Interactions on record — worth a quick check against your medications. Based on 3 of 13 ingredients. Check your meds →
Dietary supplement

Proactazyme Ingredients & Drug Interactions

by Nature's Sunshine

Proactazyme label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Proactazyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Proactazyme is a dietary supplement by Nature's Sunshine with 13 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Proactazyme by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Proactazyme by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Proactazyme by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 13 of its 13 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Proactazyme is a 13-ingredient digestive enzyme blend. The main active ingredients are proteases (Protease 4.5, Protease 3, and Protease 6)—enzymes that break down protein—along with lipase (fat digestion), and several others including amylase, cellulase, peptidase, invertase, glucoamylase, diastase, and alpha-galactosidase, all of which help your body break down different parts of food.

The product also contains potassium and a proprietary blend. The capsule and cellulose are inactive ingredients used to hold and protect the formula.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports the body's digestive process.
  • We looked for evidence on: Dyspepsia, Indigestion, Bloating, Malabsorption.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The data we hold doesn't establish that lipase works for inflammatory bowel disease, dyspepsia (indigestion), or prematurity—the evidence is too thin to rate it. We have no effectiveness ratings on file for the protease enzymes or the other digestive ingredients in this product.

That doesn't mean they don't work; it means the clinical evidence available to us isn't enough to say one way or the other.

The evidence, ingredient by ingredient Lipase Potassium Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase is generally well tolerated, though people with serious digestive conditions should use it only under medical guidance. The protease enzymes are generally well tolerated for most adults but may cause digestive upset or allergic reactions in some people.

Potassium from food is fine, but supplemental potassium can cause dangerously high blood levels, especially in people with kidney disease—so supplements should only be used under medical guidance. Common side effects of potassium supplements include belly pain, belching, diarrhea, gas, nausea, and vomiting.

Rare but serious effects include irregular heartbeat, low blood pressure, and mental confusion. During pregnancy, there isn't enough safety data on lipase or the proteases, so check with your doctor first.

Potassium from diet is considered safe in pregnancy, but supplements should only be used if your doctor advises it. While breastfeeding, safety data on lipase and the proteases is limited—talk with your healthcare provider before using this product.

Side effects, ingredient by ingredient Lipase Potassium Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking Proactazyme if you use a potassium-sparing diuretic (water pill), an ACE inhibitor, or an angiotensin receptor blocker—all carry a moderate-severity risk of high blood potassium. If you're on any other medication or have kidney disease, mention this product to your provider before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Proactazyme is a digestive enzyme supplement aimed at helping your body break down food, though the clinical evidence for its ingredients is limited. The main caution is potassium: if you take any water pill, blood pressure medication (especially ACE inhibitors or ARBs), or have kidney problems, you need to clear this with your doctor or pharmacist first because of the risk of dangerously high blood potassium.

If you're pregnant, breastfeeding, or have a serious digestive condition, talk it over with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Proactazyme, straight from the product label.

Brand Nature's Sunshine
Net contents 60 Packet(s); 180 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18237
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Proactazyme by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Amylase6300 DU--
Lipase90 FIP--
Cellulase180 CU--
Peptidase3000 HUT--
Invertase330 SU--
Glucoamylase15 AGU--
Diastase825 DP--
Alpha-Galactosidase150 GALU--
Potassium78 mg2%
Protease 4.528500 HUT--
Protease 324 SAPU--
Protease 64500 HUT--
Proprietary Blend1125 mg--

Other ingredients: Capsule, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

This 30 day program contains two types of packets marked: AM (3 Proactazyme capsules) and PM (1 Anti-Gas TCM capsule and 2 Probiotic Eleven capsules).

The basic function of the digestive system is to transform food and nutrients into energy. Each organ n this system has one sole purpose: to digest. The ingredients in this 30 day Digestive System program are formulated to support the digestive process, and to create an environment wherein food can be more readily digested, and nutrients can be more readily absorbed and then circulated throughout the body to nourish cells and muscles.*

By understanding our body's intricate and harmonious systems we can improve our own health and vitality, and share this wisdom with those we love.

Proactazyme: A plant-sourced enzyme that facilitates digestion and improves nutrient absorption. This enzyme supplement also helps with fat-soluble materials and waste, which helps detoxify the digestive system and improves elimination.*

This product contains probiotic material.

Digestive System Supports the Body's Digestive Process

30 DAY PROGRAM

Nature's Sunshine uses natural source materials in its products that are subject to color variation.

Product of U.S.A.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

FOR BEST RESULTS REFRIGERATE THIS BOX UPON RECEIPT

Precautions

This carton was sealed for your protection. Do not use if outer shrink wrap is missing or damaged.

Notice: Pregnant or lactating women should consult their health care provider prior to taking this supplement.

Seals/Symbols

Nature's Sunshine QUALITY, SERVICE, INTEGRITY(R)

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

RECOMMENDATION Take the contents of one AM packet throughout the day before meals. (Take one capsules before breakfast, one capsule before lunch and one capsule before dinner); take the contents of one PM packet with your evening meal. Follow this pattern for 30 days.

Brand IP Statement(s)

PROACTAZYME(R)

(C)2012 Nature's Sunshine Products, Inc.

General

Stock No. 5380-0

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Proactazyme by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Proactazyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Proactazyme by Nature's Sunshine

These are the 13 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amylase

6300 DU per serving

Lipase

No known
interactions
90 FIP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Cellulase

180 CU per serving

Peptidase

3000 HUT per serving

Invertase

330 SU per serving

Glucoamylase

15 AGU per serving

Diastase

825 DP per serving Form: Malt

Alpha-Galactosidase

150 GALU per serving

Potassium

Interacts with
62 drugs
78 mg per serving Form: Potassium Citrate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Protease 4.5

No known
interactions
28500 HUT per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 4.5 monograph & interactions

Protease 3

No known
interactions
24 SAPU per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 3 monograph & interactions

Protease 6

No known
interactions
4500 HUT per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 6 monograph & interactions

Proprietary Blend

1125 mg per serving Form: Beet root fiber, Beta-Glucanase, caraway, dandelion, fennel, Gentian, ginger, Hemicellulase, Phytase

Other (inactive) ingredients: Capsule, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Proactazyme by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Proactazyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Proactazyme interact with 62 drugs. Click any drug to see the details.

1 of the 13 ingredients in Proactazyme interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Proactazyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Proactazyme, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Proactazyme by Nature's Sunshine: Common Questions

Does Proactazyme by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Proactazyme has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Proactazyme contains 13 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does lipase do in this product?
Lipase is an enzyme that helps break down fat from food so your body can digest it more easily. It's one of several digestive enzymes in Proactazyme.
Will Proactazyme help my indigestion?
The data we hold shows insufficient evidence to know whether lipase works for indigestion. You might talk with your doctor about whether this product is right for your specific situation.
Is this safe to take while pregnant?
There isn't enough safety data on most of the enzymes in this product to say it's safe in pregnancy. Potassium from diet is fine, but supplemental potassium should only be used if your doctor advises it. Check with your healthcare provider before taking Proactazyme.
Can I take this if I have kidney disease?
Potassium supplements can cause dangerously high blood levels in people with kidney disease. Do not take this product without clearing it with your doctor first.
Does Proactazyme contain any fillers?
Yes—the capsule and cellulose are inactive ingredients used to hold the formula together. The active ingredients are the digestive enzymes, potassium, and the proprietary blend.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Proactazyme is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Proactazyme label
Go deeper

The Full Monographs Behind Proactazyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Proactazyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team