Saw Palmetto Complex Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Saw Palmetto Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Saw Palmetto Complex is a dietary supplement by Wonder Laboratories with 3 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 887 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi extract, Saw Palmetto extract, Pumpkin seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Saw Palmetto Complex by Wonder Laboratories
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HelloPharmacist Scorecard of Saw Palmetto Complex by Wonder Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Saw Palmetto Complex contains three active ingredients. Pumpkin seed oil is included for benign prostatic hyperplasia (enlarged prostate).
Saw palmetto extract is traditionally used for prostate and urinary symptoms. Uva ursi extract is meant to support urinary tract health.
The product also contains inactive ingredients—gelatin, vegetable glycerin, natural caramel color, silica, and soy lecithin—that serve as the capsule and binders.
Does it work?
Moderate evidence
The evidence for these ingredients is mixed. Pumpkin seed oil is possibly effective for benign prostatic hyperplasia, but evidence is insufficient for hair loss, bladder pain (interstitial cystitis), parasites, and urinary tract infections.
Saw palmetto is possibly effective for a specific prostate procedure (transurethral resection of the prostate) but possibly ineffective for benign prostatic hyperplasia itself; evidence is also insufficient for cough, hair loss, and lower urinary tract symptoms. Uva ursi is possibly ineffective for urinary tract infections, and evidence is insufficient for cough and prostate enlargement.
In short, the evidence supporting these ingredients for their traditional uses is limited or mixed.
How safe is it?
Well-documented data
Pumpkin seed oil and saw palmetto are generally well tolerated in most adults, though mild side effects like stomach discomfort, diarrhea, nausea, and headache can occur. Saw palmetto rarely causes skin reactions or changes in desire.
Uva ursi is well tolerated at low doses for short-term use only; high doses (20 grams or more of dried herb) can cause serious toxicity including convulsions and delirium, and very high doses may be fatal. Avoid uva ursi for prolonged use.
Saw palmetto is not safe during pregnancy or breastfeeding. Pumpkin as food is fine in pregnancy and lactation, but safety of concentrated seed supplements is not well studied—talk with your doctor.
Uva ursi should be avoided during pregnancy (may stimulate the uterus) and breastfeeding (insufficient safety data).
Meds to double-check
Moderate interaction found
Before you take this, double-check blood thinners or antiplatelet drugs (Moderate risk—saw palmetto may increase bleeding), estrogens and birth control pills (Moderate—saw palmetto may reduce their effectiveness), and lithium (Moderate—pumpkin seed oil and uva ursi may raise its level). Also check if you take drugs metabolized by your liver via CYP2C19 or CYP3A4 pathways, glucuronidated drugs, or urinary acidifying agents (Moderate for uva ursi, though these effects are theoretical in humans).
Use the medication checker on this page to be sure.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product combines three herbs traditionally linked to prostate and urinary health, but the evidence is weak. It's a reasonable option to discuss with your doctor if you're exploring natural support for these areas—but only if none of your medications are on the interaction list, especially blood thinners, birth control, estrogens, or lithium.
Pregnant or breastfeeding? Skip this one.
Check your exact medications before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Saw Palmetto Complex, straight from the product label.
| Brand | Wonder Laboratories |
|---|---|
| Net contents | 120 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Nov 19, 2021 |
| DSLD ID | 261211 |
| Product type | Botanical With Nutrients |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult Male (18-50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Saw Palmetto Complex by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pumpkin seed Oil | 80 mg | -- |
| Saw Palmetto extract | 160 mg | -- |
| Uva Ursi extract | 10 mg | -- |
Other ingredients: Gelatin, Vegetable Glycerin, natural Caramel color, Silica, Soy Lecithin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: For men, as a dietary supplement take 2 softgels daily, preferably with a meal.
Precautions
Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.
Keep out of reach of children
Caution: If you are pregnant or nursing, consult your physician before taking this product.
Contains soy ingredients.
Formulation
Mfg. in a FDA registered facility using Good Manufacturing Practices (GMPs)
Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.
Nutritionally supports healthy prostate function
Gluten Free
Made in USA
Storage
Keep tightly closed. Store at room temperature: 59 degrees-86 degrees F (15 degrees to 30 degrees C).
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Reorder #6053
New smaller size softgels
Formula
85-95% Fatty acids
FDA Statement of Identity
Dietary supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Saw Palmetto Complex by Wonder Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Saw Palmetto Complex by Wonder Laboratories
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Pumpkin seed Oil
Interacts with1 drug
Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...
Pumpkin seed Oil monograph & interactionsSaw Palmetto extract
Interacts with174 drugs
Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...
Saw Palmetto extract monograph & interactionsUva Ursi extract
Interacts with803 drugs
Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...
Uva Ursi extract monograph & interactionsOther (inactive) ingredients: Gelatin, Vegetable Glycerin, Natural Caramel color, Silica, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.
Saw Palmetto Complex by Wonder Laboratories Drug Interactions
HelloPharmacist Interaction Report
Saw Palmetto Complex by Wonder Laboratories contains three active ingredients, and together they interact with a significant number of medications.
The most serious concern is with saw palmetto and blood thinner or antiplatelet drugs (like warfarin or aspirin)—saw palmetto is reported to prolong bleeding time, which could raise your bleeding risk. This is a Moderate severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Saw palmetto also has Moderate interactions with estrogens and contraceptive drugs; it may have antiestrogenic effects and theoretically could reduce how well these work. Pumpkin seed oil and uva ursi both interact with lithium—both may reduce how your kidneys clear it, potentially raising lithium levels and requiring a dose adjustment.
Altogether, these interactions span 874 individual medications.
Uva ursi presents additional Moderate concerns: it may slow the metabolism of drugs processed by your liver through two major pathways (CYP2C19 and CYP3A4 substrates), drugs cleared by glucuronidation, and urinary acidifying agents may reduce uva ursi's effectiveness in the urinary tract. Uva ursi also has a Minor interaction with P-glycoprotein substrates.
Use the medication checker below to see if any of your prescriptions or over-the-counter drugs are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Saw Palmetto Complex?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Saw Palmetto Complex interact with 887 drugs. Click any drug to see the details.
3 of the 3 ingredients in Saw Palmetto Complex interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi extract Saw Palmetto extract Pumpkin seed Oil
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Saw Palmetto Complex — through 2 ingredients. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Abrocitinib interactionUva Ursi ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
Read the full Uva Ursi Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
Read the full Uva Ursi Extract + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Saw Palmetto Complex — through 2 ingredients. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Aspirin interactionSaw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Saw Palmetto Complex — through 2 ingredients. Tap an ingredient for the detail:
Saw Palmetto ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Extract + Acetaminophen, Aspirin, Caffeine interactionUva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Saw Palmetto Complex — through 1 ingredient. Tap an ingredient for the detail:
Uva Ursi ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Uva Ursi Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Saw Palmetto Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Uva Ursi extract
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.
Glucuronidated Drugs
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.
Lithium
Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.
Urinary Acidifying Agents
Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.
P-Glycoprotein Substrates
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.
Saw Palmetto extract
Anticoagulant/Antiplatelet Drugs
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.
Contraceptive Drugs
Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.
Estrogens
Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.
Pumpkin seed Oil
Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Saw Palmetto Complex, from the product label.
Wonder Laboratories
See all Wonder Laboratories products- Name
- Wonder Laboratories
- Street Address
- 115 S.C.T. Ct.
- City
- White House
- State
- TN
- ZipCode
- 37188
Saw Palmetto Complex by Wonder Laboratories: Common Questions
Does Saw Palmetto Complex by Wonder Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is it safe to use this while taking birth control?
What are the most common side effects?
Can I take this while pregnant or breastfeeding?
Does this actually work for prostate problems?
Can I take this long-term?
What if I'm on lithium for bipolar disorder?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Saw Palmetto Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Pumpkin
Interacts with 1 drugPumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...
Read the full Pumpkin monograph → Herb & supplement monographSaw Palmetto
Interacts with 174 drugsSaw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...
Read the full Saw Palmetto monograph → Herb & supplement monographUva Ursi
Interacts with 803 drugsUva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...
Read the full Uva Ursi monograph →Sources & How We Checked
Saw Palmetto Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 35 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pumpkin 5 references
- Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
- Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
- Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
- Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
- Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed
Saw Palmetto 22 references
- Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
- Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
- Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
- Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
- Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
- Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
- Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
- Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
- Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
- Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
- Agbabiaka, T. B., Pittler, M. H., Wider, B., and Ernst, E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009;32(8):637-647. PubMed
- Wargo, K. A., Allman, E., and Ibrahim, F. A possible case of saw palmetto-induced pancreatitis. South.Med.J. 2010;103(7):683-685. PubMed
- Lapi, F., Gallo, E., Giocaliere, E., Vietri, M., Baronti, R., Pieraccini, G., Tafi, A., Menniti-Ippolito, F., Mugelli, A., Firenzuoli, F., and Vannacci, A. Acute liver damage due to Serenoa repens: a case report. Br.J.Clin.Pharmacol. 2010;69(5):558-560.
- Mantovani, F. Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies. Minerva Urol.Nefrol. 2010;62(4):335-340.
- Hanaka, M., Yoshii, C., Yatera, K., Ito, C., Chojin, Y., Nagata, S., Yamasaki, K., Nishida, C., Kawanami, T., Kawanami, Y., Ishimoto, H., and Mukae, H. [A case of rhabdomyolysis caused by saw palmetto of healthy foods]. J.UOEH. 6-1-2012;34(2):193-199. PubMed
- Miroddi, M., Carni, A., Mannucci, C., Moleti, M., Navarra, M., and Calapai, G. Hot flashes in a young girl: a wake-up call concerning Serenoa repens use in children. Pediatrics 2012;130(5):e1374-e1376.
- Braeckman J. The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a multicenter open study. Current Therapeutic Research 1994;55(7):776-785. DOI
- Jipescu D, Patel A, Bohra H, Pientka A. Rare case of saw palmetto induced heart block. JACC 2017;69(11) supplement:2310.
- Morabito P, Miroddi M, Giovinazzo S, Spina E, Calapai G. Serenoa repens as an endocrine disruptor in a 10-year-Old young girl: a new case report. Pharmacology. 2015;96(1-2):41-3. doi: 10.1159/000431327.
- Gammoudi R, Ameur K, Ouni B, et al. Fixed drug eruption to Serenoa repens: first case report and consideration of the use of herbal medicine. Dermatol Ther 2020 Aug 29:e14247.
- Paulis G, Paulis A, Perletti G. Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials. Arch Ital Urol Androl 2021;93(4):475-480. PubMed
- Venkateswaran S, Declet-Bauzo R, Shodeinde M, Gilford P. Postoperative Retroperitoneal Hematoma: A Case of Saw Palmetto and the Importance of Primary Care Intervention. HCA Healthc J Med 2020;1(5):279-282. PubMed
Uva Ursi 8 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
- Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
- de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
- Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
- Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC