Prune Senna Concentrate Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Prune Senna Concentrate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Prune Senna Concentrate is a dietary supplement by Mason Natural with 3 active ingredients. Its ingredients are commonly taken for short-term constipation relief, bowel cleansing before procedures, occasional irregularity.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Senna leaf powder, Prune fruit powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Prune Senna Concentrate by Mason Natural
Ask about any prescription or over-the-counter medication and we check it for interactions with Prune Senna Concentrate by Mason Natural — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Prune Senna Concentrate by Mason Natural
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has three active ingredients: senna leaf powder, prune fruit powder, and a senna 20% extract. Senna is a stimulant laxative — it works by speeding up movement through your bowel.
Prune is a well-known natural source of fiber and compounds that support bowel regularity. Together, they're designed to help with constipation.
Does it work?
Strong evidence
Senna is likely effective for constipation and possibly effective for bowel preparation before medical procedures. Prune fruit powder is possibly effective for constipation.
The product hasn't been rated for other uses like lowering cholesterol or supporting bone density — the evidence either isn't there or isn't strong enough to say.
How safe is it?
Well-documented data
Senna is generally well tolerated when used short-term in normal doses, but it's not meant for daily long-term use without a doctor's okay. Short-term use under medical guidance is often considered acceptable.
The most common side effects are belly pain and cramping, diarrhea, gas, nausea, and urgent need for a bowel movement — your urine may also change color. Rare serious effects include skin reactions; very heavy use has been linked to unusual symptoms like finger clubbing and muscle weakness.
Prune is generally safe in normal food amounts. There isn't enough safety data on concentrated prune supplements in pregnancy and breastfeeding, so talk with your doctor or pharmacist if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Check with your pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin in high doses, others) — both ingredients may increase bleeding and bruising risk. Also flag diuretics (water pills), digoxin (a heart medication), or estrogen-based birth control or hormone therapy before you start, and don't combine this with other stimulant laxatives.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product works best as a short-term constipation aid, not a daily habit. If you take any blood thinners, heart medications, water pills, or hormone therapy, check with your pharmacist first — senna and prune both have real interactions here.
Don't use this alongside other laxatives. Talk to your doctor if you're planning to use it regularly.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Prune Senna Concentrate, straight from the product label.
| Brand | Mason Natural |
|---|---|
| Barcode (UPC) | 311845169112 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 244609 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Prune Senna Concentrate by Mason Natural, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Senna leaf powder | 100 mg | -- |
| Prune fruit powder | 60 mg | -- |
| Senna 20% extract | 57.7 mg | -- |
Other ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
Mason Guarantee Laboratory tested cGMP Certified Good Manufacturing Practice
General Statements
Certified N
Mason natural Est. 1967
Please recycle
Formulation
May support digestive health & regularity
Guaranteed no added: Wheat, gluten, soy, egg, milk, peanuts, tree nuts, fish, shellfish.
Gluten free Soy free
Manufactured in the USA for: Mason Vitamins, Inc.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Adults - Take one capsule at bedtime or when desired. Limit use to no more than one week.
FDA Disclaimer Statement
This statement has not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Warning: Not to be taken when abdominal pain, nausea or vomiting are present, consult your physician before using this product. If you have noticed a sudden change in bowel habits that persist over a week, discontinue usage.
Caution: If you are pregnant, nursing, taking any medications or have a medical condition, consult your physician before use.
Discontinue use and consult your physician if any adverse reactions occur.
Keep out of reach of children.
Tamper-evident seal: Do not use product if seal appears tampered.
Storage
Store in a dry place under controlled room temperature: 20 degrees - 25 degrees C (68 degrees - 77 degrees F).
Brand IP Statement(s)
Mason Natural is a registered trademark and does not refer to any product or ingredient claim.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Prune Senna Concentrate by Mason Natural label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Prune Senna Concentrate by Mason Natural
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Senna leaf powder
Interacts with140 drugs
Senna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasiona...
Senna leaf powder monograph & interactionsPrune fruit powder
Interacts with122 drugs
Plums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbit...
Prune fruit powder monograph & interactionsSenna 20% extract
Interacts with140 drugs
Senna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasiona...
Senna 20% extract monograph & interactionsOther (inactive) ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.
Prune Senna Concentrate by Mason Natural Drug Interactions
HelloPharmacist Interaction Report
Mason Natural's Prune Senna Concentrate contains two active ingredients — senna and prune — both of which have documented interactions with medications.
The most serious concern is with blood thinners (anticoagulants) like warfarin: the senna in this product can cause diarrhea, which increases how your blood thinner works and raises your bleeding risk. If you take warfarin, talk to your pharmacist before starting this.
Read the full breakdown — every affected drug type, severity by severity
Senna also interacts with diuretics (water pills), which raises the risk of low potassium (hypokalemia), and with digoxin, a heart medication — again through potassium depletion. It may reduce how well estrogen-based birth control or hormone therapy is absorbed.
Senna shouldn't be combined with other stimulant laxatives because of compounded fluid and electrolyte loss. Prune fruit powder has a separate documented interaction with blood thinners and antiplatelet drugs (like aspirin in high doses), which may increase bleeding and bruising risk.
Altogether, these interactions span 260 individual medications. Use the medication checker on this page to look up your exact prescriptions and over-the-counter drugs before taking this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Prune Senna Concentrate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Prune Senna Concentrate interact with 260 drugs. Click any drug to see the details.
2 of the 3 ingredients in Prune Senna Concentrate interact with drugs. Each result below shows which ingredient is responsible. Senna leaf powder Prune fruit powder
AbciximabReoPro
How Abciximab interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Senna 20% ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Senna 20% Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Senna 20% ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Senna 20% Extract + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Senna 20% ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Senna 20% Extract + Acetazolamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Acetylsalicylic Acid interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Senna 20% ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Senna 20% Extract + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Senna 20% ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Senna 20% Extract + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Argatroban interactionArmodafinilNuvigil
How Armodafinil interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Senna 20% ExtractStimulant Laxatives Moderate
Interaction Summary
Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Read the full Senna 20% Extract + Armodafinil interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Prune Senna Concentrate — through 1 ingredient. Tap an ingredient for the detail:
Prune Fruit PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, plum juice might have antiplatelet effects.
Read the full Prune Fruit Powder + Aspirin, Caffeine, Codeine Phosphate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Prune Senna Concentrate with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Senna leaf powder
Digoxin (Lanoxin)
Theoretically, senna might increase the risk of adverse effects when taken with digoxin.
Overuse/abuse of senna increases the risk of adverse effects from cardiac glycosides, such as digoxin, due to potassium depletion.
Diuretic Drugs
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of senna might compound diuretic-induced potassium loss and increase the risk for hypokalemia.
Estrogens
Theoretically, taking senna may interfere with the absorption of exogenous estrogens.
Some preliminary clinical evidence suggests that senna reduces the absorption of estradiol and decreases serum concentrations of estrone and estrone sulfate by decreasing intestinal transit time.
Stimulant Laxatives
Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Senna is a stimulant laxative; concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, excessive use of senna might increase the effects of warfarin.
Senna has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. In one case report, excessive use of senna for 3 weeks resulted in diarrhea, bloody stools, and an elevated INR of 11.9.
Prune fruit powder
Anticoagulant/Antiplatelet Drugs
Theoretically, plum juice might have antiplatelet effects.
Consuming plum juice while taking anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding. In healthy volunteers, drinking plum juice 200 mL daily for 28 days prolonged clotting time and inhibited platelet aggregation.
Brand information
Manufacturer and brand details for Prune Senna Concentrate, from the product label.
Mason Natural
See all Mason Natural products- Name
- Mason Vitamins, Inc.
- City
- Miami Lakes
- State
- FL
- ZipCode
- 33014
- Phone Number
- 1-888-860-5376
- Web Address
- www.MasonVitamins.com
Prune Senna Concentrate by Mason Natural: Common Questions
Does Prune Senna Concentrate by Mason Natural interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to use every day?
Can I take this with my birth control?
What side effects should I expect?
Does prune really help with constipation?
Can I take this if I'm pregnant or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Prune Senna Concentrate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Prune Senna Concentrate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Senna
Interacts with 140 drugsSenna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasionally and for only a few days at a time, s...
Read the full Senna monograph → Herb & supplement monographPlum
Interacts with 122 drugsPlums and their dried form (prunes) are common, nutritious foods that are best known for helping relieve constipation thanks to their fiber and sorbitol content. They are generally safe as f...
Read the full Plum monograph →Sources & How We Checked
Prune Senna Concentrate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 52 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Senna 42 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. PubMed
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Seybold U, Landauer N, Hillebrand S, Goebel FD. Senna-induced hepatitis in a poor metabolizer. Ann Intern Med 2004;141:650-1. PubMed
- Vanderperren B, Rizzo M, Angenot L, et al. Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides. Ann Pharmacother 2005;39:1353-7. PubMed
- Xing JH, Soffer EE. Adverse effects of laxatives. Dis Colon Rectum 2001;44:1201-9. PubMed
- Prior J, White I. Tetany and clubbing in patient who ingested large quantities of senna. Lancet 1978;2:947. PubMed
- Langmead L, Rampton DS. Review article: herbal treatment in gastrointestinal and liver disease--benefits and dangers. Aliment Pharmacol Ther 2001;15:1239-52. PubMed
- Joo JS, Ehrenpreis ED, Gonzalez L, et al. Alterations in colonic anatomy induced by chronic stimulant laxatives: the cathartic colon revisited. J Clin Gastroenterol 1998;26:283-6. PubMed
- Godding EW. Laxatives and the special role of senna. Pharmacology 1988;36:230-6. PubMed
- van Os FH. Anthraquinone derivatives in vegetable laxatives. Pharmacology 1976;14:7-17. PubMed
- Sondheimer JM, Gervaise EP. Lubricant versus laxative in the treatment of chronic functional constipation of children: a comparative study. J Pediatr Gastroenterol Nutr 1982;1:223-6. DOI
- Perkin JM. Constipation in childhood: a controlled comparison between lactulose and standardized senna. Curr Med Res Opin 1977;4:540-3. PubMed
- Shelton MG. Standardized senna in the management of constipation in the puerperium: A clinical trial. S Afr Med J 1980;57:78-80.
- [No authors listed] Senna in the puerperium. Pharmacology 1992;44:23-5. PubMed
- Passmore AP, Davies KW, Flanagan PG, et al. A comparison of Agiolax and lactulose in elderly patients with chronic constipation. Pharmacology 1993;47:249-52. PubMed
- Passmore AP, Wilson-Davies K, Stoker C, Scott ME. Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ 1993;307:769-71. PubMed
- MacLennan WJ, Pooler AFWM. A comparison of sodium picosulphate ("Laxoberal") with standardised senna ("Senokot") in geriatric patients. Curr Med Res Opin. 1974;2:641-7. PubMed
- Kittisupamongkol W, Nilaratanakul V, Kulwichit W. Near-fatal bleeding, senna, and the opposite of lettuce. Lancet 2008;371:784. PubMed
- Prather CM. Pregnancy-related constipation. Curr Gastroenterol Rep 2004;6:402-4. PubMed
- Werthmann WM Jr, Krees SV. Quantitative excretion of Senokot in human breast milk. Med Ann Dist Columbia 1973;42:4-5.
- Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact 1998;14:259-62. PubMed
- Faber P, Strenge-Hesse A. Senna-containing laxatives: excretion in the breast milk? Geburtshilfe Frauenheilkd 1989;49:958-62.
- Faber P, Strenge-Hesse A. Relevance of rhein excretion into breast milk. Pharmacology 1988;36 Suppl 1:212-20. PubMed
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