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Dietary supplement

Probiotic Acidophilus Ingredients & Drug Interactions

by Spring Valley

Probiotic Acidophilus label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Acidophilus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Acidophilus is a dietary supplement by Spring Valley with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus La-14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic Acidophilus by Spring Valley

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Acidophilus by Spring Valley — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic Acidophilus by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Spring Valley's Probiotic Acidophilus is a single-ingredient product: Lactobacillus acidophilus La-14, a live beneficial bacterium. This strain is meant to support your digestive tract and immune function.

The product also contains inactive ingredients — cellulose, silica, stearic acid, and vegetable magnesium stearate — which are fillers and binders that hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Necrotizing enterocolitis (NEC).

The evidence for Lactobacillus acidophilus supports its use in a few areas. It's possibly effective for irritable bowel syndrome (IBS), possibly effective for treating Helicobacter pylori infection, possibly effective for preventing antibiotic-associated diarrhea, and possibly effective for bacterial vaginosis.

For atopic disease (allergic conditions), the evidence suggests it's possibly ineffective. We don't have enough reliable evidence yet to rate it for acute respiratory distress syndrome (ARDS).

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. The most serious concern — though rare — is that the live organisms could theoretically cause an infection in people with a weakened immune system or certain underlying conditions; cases of bacteremia, sepsis, and other serious infections have been documented, though they're thought to be uncommon and often linked to bacteria moving from other parts of the body.

More commonly, some people experience mild gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea when taking this probiotic, especially if combined with other probiotics, but these are uncommon. Because safety data are limited, check with your doctor before starting, especially if you have a compromised immune system.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist about antibiotic medications you're currently taking or might take soon. Antibiotics (Moderate interaction) can reduce this probiotic's effectiveness, so timing matters.

Use the interaction checker below to look up your specific antibiotics.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Spring Valley's Probiotic Acidophilus may help with IBS, diarrhea related to antibiotics, and a few other conditions, though the evidence is modest. The main thing to watch: if you're taking antibiotics, time this probiotic separately so the antibiotic doesn't kill off the beneficial bacteria.

It's generally well tolerated, but because you're taking live organisms, run it by your doctor first — especially if your immune system is weakened.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Acidophilus, straight from the product label.

Brand Spring Valley
Barcode (UPC) 681131058551
Net contents 100 Caplet(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62991
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Acidophilus by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
UPC/BARCODE
681131058551
IngredientAmount% DV
Lactobacillus acidophilus La-1410 mg--

Other ingredients: Cellulose, Silica, Stearic Acid, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

FOR YOUR PROTECTION, DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

KEEP OUT OF REACH OF CHILDREN.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

2 Billion Active Cultures Per Caplet

DIGESTIVE HEALTH

If you are unhappy with this product, we'll replace it or refund your money.

Formula

Acidophilus is a probiotic, a beneficial bacteria that can help balance and support digestive and immune health.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Adults, take one caplet daily, with or without a meal.

Formulation

NO Gluten, Wheat, Milk or Milk Derivatives, Lactose, Sugar, Preservatives, Soy, Artificial Color, Artificial Flavor, Sodium (less than 5 mg per serving)

Storage

Store unopened container at room temperature 59(0)-86(0)F (15(0)-30(0)C). Keep bottle tightly closed. Refrigerate after opening.

Brand IP Statement(s)

QUALITY GUARANTEED Spring Valley products are produced under strict quality guidelines.

General

Item. No. 57759 B27614W 01A 108234

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Acidophilus by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Acidophilus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Acidophilus by Spring Valley

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Lactobacillus acidophilus La-14

Interacts with
182 drugs
10 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus La-14 monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Stearic Acid, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Acidophilus by Spring Valley Drug Interactions

Want to check YOUR meds against Probiotic Acidophilus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus La-14 182

Individual Drug Interactions

The ingredients in Probiotic Acidophilus interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Probiotic Acidophilus interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus La-14

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Acidophilus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus La-14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Acidophilus, from the product label.

Spring Valley

See all Spring Valley products
Name
Wal-Mart Stores, Inc.
City
Bentonville
State
AR
ZipCode
72716
Phone Number
1-866-251-1662
Web Address
Walmart.com/springvalley
Pharmacist Counseling Corner

Probiotic Acidophilus by Spring Valley: Common Questions

Does Probiotic Acidophilus by Spring Valley interact with any medications?
Yes. Based on its ingredients, Probiotic Acidophilus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Acidophilus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on an antibiotic?
Yes, but you'll need to time them carefully. Antibiotics can kill the live organisms in this product, making it less effective. Talk with your pharmacist about spacing them apart — often a few hours between doses works well.
What is Lactobacillus acidophilus and what does it do?
It's a beneficial bacterium (a probiotic) that naturally lives in your gut. The idea is that it helps support your digestive health and may ease symptoms of IBS, prevent antibiotic-associated diarrhea, and support other aspects of gut and immune function.
Is this safe if I'm pregnant or breastfeeding?
Lactobacillus acidophilus is rated possibly safe during pregnancy. We don't have safety data for breastfeeding on file, so talk with your doctor or pharmacist about whether it's right for you while nursing.
What side effects might I notice?
Most people tolerate it well. A small number of people experience mild gas, bloating, abdominal discomfort, or loose stool, especially when first taking it or when combining it with other probiotics. These effects are usually uncommon and temporary.
Does this really work for IBS or diarrhea?
The evidence suggests it's possibly effective for IBS and for diarrhea caused by antibiotics, as well as for a couple of other conditions. The evidence isn't rock solid, but it's reasonable enough that many people and doctors consider it worth trying.
Is this safe for people with a weakened immune system?
That's something to discuss with your doctor first. Although serious infections from this probiotic are very rare, they have been documented in people with severely compromised immunity. Because the evidence is limited, your doctor is the best person to weigh the risks and benefits for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Acidophilus is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Acidophilus label
Go deeper

The Full Monographs Behind Probiotic Acidophilus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic Acidophilus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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