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Dietary supplement

PurePurse Ingredients & Drug Interactions

by Advanced Nutrition by Zahler

PurePurse label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PurePurse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PurePurse is a dietary supplement by Advanced Nutrition by Zahler with 1 active ingredient. Its ingredients are commonly taken for heavy or prolonged menstrual bleeding, minor bleeding (nosebleeds, wounds), mild diuretic.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Shepherd's Purse Aerial Parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PurePurse by Advanced Nutrition by Zahler

Ask about any prescription or over-the-counter medication and we check it for interactions with PurePurse by Advanced Nutrition by Zahler — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of PurePurse by Advanced Nutrition by Zahler

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

PurePurse is a liquid supplement with one active ingredient: Shepherd's Purse Aerial Parts extract. The inactive ingredients are glycerin, purified water, and stevia leaf extract, which serve as preservatives and sweeteners.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Shepherd's Purse's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: menstrual support for heavy bleeding.
  • We looked for evidence on: Menorrhagia.
  • The closest evidence on file: Shepherd's Purse is rated "Insufficient Reliable Evidence To Rate" for Menorrhagia (Natural Medicines).

The evidence for Shepherd's Purse isn't established in our data for the uses listed—postpartum complications and heavy menstrual bleeding both carry a rating of insufficient reliable evidence. That means we don't have solid data showing whether it works for these conditions, not that it doesn't.

If you're considering it for either purpose, talk with your doctor about whether it makes sense for your situation.

The evidence, ingredient by ingredient Shepherd's Purse

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Shepherd's Purse is generally well tolerated in small amounts when used short-term, but human safety data are limited overall. Adverse effects traditionally associated with it include sedation, abnormal blood pressure (high or low), heart palpitations, abnormal thyroid function, and abnormal menstruation, though most people seem to have no trouble at all.

The safety data advise against use during pregnancy because it may stimulate the uterus. There isn't enough information to know if it's safe while breastfeeding, so it's best avoided then too.

Side effects, ingredient by ingredient Shepherd's Purse

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Shepherd's Purse.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take PurePurse, check your medicines against these two types: sedating drugs (CNS depressants like certain sleep aids, antihistamines, and some pain relievers) and thyroid hormone replacements. Both carry Moderate severity interactions with Shepherd's Purse.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

PurePurse is a single-ingredient liquid that may be considered short-term by adults, but it's worth a double-check if you take sedating medications or thyroid replacements. Pregnant people and those breastfeeding should not use it.

Talk with your pharmacist before starting, especially if you're on any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PurePurse, straight from the product label.

Brand Advanced Nutrition by Zahler
Barcode (UPC) 848998080624
Net contents 4 Fluid Ounce(s); 118.3 mL
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 301147
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Women (not pregnant or lactating), Adult Female (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PurePurse by Advanced Nutrition by Zahler, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 mL
Maximum serving Sizes:
5 mL
Servings per container
24
UPC/BARCODE
848998080624
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Shepherd's Purse Aerial Parts extract310 mg--

Other ingredients: Kosher Glycerin, Water, Purified, Stevia Leaf Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Menstrual support formula

This herb has traditionally been used to address normal but heavy menstrual bleeding.

Non-GMO Gluten free Dairy free Soy free

Vegetarian friendly

Alcohol-free liquid Shepherd's Purse

Menstrual support formula Herbal

Formula

PurePurse is derived from organic Shepherd's Purse.

Kosher Pareve D OU (Kosher) Under the strict supervision of Rabbi Sh. Stern & the Orthodox Union

Alcohol-free liquid Shepherd's Purse

Women's health

General Statements

You may need additional supplements to support a healthy diet; consult your nutritionist for a formula that is right for you or contact us at 877-ASK-ZAHLER (877-275-9245) or [email protected].

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

If pregnant, nursing or on medication, consult with your healthcare practitioner.

Warning: This product should not be taken during pregnancy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Kosher Pareve D OU (Kosher) This product was manufactured in a GMP Certified Facility

Manufactured in the USA

Storage

Store tightly closed in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Advanced Nutrition by Zahler Feel Better, Everyday

PurePurse is a trademark of Advanced Nutrition by Zahler.

Suggested/Recommended/Usage/Directions

Directions: Mix 1 teaspoon with 2 ounces of water or juice. May be taken twice a day or as directed by a healthcare practitioner. Shake well before use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PurePurse by Advanced Nutrition by Zahler label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PurePurse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PurePurse by Advanced Nutrition by Zahler

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.

Shepherd's Purse Aerial Parts extract

Interacts with
264 drugs
310 mg per serving

Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human research is ver...

Shepherd's Purse Aerial Parts extract monograph & interactions

Other (inactive) ingredients: Kosher Glycerin, Water, Purified, Stevia Leaf Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

PurePurse by Advanced Nutrition by Zahler Drug Interactions

Want to check YOUR meds against PurePurse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Shepherd's Purse Aerial Parts extract 264

Individual Drug Interactions

The ingredients in PurePurse interact with 264 drugs. Click any drug to see the details.

1 of the 1 ingredient in PurePurse interact with drugs. Each result below shows which ingredient is responsible. Shepherd's Purse Aerial Parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in PurePurse with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Shepherd's Purse Aerial Parts extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, concomitant use may interfere with thyroid dysfunction therapy.

Likelihood Possible Evidence D
Shepherd's Purse Aerial Parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PurePurse, from the product label.

Advanced Nutrition by Zahler

See all Advanced Nutrition by Zahler products
Name
Advanced Nutrition by Zahler
City
Brooklyn
State
NY
ZipCode
11230
Phone Number
877-275-9245
Web Address
www.zahlers.com
Pharmacist Counseling Corner

PurePurse by Advanced Nutrition by Zahler: Common Questions

Does PurePurse by Advanced Nutrition by Zahler interact with any medications?
Yes. Based on its ingredients, PurePurse has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PurePurse contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No, the safety data advise against it. Shepherd's Purse may stimulate the uterus, so it's not safe during pregnancy.
Is it safe to take while breastfeeding?
There isn't enough information to know either way. Because safety data are lacking, it's best to avoid it while breastfeeding and talk with your doctor or pharmacist for personalized advice.
What is Shepherd's Purse used for?
Traditionally it's been used for postpartum complications and heavy menstrual bleeding, but our data show insufficient reliable evidence for either use.
Can I take this long-term?
The safety information suggests short-term use by adults, and human safety data for long-term use are limited, so check with your pharmacist if you're thinking of using it beyond a few weeks.
What are the side effects?
When used in small amounts short-term, Shepherd's Purse seems well tolerated. Adverse effects traditionally thought to be linked to it include sedation, abnormal blood pressure, heart palpitations, abnormal thyroid function, and changes in menstruation, though most people have no problems.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PurePurse is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PurePurse label
Go deeper

The Full Monographs Behind PurePurse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Shepherd's Purse

Interacts with 264 drugs

Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human research is very limited. Because it may affect blood c...

Read the full Shepherd's Purse monograph →
Sources

Sources & How We Checked

PurePurse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Shepherd's Purse 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Naafe M, Kariman N, Keshavarz Z, et al. Effect of hydroalcoholic extracts of Capsella bursa-pastoris on heavy menstrual bleeding: A randomized clinical trial. J Altern Complement Med. 2018;24(7):694-700. PubMed
  4. Ghalandari S, Kariman N, Sheikhan Z, et al. Effect of hydroalcoholic extract of Capsella bursa pastoris on early postpartum hemorrhage: A clinical trial study. J Altern Complement Med. 2017;23(10):794-799.

See these in context on the Shepherd's Purse monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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