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Dietary supplement

Sang Ye Ingredients & Drug Interactions

by Hawaii Pharm

Sang Ye label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sang Ye against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sang Ye is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, weight management.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Sang Ye extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sang Ye by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Sang Ye by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sang Ye by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Sang Ye contains one active ingredient: certified organic white mulberry leaf extract. This is a traditional botanical used in several culinary and medicinal traditions, and it comes to you here as a concentrated liquid form.

The product also contains vegetable palm glycerin and pharmaceutical-grade alcohol as inactive ingredients—these are the base and preservative that keep the extract stable.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient White Mulberry product and its label doesn't state a use — see White Mulberry's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on white mulberry leaf for any specific health purpose isn't established in the data we hold. The supplement has been studied for androgenic alopecia (hair loss), osteoporosis, common cold, diabetes, and high cholesterol, but in each case the evidence is insufficient to rate it as effective.

That doesn't mean it doesn't work—it means the research so far hasn't been strong enough to say either way.

The evidence, ingredient by ingredient White Mulberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

White mulberry leaf is generally well tolerated when taken by mouth. In clinical trials, the most common side effects were temporary digestive ones: bloating and flatulence (in about half of users), loose stools (in a quarter), and constipation (in about one in five).

The good news is these effects often improved over time as people continued taking it. Because white mulberry leaf can lower blood sugar, use it cautiously if you're at risk for low blood sugar or already managing glucose.

During pregnancy and breastfeeding, there isn't enough safety data on medicinal amounts, so it's best avoided at those times—talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient White Mulberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — White Mulberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sang Ye, double-check with your doctor or pharmacist if you're on diabetes medications—white mulberry leaf lowers blood sugar and raises the risk of low blood sugar (hypoglycemia) when combined. Also flag any medications that use the OCT2 kidney transport system, such as metformin or certain antivirals and antibiotics, because white mulberry leaf may slow how your kidneys clear them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sang Ye is worth considering if you're interested in white mulberry leaf and you're not taking diabetes medications or OCT2-substrate drugs. If you do take any prescription or over-the-counter medications, especially for diabetes or high cholesterol, check them against the interaction tool on this page and confirm with your own doctor or pharmacist before starting.

Digestive side effects are common but often settle down.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sang Ye, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 0787699221502
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 23, 2020
DSLD ID 237591
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sang Ye by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
0787699221502
IngredientAmount% DV
certified organic Sang Ye extract970 mg--

Other ingredients: Vegetable Palm Glycerin, pharmaceutical grade Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hawaii Pharm Herbal Extract Highest quality since 2008

Made with Aloha!

Formulation

Contains no GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.

Super concentrated liquid herbal extract. Dry herb/menstruum ratio: 1:3.

Manufactured in an FDA registered facility.

Non GMO Gluten free

Made in USA, Hawaii

Suggested/Recommended/Usage/Directions

Directions for use: Shake well before using. Take about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water up to 4 times per day.

Precautions

Warning: Keep out of the reach of children.

May have contraindications. We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing or taking any medications.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Formula

(Morus alba)

FDA Statement of Identity

Herbal Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

FDA Registered Facility Made in United States of America USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sang Ye by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sang Ye label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sang Ye by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Certified organic Sang Ye extract

Interacts with
87 drugs
970 mg per serving

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

Certified organic Sang Ye extract monograph & interactions

Other (inactive) ingredients: Vegetable Palm Glycerin, Pharmaceutical grade Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sang Ye by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Sang Ye?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

certified organic Sang Ye extract 87

Individual Drug Interactions

The ingredients in Sang Ye interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sang Ye interact with drugs. Each result below shows which ingredient is responsible. certified organic Sang Ye extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sang Ye with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Sang Ye extract2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
certified organic Sang Ye extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sang Ye, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
City
Honolulu
State
HI
ZipCode
96815
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Sang Ye by Hawaii Pharm: Common Questions

Does Sang Ye by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Sang Ye has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sang Ye contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this lower my blood sugar if I don't have diabetes?
White mulberry leaf can lower blood glucose levels. If you don't have diabetes or take blood-sugar-lowering drugs, the effect may be mild, but it's something to be aware of—especially if you're fasting or have a history of low blood sugar. Your doctor or pharmacist can help you decide whether that's a concern for you.
What are the most common side effects?
Digestive upset is most common: bloating, flatulence, loose stools, and constipation. In one study, these happened in 25–50% of users, but they often got better as people kept taking it, suggesting they may be temporary.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data on medicinal amounts during pregnancy and breastfeeding, so it's best to avoid it at those times. Talk with your doctor or pharmacist about whether this is right for you.
Is this the same as mulberry fruit?
This product is made from white mulberry leaf extract, not the fruit. While mulberry fruit is common in food, concentrated leaf supplements are less studied, and the safety data we have is more limited.
Does this product contain alcohol?
Yes—pharmaceutical-grade alcohol is used as a preservative in the liquid extract. If you need to avoid alcohol entirely, let your pharmacist know and ask about other options.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sang Ye is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sang Ye label
Go deeper

The Full Monographs Behind Sang Ye’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph →
Sources

Sources & How We Checked

Sang Ye's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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