Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Energy Optimizer Ingredients & Drug Interactions

by Jarrow Formulas

Energy Optimizer label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Energy Optimizer against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Energy Optimizer is a dietary supplement by Jarrow Formulas with 7 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 1,449 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Reishi, Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Energy Optimizer by Jarrow Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Energy Optimizer by Jarrow Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Energy Optimizer by Jarrow Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “PeakO2” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Energy Optimizer contains seven active ingredients. PeakO2 is a blend whose component ingredients are detailed separately in the product.

The formula also includes lion's mane mushroom, reishi, cordyceps, King Trumpet mushroom, shiitake mushroom, and ashwagandha (under the brand name Sensoril). These are complemented by inactive ingredients including microcrystalline cellulose, hydroxypropyl methylcellulose, myceliated oats, silicon dioxide, and magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support body's everyday vitality and energy.
  • We looked for evidence on: Fatigue, Athletic performance, Cognitive function, Stress, Aging, Endurance — and 2 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Cordyceps is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

The evidence for most ingredients in this formula is limited. Ashwagandha is rated possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder.

For lion's mane, cordyceps, King Trumpet, and shiitake, the effectiveness ratings we hold show either insufficient reliable evidence (for conditions like cognitive function, athletic performance, and cancer) or possibly ineffective (cordyceps for athletic performance, shiitake for dental plaque). We have no effectiveness data on file for reishi or for PeakO2 and Turkey Tail.

The evidence, ingredient by ingredient Lion's Mane Mushroom Reishi Mushroom Cordyceps Shiitake Mushroom Ashwagandha

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane, cordyceps, and King Trumpet are each generally well tolerated as foods, though long-term supplement safety is not well studied. The most common side effects from these mushrooms are gastrointestinal—discomfort, nausea, or diarrhea.

Shiitake is generally safe as a cooked food but concentrated supplements lack sufficient safety data; raw shiitake can cause a skin rash called shiitake dermatitis. Ashwagandha is generally well tolerated short-term, though gastrointestinal upset, diarrhea, nausea, and drowsiness can occur.

Rare but serious cases of acute liver injury have been reported with ashwagandha. During pregnancy, the safety data advises against lion's mane, cordyceps, King Trumpet, and ashwagandha.

For breastfeeding, there is not enough safety data for lion's mane, cordyceps, King Trumpet, or ashwagandha, so talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Lion's Mane Mushroom Reishi Mushroom Cordyceps Shiitake Mushroom Ashwagandha

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Cordyceps, Shiitake Mushroom, Reishi Mushroom, Ashwagandha, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,450 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Energy Optimizer, double-check these medication types: central nervous system depressants (sedatives, anxiolytics) and benzodiazepines (Moderate risk); blood pressure medications, diabetes drugs, and immune-suppressing drugs (Moderate risk); thyroid hormone and drugs that may harm the liver (Moderate risk); drugs metabolized by the CYP2D6 enzyme (Moderate risk); blood thinners and antiplatelet drugs (Moderate risk); and testosterone products (Minor risk). No interactions are documented for reishi or Turkey Tail, as we hold no data for these ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Energy Optimizer may appeal to people seeking support for energy and mental clarity, but it's not right for everyone. If you take any blood thinners, diabetes medications, blood pressure drugs, benzodiazepines, immune-suppressing drugs, thyroid hormone, or sedatives, you need to check your exact medications with our tool before starting—the interactions are real and could affect how your drugs work.

Talk to your pharmacist first, especially if you're pregnant, breastfeeding, or taking other supplements.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Energy Optimizer, straight from the product label.

Brand Jarrow Formulas
Barcode (UPC) 790011350019
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 321944
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Energy Optimizer by Jarrow Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
790011350019
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
PeakO21000 mg--
Lion's Mane0 NP--
Reishi0 NP--
Cordyceps 0 NP--
King Trumpet0 NP--
Shiitake0 NP--
Sensoril250 mg--
Turkey Tail0 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, myceliated Oats, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take 3 capsules once a day or as directed by your qualified healthcare professional.

Formula

Support your body's everyday vitality. Jarrow Formulas Energy Optimizer features an energizing mushroom blend of fruiting bodies and mycelium (cordyceps, Reishi, Lion's Mane, Shiitake, King Trumpet, and Turkey Tail) to support energy, endurance and vitality. Combined with Sensoril Ashwagandha, an adaptogen derived from the Withania somnifera plant known for its rejuvenating properties to support energy by helping to reduce occasional fatigue.

Sensoril PeakO2

Mushrooms adaptogens Mycelium & fruiting bodies

Precautions

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use.

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use. Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Sensoril vitalizing mind & body Sensoril is a registered trademark of Kerry Group. PeakO2 is protected by patents pending owned by Disruptive Nutrition, LLC and under exclusive global distribution by Compound Solutions, Inc.

Copyright 2023 Jarrow Formulas

Formulation

Vegan

Gluten free

No major allergens.

FDA Statement of Identity

Dietary Supplement

General Statements

Energy

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Energy Optimizer by Jarrow Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Energy Optimizer label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Energy Optimizer by Jarrow Formulas

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

PeakO2

1000 mg per serving

Sensoril

Interacts with
1,372 drugs
250 mg per serving Form: Ashwagandha Leaf, Root Extract

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Myceliated Oats, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Energy Optimizer by Jarrow Formulas Drug Interactions

Want to check YOUR meds against Energy Optimizer?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,449Drugs
1,079 Moderate 370 Minor

Ingredients driving the most interactions

Sensoril 1,372
Reishi 375
Lion's Mane 327
Shiitake 312
Cordyceps 249

Individual Drug Interactions

The ingredients in Energy Optimizer interact with 1,449 drugs. Click any drug to see the details.

5 of the 7 ingredients in Energy Optimizer interact with drugs. Each result below shows which ingredient is responsible. Sensoril Reishi Lion's Mane Shiitake Cordyceps

Each ingredient & the kinds of drugs it affects

For each ingredient in Energy Optimizer with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril full monograph & interactions

Reishi3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi full monograph & interactions

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions

Shiitake2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake full monograph & interactions

Cordyceps 3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Energy Optimizer, from the product label.

Jarrow Formulas

See all Jarrow Formulas products
Name
Jarrow Formulas, Inc.
City
Sherman Oaks
State
CA
ZipCode
91403
Phone Number
1-866-459-4154
Web Address
www.Jarrow.com
Pharmacist Counseling Corner

Energy Optimizer by Jarrow Formulas: Common Questions

Does Energy Optimizer by Jarrow Formulas interact with any medications?
Yes. Based on its ingredients, Energy Optimizer has a known interaction with 1,449 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Energy Optimizer contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product help my energy and focus?
Ashwagandha in this formula is rated possibly effective for stress and anxiety, which can support overall wellbeing. For the other ingredients—lion's mane, cordyceps, King Trumpet, and shiitake—we don't have reliable evidence of their effectiveness for energy or focus. The evidence is either insufficient or, in cordyceps' case for athletic performance, possibly ineffective.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against lion's mane, cordyceps, King Trumpet, and ashwagandha during pregnancy. For breastfeeding, there's not enough safety information for these ingredients either. Talk with your doctor or pharmacist about whether this product is right for you at this time.
What side effects might I experience?
The most common side effects are gastrointestinal: discomfort, nausea, diarrhea, bloating, or constipation. Ashwagandha may cause drowsiness. Shiitake can rarely cause a skin rash if consumed raw. Most people tolerate the mushroom ingredients well, but if you experience persistent stomach upset or any unusual symptoms, stop and talk to your pharmacist.
Is this safe to take long-term?
Ashwagandha has been studied short-term in healthy adults and is generally well tolerated, but long-term safety data are limited. The mushroom ingredients are generally well tolerated as foods, but their safety in concentrated supplement form long-term is not well established. Quality varies widely among products. If you plan to take this regularly, check in with your pharmacist.
Why do I need to check my medications before starting?
This formula contains ingredients that interact with many common medications—blood thinners, diabetes drugs, blood pressure medications, sedatives, benzodiazepines, immune-suppressing drugs, and thyroid hormone among others. These interactions can change how your medications work or raise the risk of side effects. Use the checker on this page to verify your specific drugs.
What are the inactive ingredients, and are there fillers?
The product contains microcrystalline cellulose, hydroxypropyl methylcellulose, myceliated oats, silicon dioxide, and magnesium stearate—these are standard inactive ingredients (binders, flow agents, and capsule material). Yes, there are inactive ingredients, which is typical for capsule supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Energy Optimizer label
Go deeper

The Full Monographs Behind Energy Optimizer’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph →
Sources

Sources & How We Checked

Energy Optimizer's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 136 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
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Cordyceps 14 references
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Shiitake Mushroom 67 references
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Ashwagandha 32 references
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