Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Pure C8 MCT Oil Unflavored Ingredients & Drug Interactions

by Natural Force

Pure C8 MCT Oil Unflavored label
See full label image
Liquid Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure C8 MCT Oil Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure C8 MCT Oil Unflavored is a dietary supplement by Natural Force with 3 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 295 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Caprylic Acid, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pure C8 MCT Oil Unflavored by Natural Force

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure C8 MCT Oil Unflavored by Natural Force — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pure C8 MCT Oil Unflavored by Natural Force

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.
  • “Medium Chain Triglycerides” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Pure C8 MCT Oil contains 2 active ingredients: sodium and caprylic acid, which is a medium-chain saturated fat found naturally in coconut and palm oils. Caprylic acid is one type of MCT (medium-chain triglyceride) — a fat that's absorbed and processed differently than longer-chain fats.

The product also contains inactive ingredients including additional MCT oil as an excipient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: energy and brain fuel for ketosis.
  • We looked for evidence on: Epilepsy, cognitive function, metabolic health.
  • The closest evidence on file: Caprylic Acid is rated "Insufficient Reliable Evidence To Rate" for Epilepsy (Natural Medicines).

The data we hold does not establish effectiveness for caprylic acid as a supplement — evidence for epilepsy and essential tremor is insufficient to rate. Sodium has established uses in medical settings for certain conditions like cystic fibrosis (likely effective) and as a supportive treatment with amphotericin B (possibly effective), but these are clinical applications, not supplement roles.

For the purposes of this product as a general dietary supplement, effectiveness has not been established in our data.

The evidence, ingredient by ingredient Sodium Caprylic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is essential in small amounts, but too much is linked to high blood pressure and heart strain. Normal dietary sodium is fine, but avoid sodium supplements or very high intake without medical advice — chronic high intake increases the risk of high blood pressure, worsening kidney disease, and heart problems.

Caprylic acid seems well tolerated short-term in food amounts; mild abdominal discomfort and change in taste are the most common side effects reported, with rare reports of dizziness, headache, and fatigue. However, supplement doses of caprylic acid are less well studied than food amounts.

For pregnancy and lactation, sodium is rated possibly unsafe — talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Sodium Caprylic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Caprylic Acid, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 295 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any blood pressure medications (antihypertensives) — sodium can reduce their effectiveness. Also flag lithium, corticosteroids, blood thinners like warfarin, NSAIDs like ibuprofen or naproxen, didanosine, sodium phosphate products, or tolvaptan, as well as any other sodium-containing drugs or supplements.

All carry moderate-severity interaction risks with the sodium and caprylic acid in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is high in sodium, so it's not appropriate for anyone taking blood pressure medications, lithium, or corticosteroids without checking with their doctor first. If you take any prescription medications — especially those managing blood pressure, heart rhythm, or blood thinning — review them against this product's interaction data before starting.

Talk it over with your doctor or pharmacist to confirm it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure C8 MCT Oil Unflavored, straight from the product label.

Brand Natural Force
Barcode (UPC) 815044020613
Net contents 32 fl. Oz.; 946 mL
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 272680
Product type Fat/fatty Acid
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure C8 MCT Oil Unflavored by Natural Force, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 mL
Maximum serving Sizes:
15 mL
Servings per container
63
UPC/BARCODE
815044020613
IngredientAmount% DV
Calories125 Calorie(s)--
Total Carbohydrates0 Gram(s)--
Sodium0 Gram(s)--
Cholesterol0 Gram(s)--
Caprylic Acid130000 mg--
Total Sugars0 Gram(s)--
Total Fat14 Gram(s)22%
Saturated Fat14 Gram(s)70%
Protein0 Gram(s)--
Medium Chain Triglycerides0 NP--

Other ingredients: Caprylic Acid, MCT Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

USDA Organic

Promotes Ketosis Instant Energy Brain Fuel

Non GMO Project Verified nongmoproject.org Gluten Free

Contains no palm oil.

Always free of: Unnecessary fillers, synthetic colors, anything artificial.

Every batch 3rd party tested. Manufactured in a cGMP certified facility.

Certified Organic by Quality Assurance International (OAI).

Product of the Philippines. Bottled in Canada

Certified Vegan Vegan.org

Seals/Symbols

USDA Organic

Keto Certified Ketocertified.com Non GMO Project Verified nongmoproject.org

Certified B Corporations Certified Paleo Certified Vegan Vegan.org OU (Kosher) IFANCA Certified crescent M Halal Quality Assurance International Certified Organic

FDA Statement of Identity

Whole Food Based Dietary Supplement

Formula

Keto Certified Ketocertified.com

Fire up your day with pure C8 MCTs. We believe that C8 Caprylic Acid is the best type of MCT oil for ketosis. C8 is three steps away from being converted to energy by the body, the fastest MCT to metabolize in the brain, and will convert into ketones even if you aren't fat-adapted. This is why we created a concentrated, 100% pure C8 MCT oil. Just one dose will fire up your day and give you a rush unlike anything you have experienced before.

Coconuts sustainably and humanely harvested and processed in the Philippines.

Certified Paleo

OU (Kosher)

IFANCA Certified crescent M Halal

Suggested/Recommended/Usage/Directions

How to get started: Coffee: Blend 1 tbsp Pure C8 MCT with 8 oz warm brewed coffee. Add 1 scoop Collagen Peptides for a protein boost! Shots: Consume 1 tbsp for immediate energy. Smoothies: Add 1 tbsp to your favorite smoothie or shake recipe.

Recommended Dosage: 1-3 tbsp per day. Do not exceed recommended dosage. Excessive consumption may cause digestive discomfort.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

This is what productivity looks like.

Instagram mynaturelforce Reduce. Reuse. Recycle. Packaged in recyclable glass with a biodegradable label. BPA Free

Precautions

Allergens: Contains Tree Nuts (Coconut).

Usage Warning: MCT oils may react with certain plastics, including foam cups. Only use with containers/utensils made of metal, glass, ceramic, or safe HDPE/PET plastics.

Excessive consumption may cause digestive discomfort.

Storage

No refrigeration required.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure C8 MCT Oil Unflavored by Natural Force label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure C8 MCT Oil Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure C8 MCT Oil Unflavored by Natural Force

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size15 mL Dosage formLiquid Servings per container63 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
0 Gram(s) per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Protein

0 Gram(s) per serving

Medium Chain Triglycerides

0 NP per serving

Other (inactive) ingredients: Caprylic Acid, MCT Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure C8 MCT Oil Unflavored by Natural Force Drug Interactions

Want to check YOUR meds against Pure C8 MCT Oil Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
295Drugs
295 Moderate

Ingredients driving the most interactions

Caprylic Acid 262
Sodium 205

Individual Drug Interactions

The ingredients in Pure C8 MCT Oil Unflavored interact with 295 drugs. Click any drug to see the details.

2 of the 3 ingredients in Pure C8 MCT Oil Unflavored interact with drugs. Each result below shows which ingredient is responsible. Caprylic Acid Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure C8 MCT Oil Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Caprylic Acid3 drug types · 262 drugs

Antihypertensive Drugs

Theoretically, caprylic acid might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that caprylic acid might have positive inotropic effects, resulting in reduced arterial pressure and vascular resistance and increased cardiac output.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.
In vitro research suggests that caprylic acid might displace NSAIDs from binding sites on albumin. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, caprylic acid might increase plasma concentrations of warfarin.
In vitro research suggests that high doses of caprylic acid might displace warfarin from albumin binding sites. This effect has not been reported in humans.

Likelihood Possible Evidence D
Caprylic Acid full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure C8 MCT Oil Unflavored, from the product label.

Natural Force

See all Natural Force products
Name
Natural Force Benefit Co.
City
Jacksonville
State
FL
ZipCode
32207
Phone Number
(844) 927-3733
Web Address
NaturalForce.com
Pharmacist Counseling Corner

Pure C8 MCT Oil Unflavored by Natural Force: Common Questions

Does Pure C8 MCT Oil Unflavored by Natural Force interact with any medications?
Yes. Based on its ingredients, Pure C8 MCT Oil Unflavored has a known interaction with 295 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure C8 MCT Oil Unflavored contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this just coconut oil?
No — this is C8 MCT oil, a specific type of medium-chain fat extracted from coconut or palm oil. It's more concentrated than whole coconut oil and is absorbed and used by your body differently.
Does caprylic acid have side effects?
Short-term, caprylic acid is generally well tolerated. Mild abdominal discomfort and changes in taste are the most common effects; dizziness, headache, and fatigue have been rarely reported. Supplement doses are less well studied than the amounts found in food.
Why does this product have so much sodium?
The product facts provided do not explain the source or reason for sodium content. If you have concerns about the sodium level in this specific product, contact the manufacturer or your pharmacist for details on the formulation.
Is it safe during pregnancy?
Sodium in this product is rated possibly unsafe in pregnancy. Talk with your doctor or pharmacist before use if you're pregnant or nursing — they can advise you based on your individual health.
Can I take this with my blood pressure medication?
High sodium intake can reduce how well blood pressure medications work. Don't start this product without checking with your doctor first — they need to know about the sodium content and can advise whether it's safe with your specific medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure C8 MCT Oil Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure C8 MCT Oil Unflavored label
Go deeper

The Full Monographs Behind Pure C8 MCT Oil Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Caprylic Acid

Interacts with 262 drugs

Caprylic acid is a medium-chain fatty acid found in coconut oil and palm kernel oil that is popularly used for yeast overgrowth and gut health. While laboratory studies show it has antimicro...

Read the full Caprylic Acid monograph →
Sources

Sources & How We Checked

Pure C8 MCT Oil Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 43 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Caprylic Acid 5 references
  1. Massolini G, Aubry AF, McGann A, Wainer IW. Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases. Biochem Pharmacol 1993 PubMed
  2. Kristev A, Mitkov D, Lukanov Y, Chapkynov P. The effect of octanoic fatty acid on the cardiovascular system of the guinea pig. Cor Vasa 1989;31(4):321-7.
  3. Hayball PF, Holman JW, Nation RL. Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase. J Chromatogr B Biomed App PubMed
  4. Noctor TA, Wainer IW, Hage DS. Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. J Chromatogr 1992;5 PubMed
  5. Voller B, Lines E, McCrossin G, et al. Dose-escalation study of octanoic acid in patients with essential tremor. J Clin Invest. 2016;126(4):1451-7. PubMed

See these in context on the Caprylic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team