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Dietary supplement

L-Glutamine 1000 mg Ingredients & Drug Interactions

by Protocol For Life Balance

Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

L-Glutamine 1000 mg is a dietary supplement by Protocol For Life Balance with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Glutamine 1000 mg by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine at 1000 mg per capsule. Glutamine is an amino acid — one of the building blocks your body uses to make proteins.

The capsule also contains inactive ingredients (binders and fillers): hypromellose, hydroxypropyl cellulose, stearic acid, magnesium stearate, and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune system and gastrointestinal health.
  • We looked for evidence on: Antiretroviral-associated diarrhea, Chemotherapy-induced diarrhea, Chemotherapy-induced lymphocytopenia, Crohn disease, Cystic fibrosis, HIV/AIDS-related wasting — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Pancreatitis.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Crohn disease.

The evidence supports L-glutamine as effective for sickle cell disease. For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the data we hold rates it as possibly effective — meaning there's some evidence, but it's not as robust as we'd like.

If you're considering it for one of these uses, talk with your doctor about whether the current evidence supports it for your specific situation.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, L-glutamine is generally well tolerated in healthy adults. Common side effects from trials include belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, gastrointestinal pain, headache, cough, and musculoskeletal pain — most mild.

Dizziness and headache have been reported. Two patients with bipolar disorder reported mania and hypomania at doses up to 4 grams daily, though this is rare.

If you have kidney or liver disease, use it only under medical supervision. The safety data during pregnancy is rated likely safe, but during breastfeeding there isn't enough reliable information — talk with your doctor or pharmacist before taking supplemental doses while nursing.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your anticonvulsant medications (seizure drugs) with your pharmacist before starting. Theoretically, glutamine might reduce their effectiveness, though this hasn't been seen in patients yet.

It's still worth verifying with your exact medication.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-Glutamine might be worth considering if you have sickle cell disease or are recovering from surgery or critical illness, though the evidence for the last two is still developing. If you take anticonvulsant medications, check with your pharmacist first.

People with kidney or liver disease should only use it under a doctor's watch.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutamine 1000 mg, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359100947
Net contents 120 Veg Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 326448
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutamine 1000 mg by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
120
UPC/BARCODE
707359100947
IngredientAmount% DV
L-Glutamine1 Gram(s)--

Other ingredients: Hypromellose, Hydroxypropyl Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule 1 to 3 times daily, or as directed by your healthcare practitioner.

Formula

How it works: L-Glutamine, the most abundant amino acid in the body, is an important constituent of proteins and participates in many key metabolic processes. Glutamine helps to regulate acid/base balance, maintains nitrogen balance, and acts as a nitrogen reservoir for the production of other amino acids. It also serves as an important energy source for certain cell types, such as gut, immune, and kidney cells. Glutamine is known to support gastrointestinal integrity, normal immune system function, and the preservation of muscle tissue.

Precautions

Cautions/Interactions: L-Glutamine may interact with lactulose, anti-convulsant medications, and chemotherapy agents. If you are taking any of these medications or if you are pregnant/lactating, if you have an MSG hypersensitivity, a kidney condition, a seizure disorder, bipolar disorder, or impaired liver function, consult your healthcare practitioner before using this product.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Supports a healthy immune system Promotes gastrointestinal health

Non-GMO

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

A Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

L-Glutamine 1000 mg by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Glutamine 1000 mg by Protocol For Life Balance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
1 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: Hypromellose, Hydroxypropyl Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutamine 1000 mg by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against L-Glutamine 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Glutamine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for L-Glutamine 1000 mg, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
protocolforlife.com
Pharmacist Counseling Corner

L-Glutamine 1000 mg by Protocol For Life Balance: Common Questions

Does L-Glutamine 1000 mg by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, L-Glutamine 1000 mg has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Glutamine 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-glutamine safe during pregnancy?
Yes — the safety data rates it as likely safe during pregnancy. That said, if you're pregnant and thinking about starting a supplement, it's smart to mention it to your doctor first so they can weigh it for your specific situation.
What about taking it while breastfeeding?
There isn't enough reliable safety information available about supplemental doses during breastfeeding. Talk with your doctor or pharmacist before taking it — they can give you personalized advice.
What are the most common side effects?
Belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting are the most common, along with gastrointestinal pain and headache. Most are mild. Dizziness has been reported in a few cases.
Does L-glutamine really work for sickle cell disease?
Yes — the evidence supports it as effective for sickle cell disease. For postoperative recovery and critical illness, the evidence is promising but less established.
Can I take this if I have liver or kidney disease?
Only under medical supervision. Talk with your doctor first — they can monitor you and adjust the dose if needed.
What is glutamine and why is it in this supplement?
Glutamine is an amino acid — a building block your body uses to make proteins and fuel cells. Your body makes some naturally, but supplementing with extra may support recovery from surgery, critical illness, or certain diseases like sickle cell.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Glutamine 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutamine 1000 mg label
Go deeper

The Full Monographs Behind L-Glutamine 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Glutamine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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