ProBiota Immune Ingredients & Drug Interactions
What is this page for?
First and foremost: checking ProBiota Immune against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
ProBiota Immune is a dietary supplement by Seeking Health with 3 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,102 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Beta-Glucan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against ProBiota Immune by Seeking Health
Ask about any prescription or over-the-counter medication and we check it for interactions with ProBiota Immune by Seeking Health — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of ProBiota Immune by Seeking Health
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
ProBiota Immune contains 2 active ingredients: beta-glucans and galacto-oligosaccharides, along with a prebiotic blend. Beta-glucans are compounds derived from yeast, fungi, or grains that support immune and heart health.
Galacto-oligosaccharides are a type of prebiotic fiber that feeds beneficial bacteria in your gut. There are no inactive fillers or other ingredients listed.
Does it work?
Strong evidence
Beta-glucans in this product are likely effective for lowering cholesterol (dyslipidemia) and supporting heart health in coronary heart disease. The evidence for these benefits comes from clinical research.
We don't hold effectiveness data on galacto-oligosaccharides or the prebiotic blend specifically in our records.
How safe is it?
Well-documented data
Beta-glucans from food sources are generally well tolerated. However, concentrated supplement doses lack the safety testing that whole foods have had, so caution is warranted.
Most people don't report problems, but topical beta-glucan products have caused mild skin reactions in some users. One child in a research trial on high-dose beta-glucans developed temporary liver enzyme elevations.
There isn't enough research on supplement doses during breastfeeding to know if it's safe, so talk with your doctor or pharmacist before taking this while nursing. We don't have safety data on file for galacto-oligosaccharides or the prebiotic blend.
Meds to double-check
Moderate interaction found
Double-check this product if you take immunosuppressants (drugs that suppress your immune system, like those used after transplant or for autoimmune conditions) or antihypertensive drugs (blood pressure medications). Both types may have their effects altered by the beta-glucans in this supplement.
Altogether, these interactions span 293 individual medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
ProBiota Immune may support cholesterol and heart health through its beta-glucan content, but it's not right for anyone on blood pressure medications or immune-suppressing drugs without checking first. If you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting—the data on supplement doses in these situations isn't solid.
Use your own healthcare provider to confirm it fits your medications and health situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about ProBiota Immune, straight from the product label.
| Brand | Seeking Health |
|---|---|
| Barcode (UPC) | 828054134355 |
| Net contents | 5.3 Oz(s); 150 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2018 |
| DSLD ID | 174865 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for ProBiota Immune by Seeking Health, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Total Carbohydrates | 5 Gram(s) | 2% |
| Dietary Fiber | 4 Gram(s) | 16% |
| Galacto-oligosaccharides | 0 NP | -- |
| Beta-Glucan | 0 NP | -- |
| Prebiotic Blend (Dietary substance used by man to supplement the diet by increasing the total dietary intake) | 5 Gram(s) | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 to 2 scoops daily or as directed by your health care professional. Mix powder in cold, warm, or hot foods or beverages as desired.
Precautions
Do not use if full-bottle shrinkwrap is broken or missing.
Keep out of reach of children.
Storage
Store in a cool, dry place (59(0)F-85(0)F) away from direct light.
General Statements
This product was made in a GMP and ISO 9001:2008 registered facility. Find other effective health products at: www.seekinghealth.com
Physician formulated
FDA Statement of Identity
Prebiotic Supplement
Formulation
Does Not Contain: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat/gluten, corn, and soybeans. Contains no artificial colors, flavors, or preservatives.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
ProBiota Immune by Seeking Health label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in ProBiota Immune by Seeking Health
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 tsp Dosage formPowder Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsPrebiotic Blend (Dietary substance used by man to supplement the diet by increasing the total dietary intake)
- › Galacto-oligosaccharides
- › Beta-Glucan
Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
ProBiota Immune by Seeking Health Drug Interactions
HelloPharmacist Interaction Report
ProBiota Immune by Seeking Health contains beta-glucans, which has documented interactions with two medication types.
The most serious concern is with immunosuppressants (drugs that weaken your immune system): beta-glucans may interfere with how these medications work, since beta-glucans themselves stimulate immune activity. This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Antihypertensive drugs (blood pressure medications) are also affected. Taking beta-glucans alongside these drugs might increase the risk of excessively low blood pressure (hypotension), since beta-glucans can lower blood pressure on their own—also a Moderate-severity interaction.
The product also contains galacto-oligosaccharides, an ingredient we could not check for interactions. Additionally, there's a prebiotic blend listed; we hold no interaction data for it as a whole.
If you take any blood pressure or immune-suppressing medications, run your exact drugs through the search tool below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against ProBiota Immune?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in ProBiota Immune interact with 2,102 drugs. Click any drug to see the details.
2 of the 3 ingredients in ProBiota Immune interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Beta-Glucan
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + 6-mercaptopurine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Abrocitinib interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abrocitinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Acebutolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Acetazolamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetazolamide interactionAdalimumabHumira
How Adalimumab interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Adalimumab-bwwd interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Adalimumab-fkjp interactionAlefaceptAmevive
How Alefacept interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Alemtuzumab interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Aliskiren interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Aliskiren interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Alogliptin, Metformin interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Ambrisentan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Amiloride interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Amiloride, Hydrochlorothiazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Amlodipine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Amlodipine Benzoate interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Amlodipine Besilate interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Amlodipine Besylate interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Amlodipine Besylate, Benazepril interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Amlodipine, Celecoxib interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Ammonium Chloride interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ammonium Chloride interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Anifrolumab-fnia interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with ProBiota Immune — through 1 ingredient. Tap an ingredient for the detail:
Beta-glucanImmunosuppressants Moderate
Interaction Summary
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Read the full Beta-glucan + Antithymocyte Globulin interactionAprocitentanTryvio
How Aprocitentan interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Aprocitentan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Atenolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with ProBiota Immune — through 2 ingredients. Tap an ingredient for the detail:
Beta-glucanAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucan + Atenolol, Chlortalidone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Atenolol, Chlortalidone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in ProBiota Immune with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Beta-Glucan
Antihypertensive Drugs
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.
Immunosuppressants
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.
Brand information
Manufacturer and brand details for ProBiota Immune, from the product label.
Seeking Health
See all Seeking Health products- Name
- Seeking Health
- Street Address
- 3140 Mercer Ave
- City
- Bellingham
- State
- WA
- ZipCode
- 98225
- Phone Number
- (800) 547-9812
- Web Address
- www.seekinghealth.com
ProBiota Immune by Seeking Health: Common Questions
Does ProBiota Immune by Seeking Health interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does beta-glucan actually lower cholesterol?
Can I take this if I'm on blood pressure medication?
What's the difference between beta-glucans and galacto-oligosaccharides?
Are there any side effects I should watch for?
Is this safe during pregnancy?
Can I take this while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if ProBiota Immune is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind ProBiota Immune’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographBeta-glucans
Interacts with 293 drugsBeta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...
Read the full Beta-glucans monograph →Sources & How We Checked
ProBiota Immune's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 29 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Beta-glucans 11 references
- Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
- Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
- Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
- Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
- Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
- Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
- McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
- Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
- Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
- Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
- Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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