Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

PS100 100 mg Ingredients & Drug Interactions

by Jarrow Formulas

PS100 100 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PS100 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PS100 100 mg is a dietary supplement by Jarrow Formulas with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PS100 100 mg by Jarrow Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with PS100 100 mg by Jarrow Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of PS100 100 mg by Jarrow Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

PS100 contains one active ingredient: phosphatidylserine at 100 mg per softgel. Phosphatidylserine is a naturally occurring compound found in cell membranes, thought to support brain function and cognitive health.

The capsule also contains several inactive ingredients — medium chain triglyceride, bovine gelatin, glycerin, water, sunflower lecithin, silicon dioxide, mixed tocopherols, and ascorbyl palmitate — which serve as the capsule shell and preservatives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: brain health and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Dementia, Alzheimer disease, memory, mental clarity — and 1 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Dementia.

The evidence for phosphatidylserine is mixed. It's rated possibly effective for age-related cognitive decline and Alzheimer disease, meaning there's some supportive evidence but it's not definitive.

For athletic performance, ADHD, general cognitive function, and dementia, the evidence is too limited or unreliable to rate it either way — we don't have enough good data to say whether it works for those uses.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety data is limited. The most common side effects from oral use are flatulence, gastrointestinal upset, headache, insomnia, and nausea — with gastrointestinal symptoms possible at doses around 200–300 mg daily and insomnia more likely at higher doses (around 600 mg).

There isn't enough safety information to use this supplement during pregnancy, so it's best to avoid it. Safety while breastfeeding is also unknown, so avoidance is recommended if you're nursing.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PS100, check with your pharmacist if you use anticholinergic drugs (like some antihistamines, antispasmodics, or medications for urinary symptoms) or cholinergic drugs (like some medications for myasthenia gravis or Alzheimer disease). Both carry Moderate interaction risk.

Use the medication search tool on this page to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PS100 may be worth considering if you're interested in supporting cognitive health, especially for age-related mental decline or Alzheimer disease. If you take anticholinergic or cholinergic medications, check with your pharmacist first.

Watch for headache, insomnia, or stomach upset when you start. Avoid it during pregnancy and while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PS100 100 mg, straight from the product label.

Brand Jarrow Formulas
Barcode (UPC) 790011160052
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 321959
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PS100 100 mg by Jarrow Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
790011160052
IngredientAmount% DV
Phosphatidylserine100 mg--

Other ingredients: Medium Chain Triglyceride, Bovine Gelatin, Glycerin, Water, Sunflower Lecithin, Silicon Dioxide, Mixed Tocopherols, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 softgel 1-3 times a day with a meal or as directed by your qualified healthcare professional.

Formula

Phosphatidylserine (PS) is a phospholipid that is a structural component of cell membranes. It is an important phospholipid present in the brain and supports brain health. Jarrow Formulas PS100 featuring Sharp-PS, utilize a concentrated form of phosphatidylserine from sunflower lecithin (soy-free) that offers excellent stability.

Phosphatidylserine Cogni-PS Phosphatidylserine Sharp-PS green

Precautions

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reaction occur, discontinue use.

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reaction occur, discontinue use. Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Sharp-PS is a registered trademark of IFF or its affiliates.

Copyright 2023 Jarrow Formulas

Formulation

Note: Color may vary from batch to batch.

Cognition Support Promotes brain health

Gluten free

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts or sesame.

General Statements

Brain health

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PS100 100 mg by Jarrow Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PS100 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PS100 100 mg by Jarrow Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Medium Chain Triglyceride, Bovine Gelatin, Glycerin, Water, Sunflower Lecithin, Silicon Dioxide, Mixed Tocopherols, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

PS100 100 mg by Jarrow Formulas Drug Interactions

Want to check YOUR meds against PS100 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in PS100 100 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in PS100 100 mg interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in PS100 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PS100 100 mg, from the product label.

Jarrow Formulas

See all Jarrow Formulas products
Name
Jarrow Formulas, Inc.
City
Sherman Oaks
State
CA
ZipCode
91403
Phone Number
1-866-459-4154
Web Address
www.Jarrow.com
Pharmacist Counseling Corner

PS100 100 mg by Jarrow Formulas: Common Questions

Does PS100 100 mg by Jarrow Formulas interact with any medications?
Yes. Based on its ingredients, PS100 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PS100 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's phosphatidylserine, and why is it in this supplement?
Phosphatidylserine is a natural compound that's a building block of cell membranes, especially in the brain. It's thought to support brain function and cognitive health, which is why it's used in supplements aimed at memory and mental sharpness.
Can I take this if I'm pregnant or breastfeeding?
No. There isn't enough safety data to use phosphatidylserine during pregnancy, so avoidance is recommended. The same goes for breastfeeding — safety is unknown, so it's best to skip it if you're nursing. Talk with your doctor or pharmacist if you have questions about your specific situation.
What side effects might I get from this supplement?
The most common ones are flatulence, stomach upset, nausea, headache, and insomnia. Stomach problems can show up at doses around 200–300 mg daily, and insomnia is more likely with higher doses. Most people tolerate it well, but long-term safety data is limited.
Does phosphatidylserine actually work for memory or cognitive decline?
The evidence is mixed. It's rated possibly effective for age-related cognitive decline and Alzheimer disease — meaning there's some support, but it's not definitive. For other uses like ADHD or general cognitive function, we don't have enough reliable data to say whether it works.
Why do I need to check my anticholinergic or cholinergic medications before taking this?
Phosphatidylserine is thought to increase acetylcholine levels in your body. Anticholinergic drugs block acetylcholine, so phosphatidylserine may make them less effective. Cholinergic drugs boost acetylcholine, so together they might cause too much cholinergic activity. Your pharmacist can check your specific medications to see if there's a real concern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PS100 100 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PS100 100 mg label
Go deeper

The Full Monographs Behind PS100 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

PS100 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team