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Dietary supplement

Rutin (500 mg) Ingredients & Drug Interactions

by BulkSupplements.com

Rutin (500 mg) label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rutin (500 mg) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rutin (500 mg) is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for varicose veins and chronic venous insufficiency, hemorrhoids, easy bruising and fragile capillaries.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rutin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Rutin (500 mg) by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Rutin (500 mg) by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Rutin (500 mg) by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: rutin, a compound found naturally in plants and some foods. Rutin is a type of flavonoid — a plant chemical with antioxidant properties.

Each capsule delivers 500 mg of rutin. The capsule itself is made from bovine gelatin, which is an inactive ingredient that holds the rutin inside.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Rutin product and its label doesn't state a use — see Rutin's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that rutin works reliably for any of the conditions it's marketed for — aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-related respiratory infections, or hemorrhoids. Our data shows insufficient reliable evidence to rate it for all of these uses, which means human studies are either lacking, small, or inconclusive.

That doesn't mean it doesn't work; it means the scientific backing isn't there yet to say one way or the other.

The evidence, ingredient by ingredient Rutin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rutin is generally well tolerated when you eat it in food or take it as a short-term supplement, but long-term safety data at supplement doses are limited — we just don't have enough long-term studies. Some people report headache, flushing, or rash when taking it orally, though these appear to be uncommon.

Regarding pregnancy and breastfeeding: rutin is rated as likely safe during pregnancy based on the data we hold, so if you're pregnant, that's a reasonable sign — but talk it over with your doctor for your individual situation. Safety during breastfeeding is unknown, so the recommendation is to avoid supplement doses unless your doctor advises otherwise.

There isn't enough data to know either way, so a conversation with your doctor or pharmacist will help you decide what's right for you.

Side effects, ingredient by ingredient Rutin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rutin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs — insulin, metformin, sulfonylureas, or any other medication to lower blood sugar — check with your doctor or pharmacist before adding rutin. The combination could theoretically lower your blood sugar too much.

No other medication categories show documented interactions in our data, but run your complete list through the search tool on this page to be thorough.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Rutin might be worth considering if you're looking into plant-based antioxidants, but the evidence that it actually works for common uses isn't solid yet. If you take any diabetes medication, check with your doctor or pharmacist before starting it — the blood sugar interaction is real.

Long-term safety data are thin, so this isn't a take-it-forever kind of supplement without medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rutin (500 mg), straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000SFTR4D
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 254328
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rutin (500 mg) by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
X000SFTR4D
IngredientAmount% DV
Rutin500 mg--

Other ingredients: Bovine Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule once daily, or as directed by a physician.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rutin (500 mg) by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rutin (500 mg) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rutin (500 mg) by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Rutin

Interacts with
86 drugs
500 mg per serving

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin monograph & interactions

Other (inactive) ingredients: Bovine Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rutin (500 mg) by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Rutin (500 mg)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Rutin 86

Individual Drug Interactions

The ingredients in Rutin (500 mg) interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Rutin (500 mg) interact with drugs. Each result below shows which ingredient is responsible. Rutin

Each ingredient & the kinds of drugs it affects

For each ingredient in Rutin (500 mg) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rutin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rutin (500 mg), from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Rutin (500 mg) by BulkSupplements.com: Common Questions

Does Rutin (500 mg) by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Rutin (500 mg) has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rutin (500 mg) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does rutin actually help with diabetes?
The evidence we hold doesn't establish that it does. Our data shows insufficient reliable evidence to rate rutin for diabetes — meaning studies are lacking or inconclusive so far. Animal research hints that rutin may lower blood sugar, which is actually why it's a concern when combined with diabetes medications, but that's different from proof it helps people with diabetes.
What side effects might I notice?
Most people tolerate rutin well. Some people report headache, flushing, or rash when taking it by mouth, though these don't appear to be common. Long-term safety data at supplement doses are limited, so we're really not sure what happens if you take it for years.
Is rutin safe during pregnancy?
Yes — rutin is rated as likely safe during pregnancy based on our data. That said, any decision about supplements in pregnancy is best made with your doctor, who knows your full health picture and can give you personalized advice.
Can I take this while breastfeeding?
Safety during breastfeeding is unknown, so the recommendation in our data is to avoid supplement doses unless your doctor advises otherwise. There isn't enough information to say it's safe or unsafe, so talk with your doctor or pharmacist to figure out what's right for you and your baby.
What exactly is rutin?
Rutin is a flavonoid — a type of plant compound with antioxidant properties — found naturally in many plants and foods. Each capsule in this product delivers 500 mg of it.
Are there any fillers or other ingredients I should know about?
The capsule is made from bovine gelatin. There are no other active ingredients — rutin is the only one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Rutin (500 mg) is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rutin (500 mg) label
Go deeper

The Full Monographs Behind Rutin (500 mg)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph →
Sources

Sources & How We Checked

Rutin (500 mg)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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