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Dietary supplement

Rutin 450 mg Ingredients & Drug Interactions

by NOW

Rutin 450 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rutin 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rutin 450 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for varicose veins and chronic venous insufficiency, hemorrhoids, easy bruising and fragile capillaries.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rutin powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Rutin 450 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Rutin 450 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Rutin 450 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: rutin powder at 450 mg per capsule. Rutin is a plant compound (a flavonoid) found naturally in foods like buckwheat, citrus, and berries.

The capsule also holds inactive ingredients—cellulose, stearic acid, and silica—which are common binders and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Rutin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: vascular health and free radical support.
  • We looked for evidence on: Varicose veins, Hemorrhoids, Postoperative swelling, chronic venous insufficiency, capillary fragility, edema.
  • The closest evidence on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids (Natural Medicines).
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Lymphedema, Varicose veins, Postoperative swelling.

The evidence we hold doesn't establish that rutin works reliably for any condition. We rate it insufficient reliable evidence for aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-induced respiratory infections, and hemorrhoids.

That means the research so far hasn't been strong enough to confirm whether it helps or doesn't. If you're considering rutin for a specific reason, talk it over with your doctor about what the current science says.

The evidence, ingredient by ingredient Rutin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rutin is generally well tolerated in food and short-term supplement use, though good long-term safety data at supplement doses are limited. Some people report headache, flushing, or rashes when taking it by mouth.

The safety data for supplement doses during pregnancy aren't adequate, so if you're pregnant, check with your doctor before starting. Breastfeeding safety is unknown; avoid supplement doses unless your doctor says otherwise.

Side effects, ingredient by ingredient Rutin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rutin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs—insulin, metformin, sulfonylureas, or others—double-check with your doctor or pharmacist before adding this rutin supplement. The risk is Moderate; rutin may increase the chance of low blood sugar when combined with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

NOW's Rutin 450 mg is a single-ingredient supplement with limited evidence for its intended uses. Its main caution is a Moderate interaction risk with diabetes drugs, which can lower blood sugar further.

If you take diabetes medication, are pregnant, or breastfeeding, talk with your doctor or pharmacist before starting rutin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rutin 450 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739007353
Net contents 100 Veg Capsule(s)
Market status On market
Date entered into DSLD Aug 25, 2015
DSLD ID 48135
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rutin 450 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
UPC/BARCODE
733739007353
IngredientAmount% DV
Rutin powder450 mg--

Other ingredients: Cellulose, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule 1 to 2 times daily, preferably with food.

General Statements

Rutin is a bioflavonoid related to quercetin and hesperidin found in both citrus and non-citrus fruits, as well as other foods such as buckwheat. Rutin is a powerful combatant of free radicals and is best known for its role in vascular health.* Rutin helps to maintain the structural integrity of blood vessels, such as veins and capillaries.* Scientific studies suggest that it may help to support vascular function and promote healthy circulation.*

Natural color variation may occur in this product.

CAPSULE SIZE

Cell Defense*

~ Free Radical Scavenger* ~ Supports Vascular Strength*

Vitamins

Family owned since 1968.

Please Recycle.

Formulation

NOW(R) Rutin is vegetarian and derived from a non-citrus source.

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do Not Eat Freshness Packet. Keep in Bottle.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

General

CODE 0735B V3

Seals/Symbols

Non-GMO

GMP Quality Assured

FDA Statement of Identity

A Dietary Supplement

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rutin 450 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rutin 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rutin 450 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Amounts shown are per serving.

Rutin powder

Interacts with
86 drugs
450 mg per serving Form: Sophora japonica

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin powder monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rutin 450 mg by NOW Drug Interactions

Want to check YOUR meds against Rutin 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Rutin powder 86

Individual Drug Interactions

The ingredients in Rutin 450 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Rutin 450 mg interact with drugs. Each result below shows which ingredient is responsible. Rutin powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Rutin 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rutin powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutin powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rutin 450 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Rutin 450 mg by NOW: Common Questions

Does Rutin 450 mg by NOW interact with any medications?
Yes. Based on its ingredients, Rutin 450 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rutin 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will rutin help my blood sugar?
We don't have reliable evidence that it works for diabetes. Animal research suggests rutin *may* lower blood sugar, but human trials haven't confirmed it yet. If you're interested in trying it, talk with your doctor first—especially if you're on diabetes medication.
Can I take this if I'm pregnant?
The safety data suggest it's likely safe during pregnancy, so it's not ruled out. But if you're pregnant, check with your doctor before starting any supplement to make sure it's right for your situation.
Is it safe to breastfeed while taking rutin?
Safety during breastfeeding is unknown, so the data advises against supplement doses unless your doctor recommends it. If you're breastfeeding, talk with your doctor or pharmacist before using this product.
What side effects might I notice?
Some people report headache, flushing (warmth and redness), or rashes. These aren't common, but if any of these show up, stop and let your pharmacist know.
How long can I safely take rutin?
Short-term use is generally well tolerated. Long-term safety data at supplement doses are limited, so if you're planning to use it regularly for months, talk with your doctor about monitoring.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Rutin 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rutin 450 mg label
Go deeper

The Full Monographs Behind Rutin 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph →
Sources

Sources & How We Checked

Rutin 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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