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Dietary supplement

Sinupret Adult Strength Sinus+Immune Support Ingredients & Drug Interactions

by Bionorica

Sinupret Adult Strength Sinus+Immune Support label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sinupret Adult Strength Sinus+Immune Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sinupret Adult Strength Sinus+Immune Support is a dietary supplement by Bionorica with 5 active ingredients. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gentian, Sorrel. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sinupret Adult Strength Sinus+Immune Support by Bionorica

Ask about any prescription or over-the-counter medication and we check it for interactions with Sinupret Adult Strength Sinus+Immune Support by Bionorica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sinupret Adult Strength Sinus+Immune Support by Bionorica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Sinupret contains five active herbal ingredients: gentian root, sorrel, European elder, cowslip, and European vervain. These are combined in a tablet along with inactive ingredients including microcrystalline cellulose, potato starch, and several binding and coating agents.

Each ingredient is traditionally used to support sinus and respiratory health, though the scientific evidence for most of them in this combination remains limited.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promotes healthy nasal passages and immune function.
  • We looked for evidence on: Rhinosinusitis, Sinusitis, Sinus congestion, Nasal inflammation, Upper respiratory support.
  • The strongest evidence on file: Cowslip is rated "Possibly Effective" for Sinusitis (Natural Medicines).
  • Also on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis.
  • Also on file: Sorrel is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis.

The evidence for these ingredients is sparse. Cowslip is rated possibly effective for sinusitis — that's the strongest claim in the product.

Gentian, sorrel, European elder, and European vervain all lack sufficient reliable evidence for us to rate their effectiveness for sinus health, respiratory support, or any other condition. If you're looking for established proof that this formula works, the data we hold doesn't provide it.

The evidence, ingredient by ingredient Gentian Sorrel Cowslip

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gentian is generally tolerated in small amounts but can upset your stomach and hasn't been well studied at high doses. Sorrel is safe as a food in normal amounts, but its high oxalate content can be a concern with larger or concentrated doses — in rare cases, concentrated sorrel has been linked to kidney issues.

Both gentian and sorrel have caused nausea, vomiting, diarrhea, and bloating in some people, particularly in combination with other herbs. Cowslip may trigger allergic reactions in sensitive individuals, and cross-sensitivity with weed pollen allergies is possible.

Gentian is not recommended during pregnancy or while breastfeeding due to limited safety data. Sorrel is rated possibly safe during pregnancy but should be avoided while breastfeeding.

Cowslip safety data during pregnancy and lactation are not sufficient — it's best avoided in both. We have no pregnancy or breastfeeding safety information on file for European Elder and European Vervain.

Side effects, ingredient by ingredient Gentian Sorrel Cowslip

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Gentian, Sorrel.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 333 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Sinupret, check if you're on blood pressure medications (antihypertensive drugs) — gentian may increase their effect (Moderate concern). If you take blood thinners or antiplatelet drugs, sorrel may add to their effects, so verify that first (Moderate concern).

If you take fexofenadine (Allegra) for allergies, sorrel might reduce how well it works (Moderate concern). Run your exact medications through our checker before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sinupret is a traditional herbal blend that's generally well tolerated for sinus support, though the scientific backing is limited. If you take blood pressure medications or blood thinners, you should check with us before starting — gentian and sorrel could affect how those work.

Talk to your pharmacist about whether this product fits your health needs and current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sinupret Adult Strength Sinus+Immune Support, straight from the product label.

Brand Bionorica
Barcode (UPC) 897618000023
Net contents 50 Tablet(s)
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 26427
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sinupret Adult Strength Sinus+Immune Support by Bionorica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
50
UPC/BARCODE
897618000023
IngredientAmount% DV
Gentian12 mg--
Sorrel36 mg--
European Elder36 mg--
Cowslip36 mg--
European Vervain36 mg--

Other ingredients: Microcrystalline Cellulose, hydroxypropylmethyl cellulose, Potato Starch, Glycerol, Magnesium Stearate, Titanium Dioxide, Calcium Carbonate, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Lot #/Best if used by:

Safe Natural Clinically studied

Promotes healthy nasal passages and sinuses Promotes the body's natural immune function

Product of Germany

Seals/Symbols

heart safe stimulant free

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

BIONORICA(R) The phytolution company

Sinupret(R), Bionorica(R) The phytolution company are trademarks of Bionorica SE used under license.

Suggested/Recommended/Usage/Directions

Directions: Adults 1 tablet three times daily or as directed by your health care practitioner.

Recommended for use from 7 up to 14 days or as directed by your health care practitioner.

Precautions

Not to be taken by children under the age of twelve.

Cautions: Not recommended for pregnant or lactating women or women planning to become pregnant.

Do not take Sinupret(R) Adult Strength if you are hypersensitive to one of the active ingredients or to any other ingredient of the product. Discontinue use immediately and consult a physician if you experience any allergic reaction or gastrointestinal distress to this product.

Keep out of reach of children.

Formulation

Heart safe—does not contain stimulants, such as caffeine.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sinupret Adult Strength Sinus+Immune Support by Bionorica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sinupret Adult Strength Sinus+Immune Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sinupret Adult Strength Sinus+Immune Support by Bionorica

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gentian

Interacts with
172 drugs
12 mg per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian monograph & interactions

Sorrel

Interacts with
169 drugs
36 mg per serving

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for an...

Sorrel monograph & interactions

European Elder

36 mg per serving

Cowslip

No known
interactions
36 mg per serving

Cowslip is a traditional European herb whose flowers and roots have long been used as a tea or syrup, mainly for coughs and congestion. Solid human st...

Cowslip monograph & interactions

European Vervain

36 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropylmethyl cellulose, Potato Starch, Glycerol, Magnesium Stearate, Titanium Dioxide, Calcium Carbonate, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sinupret Adult Strength Sinus+Immune Support by Bionorica Drug Interactions

Want to check YOUR meds against Sinupret Adult Strength Sinus+Immune Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
333Drugs
333 Moderate

Ingredients driving the most interactions

Gentian 172
Sorrel 169

Individual Drug Interactions

The ingredients in Sinupret Adult Strength Sinus+Immune Support interact with 333 drugs. Click any drug to see the details.

2 of the 5 ingredients in Sinupret Adult Strength Sinus+Immune Support interact with drugs. Each result below shows which ingredient is responsible. Gentian Sorrel

Each ingredient & the kinds of drugs it affects

For each ingredient in Sinupret Adult Strength Sinus+Immune Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian full monograph & interactions

Sorrel3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Sorrel full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sinupret Adult Strength Sinus+Immune Support, from the product label.

Bionorica

See all Bionorica products
Name
Bioforce USA
Street Address
6 Grandinetti Drive
City
Ghent
State
New York
ZipCode
12075
Phone Number
1 (800) 264-2325
Pharmacist Counseling Corner

Sinupret Adult Strength Sinus+Immune Support by Bionorica: Common Questions

Does Sinupret Adult Strength Sinus+Immune Support by Bionorica interact with any medications?
Yes. Based on its ingredients, Sinupret Adult Strength Sinus+Immune Support has a known interaction with 333 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sinupret Adult Strength Sinus+Immune Support contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
Not without talking to your doctor first. Gentian and cowslip should be avoided during pregnancy and breastfeeding due to insufficient safety data. Sorrel is possibly safe in pregnancy but should be avoided while breastfeeding. We don't have safety information for European elder and European vervain in pregnancy or lactation, so you'd need personalized medical advice.
Will Sinupret actually help my sinus problems?
Only cowslip is rated possibly effective for sinusitis in our data. The other ingredients lack sufficient evidence to say whether they work for sinus health. Your best bet is to talk with your pharmacist about whether this product makes sense for your situation.
What side effects might I experience?
Stomach upset, nausea, vomiting, diarrhea, and bloating have been reported, especially when these herbs are combined with others. Sorrel's high oxalate content could theoretically be an issue at higher doses. Some people may have allergic reactions to cowslip if they're sensitive to weed pollen.
Is this safe for people with kidney problems?
Sorrel contains oxalates, and in rare cases concentrated sorrel has been linked to kidney damage. If you have kidney disease or a history of kidney stones, talk to your pharmacist or doctor before taking this product.
Does this product have fillers?
Yes, it contains several inactive ingredients including microcrystalline cellulose, potato starch, magnesium stearate, and others that serve as binders and coatings.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sinupret Adult Strength Sinus+Immune Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sinupret Adult Strength Sinus+Immune Support label
Go deeper

The Full Monographs Behind Sinupret Adult Strength Sinus+Immune Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph → Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph → Herb & supplement monograph

Cowslip

Cowslip is a traditional European herb whose flowers and roots have long been used as a tea or syrup, mainly for coughs and congestion. Solid human studies are very limited, so its benefits...

Read the full Cowslip monograph →
Sources

Sources & How We Checked

Sinupret Adult Strength Sinus+Immune Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Sorrel 8 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
  4. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
  5. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
  6. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
  7. Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
  8. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

See these in context on the Sorrel monograph →

Cowslip 3 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Peric A, Kovacevic SV, Gacesa D, Peric AV. Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray. ENT Updates 2017;7(2):68-74. DOI

See these in context on the Cowslip monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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