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Dietary supplement

Probiotic Acidophilus 2 mg Ingredients & Drug Interactions

by Nature's Truth

Probiotic Acidophilus 2 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Acidophilus 2 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Acidophilus 2 mg is a dietary supplement by Nature's Truth with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic Acidophilus 2 mg by Nature's Truth

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Acidophilus 2 mg by Nature's Truth — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic Acidophilus 2 mg by Nature's Truth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Probiotic Acidophilus 2 mg contains one active ingredient: Lactobacillus acidophilus, a live beneficial bacterium meant to support digestive health. The capsule also contains inactive ingredients — cellulose, gelatin, and magnesium stearate — that serve as the capsule material and a flow agent.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive wellness and microflora balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance.

The evidence shows Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It appears possibly ineffective for atopic disease (allergic conditions), and we don't have enough reliable evidence yet to rate it for acute respiratory distress syndrome (ARDS).

Talk with your doctor about whether this makes sense for what you're trying to address.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. However, because it contains live, active organisms, there is a small theoretical risk of infection in certain patients — though most documented cases appear to involve people who already had a reason the bacteria could move into the bloodstream.

When combined with other probiotics, some people report mild gastrointestinal side effects like bloating, gas, or mild stomach discomfort, but these are uncommon. The data on safety during pregnancy are limited but suggest it's possibly safe; safety information during breastfeeding isn't on file.

Check with your doctor before starting this product to make sure it's appropriate for your individual situation.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Probiotic Acidophilus 2 mg, check whether you're taking any antibiotic drugs (Moderate interaction). Antibiotics can kill the live organisms in this supplement and make it less effective, so you'll need to space them apart.

Ask your pharmacist or doctor how many hours apart to take them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, traveler's diarrhea after antibiotics, and certain other digestive concerns, though the evidence is preliminary. The main thing to watch for is timing — don't take it at the same time as antibiotics, since they'll kill each other off.

If you have a weakened immune system or any serious health condition, talk with your doctor first. Run any antibiotics you're on through the checker below before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Acidophilus 2 mg, straight from the product label.

Brand Nature's Truth
Net contents 100 Quick Release Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 306795
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Acidophilus 2 mg by Nature's Truth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Quick Release Capsule(s)
Maximum serving Sizes:
2 Quick Release Capsule(s)
Servings per container
50
IngredientAmount% DV
Lactobacillus acidophilus2 mg--

Other ingredients: Cellulose, Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

500 Million CFU active cultures Nature's Truth Probiotic Acidophilus provides over 500 million active cultures per serving (including the naturally-occurring metabolic product produced by Lactobacilli) at the time of manufacture. Probiotic Acidophilus 2 mg per serving

Nature's Truth Probiotic Acidophilus provides 500 million active cultures per serving, which work to naturally colonize your intestines to support digestive wellness. As one of the most important probiotic strains for overall health and well-being, Acidophilus helps maintain the delicate microflora balance of the digestive tract. These quick-release capsules supply you with the Acidophilus you need to support optimal digestive health by encouraging proper nutrient absorption throughout the intestines.

Formulation

Gluten free Non GMO

Stomach friendly Digestive support Microflora balance

Non-GMO No gluten, wheat, soy, artificial color, artificial flavor, artificial sweetener, preservatives.

Microflora balance Stomach friendly

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) quick release capsules twice daily, preferably with meals.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

Keep out of reach of children.

Storage

Store unopened container in a cool, dry place. Refrigerate after opening.

Brand IP Statement(s)

Copyright 2021 Nature's Truth LLC

Seals/Symbols

Our non-GMO pledge Visit our website

General Statements

100% Satisfaction guarantee

Vitamins

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Acidophilus 2 mg by Nature's Truth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Acidophilus 2 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Acidophilus 2 mg by Nature's Truth

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Quick Release Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Lactobacillus acidophilus

Interacts with
182 drugs
2 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Other (inactive) ingredients: Cellulose, Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Acidophilus 2 mg by Nature's Truth Drug Interactions

Want to check YOUR meds against Probiotic Acidophilus 2 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Probiotic Acidophilus 2 mg interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Probiotic Acidophilus 2 mg interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Acidophilus 2 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Acidophilus 2 mg, from the product label.

Nature's Truth

See all Nature's Truth products
Name
Nature's Truth LLC
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-844-544-1030
Web Address
NaturesTruth.com
Pharmacist Counseling Corner

Probiotic Acidophilus 2 mg by Nature's Truth: Common Questions

Does Probiotic Acidophilus 2 mg by Nature's Truth interact with any medications?
Yes. Based on its ingredients, Probiotic Acidophilus 2 mg has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Acidophilus 2 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
When should I take this if I'm on an antibiotic?
Don't take them at the same time. The antibiotic will kill the live bacteria in the probiotic, and it won't work as well. Your doctor or pharmacist can tell you how many hours apart to space them — usually it's several hours or even a full day between doses. Check with your own healthcare provider for the best timing with your specific antibiotic.
Does this really help with IBS or diarrhea?
The evidence suggests it possibly helps with irritable bowel syndrome, antibiotic-associated diarrhea, and a couple of other conditions. But the data aren't conclusive yet, so results vary from person to person. It's worth trying if your doctor thinks it makes sense for you, but don't expect it to be a complete fix on its own.
What side effects might I get?
Most people tolerate it well. Uncommonly, when it's combined with other probiotics, people report mild digestive symptoms like bloating, gas, or mild stomach discomfort. There's also a small theoretical risk of infection from live organisms in immunocompromised people, though this is rare. If you have a weakened immune system, talk with your doctor before starting.
Is it safe to take during pregnancy?
The data suggest it's possibly safe during pregnancy, but the evidence is limited. Breastfeeding safety information isn't on file for this ingredient. Talk with your doctor or midwife before taking it while pregnant or nursing so you can make a decision that fits your situation.
Can I take this with food?
The product facts we have don't include guidance on whether to take it with or without food. Ask your pharmacist — that detail can affect how well the live organisms survive and work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Acidophilus 2 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Acidophilus 2 mg label
Go deeper

The Full Monographs Behind Probiotic Acidophilus 2 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic Acidophilus 2 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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