Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Raspberry Ketones+ Gummies Mixed Fruit Ingredients & Drug Interactions

by Herbal Zen Weight Loss

Gummy Or Jelly Category: Botanical
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Raspberry Ketones+ Gummies Mixed Fruit is a dietary supplement by Herbal Zen Weight Loss with 6 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 374 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Cormino seed extract, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Raspberry Ketones+ Gummies Mixed Fruit by Herbal Zen Weight Loss

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Herbal Weight Loss Blend” is a proprietary blend — the label gives one combined amount (155 mg) without saying how much of each component you get.

This product contains 5 ingredients. Calcium is the primary active mineral — it helps build and maintain bone strength and plays roles in nerve and muscle function.

Wild olive leaf extract, cormino seed extract (cumin), horsemint leaf extract, and frauenmantle leaf extract round out the formula. The gummies also contain several inactive ingredients like corn syrup, pectin, and natural flavors to make them palatable.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Hyperkalemia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Dyspepsia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Hypocalcemia — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Kidney failure — rated "Effective" (Calcium) (Natural Medicines).
  • On file: Hyperparathyroidism — rated "Likely Effective" (Calcium) (Natural Medicines).

Calcium in this product is likely effective for osteoporosis and effective for preventing kidney failure, low blood calcium (hypocalcemia), high potassium (hyperkalemia), and indigestion. The other active ingredients — wild olive leaf, cumin, horsemint, and frauenmantle leaf — do not have established evidence of effectiveness in our data.

For most of the conditions cumin and olive leaf are marketed for (blood sugar control, weight management, inflammation), the evidence is insufficient to rate them.

The evidence, ingredient by ingredient Calcium Olive Cumin Horsemint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated when taken at recommended amounts, though high doses can cause problems. Common side effects are belching, constipation, diarrhea, stomach upset, and gas.

There is some concern that very high calcium doses (over 1500–2000 mg daily) may be linked to prostate cancer risk and possibly increased cardiovascular risk, though research remains mixed. Calcium is likely safe in pregnancy when kept at recommended levels and safe during breastfeeding.

Wild olive leaf extract is generally well tolerated; concentrated supplements are less studied than the food form, with occasional reports of headache and stomach discomfort. Horsemint leaf extract carries caution in pregnancy (possibly unsafe) and should be avoided during breastfeeding due to insufficient safety data.

Cormino seed extract (cumin) is well tolerated at food spice amounts but has limited safety data at supplement doses; rare allergic reactions including anaphylaxis have been reported in sensitive individuals.

Side effects, ingredient by ingredient Calcium Olive Cumin Horsemint

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Cumin, Calcium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 374 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your pharmacist if you're on HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir), the antibiotic ceftriaxone, levothyroxine (thyroid medication), sotalol (heart rhythm drug), diltiazem (blood pressure medication), calcipotriene (psoriasis topical), anticoagulants or blood thinners, diabetes medications, or rifampin (TB antibiotic). Calcium can reduce the effectiveness of several of these, and cumin may theoretically thin your blood or lower blood sugar.

Timing and separation of doses is critical for some.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Calcium is the workhorse here, and it's effective for bone health and several medical uses — but it can interfere with HIV drugs, thyroid medication, heart drugs, and antibiotics. If you're on any prescription medications, especially those listed above, talk to your pharmacist before you start.

The other ingredients bring limited proven benefit for weight loss or metabolic support based on current evidence.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Raspberry Ketones+ Gummies Mixed Fruit, straight from the product label.

Brand Herbal Zen Weight Loss
Barcode (UPC) 631656604122
Net contents 60 Gummie(s)
Market status Off market
Date entered into DSLD Sep 25, 2013
DSLD ID 25650
Product type Botanical
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Raspberry Ketones+ Gummies Mixed Fruit by Herbal Zen Weight Loss, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummie(s)
Maximum serving Sizes:
2 Gummie(s)
Servings per container
30
UPC/BARCODE
631656604122
IngredientAmount% DV
Calories30 {Calories}--
Total Carbohydrates8 Gram(s)3%
Sugar5 Gram(s)--
Calcium40 mg5%
Wild olive leaf extract0 Not Present--
Herbal Weight Loss Blend155 mg--
Cormino seed extract0 Not Present--
Horsemint leaf extract0 Not Present--
Frauenmantle leaf extract0 Not Present--

Other ingredients: Corn Syrup, Maltodextrin, Pectin, Citric Acid, Natural flavors, BLACK CARROT JUICE CONCENTRATE, FRACTIONATED COCONUT OIL, LO HAN FRUIT CONCENTRATE, Carnauba wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Iovate health Sciences also makes America's #1 Selling Weight Loss Supplement Brand, based on IRI FDMx sales data.

Made in the U.S.A. from international ingredients.

For lot no. and expiry date: see bottle.

From the Makers of America's #1 Selling Weight Loss Supplement Brand.

GREAT TASTING

Lose Weight with Herbal Weight Loss Blend Non-Stimulant

Natural Flavors & Colors

100% premium

We're committed to sourcing pure, premium ingredients from around the world.

Raspberry Ketones are the primary aroma compound of red raspberries.

Average weight loss with Herbal Weight Loss Blend (frauenmantle leaf, wild olive leaf, cormino seed, and horsemint leaf) was 20.94 lbs. in a 12-week study and 16.50 lbs. in an 8-week study. All groups followed a calorie-reduced diet.

Brand IP Statement(s)

Patent pending. (C) 2013.

Razberi-K(R) is a registered trademark of Integrity Nutraceuticals International, Inc.

Lose weight with Herbal Zen Weight Loss(TM) products.

Herbal Zen Weight Loss(TM) Raspberry Ketones Gummies contain no fat.

General

8972US 0613

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: For adult use only.

Do not use if pregnant or nursing. Consult a doctor before use if you have a medical condition and before starting a diet or exercise program.

Do not use if packaging has been tampered with.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Razberi-K(R)

FDA Statement of Identity

dietary supplement

Formula

CONTAINS COCONUT INGREDIENTS.

Plus, this product contains clinically proven key weight loss ingredients (Herbal Weight Loss Blend: frauenmantle leaf extract, wild olive leaf extract, cormino seed extract and horsemint leaf extract) which have been shown in scientific research to help people lose weight.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 1 serving (2 gummies) three times daily with a glass of water, 30 to 60 minutes before meals. Do not exceed 3 servings (6 gummies) in a 24-hour period. For best results, use for a minimum of 60 days in conjunction with a calorie-reduced diet and regular exercise program.

Storage

Store in a cool, dry place 60(0)F to 80(0)F.

See for yourself

Raspberry Ketones+ Gummies Mixed Fruit by Herbal Zen Weight Loss label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Raspberry Ketones+ Gummies Mixed Fruit by Herbal Zen Weight Loss

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummie(s) Dosage formGummy Or Jelly Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

5 Gram(s) per serving

Calcium

Interacts with
168 drugs
40 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Herbal Weight Loss Blend

155 mg per serving

Other (inactive) ingredients: Corn Syrup, Maltodextrin, Pectin, Citric Acid, Natural flavors, BLACK CARROT JUICE CONCENTRATE, FRACTIONATED COCONUT OIL, LO HAN FRUIT CONCENTRATE, Carnauba wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Raspberry Ketones+ Gummies Mixed Fruit by Herbal Zen Weight Loss Drug Interactions

Want to check YOUR meds against Raspberry Ketones+ Gummies Mixed Fruit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
374Drugs
7 Major 349 Moderate 18 Minor

Ingredients driving the most interactions

Calcium 168

Each ingredient & the kinds of drugs it affects

For each ingredient in Raspberry Ketones+ Gummies Mixed Fruit with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cormino seed extract3 drug types · 211 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cumin might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro evidence suggests that cumin can inhibit platelet aggregation. Theoretically, cumin might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that cumin can lower blood sugar in diabetic animals. However, research in humans with and without diabetes has found conflicting results.

Likelihood Probable Evidence D
Rifampin (Rifadin)

Theoretically, cumin might increase the effects and adverse effects of rifampin.
Animal research suggests that an aqueous extract of cumin containing a specific flavonoid glycoside can increase the bioavailability and plasma levels of rifampin.

Likelihood Possible Evidence D

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Raspberry Ketones+ Gummies Mixed Fruit, from the product label.

Herbal Zen Weight Loss

See all Herbal Zen Weight Loss products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 N. Market St., Ste. 1330
City
Wilmington
State
DE
ZipCode
19801
Pharmacist Counseling Corner

Raspberry Ketones+ Gummies Mixed Fruit by Herbal Zen Weight Loss: Common Questions

Does Raspberry Ketones+ Gummies Mixed Fruit by Herbal Zen Weight Loss interact with any medications?
Yes. Based on its ingredients, Raspberry Ketones+ Gummies Mixed Fruit has a known interaction with 374 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Raspberry Ketones+ Gummies Mixed Fruit contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take during pregnancy?
The calcium in this product is likely safe in pregnancy if kept at recommended levels. However, horsemint leaf extract is rated possibly unsafe in pregnancy. Talk with your doctor or pharmacist before starting — they can advise you on the whole product.
Is this safe while breastfeeding?
Calcium needs can be met during breastfeeding at recommended amounts. Horsemint leaf extract has no reliable safety data during breastfeeding and should be avoided. Check with your provider about whether this product is right for you.
Will this help me lose weight?
The evidence for cumin and the other herbal ingredients in weight loss is insufficient in our data — we can't say whether they work for that purpose. Calcium itself is not marketed as a weight-loss ingredient.
Can this cause side effects?
Calcium can cause belching, constipation, diarrhea, stomach upset, and gas. Cumin may cause stomach upset, and there's rare risk of allergic reaction. Olive leaf extract sometimes causes headache or mild stomach discomfort. Most people tolerate these ingredients well at normal doses.
What is cormino seed extract?
That's cumin — a common spice used for cooking. When concentrated into a supplement, it may lower blood sugar or increase bleeding risk in theory, though human evidence is mixed. As a spice in food it's very safe.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Raspberry Ketones+ Gummies Mixed Fruit label
Sources

Sources & How We Checked

Raspberry Ketones+ Gummies Mixed Fruit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 75 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  16. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  17. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  18. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  19. Decktor DL, Robinson M, Maton PN, et al. Effects of aluminum/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn. Am J Ther 1995;2:546-52. PubMed
  20. Simoneau G. Absence of rebound effect with calcium carbonate. Eur J Drug Metab Pharmacokinet 1996;21:351-7. PubMed
  21. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  22. Bourke JF, Mumford R, Whittaker P, et al. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. J Am Acad Dermatol 1997;37:929-34.
  23. Gueguen L, Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr 2000;19:119s-136s. PubMed
  24. Vella A, Gerber TC, Hayes DL, Reeder GS. Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 1999;75:554-6. PubMed
  25. Bania TC, Blaufeux B, Hughes S, et al. Calcium and digoxin vs. calcium alone for severe verapamil toxicity. Acad Emerg Med 2000;7:1089-96. PubMed
  26. Tseng M, Breslow RA, Graubard BI, Ziegler RG. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 2005;81:1147-54. PubMed
  27. Weingarten MA, Zalmanovici A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev 2004;(1):CD003548. PubMed
  28. Tavani A, Bertuccio P, Bosetti C, et al. Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 2005;48:27-33. PubMed
  29. Giovannucci E, Liu Y, Stampfer MJ, Willett WC. A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 2006;15:203-10. PubMed
  30. Rocephin (ceftriaxone) and calcium interaction. Pharmacist's Letter / Prescriber's Letter 2007;23(10):231005.
  31. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised control trial. BMJ 2008;336:262-6.
  32. Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341:c3691. PubMed
  33. Calcium supplementation and vascular events. Pharmacist's Letter / Prescriber's Letter 2008;24(3):240306.
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Olive 2 references
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Cumin 10 references
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Horsemint 1 reference
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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