Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Regains Ingredients & Drug Interactions

by REVSCI

Regains label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Regains against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Regains is a dietary supplement by REVSCI with 7 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 454 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Arginine, L-Glutamine, L-Lysine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Regains by REVSCI

Ask about any prescription or over-the-counter medication and we check it for interactions with Regains by REVSCI — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Regains by REVSCI

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Regains contains 7 active ingredients: amino acids L-Glutamine, L-Lysine Hydrochloride, L-Glycine, L-Ornithine Hydrochloride, L-Arginine, and Ornithine Alpha-Ketoglutarate, plus Colostrum Powder. These amino acids support muscle recovery, immune function, and tissue repair.

The product also includes inactive ingredients — gelatin, rice flour, magnesium stearate, and silicon dioxide — which serve as capsule material and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support body's natural human growth hormone production.
  • We looked for evidence on: Aging, Athletic performance, Child growth, Cognitive function, Exercise-induced muscle damage, Muscle strength — and 4 related terms.
  • The strongest evidence on file: Ornithine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.

The evidence for this product varies by ingredient and use. L-Glutamine is effective for sickle cell disease and possibly effective for muscle wasting related to HIV/AIDS, recovery after surgery, and critical illness from trauma.

L-Lysine is possibly effective for cold sores. L-Glycine is possibly effective for schizophrenia.

L-Ornithine and Ornithine Alpha-Ketoglutarate are possibly effective for athletic performance. For other claimed uses like growth, pressure ulcers, insomnia, and skin health, the evidence we hold is insufficient to rate them.

The evidence, ingredient by ingredient Glutamine Lysine Glycine Ornithine L-arginine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is likely safe in pregnancy and generally well tolerated by healthy adults, though people with kidney or liver disease should use it only with medical supervision. Supplement doses should be avoided while breastfeeding unless your doctor recommends it.

Common side effects include belching, bloating, constipation, diarrhea, nausea, vomiting, and headache; high doses may worsen these. L-Lysine is generally well tolerated at typical doses but may cause stomach upset, and its safety in pregnancy and while breastfeeding is not well studied.

L-Glycine is generally well tolerated but has limited long-term safety data; data on pregnancy and breastfeeding safety is insufficient — avoid unless your doctor approves. L-Ornithine and Ornithine Alpha-Ketoglutarate lack adequate safety data in pregnancy and breastfeeding — avoid supplemental doses unless medically advised.

L-Arginine is possibly safe in pregnancy but generally well tolerated short-term; it can lower blood pressure and safety for self-treatment is not established. Colostrum Powder safety data are not on file.

Side effects, ingredient by ingredient Glutamine Lysine Glycine Ornithine L-arginine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Lysine, L-arginine, Glutamine, Glycine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications.
  • For scale: 454 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Regains, check your medications against these: blood pressure drugs (antihypertensives, ACE inhibitors, ARBs), potassium-sparing diuretics, blood thinners and antiplatelet drugs, diabetes medications, erectile dysfunction drugs like sildenafil, anticonvulsants, clozapine for schizophrenia, and 5-HT4 agonists for gut motility. L-Arginine is responsible for the bulk of these Moderate-severity interactions.

We could not check Colostrum Powder — no data are on file.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Regains is worth considering if you're supporting muscle recovery or managing sickle cell disease, but the L-Arginine and other blood pressure effects mean you should check with your pharmacist before taking it — especially if you're on blood pressure drugs, blood thinners, diabetes medications, or diuretics. Pregnancy and breastfeeding?

Talk to your doctor first, as the safety data are incomplete. Anyone with kidney or liver disease needs medical supervision.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Regains, straight from the product label.

Brand REVSCI
Barcode (UPC) X002X9IQQ7
Net contents 150 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 289168
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Regains by REVSCI, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
8 Capsule(s)
Servings per container
75
UPC/BARCODE
X002X9IQQ7
IngredientAmount% DV
L-Glutamine300 mg--
L-Lysine Hydrochloride100 mg--
L-Glycine100 mg--
L-Ornithine Hydrochloride300 mg--
L-Arginine400 mg--
Colostrum Powder200 mg--
Ornithine Alpha-Ketoglutarate100 mg--

Other ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Regains contains 7 powerful, scientifically-backed ingredients that help support the body's natural production of human growth hormone (HGH). Higher levels of HGH are associated with increased lean muscle mass, decreased body fat, strong bones/joints, increased energy/endurance, increased metabolism, and fast recovery.

Made with only the highest quality, non-GMO ingredients.

Made with only the highest quality, non-GMO ingredients. Sourced from a GMP facility in the USA.

Advanced HGH support Supports strength, performance, energy, and recovery

Made with premium ingredients

Non GMO

Suggested/Recommended/Usage/Directions

Suggested use: On non-training days, take 2 capsules. On training or exercise days, take 2 capsules if your current body weight is 150 Ib or less. Increase by capsule for every 25 Ib of bodyweight up to 8 capsules. Take within 30 minutes prior to bed for optimal results. Under 150 Ibs = 2, 175 Ibs = 3, 200 Ibs = 4, 225 Ibs = 5, 250 Ibs = 6, 275 Ibs = 7, 300+ Ibs = 8 capsules.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Allergen warning: Contains milk (colostrum).

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Sourced from a GMP Certified Facility Formulated in the USA Premium Quality

3rd Party Certified for Purity & Potency Lab Tested

Formula

Regains 1500 mg per serving

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Regains by REVSCI label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Regains label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Regains by REVSCI

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container75 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
300 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

L-Lysine Hydrochloride

Interacts with
1 drug
100 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine Hydrochloride monograph & interactions

L-Glycine

Interacts with
1 drug
100 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

L-Glycine monograph & interactions

L-Ornithine Hydrochloride

No known
interactions
300 mg per serving

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...

L-Ornithine Hydrochloride monograph & interactions

L-Arginine

Interacts with
403 drugs
400 mg per serving Form: L-Arginine

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine monograph & interactions

Colostrum Powder

200 mg per serving Form: Bovine

Ornithine Alpha-Ketoglutarate

No known
interactions
100 mg per serving

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...

Ornithine Alpha-Ketoglutarate monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Regains by REVSCI Drug Interactions

Want to check YOUR meds against Regains?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
454Drugs
445 Moderate 9 Minor

Ingredients driving the most interactions

L-Arginine 403
L-Glutamine 50
L-Lysine Hydrochloride 1
L-Glycine 1

Individual Drug Interactions

The ingredients in Regains interact with 454 drugs. Click any drug to see the details.

4 of the 7 ingredients in Regains interact with drugs. Each result below shows which ingredient is responsible. L-Arginine L-Glutamine L-Lysine Hydrochloride L-Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in Regains with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine Hydrochloride full monograph & interactions

L-Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
L-Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Regains, from the product label.

REVSCI

See all REVSCI products
Name
Revolution Science
City
East Brunswick
State
NJ
ZipCode
08816
Phone Number
(732) 595-8785
Web Address
rvsci.com
Pharmacist Counseling Corner

Regains by REVSCI: Common Questions

Does Regains by REVSCI interact with any medications?
Yes. Based on its ingredients, Regains has a known interaction with 454 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Regains contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-Arginine safe to take if I'm already on blood pressure medication?
No — L-Arginine can lower blood pressure itself, so combining it with antihypertensive drugs poses a Moderate risk of dangerously low blood pressure. Check with your pharmacist or doctor before starting Regains.
Can I take this while pregnant or breastfeeding?
It depends on the ingredient. L-Glutamine is likely safe in pregnancy, but L-Lysine, L-Glycine, L-Ornithine, and Ornithine Alpha-Ketoglutarate don't have enough safety data — avoid them in pregnancy unless your doctor advises otherwise. For breastfeeding, data are insufficient across the board except for L-Glutamine, which should also be avoided unless medically recommended. Talk to your doctor.
What does L-Arginine actually do?
L-Arginine increases nitric oxide in your body, which relaxes blood vessels and can lower blood pressure. It may also help with diabetes control and blood flow, but that's why it interacts with so many medications.
Will this help me build muscle?
Regains contains amino acids that support muscle repair and recovery — L-Glutamine, L-Ornithine, and Ornithine Alpha-Ketoglutarate are possibly effective for athletic performance — but the product's overall muscle-building benefit is not established in our data.
What are the most common side effects?
L-Glutamine and L-Lysine can cause stomach upset — nausea, diarrhea, bloating, constipation, and abdominal pain. L-Glycine may rarely cause mild sedation, nausea, or soft stools. L-Arginine can cause abdominal pain, nausea, diarrhea, headache, and flushing. Most of these are mild and dose-related.
Is this safe if I have kidney or liver disease?
No — L-Glutamine should only be used under medical supervision if you have kidney or liver disease. Talk to your doctor before starting Regains.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Regains label
Go deeper

The Full Monographs Behind Regains’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph →
Sources

Sources & How We Checked

Regains's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 90 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
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