Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Pro-Intensive Ingredients & Drug Interactions

by Higher Nature

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Pro-Intensive is a dietary supplement by Higher Nature with 4 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus (CUL60), Bifidobacterium animalis subsp. lactis (CUL34 ), Bifidobacterium bifidum (CUL20). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Pro-Intensive by Higher Nature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Bacteria Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Pro-Intensive contains four active probiotic ingredients: Lactobacillus acidophilus (CUL60), Bifidobacterium animalis subsp. lactis (CUL34), Bifidobacterium bifidum (CUL20), and Lactobacillus casei (CUL06). These are live beneficial bacteria designed to support your gut health.

The product also contains several inactive ingredients — microcrystalline cellulose, calcium stearate, and a capsule — that serve as fillers and help deliver the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: gut health and digestive balance support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Dysbiosis, Gut microbiome balance — and 2 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Animalis Subsp. Lactis is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).

The evidence for these probiotics is strongest for irritable bowel syndrome (IBS) and respiratory tract infections, where all three checked ingredients are rated possibly effective. Lactobacillus acidophilus is also possibly effective for antibiotic-associated diarrhea and bacterial vaginosis.

Bifidobacterium animalis subsp. lactis is possibly effective for constipation. For other uses — like Alzheimer disease, generalized anxiety, and allergic rhinitis — the evidence is either insufficient or suggests the probiotics may be ineffective (atopic disease).

We don't have effectiveness data on file for Lactobacillus casei.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus and Bifidobacterium bifidum are both rated possibly safe in pregnancy; we don't have lactation data for either. Bifidobacterium animalis subsp. lactis has insufficient data on pregnancy and lactation — talk with your doctor or pharmacist for personalized advice if you're pregnant or breastfeeding.

All three checked ingredients are generally well tolerated in healthy people, though gastrointestinal side effects like bloating, flatulence, diarrhea, and abdominal discomfort can occur, especially early on — these are uncommon. Very rarely, probiotics have been associated with serious infections in people with weakened immune systems or those who are critically ill, though most documented cases are thought to involve translocation from other parts of the body.

One clinical trial of a probiotic combination reported two cases of rash and one of itching, but it's unclear whether these were due to this ingredient, others, or something else entirely.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Animalis Subsp. Lactis, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, separate them from Pro-Intensive by several hours — ask your own doctor or pharmacist exactly how long. Antibiotics can kill the live bacteria in this supplement and reduce its effectiveness.

No other interactions are documented for the ingredients we could check, though we have no data on Lactobacillus casei.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pro-Intensive is a multi-strain probiotic that's generally well tolerated and possibly effective for IBS, respiratory infections, and a few other digestive and immune concerns. The main thing to watch out for is antibiotic use — you'll need to space out when you take them.

If you have a weakened immune system or are critically ill, talk with your doctor before starting. Check your medications with our tool and bring the results to your doctor or pharmacist before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pro-Intensive, straight from the product label.

Brand Higher Nature
Barcode (UPC) 5031013103797
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 245760
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pro-Intensive by Higher Nature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
5031013103797
IngredientAmount% DV
Bacteria Blend0 NP--
Lactobacillus acidophilus (CUL60)0 NP--
Bifidobacterium animalis subsp. lactis (CUL34 )0 NP--
Bifidobacterium bifidum (CUL20)0 NP--
Lactobacillus casei (CUL06)0 NP--

Other ingredients: Microcrystalline Cellulose, Capsule, Lactobacillus acidophilus, Lactobacillus casei, Calcium Stearate, Bifidobacterium bifidum, Bifidobacterium animalis subsp. lactis

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Food Supplement

Formula

Multi strain formula 9 billion live cultures per daily dose guaranteed until end of shelf life if stored according to instructions

Everyday support for adults and children over 8

Lactobacillus and bifidobacterium are part of a gut ecosystem

Multi strain bacteria 9 billion live organisms per daily dose

Suggested/Recommended/Usage/Directions

Directions: Adults take 1 capsule 3 times a day, children 8 years and over take 1 capsule up to twice a day, with a glass of water immediately before a meal.

Precautions

Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Storage: Store in a cool, dry place out of reach of children.

Formulation

Free from: Artificial colours, flavourings or preservatives, corn, dairy products, gluten, lactose, maize, salt, soya, starch, wheat, yeast.

Vegetarian and vegan

Storage

Storage: Store in a cool, dry place out of reach of children. No need for refrigeration.

General Statements

This product has not been tested on animals. Everyday Essentials

See for yourself

Pro-Intensive by Higher Nature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pro-Intensive by Higher Nature

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bacteria Blend

0 NP per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Capsule, Lactobacillus acidophilus, Lactobacillus casei, Calcium Stearate, Bifidobacterium bifidum, Bifidobacterium animalis subsp. lactis. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pro-Intensive by Higher Nature Drug Interactions

Want to check YOUR meds against Pro-Intensive?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Each ingredient & the kinds of drugs it affects

For each ingredient in Pro-Intensive with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus (CUL60)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D

Bifidobacterium animalis subsp. lactis (CUL34 )1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B. lactis.
Since B. lactis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. lactis preparations by at least 2 hours.

Likelihood Probable Evidence D

Bifidobacterium bifidum (CUL20)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Pro-Intensive, from the product label.

Higher Nature

See all Higher Nature products
Name
Higher Nature Ltd
Street Address
10 Discovery Way
City
Horam, East Sussex
ZipCode
TN21 0GE
Web Address
highernature.com
Pharmacist Counseling Corner

Pro-Intensive by Higher Nature: Common Questions

Does Pro-Intensive by Higher Nature interact with any medications?
Yes. Based on its ingredients, Pro-Intensive has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pro-Intensive contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm on antibiotics?
No, not if you take them together. The antibiotic will kill the live bacteria in Pro-Intensive. You need to separate the timing — your doctor or pharmacist can tell you how many hours apart to take them. This way, the probiotic can still help once your antibiotic course is finished.
What does this probiotic actually do?
It's designed to support your gut health. The evidence is strongest for irritable bowel syndrome, antibiotic-associated diarrhea, and respiratory infections, where it's rated possibly effective. It may also help with constipation and bacterial vaginosis.
Can I take this while pregnant?
Lactobacillus acidophilus and Bifidobacterium bifidum are both rated possibly safe in pregnancy. Bifidobacterium animalis subsp. lactis doesn't have enough data to know either way. Talk with your doctor or pharmacist before starting — they know your individual health situation.
What side effects might I get?
Most people tolerate it well. Gastrointestinal side effects like bloating, flatulence, diarrhea, and abdominal discomfort can happen, especially when you first start, but they're uncommon. Rash and itching have been reported rarely in clinical trials, though it's unclear if the probiotics caused them.
Is it safe if my immune system is weakened?
You should check with your doctor first. Probiotics are generally low-risk, but there's a theoretical concern about infection in people with weakened immune systems or those who are critically ill. Your doctor can weigh the benefit against that risk for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pro-Intensive is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pro-Intensive label
Sources

Sources & How We Checked

Pro-Intensive's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Animalis Subsp. Lactis 8 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Phuapradit P, Varavithya W, Vathanophas K, et al. Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula. J Med Assoc Thai 1999;82:S43-8.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  5. Taipale TJ, Pienihäkkinen K, Isolauri E, Jokela JT, Söderling EM. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood. Pediatr Res. 2016;79(1-1):65-9. PubMed
  6. Amat-Bou M, Garcia-Ribera S, Climent E, et al. Effects of Bifidobacterium animalis Subsp. lactis (BPL1) supplementation in children and adolescents with prader-willi syndrome: A randomized crossover trial. Nutrients. 2020;12(10):3123. PubMed
  7. Mäkelä SM, Forssten SD, Kailajärvi M, et al. Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti-inflammatory drug: A randomized, placebo-controlled, double-blind clinical trial. Br J Clin Ph
  8. Wildt S, Munck LK, Vinter-Jensen L, et al. Probiotic treatment of collagenous colitis: a randomized, double-blind, placebo-controlled trial with Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis. Inflamm Bowel Dis 2006;12(5):395-401. PubMed

See these in context on the Bifidobacterium Animalis Subsp. Lactis monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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