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Dietary supplement

Shu Di Huang Ingredients & Drug Interactions

by Hawaii Pharm

Shu Di Huang label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Shu Di Huang against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Shu Di Huang is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for kidney and adrenal support, anemia and blood building (traditional), inflammatory conditions.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Shu Di Huang extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Shu Di Huang by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Shu Di Huang by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Shu Di Huang by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: certified organic Shu Di Huang extract, which is rehmannia — a root used in traditional Chinese medicine. The liquid also includes vegetable palm glycerin and pharmaceutical grade alcohol as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Rehmannia's overall clinical evidence instead.

Moderate

Some clinical evidence supports Rehmannia for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Chronic kidney disease (CKD) — rated "Possibly Effective" (Natural Medicines).

The clearest evidence is for chronic kidney disease (CKD), where rehmannia is rated possibly effective. For other uses — aplastic anemia, atopic disease (allergic conditions), osteoporosis, diabetes, and diabetic kidney damage — the evidence in our data is insufficient to rate whether it works.

That doesn't mean it doesn't; it means we don't have enough reliable human studies yet to say.

The evidence, ingredient by ingredient Rehmannia

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Shu Di Huang is used in traditional medicine, but human safety data are limited and product quality varies. The safety information available advises against using it during pregnancy or while breastfeeding — there isn't enough data to know whether it's safe in those situations.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Rehmannia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rehmannia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check it with your doctor or pharmacist if you're on blood pressure medications or diabetes drugs. Both carry Moderate interaction risks with rehmannia — low blood pressure or low blood sugar could result.

Make sure your healthcare provider knows about both your prescription and this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.

Shu Di Huang may be worth considering if you have chronic kidney disease and want to explore traditional herbal options, but it's not for everyone. If you take blood pressure or diabetes medications, you'll need to check with your doctor or pharmacist first — the interactions are real enough that combining them could be risky.

Pregnant or breastfeeding folks should skip it until there's more safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Shu Di Huang, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 0787699221984
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 237633
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Shu Di Huang by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
0787699221984
IngredientAmount% DV
certified organic Shu Di Huang extract970 mg--

Other ingredients: Vegetable Palm Glycerin, pharmaceutical grade Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hawaii Pharm Herbal Extract Highest quality since 2008

Made with Aloha!

Formulation

Contains no GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.

Super concentrated liquid herbal extract. Dry herb/menstruum ratio: 1:3.

Manufactured in an FDA registered facility.

Non GMO Gluten free

Made in USA, Hawaii

Suggested/Recommended/Usage/Directions

Directions for use: Shake well before using. Take about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water up to 4 times per day.

Precautions

Warning: Keep out of the reach of children.

May have contraindications. We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing or taking any medications.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Formula

(Rehmannia glutinosa)

FDA Statement of Identity

Herbal Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

FDA Registered Facility Made in United States of America USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Shu Di Huang by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Shu Di Huang label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Shu Di Huang by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Certified organic Shu Di Huang extract

Interacts with
258 drugs
970 mg per serving

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human eviden...

Certified organic Shu Di Huang extract monograph & interactions

Other (inactive) ingredients: Vegetable Palm Glycerin, Pharmaceutical grade Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Shu Di Huang by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Shu Di Huang?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

certified organic Shu Di Huang extract 258

Individual Drug Interactions

The ingredients in Shu Di Huang interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Shu Di Huang interact with drugs. Each result below shows which ingredient is responsible. certified organic Shu Di Huang extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Shu Di Huang with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Shu Di Huang extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
certified organic Shu Di Huang extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Shu Di Huang, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
City
Honolulu
State
HI
ZipCode
96815
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Shu Di Huang by Hawaii Pharm: Common Questions

Does Shu Di Huang by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Shu Di Huang has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Shu Di Huang contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Shu Di Huang if I'm on blood pressure medication?
Not without checking first with your doctor or pharmacist. Rehmannia may lower blood pressure on its own, so combining it with blood pressure drugs carries a Moderate risk of dangerously low blood pressure. Your provider needs to know about both.
What's Shu Di Huang used for?
It's possibly effective for chronic kidney disease. For other traditional uses — like aplastic anemia, allergic conditions, osteoporosis, or diabetes — the evidence in our data isn't strong enough yet to say whether it works.
Is Shu Di Huang safe to take while breastfeeding?
The safety information advises against it — there isn't enough data to know either way. Talk with your doctor or pharmacist for personalized advice on whether it's right for you.
What if I'm diabetic and interested in this product?
You'll want to talk with your doctor or pharmacist first. Rehmannia may lower blood sugar, so taking it with diabetes medications carries a Moderate risk of your blood sugar dropping too low.
What's in this liquid besides the active ingredient?
Vegetable palm glycerin and pharmaceutical grade alcohol are added as inactive ingredients to make the liquid formulation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Shu Di Huang is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Shu Di Huang label
Go deeper

The Full Monographs Behind Shu Di Huang’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph →
Sources

Sources & How We Checked

Shu Di Huang's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

See these in context on the Rehmannia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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