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Dietary supplement

Sceletium Tortuosum 25 mg Ingredients & Drug Interactions

by Nutricost

Sceletium Tortuosum 25 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sceletium Tortuosum 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sceletium Tortuosum 25 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, low mood, mental focus and cognition.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zembrin extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sceletium Tortuosum 25 mg by Nutricost

Ask about any prescription or over-the-counter medication and we check it for interactions with Sceletium Tortuosum 25 mg by Nutricost — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sceletium Tortuosum 25 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: zembrin extract, a form of Sceletium tortuosum, a plant with a history of traditional use. The capsule also contains inactive ingredients — rice flour, hypromellose (a capsule binder), and magnesium stearate — that help hold the supplement together.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: mood and anxiety support.
  • We looked for evidence on: Anxiety, Stress, Depression, low mood, emotional wellness.
  • The closest evidence on file: Sceletium is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Sceletium is rated "Insufficient Reliable Evidence To Rate" for Depression, Stress.

The evidence on sceletium for its claimed uses — anxiety, depression, stress, alcohol use disorder, athletic performance, and weight — is insufficient to rate. That means we don't yet have enough reliable data to say whether it works.

If you're considering it for one of these reasons, that's worth knowing upfront.

The evidence, ingredient by ingredient Sceletium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sceletium appears generally well tolerated in small studies, but long-term safety hasn't been established. The most commonly reported side effects in oral form are anxiety, headache, insomnia, irritability, and nausea.

There are also anecdotal reports of headache, depression, and listlessness, and a report of high blood pressure. The safety data advise against use during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Sceletium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sceletium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check your medications against CNS depressants — sedatives, sleep aids, some anti-anxiety drugs, and certain pain relievers. A pharmacist can help you review your exact list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sceletium is a single-ingredient supplement with limited evidence on how well it works and a documented interaction with sedating drugs. If you take any CNS depressants or multiple medications, talk with your pharmacist before starting.

Long-term safety isn't yet well understood.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sceletium Tortuosum 25 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 810014671284
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 270734
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sceletium Tortuosum 25 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
810014671284
IngredientAmount% DV
Zembrin extract25 mg--

Other ingredients: Rice Flour, Hypromellose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule daily with 8-12 oz of water or as directed by your healthcare professional. Daily dose should not exceed 25 mg.

Precautions

Warning: For healthy individuals 18 years and older.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Notice: Store in a cool, dry place.

Formula

Made with Zembrin 25 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Guaranteed Nutricost

Formulation

Vegetarian product

Gluten-Free Product Non-GMO Product

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Zembrin is a trademark of HG+H Pharmaceuticals (Pty) Limited. U.S. Patents #6,288,104, #8,552,051 and #8,980,338 B2.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sceletium Tortuosum 25 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sceletium Tortuosum 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sceletium Tortuosum 25 mg by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Zembrin extract

Interacts with
248 drugs
25 mg per serving

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, s...

Zembrin extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sceletium Tortuosum 25 mg by Nutricost Drug Interactions

Want to check YOUR meds against Sceletium Tortuosum 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Zembrin extract 248

Individual Drug Interactions

The ingredients in Sceletium Tortuosum 25 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sceletium Tortuosum 25 mg interact with drugs. Each result below shows which ingredient is responsible. Zembrin extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sceletium Tortuosum 25 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zembrin extract1 drug type · 248 drugs

Cns Depressants

Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Some evidence suggests that sceletium has sedative properties.

Likelihood Possible Evidence D
Zembrin extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sceletium Tortuosum 25 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

Sceletium Tortuosum 25 mg by Nutricost: Common Questions

Does Sceletium Tortuosum 25 mg by Nutricost interact with any medications?
Yes. Based on its ingredients, Sceletium Tortuosum 25 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sceletium Tortuosum 25 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's in this supplement?
One active ingredient — zembrin extract, which comes from Sceletium tortuosum. The rest is inactive ingredients that make up the capsule.
Does it actually work for anxiety or depression?
The evidence isn't reliable enough to say yet. We rate it as insufficient evidence for both anxiety and depression, as well as for stress, alcohol use disorder, athletic performance, and weight management.
What side effects has it caused?
The most common ones reported are anxiety, headache, insomnia, irritability, and nausea. There are also anecdotal reports of depression, listlessness, and high blood pressure, though information is still limited.
Is it safe to take while pregnant or breastfeeding?
No — the safety data advise against use during pregnancy and while breastfeeding. Talk with your doctor if you're pregnant, planning to become pregnant, or nursing.
What if I take sleeping pills or anti-anxiety medication?
That's the main interaction to watch. Sceletium may add to the sedative effect of those drugs. Check your exact medications with the tool on this page or ask your pharmacist before you start.
How long has this been studied?
In small studies it appears generally well tolerated, but long-term safety hasn't been well established. That's important to keep in mind if you're thinking about taking it regularly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sceletium Tortuosum 25 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sceletium Tortuosum 25 mg label
Go deeper

The Full Monographs Behind Sceletium Tortuosum 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sceletium

Interacts with 248 drugs

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk...

Read the full Sceletium monograph →
Sources

Sources & How We Checked

Sceletium Tortuosum 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sceletium 3 references
  1. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
  2. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum
  3. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed

See these in context on the Sceletium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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