Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Pycnogenol 50 mg Ingredients & Drug Interactions

by Natural Nutra

Pycnogenol 50 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pycnogenol 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pycnogenol 50 mg is a dietary supplement by Natural Nutra with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pycnogenol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pycnogenol 50 mg by Natural Nutra

Ask about any prescription or over-the-counter medication and we check it for interactions with Pycnogenol 50 mg by Natural Nutra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pycnogenol 50 mg by Natural Nutra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: 50 mg of Pycnogenol, a standardized extract from maritime pine bark. The inactive ingredients are cellulose, stearic acid, silica, calcium stearate, and glycerin — typical tablet binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy capillaries and circulation.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Varicose veins, Raynaud syndrome, Hemorrhoids, Atherosclerosis, Hypertension — and 4 related terms.
  • The strongest evidence on file: Maritime Pine is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Maritime Pine is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Atherosclerosis, Hemorrhoids, Hypertension, and more.

Pycnogenol shows possibly effective evidence for osteoarthritis and chronic venous insufficiency (a condition where veins in the legs don't return blood efficiently). For asthma, the evidence is also possibly effective.

However, for high cholesterol (hyperlipidemia), the data we hold rates it as possibly ineffective. These ratings mean the research suggests a benefit in some studies, but it's not definitive — more evidence would help clarify.

The evidence, ingredient by ingredient Maritime Pine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maritime pine bark extract is generally well tolerated in clinical studies, but long-term safety data are incomplete. The most commonly reported side effects are gastrointestinal complaints, dizziness, and vertigo — a small number of trial participants also reported headache.

Two isolated cases of heart-related events (chest pain and worsening heart failure) were reported, though neither was clearly linked to the extract. The safety data advise against using Pycnogenol during pregnancy and breastfeeding because there isn't enough information to know it's safe in those situations.

Talk with your doctor or pharmacist about whether it's right for you if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Maritime Pine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maritime Pine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Pycnogenol, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin) — the extract may increase bleeding risk. Also flag diabetes medications, since maritime pine may lower blood sugar further.

If you're on immunosuppressants, those should be checked too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pycnogenol may help with osteoarthritis, leg vein problems, or asthma symptoms based on current evidence, but it's not established for high cholesterol. If you take blood thinners, diabetes drugs, or immune-suppressing medications, you'll need to check with your doctor or pharmacist before starting it — the interactions are real, even if their clinical impact isn't fully clear.

Pregnancy and breastfeeding aren't recommended without professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pycnogenol 50 mg, straight from the product label.

Brand Natural Nutra
Net contents 30 Vegan Tablet(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 247062
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pycnogenol 50 mg by Natural Nutra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
IngredientAmount% DV
Pycnogenol50 mg--

Other ingredients: Cellulose, Stearic Acid, Silica, Calcium Stearate, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no artificial colors, flavors or preservatives; no wheat, gluten, milk, eggs, peanuts, tree nuts, soy, crustacean shellfish or fish.

Suitable for vegans.

Pycnogenol is a naturally occurring complex of flavonoids (OPC's) extracted from French maritime pine bark. A vegetarian sourced antioxidant, our Pycnogenol supplement supports healthy capillaries and circulation. By maintaining elasticity and flexibility of connective tissues, it helps promote smooth skin and joint health. Its water-soluble characteristics ensure excellent absorption.

Purity + potency guaranteed

Promotes healthy skin and circulation

Vegan

Gluten free

Brand IP Statement(s)

Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

French Maritime Pine Bark extract

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take one tablet daily with food.

Precautions

Keep out of reach of children.

General Statements

To report a serious adverse event, call 1-888-710-0006

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pycnogenol 50 mg by Natural Nutra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pycnogenol 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pycnogenol 50 mg by Natural Nutra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Pycnogenol

Interacts with
327 drugs
50 mg per serving

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...

Pycnogenol monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Silica, Calcium Stearate, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pycnogenol 50 mg by Natural Nutra Drug Interactions

Want to check YOUR meds against Pycnogenol 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Pycnogenol 327

Individual Drug Interactions

The ingredients in Pycnogenol 50 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pycnogenol 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pycnogenol

Each ingredient & the kinds of drugs it affects

For each ingredient in Pycnogenol 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pycnogenol3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Pycnogenol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pycnogenol 50 mg, from the product label.

Natural Nutra

See all Natural Nutra products
Name
Hurd Dynamics LLC, DBA Natural Nutra
City
Tampa
State
FL
ZipCode
33615
Phone Number
1-888-710-0006
Web Address
www.natnutra.com
Pharmacist Counseling Corner

Pycnogenol 50 mg by Natural Nutra: Common Questions

Does Pycnogenol 50 mg by Natural Nutra interact with any medications?
Yes. Based on its ingredients, Pycnogenol 50 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pycnogenol 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Pycnogenol if I'm pregnant or breastfeeding?
The safety data aren't robust enough to recommend it during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can weigh the potential benefit against the unknowns for your specific situation.
What are the most common side effects?
Gastrointestinal complaints, dizziness, and vertigo are the most frequently reported. A few people in studies also reported headache. Most people tolerate it well in short-term use.
Will Pycnogenol help my osteoarthritis?
The evidence says possibly effective, meaning some studies show benefit but it's not definitive yet. It may be worth discussing with your doctor as part of your overall treatment plan.
Is this effective for high cholesterol?
No — the evidence we have rates it as possibly ineffective for high cholesterol, so it's not a reliable choice for that goal.
Why do I need to worry about bleeding if I'm on a blood thinner?
Maritime pine bark extract can slow platelet clumping, which is how your blood clots. Combined with a blood thinner, this theoretically raises your bleeding risk — so your doctor needs to know you're adding it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pycnogenol 50 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pycnogenol 50 mg label
Go deeper

The Full Monographs Behind Pycnogenol 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maritime Pine

Interacts with 327 drugs

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...

Read the full Maritime Pine monograph →
Sources

Sources & How We Checked

Pycnogenol 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maritime Pine 14 references
  1. Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  2. Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
  3. Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
  4. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
  5. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
  6. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
  7. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
  8. Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
  9. Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
  10. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
  11. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
  12. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
  13. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
  14. Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

See these in context on the Maritime Pine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team