Purely-E Ingredients & Drug Interactions
by North American Herb & Spice
What is this page for?
First and foremost: checking Purely-E against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Purely-E is a dietary supplement by North American Herb & Spice with 4 active ingredients. Its ingredients are commonly taken for memory and concentration, digestive upset, hair growth.Based on those ingredients, 373 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wild Rosemary Oil, Red Palm Oil, Pumpkin seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Purely-E by North American Herb & Spice
Ask about any prescription or over-the-counter medication and we check it for interactions with Purely-E by North American Herb & Spice — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Purely-E by North American Herb & Spice
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This liquid contains four active ingredients. Wild rosemary oil is traditionally used for memory support.
Red palm oil provides vitamin A, pumpkin seed oil is used for prostate health, and there's a proprietary blend — a mix of other components the manufacturer doesn't detail individually on the label. The product contains no inactive fillers listed.
Does it work?
Strong evidence
Rosemary is possibly effective for memory. Red palm oil is likely effective for vitamin A deficiency.
Pumpkin seed oil is possibly effective for benign prostatic hyperplasia — an enlarged prostate that can slow urination. The effectiveness of the proprietary blend isn't established in our data.
How safe is it?
Well-documented data
Rosemary is safe in normal food amounts, but concentrated extracts and undiluted oil need caution. Large or medicinal doses should be avoided in pregnancy and breastfeeding.
Red palm oil is fine as a food but is high in saturated fat — use in moderation — and concentrated supplements aren't well studied in pregnancy or breastfeeding. Pumpkin seed oil is generally well tolerated, though it may cause mild stomach discomfort, diarrhea, nausea, or vomiting.
In rare cases, anaphylaxis has been reported. Rosemary oil can potentially trigger seizures if undiluted, and topical use may cause allergic reactions, rash, or photosensitivity in sensitive people.
Meds to double-check
Moderate interaction found
Double-check blood thinners (anticoagulants and antiplatelets) and aspirin-type drugs before using this product, as rosemary may increase bleeding risk. Also screen diabetes medications (risk of low blood sugar), lithium (pumpkin seed oil may raise levels), and any medications your liver breaks down quickly through the CYP1A2 pathway.
The proprietary blend wasn't checked for interactions.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may work for memory and prostate health, but it carries interaction risks with blood thinners, diabetes drugs, lithium, and some other medications. If you take any prescription drugs — especially for bleeding or diabetes — check them here before starting.
Talk with your pharmacist about whether it fits your routine.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Purely-E, straight from the product label.
| Brand | North American Herb & Spice |
|---|---|
| Barcode (UPC) | 635824005070 |
| Net contents | 1 Fluid Ounce(s); 30 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | Feb 21, 2023 |
| DSLD ID | 270078 |
| Product type | Botanical With Nutrients |
| Supplement form | Liquid |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Purely-E by North American Herb & Spice, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| wild Rosemary Oil | 0 NP | -- |
| Red Palm Oil | 0 NP | -- |
| Pumpkin seed Oil | 0 NP | -- |
| Proprietary Blend | 60 IU | 200% |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take three drops under the tongue or in juice/water once daily. Add to smoothies. For skin health support also may be used topically.
Formula
Purely-E is the only whole vitamin E complex from naturally grown sunflower seeds.
Sunflower seed vitamin E
Formulation
Non-GMO, gluten-free, no additives, nothing artificial, soy-free
Skin health support-plus
Soy-free, non-GMO
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Purely-E by North American Herb & Spice label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Purely-E by North American Herb & Spice
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Drop(s) Dosage formLiquid Servings per container286 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Wild Rosemary Oil
Interacts with372 drugs
Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory...
Wild Rosemary Oil monograph & interactionsRed Palm Oil
Interacts with122 drugs
Palm oil is a widely used edible oil pressed from the fruit of the oil palm tree, and red palm oil is a notable source of vitamin A and vitamin E comp...
Red Palm Oil monograph & interactionsPumpkin seed Oil
Interacts with1 drug
Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...
Pumpkin seed Oil monograph & interactionsProprietary Blend
Purely-E by North American Herb & Spice Drug Interactions
HelloPharmacist Interaction Report
Purely-E by North American Herb & Spice contains ingredients with documented interactions.
The most serious concern is wild rosemary oil, which theoretically increases bleeding risk when used with blood thinners (anticoagulants) or antiplatelet drugs like aspirin or clopidogrel. Rosemary contains salicylates and may inhibit platelet clumping.
Read the full breakdown — every affected drug type, severity by severity
Rosemary also raises theoretical risk of low blood sugar (hypoglycemia) if combined with diabetes medications, since animal research shows it can lower blood glucose — though human evidence is mixed. Red palm oil may decrease effectiveness of blood thinners by increasing platelet clumping.
Pumpkin seed oil can reduce how your kidneys clear lithium, potentially raising lithium levels to unsafe ranges.
Rosemary may also speed up how your liver processes certain medications (CYP1A2 substrates) like theophylline or some antihistamines, which could weaken their effects. Altogether, these interactions span 372 individual medications.
We could not check the proprietary blend ingredient for interactions. Run your exact medications through the checker below before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Purely-E?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Purely-E interact with 373 drugs. Click any drug to see the details.
3 of the 4 ingredients in Purely-E interact with drugs. Each result below shows which ingredient is responsible. wild Rosemary Oil Red Palm Oil Pumpkin seed Oil
AbciximabReoPro
How Abciximab interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Red Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Abciximab interactionWild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Abrocitinib interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Purely-E — through 1 ingredient. Tap an ingredient for the detail:
Wild Rosemary OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Wild Rosemary Oil + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Acenocoumarol interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wild Rosemary Oil + Acetaminophen, Aspirin interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAspirin, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Wild Rosemary Oil + Acetaminophen, Aspirin, Caffeine interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wild Rosemary Oil + Acetaminophen, Ibuprofen interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Purely-E — through 1 ingredient. Tap an ingredient for the detail:
Wild Rosemary OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Wild Rosemary Oil + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Wild Rosemary Oil + Acetylsalicylic Acid interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Purely-E — through 1 ingredient. Tap an ingredient for the detail:
Wild Rosemary OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Wild Rosemary Oil + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Purely-E — through 1 ingredient. Tap an ingredient for the detail:
Wild Rosemary OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Wild Rosemary Oil + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Purely-E — through 1 ingredient. Tap an ingredient for the detail:
Wild Rosemary OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Wild Rosemary Oil + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Purely-E — through 1 ingredient. Tap an ingredient for the detail:
Wild Rosemary OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Wild Rosemary Oil + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Alteplase, Tpa interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Red Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionWild Rosemary OilAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Wild Rosemary Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Anacaulase-bcdb interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wild Rosemary Oil + Anagrelide interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Red Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Anisindione interactionWild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Purely-E — through 1 ingredient. Tap an ingredient for the detail:
Wild Rosemary OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Wild Rosemary Oil + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Antithrombin Iii interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Red Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Apixaban interactionWild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Argatroban interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wild Rosemary Oil + Aspirin interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Wild Rosemary Oil + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Red Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aspirin, Butalbital interactionWild Rosemary OilAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Wild Rosemary Oil + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wild Rosemary Oil + Aspirin, Butalbital, Caffeine interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilAspirin, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Wild Rosemary Oil + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Red Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aspirin, Butalbital, Caffeine, Phenacetin interactionWild Rosemary OilAspirin, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Wild Rosemary Oil + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Purely-E — through 2 ingredients. Tap an ingredient for the detail:
Wild Rosemary OilCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wild Rosemary Oil + Aspirin, Caffeine interactionRed Palm OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
Read the full Red Palm Oil + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Purely-E with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
wild Rosemary Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.
Antidiabetes Drugs
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.
Aspirin
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.
Choline Magnesium Trisalicylate (Trilisate)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.
Salsalate (Disalcid)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.
Red Palm Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
The palm olein constituent in palm oil seems to increase platelet aggregation.
Pumpkin seed Oil
Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Purely-E, from the product label.
North American Herb & Spice
See all North American Herb & Spice products- Name
- North American Herb & Spice
- Street Address
- 13900 W. Polo Trail Drive
- City
- Lake Forest
- State
- IL
- ZipCode
- 60045
- Phone Number
- 1-800-243-5242
- Web Address
- www.oreganol.com
Purely-E by North American Herb & Spice: Common Questions
Does Purely-E by North American Herb & Spice interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is rosemary oil safe to take if I'm on aspirin?
Will this help my memory?
Can I take this while pregnant?
What side effects might I notice?
Does this product have fillers or additives?
What is the proprietary blend in here?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Purely-E is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Purely-E’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Rosemary
Interacts with 372 drugsRosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...
Read the full Rosemary monograph → Herb & supplement monographPalm Oil
Interacts with 122 drugsPalm oil is a widely used edible oil pressed from the fruit of the oil palm tree, and red palm oil is a notable source of vitamin A and vitamin E compounds called tocotrienols. As a food it...
Read the full Palm Oil monograph → Herb & supplement monographPumpkin
Interacts with 1 drugPumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...
Read the full Pumpkin monograph →Sources & How We Checked
Purely-E's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Rosemary 20 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Cartier LC, Lehrer A, Malo JL. Occupational asthma caused by aromatic herbs. Allergy 1996;51:647-9. DOI
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
- Swain AR, Dutton SP, Truswell AS. Salicylates in foods. J Am Diet.Assoc 1985;85(8):950-60. DOI
- Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-7. PubMed
- Debersac P, Heydel JM, Amiot MJ, et al. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39(9):907-18. PubMed
- Debersac P, Vernevaut MF, Amiot MJ, et al. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39(2):109-17. PubMed
- Lee JJ, Jin YR, Lee JH, et al. Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Planta Med 2007;73(2):121-7.
- Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
- Naemura A, Ura M, Yamashita T, et al. Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 2008;122(4):517-22. PubMed
- Lee JJ, Jin YR, Lim Y, et al. Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. Vascul Pharmacol 2006;45:148-53. PubMed
- Bakirel, T., Bakirel, U., Keles, O. U., Ulgen, S. G., and Yardibi, H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 2-28-2008;116(1):64-73. PubMed
- Erenmemisoglu, A., Saraymen, R., and Ustun, S. Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice. Pharmazie 1997;52(8):645-646.
- Valones MAA, Silva ICG, Gueiros LAM, Leão JC, Caldas AF Jr, Carvalho AAT. Clinical assessment of rosemary-based toothpaste (Rosmarinus officinalis Linn.): A randomized controlled double-blind study. Braz Dent J. 2019;30(2):146-151. PubMed
- Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, et al. A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD). J Popul Ther Clin Pharmacol. 2019;26(4):e18-e28.
- Al Jamal A. Effect of rosemary (Rosmarinus officinalis) on lipid profiles and blood glucose in human diabetic patients (type-2). African J. Biochem. Res. 2014;8(8):147-50. DOI
Palm Oil 12 references
- Radhika MS, Bhaskaram P, Balakrishna N, Ramalakshmi BA. Red palm oil supplementation: a feasible diet-based approach to improve vitamin A status of pregnant women and their infants. Food Nutr Bull 2003;24:208-17.
- Zagre NM, Delpeuch F, Traissac P, Delisle H. Red palm oil as a source of vitamin A for mothers and children: impact of a pilot project in Burkina Faso. Public Health Nutr 2003;6:733-42. PubMed
- Lietz G, Henry CJ, Mulokozi G, et al. Comparison of the effects of supplemental red palm oil and sunflower oil on maternal vitamin A status. Am J Clin Nutr 2001;74:501-9. PubMed
- Sanchez-Muniz FJ, Oubina P, Rodenas S, et al. Platelet aggregation, thromboxane production and thrombogenic ratio in postmenopausal women consuming high oleic acid-sunflower oil or palmolein. Eur J Nutr 2003:42:299-306. PubMed
- Vega-Lopez, S., Ausman, L. M., Jalbert, S. M., Erkkila, A. T., and Lichtenstein, A. H. Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects. Am J Cli
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Fattore E, Bosetti C, Brighenti F, et al. Palm oil and blood lipid-related markers of cardiovascular disease: a systematic review and meta-analysis of dietary intervention trials. Am J Clin Nutr 2014;99:1331-50. PubMed
- Sun Y, Neelakantan N, Wu Y, et al. Palm oil consumption increases LDL cholesterol compared with vegetable oils low in saturated fat in a meta-analysis of clinical trials. J Nutr 2015;145:1549-58. PubMed
- Chen BK, Seligman B, Farquhar JW, Goldhaber-Fiebert JD. Multi-Country analysis of palm oil consumption and cardiovascular disease mortality for countries at different stages of economic development: 1980-1997. Global Health 2011;7:45. PubMed
- Voon PT, Lee ST, Ng TKW, et al. Intake of palm olein and lipid status in healthy adults: a meta-analysis. Adv Nutr 2019;10(4):647-59. PubMed
- Wang F, Zhao D, Yang Y, Zhang L. Effect of palm oil consumption on plasma lipid concentrations related to cardiovascular disease: a systematic review and meta-analysis. Asia Pac J Clin Nutr 2019;28(3):495-506.
- Hisham MDB, Aziz Z, Huin WK, Teoh CH, Jamil AHA. The effects of palm oil on serum lipid profiles: A systematic review and meta-analysis. Asia Pac J Clin Nutr 2020;29(3):523-536.
Pumpkin 5 references
- Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
- Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
- Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
- Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
- Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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