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Dietary supplement

Sleep Strawberry Lemon Ingredients & Drug Interactions

by Vitamin Friends

Gummy Or Jelly Category: Botanical With Nutrients
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sleep Strawberry Lemon is a dietary supplement by Vitamin Friends with 4 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 1,053 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chamomile, Valerian, Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Sleep Strawberry Lemon by Vitamin Friends

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Sleep Strawberry Lemon contains 4 active ingredients: vitamin D, lemon balm, chamomile, and valerian. Vitamin D supports bone health and is used to treat conditions like rickets and low bone turnover from kidney disease.

Lemon balm and chamomile are herbal extracts traditionally used to ease stress and support sleep, while valerian is a root extract commonly taken for insomnia. The gummy also contains inactive ingredients—cane sugar, tapioca syrup, pectin, citric acid, natural flavors, and a few other binders and texture agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: help children naturally fall asleep.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), insomnia, sleep onset latency, restlessness.
  • The strongest evidence on file: Valerian is rated "Possibly Effective" for Insomnia (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.
  • Also on file: Valerian is rated "Insufficient Reliable Evidence To Rate" for Pre-procedural anxiety.

Vitamin D is effective for treating specific conditions like rickets, osteomalacia, hypoparathyroidism, and renal bone disease, but those aren't typical reasons someone takes a sleep product. Lemon balm and chamomile have only possibly effective evidence for stress and cold sore relief—the data we hold doesn't establish how well they work for sleep itself.

Valerian is possibly effective for insomnia, making it the ingredient in this product most directly tied to its sleep purpose. Overall, solid evidence for the sleep-specific benefit of this combination isn't established in our data.

The evidence, ingredient by ingredient Vitamin D Lemon Balm German Chamomile Valerian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, though very high amounts taken long-term can build up and cause toxicity with symptoms like high blood calcium levels. The safety notes flag that it's often used in pregnancy at recommended amounts but only under a doctor's guidance, and higher doses during pregnancy carry some caution.

Lemon balm and chamomile are generally well tolerated short-term but long-term safety isn't well studied; chamomile can trigger allergic reactions in people sensitive to ragweed. Both lemon balm and chamomile carry a caution for pregnancy and breastfeeding—there isn't enough reliable data, so talk with your doctor before using during these times.

Valerian is generally well tolerated short-term but should be avoided in pregnancy and breastfeeding due to insufficient safety data. When stopping valerian after regular use, taper slowly to avoid withdrawal symptoms like anxiety and insomnia.

Side effects, ingredient by ingredient Vitamin D Lemon Balm German Chamomile Valerian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lemon Balm, Valerian, Vitamin D, German Chamomile.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 1,054 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any of the following: digoxin or other heart rhythm medications (Major risk from high blood calcium), thiazide water pills, verapamil or diltiazem, atorvastatin, calcipotriene for psoriasis, or warfarin and other blood thinners. Also double-check if you're on CNS depressants like sedatives or sleep aids, alprazolam or other anxiety medications, alcohol, oral contraceptives, estrogen or hormone replacement therapy, tamoxifen, or any drugs your liver breaks down via CYP2D6, CYP2C9, or CYP3A4 enzymes.

No interactions are documented in our data for the inactive ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is geared toward sleep support, particularly through its valerian content, but the overall evidence for how well this specific combination works for that purpose isn't established in our data. It's worth checking your medications first—especially if you take heart rhythm drugs, blood thinners, sleep aids, or hormone medications—because vitamin D, lemon balm, chamomile, and valerian can all interact with different drug classes.

Talk with your doctor or pharmacist before starting, particularly if you're pregnant, breastfeeding, or taking any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep Strawberry Lemon, straight from the product label.

Brand Vitamin Friends
Barcode (UPC) 852386008510
Net contents 60 Gummy(ies)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229165
Product type Botanical With Nutrients
Supplement form Gummy Or Jelly
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep Strawberry Lemon by Vitamin Friends, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
Servings per container
30
UPC/BARCODE
852386008510
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)3%, 2%
Vitamin D20 mcg100%, 133%
Added Sugars3 Gram(s)12%, 6%
Total Sugars3 Gram(s)--
Lemon Balm50 mg--
Chamomile50 mg--
Valerian50 mg--

Other ingredients: Cane Sugar, Tapioca Syrup, Water, Pectin, Natural Flavors, Citric Acid, Sodium Citrate Dihydrate, Black Elderberry juice extract, organic Sunflower Oil, organic Carnauba Wax, Tapioca Starch

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vitamin Friends created a truly non-habit-forming sleep gummy to hep the little ones naturally fall asleep.

Free of gluten, egg, crustacean, fish, peanuts, nuts, milk & soy.

Certified Organic by Oregon Tilth

Certified Vegan Vegan.org

Melatonin free!

Vegan gummies

Supports healthy sleep

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 2 gummies 30 minutes before bedtime.

Precautions

Warning: Not recommended for children under 24 months.

Consult a physician or qualified health care professional before using this product if you are pregnant or nursing, or if you have any medical conditions, or if you are using any prescription drug.

Do not exceed recommended serving. Use only as directed.

Keep out of reach of children.

Storage

Store at 55 degrees to 78 degrees F in a dry place.

Seals/Symbols

Certified Vegan Vegan.org

Current Good Manufacturing Practice cGMP Certified Facility

Certified Organic Oregon Tilth

Free of 8 Major Allergens Guaranteed Allergen free

Proudly Made in California, USA

OU Kosher Pareve

General Statements

Manufactured by Better Nutritionals

Red Sneakers for Oakley

Autism Hope Alliance Autism Approved

Formula

Made with organic Tapioca

Natural flavor Chamomile, lemon balm, valerian root, vitamin D

OU Kosher Pareve

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Sleep Strawberry Lemon by Vitamin Friends label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sleep Strawberry Lemon by Vitamin Friends

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummy(ies) Dosage formGummy Or Jelly Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D

Interacts with
715 drugs
20 mcg per serving Form: Ergocalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Lemon Balm

Interacts with
264 drugs
50 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm monograph & interactions

Chamomile

Interacts with
960 drugs
50 mg per serving

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible b...

Chamomile monograph & interactions

Valerian

Interacts with
902 drugs
50 mg per serving

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...

Valerian monograph & interactions

Other (inactive) ingredients: Cane Sugar, Tapioca Syrup, Water, Pectin, Natural Flavors, Citric Acid, Sodium Citrate Dihydrate, Black Elderberry juice extract, Organic Sunflower Oil, Organic Carnauba Wax, Tapioca Starch. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep Strawberry Lemon by Vitamin Friends Drug Interactions

Want to check YOUR meds against Sleep Strawberry Lemon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,053Drugs
1,035 Moderate 18 Minor

Ingredients driving the most interactions

Chamomile 960
Valerian 902
Vitamin D 715

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep Strawberry Lemon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chamomile9 drug types · 960 drugs

Cns Depressants

Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.

Likelihood Possible Evidence D
Estrogens

Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.

Likelihood Possible Evidence D
Warfarin (Coumadin)

German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.

Likelihood Possible Evidence D

Valerian6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D

Lemon Balm2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Sleep Strawberry Lemon, from the product label.

Vitamin Friends

See all Vitamin Friends products
Name
Vitamin Friends, LLC
Street Address
17120 S. Figueroa St.
City
Gardena
State
CA
ZipCode
90248
Phone Number
1310-356-9018
Web Address
vitaminfriends.com
Pharmacist Counseling Corner

Sleep Strawberry Lemon by Vitamin Friends: Common Questions

Does Sleep Strawberry Lemon by Vitamin Friends interact with any medications?
Yes. Based on its ingredients, Sleep Strawberry Lemon has a known interaction with 1,053 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep Strawberry Lemon contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
Vitamin D at recommended amounts is often used in pregnancy under a doctor's guidance, though higher doses warrant caution. Lemon balm, chamomile, and valerian all lack enough safety data in pregnancy, so they're best avoided unless your doctor advises otherwise. This is a conversation to have with your healthcare provider before you start.
Can I take this while breastfeeding?
Vitamin D at recommended doses is generally considered acceptable while breastfeeding, but check with your doctor before taking higher amounts. Lemon balm and chamomile have limited safety data, so use caution and talk to your doctor first. Valerian should be avoided while breastfeeding due to insufficient safety information.
What side effects might I notice?
Valerian commonly causes drowsiness, dizziness, headache, or vivid dreams. Lemon balm and chamomile may cause dizziness or sedation in some people, though this doesn't happen more often than with placebo. At recommended doses, vitamin D is well tolerated, but very high doses over time can cause toxicity with symptoms like high blood calcium.
Will this actually help me sleep?
Valerian, one of the four active ingredients, is possibly effective for insomnia based on the data we hold. Lemon balm and chamomile have possibly effective evidence for stress, but the evidence for how well this specific combination works for sleep isn't established in our data.
What is valerian and why is it in a sleep product?
Valerian is an herbal root extract traditionally used to ease insomnia and is the ingredient in this product most directly linked to sleep support. It's possibly effective for sleep, though it commonly causes drowsiness, dizziness, or vivid dreams.
Is it safe to take this long-term?
Long-term safety for lemon balm, chamomile, and valerian isn't well studied. Valerian in particular can cause withdrawal symptoms—anxiety, insomnia, agitation—if stopped abruptly after regular use, so you'd need to taper slowly. Talk with your doctor about how long you plan to take it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep Strawberry Lemon label
Sources

Sources & How We Checked

Sleep Strawberry Lemon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 90 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
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Lemon Balm 12 references
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Valerian 37 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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