Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

RememBrain Ingredients & Drug Interactions

by NOW

RememBrain label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking RememBrain against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

RememBrain is a dietary supplement by NOW with 4 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 239 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidyl Serine, Vitamin B12, Alpha-GPC. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against RememBrain by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with RememBrain by NOW — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of RememBrain by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

RememBrain contains four active ingredients. Vitamin B12 is an essential nutrient your body needs for nerve function, red blood cells, and DNA; this product supplies it in a form your body can use.

Phosphatidyl serine is a compound found naturally in your brain cells that plays a role in cell communication. Alpha-GPC is another brain-supporting compound that supplies choline, which your body uses to make acetylcholine (a chemical messenger in the brain).

The fourth ingredient is huperzine A, a plant-derived compound. The product also contains several inactive ingredients—cellulose, cellulose powder, silica, magnesium stearate, and stearic acid—which serve as binders and fillers to hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: mental alertness and learning support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention, Cognitive function, Cognitive impairment, Dementia — and 4 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease.

The evidence for RememBrain's ingredients is mixed. Vitamin B12 is effective for treating B12 deficiency itself, and is likely effective for cyanide poisoning; it's possibly effective for canker sores and postherpetic neuralgia (nerve pain after shingles).

Phosphatidyl serine is possibly effective for age-related cognitive decline and Alzheimer disease, but evidence is insufficient for ADHD, cognitive function generally, or dementia. Alpha-GPC is possibly effective for Alzheimer disease, but evidence is insufficient for brain tumors, cognitive function, vascular dementia, or stroke.

We hold no effectiveness data on huperzine A.

The evidence, ingredient by ingredient Vitamin B12 Phosphatidylserine Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very safe and is needed during both pregnancy and breastfeeding at normal recommended amounts; follow your provider's guidance. Phosphatidyl serine is generally well tolerated in studies, but long-term safety isn't fully established, and the data advises against use in pregnancy and while breastfeeding because there isn't enough safety information.

Alpha-GPC is also generally well tolerated in studies, but long-term safety isn't fully established, and the data advises against it in pregnancy and while breastfeeding unless your doctor directs you to use it. Common side effects with phosphatidyl serine include flatulence, stomach upset, headache, insomnia (especially at higher doses), and nausea.

Alpha-GPC is rarely associated with dizziness, headache, insomnia, nausea, heartburn, or diarrhea; rarely, it has been linked with stroke when used for at least two months. Vitamin B12 is very well tolerated when taken by mouth, though allergic reactions like rash or hives are possible.

Side effects, ingredient by ingredient Vitamin B12 Phosphatidylserine Alpha-gpc

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Vitamin B12, Phosphatidylserine, Alpha-gpc.
  • The most serious interaction on file is rated Moderate.
  • For scale: 239 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking RememBrain, double-check with your doctor or pharmacist if you take anticholinergic drugs (such as medications for overactive bladder or certain neurological conditions) or cholinergic drugs (such as medications for myasthenia gravis or Alzheimer disease)—phosphatidyl serine may interfere with how these work. Also check if you take metformin for diabetes, as vitamin B12 and metformin can interact and affect your B12 levels.

If you use a scopolamine patch (Transderm Scop) for motion sickness, alpha-GPC may decrease its effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

RememBrain may be worth considering if you're interested in cognitive support and have a B12 deficiency, but the evidence for the other ingredients in supporting healthy brain function is limited. If you take anticholinergic or cholinergic medications, use a scopolamine patch, or take metformin, check with your doctor or pharmacist before starting—this product may affect how your medications work.

Talk with your own healthcare provider before starting any new supplement, especially during pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about RememBrain, straight from the product label.

Brand NOW
Barcode (UPC) 733739034144
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2017
DSLD ID 72682
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for RememBrain by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg. Capsule(s)
Maximum serving Sizes:
2 Veg. Capsule(s)
Servings per container
30
UPC/BARCODE
733739034144
IngredientAmount% DV
Vitamin B125 mg208333%
Phosphatidyl Serine300 mg--
Alpha-GPC300 mg--
Hurperzine A200 mg--

Other ingredients: Cellulose, Cellulose powder, Silica, Magnesium Stearate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

RememBRAIN is a formulation that supports mental alertness and learning by promoting proper Acetylcholine (ACh) production and activity.*

Suggested/Recommended/Usage/Directions

Suggested Usage: Take 2 capsules 1 to 2 times daily.

General Statements

ACh is a neurotransmitter that is necessary for normal neurological and cognitive function, and whose production tends to decrease with age.*

Cognitive health*

~ Supports memory, learning and alertness*

General/Health Family owned since 1968.

Formula

RememBrain combines Alpha-GPC (a bioavailable form of choline) to promote ACh production with Huperzine A to maintain ACh levels in the brain.* Phosphatidyl Serine is also included to support healthy membranes and efficient nerve cell signaling.*

~ With huperzine A, alpha-GPC & phosphatidyl serine

Phosphatidyl Serine from soy.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Do not use if pregnant or nursing. Consult physician if taking medication (especially medications that affect the central nervous system) or have a medical condition (especially heart or lung conditions).

Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

Phosphatidyl Serine from soy.

Not manufactured with wheat, gluten, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

General

CODE 3414B V3

FDA Statement of Identity

A Dietary Supplement

Formulation

Vegetarian/Vegan

Not manufactured with wheat, gluten, milk, egg, fish, shellfish or tree nut ingredients.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

RememBrain by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

RememBrain label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in RememBrain by NOW

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Veg. Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
5 mg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Phosphatidyl Serine

Interacts with
219 drugs
300 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidyl Serine monograph & interactions

Alpha-GPC

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-GPC monograph & interactions

Hurperzine A

200 mg per serving Form: Huperzia serrata extract

Other (inactive) ingredients: Cellulose, Cellulose powder, Silica, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

RememBrain by NOW Drug Interactions

Want to check YOUR meds against RememBrain?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
239Drugs
219 Moderate 20 Minor

Ingredients driving the most interactions

Phosphatidyl Serine 219
Vitamin B12 20
Alpha-GPC 16

Individual Drug Interactions

The ingredients in RememBrain interact with 239 drugs. Click any drug to see the details.

3 of the 4 ingredients in RememBrain interact with drugs. Each result below shows which ingredient is responsible. Phosphatidyl Serine Vitamin B12 Alpha-GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in RememBrain with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidyl Serine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidyl Serine full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Alpha-GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for RememBrain, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

RememBrain by NOW: Common Questions

Does RememBrain by NOW interact with any medications?
Yes. Based on its ingredients, RememBrain has a known interaction with 239 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
RememBrain contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take RememBrain if I'm pregnant or breastfeeding?
Vitamin B12 is considered safe during pregnancy and breastfeeding at normal recommended amounts. However, phosphatidyl serine and alpha-GPC do not have enough safety information, and the data advises against their use during pregnancy and while breastfeeding unless your doctor directs you otherwise. Talk with your doctor or pharmacist about whether this product is right for you.
What are the most common side effects?
Phosphatidyl serine may cause flatulence, stomach upset, headache, insomnia (especially at higher doses), and nausea. Alpha-GPC is rarely associated with dizziness, headache, insomnia, nausea, heartburn, and diarrhea. Vitamin B12 taken by mouth is generally very well tolerated, though allergic reactions like rash are rare.
Does RememBrain actually help with memory or brain function?
The evidence is limited. Phosphatidyl serine and alpha-GPC are possibly effective for Alzheimer disease and age-related cognitive decline, but evidence is insufficient for general cognitive function, ADHD, dementia, or stroke prevention. Vitamin B12 is effective for treating B12 deficiency itself, which is important for nerve health. We hold no data on huperzine A's effectiveness.
What is phosphatidyl serine, and why is it in this product?
Phosphatidyl serine is a compound found naturally in your brain cells that's involved in cell communication. It's included because some research suggests it may support cognitive health, particularly in age-related cognitive decline and Alzheimer disease, though the evidence is still limited.
Can I take this with my diabetes medication?
If you take metformin (Glucophage) for type 2 diabetes, you should check with your doctor or pharmacist first. Metformin can lower your vitamin B12 levels by interfering with absorption in your digestive system, and this product contains B12, so your provider may want to monitor your levels or adjust your timing.
Does this product have any fillers?
Yes, RememBrain contains inactive ingredients including cellulose, cellulose powder, silica, magnesium stearate, and stearic acid, which serve as binders and fillers to hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if RememBrain is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

RememBrain label
Go deeper

The Full Monographs Behind RememBrain’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

RememBrain's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 43 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team