Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

ProtoDophilus Woman 20 Billion Ingredients & Drug Interactions

by Protocol For Life Balance

ProtoDophilus Woman 20 Billion label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ProtoDophilus Woman 20 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ProtoDophilus Woman 20 Billion is a dietary supplement by Protocol For Life Balance with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus La-14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ProtoDophilus Woman 20 Billion by Protocol For Life Balance

Ask about any prescription or over-the-counter medication and we check it for interactions with ProtoDophilus Woman 20 Billion by Protocol For Life Balance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ProtoDophilus Woman 20 Billion by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Blend of Probiotic Bacteria” is a proprietary blend — the label doesn't break down how much of each component you get.

ProtoDophilus Woman 20 Billion delivers three live probiotic bacterial strains in each capsule: Lactobacillus acidophilus La-14, Bifidobacterium animalis lactis HN019, and Lactobacillus rhamnosus HN001. These are the active ingredients — the ones meant to support your gut health.

The capsule also contains microcrystalline cellulose, hypromellose, magnesium stearate, and silicon dioxide, which are inactive ingredients used to hold the formula together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports vaginal health and reduces bloating.
  • We looked for evidence on: Bacterial vaginosis, Vaginal candidiasis, Antibiotic-associated diarrhea, Lactose intolerance, Urogenital health, Digestive comfort — and 1 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis.
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Lactose intolerance, Vaginal candidiasis.

The evidence for Lactobacillus acidophilus La-14 — one of the three strains in this product — shows it may help with irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. For the other two strains in this blend, we don't hold effectiveness ratings in our data.

Since this is a combination product, the overall benefit depends on all three strains working together, and we have limited data on how the blend performs as a whole.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. That said, since it contains live microorganisms, there's some theoretical concern about infection in certain patients — though most documented cases involve people with serious underlying conditions.

Oral use may occasionally cause mild gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea, but these are uncommon. Because the data are limited, check with your doctor or pharmacist before starting, especially if you have a compromised immune system or serious illness.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take ProtoDophilus Woman 20 Billion, check your antibiotic medications using the tool on this page. Antibiotics are the main documented concern — they can reduce the effectiveness of the Lactobacillus acidophilus in the product.

For the other two probiotic strains, we don't hold interaction data yet, so running through your full medication list is especially important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic blend may be worth considering if you're dealing with IBS, diarrhea after antibiotics, or certain bacterial infections — the evidence for at least one strain is encouraging. If you take antibiotics, space them out from this product so the pills don't interfere with each other.

Talk to your pharmacist or doctor first, particularly if you have a weakened immune system or are taking multiple medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ProtoDophilus Woman 20 Billion, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359129061
Net contents 50 Veg Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 326469
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Pregnant Women, Girls: (All), Adult Female (18 - 50 Years), Lactating
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ProtoDophilus Woman 20 Billion by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
50
UPC/BARCODE
707359129061
IngredientAmount% DV
Blend of Probiotic Bacteria0 NP--
Bifidobacterium animalis lactis HN0190 NP--
Lactobacillus rhamnosus HN0010 NP--
Lactobacillus acidophilus La-140 NP--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 capsule daily, or as directed by your healthcare practitioner.

Storage

Refrigerate to maintain potency.

Formula

How it works: ProtoDophilus Woman has been specially formulated using three clinically tested probiotic strains to support women's health through every stage of life. This product features L. rhamnosus HN001 and L. acidophilus La-14 which have been shown to colonize the vaginal tract and help to maintain healthy vaginal pH when taken orally. The HN019 and HN001 probiotic strains have been shown to support healthy immune system function in women of all ages, including pregnant and nursing women. HN019 also supports GI regularity and reduces occasional gas and bloating.

Precautions

Caution/interactions: Consult physician if pregnant/nursing, taking medication (especially immune-suppressing drugs), or have a medical condition (especially if immune system is compromised).

Keep out of reach of children.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

The probiotic strains in this product have been identity-verified using DNA-fingerprinting technology.

Supports vaginal health Reduces occasional bloating

Vegetarian/vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Strain Verified

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ProtoDophilus Woman 20 Billion by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ProtoDophilus Woman 20 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ProtoDophilus Woman 20 Billion by Protocol For Life Balance

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Blend of Probiotic Bacteria

0 NP per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

ProtoDophilus Woman 20 Billion by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against ProtoDophilus Woman 20 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus La-14 182

Individual Drug Interactions

The ingredients in ProtoDophilus Woman 20 Billion interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in ProtoDophilus Woman 20 Billion interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus La-14

Each ingredient & the kinds of drugs it affects

For each ingredient in ProtoDophilus Woman 20 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus La-14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ProtoDophilus Woman 20 Billion, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
protocolforlife.com
Pharmacist Counseling Corner

ProtoDophilus Woman 20 Billion by Protocol For Life Balance: Common Questions

Does ProtoDophilus Woman 20 Billion by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, ProtoDophilus Woman 20 Billion has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ProtoDophilus Woman 20 Billion contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
You can, but timing matters. Antibiotics can kill the live bacteria in this supplement, making it less effective. Try to take them a few hours apart — ask your pharmacist for the best spacing for your specific antibiotic.
What's the difference between the three bacterial strains in here?
Each strain may support your gut in slightly different ways. Lactobacillus acidophilus has the most research behind it for IBS, antibiotic-associated diarrhea, and related issues. We don't have specific effectiveness data on the other two strains in this product.
Will this give me side effects?
Most people tolerate it well, but some experience mild bloating, gas, or loose stools — these are uncommon and usually temporary. Since it contains live organisms, people with very weak immune systems should check with their doctor first.
Is this safe during pregnancy or breastfeeding?
We don't have pregnancy or breastfeeding safety data on file for any of the strains in this product. Talk to your doctor or midwife before taking it while pregnant or nursing.
How many active ingredients are in this?
Three: Lactobacillus acidophilus La-14, Bifidobacterium animalis lactis HN019, and Lactobacillus rhamnosus HN001. The rest of what's in the capsule is inactive — just fillers and binders.
Does this actually work?
For Lactobacillus acidophilus, the evidence suggests it may help with IBS, antibiotic-associated diarrhea, and a couple of other issues. The evidence is encouraging but not definitive. We don't have established effectiveness data for the other two strains.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ProtoDophilus Woman 20 Billion is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ProtoDophilus Woman 20 Billion label
Go deeper

The Full Monographs Behind ProtoDophilus Woman 20 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

ProtoDophilus Woman 20 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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