Sereni-Pro Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sereni-Pro against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sereni-Pro is a dietary supplement by Bioclinic Naturals with 4 active ingredients. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,499 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril(R) Ashwagandha, Rhodiola, Eleuthero. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sereni-Pro by Bioclinic Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Sereni-Pro by Bioclinic Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sereni-Pro by Bioclinic Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Sereni-Pro has 5 active ingredients. It contains Sensoril Ashwagandha (8% withanolides), Eleuthero (0.8% eleutherosides), and Rhodiola (3.5% rosavins and 1% salidrosides) — all adaptogens, which are plants traditionally used to help your body manage stress.
It also includes lavender, an herb with a long history in herbal medicine. The capsule itself is vegetarian, and the inactive ingredients are rice powder and magnesium stearate.
Does it work?
Not established
In our data, lavender is possibly effective for period pain (dysmenorrhea) but possibly ineffective for cancer-related pain. For alopecia areata, perioperative anxiety, and cancer-related fatigue, the evidence is too limited to rate.
We don't hold effectiveness ratings for Sensoril Ashwagandha, Eleuthero, or Rhodiola on file.
How safe is it?
Well-documented data
Lavender is generally well tolerated when taken by mouth in food or supplement amounts. The most common side effects are breath odor, constipation, diarrhea, indigestion, belching, headache, and nausea.
Topically, lavender oil may cause allergic rashes in some people, and rare cases of breast enlargement in young boys using lavender oil have been reported. The safety data for lavender's medicinal use is not complete, so talk with your doctor or pharmacist before taking medicinal amounts unless they've already approved it.
We hold no pregnancy or breastfeeding safety information for any of the ingredients in this product — if you're pregnant, nursing, or planning to be, ask your doctor or pharmacist whether Sereni-Pro is right for you.
Meds to double-check
Moderate interaction found
Before taking Sereni-Pro, check your medications against our tool if you take CNS depressants — sedatives, sleep aids, anti-seizure drugs, or other medications that calm the nervous system. Lavender may strengthen their effects and side effects.
For the other active ingredients in this product, we could not check interactions, so run your full medication list through the checker on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Sereni-Pro is mainly for stress support and includes an herb with some evidence for period pain. If you take sedatives, sleep aids, or anti-anxiety medications, you'll want to check those against our interaction tool before starting it.
Talk with your doctor or pharmacist about whether it fits your health plan, especially if you're on any prescription medications or have pregnancy or nursing questions.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sereni-Pro, straight from the product label.
| Brand | Bioclinic Naturals |
|---|---|
| Barcode (UPC) | 629022092802 |
| Net contents | 90 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2013 |
| DSLD ID | 20872 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sereni-Pro by Bioclinic Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sensoril(R) Ashwagandha | 250 mg | -- |
| minimum 8% Withanolides | 20 mg | -- |
| Eleuthero | 150 mg | -- |
| 0.8% Eleutherosides | 1.2 mg | -- |
| Lavender | 150 mg | -- |
| Rhodiola | 75 mg | -- |
| 3.5% Rosavins | 2.6 mg | -- |
| 1% Salidrosides | 0.75 mg | -- |
Other ingredients: Vegetarian capsule, Rice powder, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: 1-2 capsules 2 times per day or as directed by a health care professional.
Brand IP Statement(s)
Sereni-Pro(TM) is an adaptogenic herbal formula that helps strengthen adrenal and nerve function for a renewed sense of clarity and energy.*
Sensoril(R) is protected under U.S. Patent 6,713,092 and is a registered trademark of Natreon, Inc.
General Statements
Provides relief from occasional nervous tension caused by everyday stress.* Supports healthy immune function and may help to reduce stress hormones.* Elevated stress hormones may be associated with overall health decline.*
Bioclinic Naturals products are guaranteed to meet or exceed Good Manufacturing Practices (GMP) of the Canadian Government and the Therapeutic Goods Administration (TGA) regulations of Australia-among the world's highest standards for natural products.
Recyclable container. PRODUCT OF CANADA LOT202550 EXPJN2012
Herbal Adaptogen Formula
Formulation
Contains no artificial preservatives, colors or sweeteners; no dairy, gluten, soy, wheat or yeast.
Precautions
Sealed for your protection. Do not use if seal is broken.
Storage
For freshness, store in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
PURE POTENT TRUSTED TESTED
{recycle}
FDA Statement of Identity
DIETARY SUPPLEMENT
General
R0
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sereni-Pro by Bioclinic Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sereni-Pro by Bioclinic Naturals
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sensoril(R) Ashwagandha
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Sensoril(R) Ashwagandha monograph & interactions- › Minimum 8% Withanolides
Eleuthero
Interacts with1,140 drugs
Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...
Eleuthero monograph & interactions- › 0.8% Eleutherosides
Lavender
Interacts with248 drugs
Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standard...
Lavender monograph & interactionsRhodiola
Interacts with1,271 drugs
Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...
Rhodiola monograph & interactions- › 3.5% Rosavins
- › 1% Salidrosides
Other (inactive) ingredients: Vegetarian capsule, Rice powder, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Sereni-Pro by Bioclinic Naturals Drug Interactions
HelloPharmacist Interaction Report
Sereni-Pro by Bioclinic Naturals contains lavender, which interacts with CNS depressants (medications that calm the nervous system, like sedatives and sleep aids) — a Moderate interaction.
Lavender may strengthen both the intended and unwanted effects of these drugs.
Read the full breakdown — every affected drug type, severity by severity
We could not check the interactions for the other four active ingredients in this product. Sensoril Ashwagandha, Eleuthero, and Rhodiola are blend containers, so their breakdown isn't on file here.
We also hold no data for the withanolide, eleutherosides, rosavins, and salidroside components.
Altogether, these interactions span 248 individual medications. Before you start Sereni-Pro, use the medication checker on this page to run through your exact prescriptions — especially if you take anything to help you sleep, calm anxiety, or manage seizures.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sereni-Pro?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sereni-Pro interact with 1,499 drugs. Click any drug to see the details.
4 of the 4 ingredients in Sereni-Pro interact with drugs. Each result below shows which ingredient is responsible. Sensoril(R) Ashwagandha Rhodiola Eleuthero Lavender
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero + 6-mercaptopurine interactionSensoril(r) AshwagandhaHepatotoxic Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril(r) Ashwagandha + 6-mercaptopurine interactionRhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Sereni-Pro — through 1 ingredient. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril(r) Ashwagandha + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Sereni-Pro — through 1 ingredient. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril(r) Ashwagandha + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Sereni-Pro — through 1 ingredient. Tap an ingredient for the detail:
EleutheroAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero + Abciximab interactionAbiraterone
How Abiraterone interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril(r) Ashwagandha + Abiraterone interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Abiraterone interactionEleutheroCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril(r) Ashwagandha + Abiraterone Acetate interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Abiraterone Acetate interactionEleutheroCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroAnticoagulant/antiplatelet Drugs, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero + Abrocitinib interactionSensoril(r) AshwagandhaImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Sensoril(r) Ashwagandha + Abrocitinib interactionRhodiolaImmunosuppressants, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
RhodiolaP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola + Acalabrutinib interactionEleutheroCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero + Acalabrutinib interactionSensoril(r) AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril(r) Ashwagandha + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero + Acarbose interactionRhodiolaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola + Acarbose interactionSensoril(r) AshwagandhaAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Sensoril(r) Ashwagandha + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Sereni-Pro — through 2 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaHepatotoxic Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril(r) Ashwagandha + Acebutolol interactionRhodiolaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Sereni-Pro — through 1 ingredient. Tap an ingredient for the detail:
EleutheroAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaCns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Sensoril(r) Ashwagandha + Acepromazine interactionLavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acepromazine interactionRhodiolaCns Depressants Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen interactionSensoril(r) AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen interactionRhodiolaCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Aspirin interactionEleutheroAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero + Acetaminophen, Aspirin interactionRhodiolaCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Aspirin, Caffeine interactionSensoril(r) AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Aspirin, Caffeine interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionSensoril(r) AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionRhodiolaCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Butalbital interactionEleutheroCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Butalbital interactionRhodiolaCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Butalbital, Caffeine interactionSensoril(r) AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Butalbital, Caffeine interactionRhodiolaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Sereni-Pro — through 4 ingredients. Tap an ingredient for the detail:
LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Butalbital, Caffeine, Codeine interactionSensoril(r) AshwagandhaHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Butalbital, Caffeine, Codeine interactionEleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Butalbital, Caffeine, Codeine interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Sereni-Pro — through 4 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Butalbital, Codeine interactionLavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Butalbital, Codeine interactionEleutheroCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero + Acetaminophen, Butalbital, Codeine interactionRhodiolaCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Sereni-Pro — through 4 ingredients. Tap an ingredient for the detail:
EleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Butalbital, Codeine Phosphate interactionSensoril(r) AshwagandhaHepatotoxic Drugs, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Butalbital, Codeine Phosphate interactionLavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Butalbital, Codeine Phosphate interactionRhodiolaCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Sereni-Pro — through 4 ingredients. Tap an ingredient for the detail:
LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionEleutheroCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionSensoril(r) AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Sereni-Pro — through 4 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Caffeine, Codeine interactionEleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Caffeine, Codeine interactionLavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Caffeine, Codeine interactionRhodiolaCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Sereni-Pro — through 4 ingredients. Tap an ingredient for the detail:
EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero + Acetaminophen, Caffeine, Codeine, Salicylamide interactionSensoril(r) AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Caffeine, Codeine, Salicylamide interactionLavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Caffeine, Codeine, Salicylamide interactionRhodiolaCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Sereni-Pro — through 4 ingredients. Tap an ingredient for the detail:
LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Caffeine, Dihydrocodeine interactionEleutheroCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero + Acetaminophen, Caffeine, Dihydrocodeine interactionSensoril(r) AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Caffeine, Dihydrocodeine interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Caffeine, Isometheptene interactionEleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Caffeine, Isometheptene interactionRhodiolaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero + Acetaminophen, Caffeine, Pyrilamine interactionSensoril(r) AshwagandhaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Caffeine, Pyrilamine interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionRhodiolaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Sereni-Pro — through 4 ingredients. Tap an ingredient for the detail:
Sensoril(r) AshwagandhaCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +3 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRhodiolaCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Minor
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Sereni-Pro — through 3 ingredients. Tap an ingredient for the detail:
EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionSensoril(r) AshwagandhaSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Sensoril(r) Ashwagandha + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sereni-Pro with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Sensoril(R) Ashwagandha
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Rhodiola
Antidiabetes Drugs
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.
Antihypertensive Drugs
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
Immunosuppressants
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.
Losartan (Cozaar)
Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
P-Glycoprotein Substrates
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.
Antidepressant Drugs
Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.
Cns Depressants
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.
Eleuthero
Anticoagulant/Antiplatelet Drugs
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.
Antidiabetes Drugs
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.
Digoxin (Lanoxin)
Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.
Immunosuppressants
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.
P-Glycoprotein Substrates
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.
Lavender
Cns Depressants
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.
Brand information
Manufacturer and brand details for Sereni-Pro, from the product label.
Sereni-Pro by Bioclinic Naturals: Common Questions
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What does 'Sensoril Ashwagandha' mean?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sereni-Pro’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Ashwagandha
Interacts with 1,372 drugsAshwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...
Read the full Ashwagandha monograph → Herb & supplement monographEleuthero
Interacts with 1,140 drugsEleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...
Read the full Eleuthero monograph → Herb & supplement monographLavender
Interacts with 248 drugsLavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...
Read the full Lavender monograph → Herb & supplement monographRhodiola
Interacts with 1,271 drugsRhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...
Read the full Rhodiola monograph →Sources & How We Checked
Sereni-Pro's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 89 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
- Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
- Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
- Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
- Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
- Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
- Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
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