monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Lecithin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

PRO-IBS Support+ by Hyperbiotics Drug Interactions

Want to check YOUR meds against PRO-IBS Support+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

Indian Frankincense Phytosome 952

Individual Drug Interactions

The ingredients in PRO-IBS Support+ interact with 952 drugs. Click any drug to see the details.

1 of the 2 ingredients in PRO-IBS Support+ interact with drugs. Each result below shows which ingredient is responsible. Indian Frankincense Phytosome

Each ingredient & the kinds of drugs it affects

For each ingredient in PRO-IBS Support+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Indian Frankincense Phytosome6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
Indian Frankincense Phytosome full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PRO-IBS Support+, from the product label.

Hyperbiotics

See all Hyperbiotics products
Name
Hyperbiotics
Street Address
45 Kenneth Dooley Drive
City
Middletown
State
CT
ZipCode
06457
Web Address
hyperbiotics.com
Pharmacist Counseling Corner

PRO-IBS Support+ by Hyperbiotics: Common Questions

Does PRO-IBS Support+ by Hyperbiotics interact with any medications?
Yes. Based on its ingredients, PRO-IBS Support+ has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PRO-IBS Support+ contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Lactobacillus plantarum Lp299v?
It's a probiotic strain added to support digestive health. We don't have interaction data on file for this particular strain, so we can't tell you which medications it may or may not affect.
Will this product cause side effects?
Boswellia serrata is generally well tolerated, but common side effects include abdominal pain, diarrhea, headache, heartburn, itching, and nausea. Dizziness and vertigo have also been reported in some users. Very large amounts may rarely cause a blockage in the stomach.
Is it safe to take while pregnant or breastfeeding?
No—the safety data advises against use during pregnancy and while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this supplement.
How much evidence is there that this works for IBS?
Boswellia is possibly effective for osteoarthritis, but the evidence for other digestive or inflammatory conditions—including what IBS symptoms this may help—is either insufficient or not on file. Talk to your pharmacist about what the research actually supports.
Can I take this with my blood pressure or heart medication?
Many heart and blood-pressure drugs are broken down by liver enzymes that Boswellia may slow down, potentially raising drug levels. Use the interaction checker on this page with your exact medications, then confirm the results with your doctor or pharmacist before starting—they may need to adjust your dose or watch you more closely.
What are the inactive ingredients?
The capsule contains microcrystalline cellulose, hydroxypropyl methylcellulose, lecithin, magnesium stearate, and silicon dioxide—all standard fillers and binders with no active role.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PRO-IBS Support+ label
Go deeper

The Full Monographs Behind PRO-IBS Support+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

PRO-IBS Support+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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