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Dietary supplement

Sea Buckthorn Force Ingredients & Drug Interactions

by New Chapter

Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sea Buckthorn Force is a dietary supplement by New Chapter with 3 active ingredients. Its ingredients are commonly taken for memory and concentration, digestive upset, hair growth.Based on those ingredients, 717 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rosemary supercritical extract, Sea Buckthorn (fruit and seed) supercritical extract, Calendula supercritical extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Sea Buckthorn Force by New Chapter

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.
  • “Calendula supercritical extract” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Sea Buckthorn Force contains three active ingredients. Rosemary supercritical extract and sea buckthorn fruit and seed supercritical extract are the named actives; the product also includes a proprietary blend, whose specific components aren't detailed on the label.

Palmitoleic acid (a fatty acid) is listed, though we could not verify its interaction profile. The capsule itself and organic sunflower oil are inactive ingredients that help deliver the product.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: whole food nutritional support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for rosemary is strongest for memory — it's rated possibly effective for that use. For age-related cognitive decline and other conditions like alopecia areata and fatty liver disease, the evidence isn't established in our data.

Sea buckthorn shows possibly effective evidence for burns, though it's rated possibly ineffective for eczema. For skin aging, cholesterol levels, and other uses, the evidence we hold is insufficient to rate.

Talk with your doctor about whether this product fits your health goals.

The evidence, ingredient by ingredient Rosemary Sea Buckthorn Calendula

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rosemary in food amounts is considered safe; however, concentrated extracts like this one require caution. During pregnancy, food amounts are likely fine, but medicinal doses are not well studied — the safety data advises against large or medicinal doses in pregnancy.

Breastfeeding safety data is similarly limited, so avoid medicinal doses while nursing. Sea buckthorn is generally well tolerated as a food, but supplement safety hasn't been fully studied; breastfeeding safety data is also incomplete.

Side effects from rosemary can include allergic reactions when applied to skin or mouth, and in rare cases, occupational asthma or topical photosensitivity. Sea buckthorn at high doses may cause yellow skin staining, and topical use has caused dryness, redness, and rash in some users.

Side effects, ingredient by ingredient Rosemary Sea Buckthorn Calendula

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Rosemary, Sea Buckthorn.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 534 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs — rosemary and sea buckthorn may increase bleeding risk. Also flag diabetes medications (risk of low blood sugar), blood pressure medications (risk of low blood pressure), aspirin, or salicylate-containing pain relievers.

Rosemary may also affect how your liver processes certain medications, so run any prescriptions through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to people interested in supporting memory and circulation, but it carries documented interaction risks with blood thinners, diabetes drugs, blood pressure medications, and aspirin-type pain relievers. If you take any prescription medication — especially for bleeding, blood sugar, or blood pressure — check with your doctor or pharmacist before starting.

Pregnant or breastfeeding? Talk it over with your healthcare provider, since medicinal doses haven't been well studied in these situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 27, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sea Buckthorn Force, straight from the product label.

Brand New Chapter
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Oct 27, 2014
DSLD ID 38385
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sea Buckthorn Force by New Chapter, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
IngredientAmount% DV
Proprietary Blend500 mg--
Palmitoleic Acid100 mg--
Rosemary supercritical extract0 NP--
Sea Buckthorn (fruit and seed) supercritical extract0 NP--
Calendula supercritical extract0 NP--

Other ingredients: Capsule, organic Sunflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Discover the force of the Whole Sea Buckthorn contains Palmitoleic acid, an Omega-7 fatty acid recognized as one of Nature’s “good fats.”

A superfood botanical that’s a staple of traditional herbal systems, Sea Buckthorn is also being researched for its many benefits. Our full-spectrum process extracts precious plant compounds to preserve Nature’s full complexity, delivering super-pure, super-potent herbal extracts. Full-Spectrum Extraction: Our Difference Many companies isolate elements from an herb, concentrate them, and label it “whole herb.”

Please recycle this bottle after use.

Brand IP Statement(s)

The full spectrum of beneficial compounds found in Sea Buckthorn Force(R) is delivered using a supercritical extraction, wholefood approach to herbal supplementation.

New Chapter(R) delivers the wisdom of whole food. Using only natural supercritical CO2 or traditional techniques of extraction, our Force extracts guarantee the fullest spectrum of beneficial phytonutrients in their natural profile.

(C) 2014 New Chapter, Inc.

Suggested/Recommended/Usage/Directions

Suggested use: One softgel daily.

Precautions

Caution: As with any dietary or herbal supplement, you should advise your healthcare practitioner of the use of this product.

If you are nursing, pregnant, or considering pregnancy, you should consult your healthcare practitioner prior to using this product.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Non-GMO VERIFIED FORMULA

Naturally gluten free; our premium softgel capsules are BSE free.

Seals/Symbols

NON GMO Project VERIFIED

Formula

Delivers 100 mg of Omega-7

Supercritical Sea Buckthorn Delivers Plant-Sourced Omega Fatty Acids

FDA Statement of Identity

DIETARY SUPPLEMENT

General

4098-06

See for yourself

Sea Buckthorn Force by New Chapter label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sea Buckthorn Force by New Chapter

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Capsule, Organic Sunflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sea Buckthorn Force by New Chapter Drug Interactions

Want to check YOUR meds against Sea Buckthorn Force?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
717Drugs
379 Moderate 338 Minor

Each ingredient & the kinds of drugs it affects

For each ingredient in Sea Buckthorn Force with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rosemary supercritical extract6 drug types · 372 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Aspirin

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.

Likelihood Possible Evidence D
Choline Magnesium Trisalicylate (Trilisate)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Salsalate (Disalcid)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Unlikely Evidence D

Sea Buckthorn (fruit and seed) supercritical extract2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that sea buckthorn fruit extracts can inhibit platelet aggregation and adhesion to collagen and fibrinogen.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Taking sea buckthorn appears to reduce blood pressure in some patients.

Likelihood Possible Evidence D

Calendula supercritical extract1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Sea Buckthorn Force, from the product label.

New Chapter

See all New Chapter products
Name
NEW CHAPTER, INC.
Street Address
90 TECHNOLOGY DRIVE
City
BRATTLEBORO
State
VT
ZipCode
05301
Pharmacist Counseling Corner

Sea Buckthorn Force by New Chapter: Common Questions

Does Sea Buckthorn Force by New Chapter interact with any medications?
Yes. Based on its ingredients, Sea Buckthorn Force has a known interaction with 717 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sea Buckthorn Force contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
The safety data for medicinal doses of rosemary during pregnancy advises against it. Sea buckthorn safety in pregnancy hasn't been well studied at supplement doses. Food amounts of both are likely fine, but this is a medicinal supplement. Talk with your doctor before taking it while pregnant — that's a decision that needs your personal medical history.
Can I take this if I'm breastfeeding?
Rosemary in food amounts is likely safe, but medicinal doses during breastfeeding haven't been well studied. Sea buckthorn safety data while breastfeeding is also incomplete. Check with your doctor or pharmacist before starting — they can weigh the risks and benefits for your situation.
Does rosemary really help memory?
Rosemary is rated possibly effective for memory in our data, meaning there's some evidence it may help, but the research isn't conclusive. If memory support is your goal, it's worth discussing with your doctor whether this product makes sense for you.
What side effects might I notice?
Rosemary can trigger allergic reactions, especially on skin or in the mouth. Sea buckthorn at high doses may cause yellow skin staining, and topical use has caused redness and rash in some users. Most people don't report side effects, but if you notice any unusual reactions, stop and talk to your pharmacist.
What's in the proprietary blend?
The label doesn't break down the specific ingredients or amounts in the proprietary blend — only that it's there. That means we can't tell you exactly what you're getting or in what dose. If you want full transparency, reach out to New Chapter directly.
I take blood pressure medication — is this safe for me?
Sea buckthorn in this product may lower blood pressure, which could add to your medication's effect and cause your pressure to drop too far. Check with your doctor or pharmacist before starting — they'll know your blood pressure history and can advise whether it's safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sea Buckthorn Force is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sea Buckthorn Force label
Sources

Sources & How We Checked

Sea Buckthorn Force's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rosemary 20 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  6. Cartier LC, Lehrer A, Malo JL. Occupational asthma caused by aromatic herbs. Allergy 1996;51:647-9. DOI
  7. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  8. Swain AR, Dutton SP, Truswell AS. Salicylates in foods. J Am Diet.Assoc 1985;85(8):950-60. DOI
  9. Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-7. PubMed
  10. Debersac P, Heydel JM, Amiot MJ, et al. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39(9):907-18. PubMed
  11. Debersac P, Vernevaut MF, Amiot MJ, et al. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39(2):109-17. PubMed
  12. Lee JJ, Jin YR, Lee JH, et al. Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Planta Med 2007;73(2):121-7.
  13. Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
  14. Naemura A, Ura M, Yamashita T, et al. Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 2008;122(4):517-22. PubMed
  15. Lee JJ, Jin YR, Lim Y, et al. Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. Vascul Pharmacol 2006;45:148-53. PubMed
  16. Bakirel, T., Bakirel, U., Keles, O. U., Ulgen, S. G., and Yardibi, H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 2-28-2008;116(1):64-73. PubMed
  17. Erenmemisoglu, A., Saraymen, R., and Ustun, S. Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice. Pharmazie 1997;52(8):645-646.
  18. Valones MAA, Silva ICG, Gueiros LAM, Leão JC, Caldas AF Jr, Carvalho AAT. Clinical assessment of rosemary-based toothpaste (Rosmarinus officinalis Linn.): A randomized controlled double-blind study. Braz Dent J. 2019;30(2):146-151. PubMed
  19. Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, et al. A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD). J Popul Ther Clin Pharmacol. 2019;26(4):e18-e28.
  20. Al Jamal A. Effect of rosemary (Rosmarinus officinalis) on lipid profiles and blood glucose in human diabetic patients (type-2). African J. Biochem. Res. 2014;8(8):147-50. DOI

See these in context on the Rosemary monograph →

Sea Buckthorn 7 references
  1. Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
  2. Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed
  3. Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.
  4. Chang BB, Wang F Xu TY Zhang QQ He J Zhang XJ Li J. Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine. 2009;9(11):1207-1213. DOI
  5. Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.
  6. Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed
  7. De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed

See these in context on the Sea Buckthorn monograph →

Calendula 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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