Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Sleep Well One Daily Multiherbal Ingredients & Drug Interactions

by New Chapter

Sleep Well One Daily Multiherbal label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sleep Well One Daily Multiherbal against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sleep Well One Daily Multiherbal is a dietary supplement by New Chapter with 4 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep and relaxation, digestive upset.Based on those ingredients, 1,419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Chamomile, Passionflower Aerial Parts Hydroethanolic Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sleep Well One Daily Multiherbal by New Chapter

Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep Well One Daily Multiherbal by New Chapter — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sleep Well One Daily Multiherbal by New Chapter

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Chamomile” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.

Sleep Well One Daily Multiherbal contains 5 active herbal ingredients. Ashwagandha (as Sensoril) is an adaptogenic herb traditionally used to help with stress and sleep.

Chamomile appears twice—once as a hydroethanolic extract and once as a supercritical extract—both forms of German chamomile, a gentle herb with mild sedative properties. Passionflower aerial parts (the above-ground portion) are included for their calming effects.

Sour cherry, typically known for supporting athletic recovery, rounds out the blend. The softgel capsule also contains inactive ingredients: modified tapioca starch, glycerin, purified water, annatto (a natural colorant), extra virgin olive oil, sunflower lecithin, and yellow beeswax.

These are excipients that help form and deliver the softgel.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Sleep support.
  • We looked for evidence on: Insomnia, Anxiety, Generalized anxiety disorder (GAD), Fatigue, Sleep quality, Restlessness — and 1 related terms.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Insomnia.
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD), Insomnia.

For insomnia, both ashwagandha and passionflower are rated possibly effective—meaning there's preliminary evidence they may help, but stronger studies are needed. Ashwagandha is also rated possibly effective for anxiety, stress, and generalized anxiety disorder.

Passionflower carries a possibly effective rating for pre-procedural anxiety as well. For other uses listed in the product—athletic performance, cognitive function, exercise-related muscle soreness and infections, fibromyalgia, attention deficit-hyperactivity disorder (ADHD), and benzodiazepine withdrawal—the evidence in our data is rated insufficient to establish whether these ingredients work.

Chamomile's effectiveness for any of its listed uses (hay fever, anorexia, sexual dysfunction, anxiety, ADHD) is similarly not established in our data.

The evidence, ingredient by ingredient German Chamomile Ashwagandha Sour Cherry Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ashwagandha is generally well tolerated short-term in healthy adults, though long-term safety data are limited. The most common side effects are diarrhea, gastrointestinal upset, nausea, and vomiting, though these don't occur commonly at typical doses.

Rarely, ashwagandha has been linked to serious liver problems including hepatitis and liver failure. There's also a rare case report of intracranial bleeding with reversible cerebral vasoconstriction.

During pregnancy, ashwagandha is considered likely unsafe due to traditional concerns about miscarriage risk; avoid it. It's not safe to use while breastfeeding because there isn't enough safety information.

Chamomile (both extracts) is generally well tolerated but can trigger allergic reactions in people sensitive to ragweed and related plants, including anaphylaxis in rare cases. There isn't enough reliable safety information to use chamomile during pregnancy without your doctor's approval.

Limited breastfeeding data exist, so check with your doctor or pharmacist first. Passionflower is generally well tolerated short-term but can cause drowsiness, dizziness, and confusion.

It should be avoided during pregnancy due to lack of safety data and possible uterine effects, and it lacks enough safety information for breastfeeding. Sour cherry is likely safe during pregnancy and lactation when consumed as whole fruit, though concentrated supplements have limited safety data.

Side effects, ingredient by ingredient German Chamomile Ashwagandha Sour Cherry Passion Flower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Passion Flower, German Chamomile, Ashwagandha.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,420 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications with your doctor or pharmacist, especially: sedating medications and benzodiazepines (risk of increased drowsiness), blood pressure medications (risk of dangerously low blood pressure), diabetes drugs (risk of low blood sugar), blood thinners like warfarin (risk of bleeding), thyroid hormones, immune-suppressing drugs, and any medications broken down by the liver—particularly those metabolized by CYP2D6, CYP2C9, CYP3A4, or CYP1A2 enzymes. Ashwagandha can also pose a risk if you take any hepatotoxic drugs (medications that may damage the liver).

Additionally, if you take birth control pills, hormone replacement therapy, or tamoxifen, the chamomile in this product may reduce their effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help you fall asleep or ease anxiety if you're looking for herbal support—ashwagandha and passionflower carry preliminary evidence for insomnia, and ashwagandha for anxiety. But before you start, check with your own doctor or pharmacist if you take any prescription medications, especially blood pressure drugs, diabetes medications, sedatives, blood thinners, thyroid hormones, or cancer drugs.

If you're pregnant or breastfeeding, talk it over with your healthcare provider first, as several ingredients carry safety concerns in these situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep Well One Daily Multiherbal, straight from the product label.

Brand New Chapter
Net contents 30 Vegetarian Softgel(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 288220
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep Well One Daily Multiherbal by New Chapter, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
IngredientAmount% DV
Chamomile50 mg--
Sensoril50 mg--
Sour Cherry200 mg--
Chamomile hydroethanolic extract25 mg--
Chamomile supercritical extract25 mg--
Passionflower Aerial Parts Hydroethanolic Extract25 mg--

Other ingredients: modified Tapioca Starch, Glycerin, Water, Purified, Annatto, Extra Virgin Olive Oil, Sunflower Lecithin, Yellow Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 softgel daily with food

Formulation

Certified gluten free by NSF; 100% vegetarian; no artificial flavors or colors.

Certified gluten free by NSF; 100% vegetarian; no artificial flavors or colors.

Pure & potent extracts Healthy, restful sleep

Non GMO Project Verified Nongmoproject.org NSF Certified Gluten Free

General Statements

Please refer to newchapter.com for more information about this product and its benefits.

The New Chapter money-back guarantee We proudly stand behind every product we make. However, if you are not satisfied, please visit www.newchapter.com/guarantee for refund details. Please recycle this bottle after use.

For questions or comments call 888-874-4461

Precautions

Caution: As with any dietary supplement, you should advise your healthcare professional of the use of this product if you have a medical condition or are taking medication. If you are nursing, pregnant, or considering pregnancy, consult your healthcare professional prior to using this product.

Discontinue use and contact your healthcare professional if you experience a side effect or an allergic reaction.

Do not exceed suggested use.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Copyright 2020 New Chapter, Inc.

New Chapter Est. 1982

Sensoril is protected under U.S. Patent No. 7,318,938 and CA Patent No. 2,508,478, and is a registered trademark of Natreon, Inc.

Seals/Symbols

Non GMO Project Verified Nongmoproject.org NSF Certified Gluten Free OU (Kosher)

Formula

OU (Kosher)

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sleep Well One Daily Multiherbal by New Chapter label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sleep Well One Daily Multiherbal label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sleep Well One Daily Multiherbal by New Chapter

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chamomile

Interacts with
960 drugs
50 mg per serving

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible b...

Chamomile monograph & interactions

Sensoril

Interacts with
1,372 drugs
50 mg per serving Form: Ashwagandha Aerial Parts Extract, Aqueous, Ashwagandha Root Extract, Aqueous

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril monograph & interactions

Sour Cherry

No known
interactions
200 mg per serving Form: Prunus cerasus

Sour cherry (often sold as tart cherry or Montmorency cherry) is a fruit-based supplement rich in antioxidants that people use for muscle recovery, jo...

Sour Cherry monograph & interactions

Passionflower Aerial Parts Hydroethanolic Extract

Interacts with
836 drugs
25 mg per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passionflower Aerial Parts Hydroethanolic Extract monograph & interactions

Other (inactive) ingredients: Modified Tapioca Starch, Glycerin, Water, Purified, Annatto, Extra Virgin Olive Oil, Sunflower Lecithin, Yellow Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep Well One Daily Multiherbal by New Chapter Drug Interactions

Want to check YOUR meds against Sleep Well One Daily Multiherbal?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,419Drugs
1,360 Moderate 59 Minor

Ingredients driving the most interactions

Sensoril 1,372
Chamomile 960
Passionflower Aerial Parts Hydroethanolic Extract 836

Individual Drug Interactions

The ingredients in Sleep Well One Daily Multiherbal interact with 1,419 drugs. Click any drug to see the details.

3 of the 4 ingredients in Sleep Well One Daily Multiherbal interact with drugs. Each result below shows which ingredient is responsible. Sensoril Chamomile Passionflower Aerial Parts Hydroethanolic Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep Well One Daily Multiherbal with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril full monograph & interactions

Chamomile9 drug types · 960 drugs

Cns Depressants

Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.

Likelihood Possible Evidence D
Estrogens

Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.

Likelihood Possible Evidence D
Warfarin (Coumadin)

German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.

Likelihood Possible Evidence D
Chamomile full monograph & interactions

Passionflower Aerial Parts Hydroethanolic Extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passionflower Aerial Parts Hydroethanolic Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sleep Well One Daily Multiherbal, from the product label.

New Chapter

See all New Chapter products
Name
New Chapter, Inc.
Street Address
90 Technology Drive
City
Brattleboro
State
VT
ZipCode
05301
Phone Number
888-874-4461
Web Address
www.newchapter.com
Pharmacist Counseling Corner

Sleep Well One Daily Multiherbal by New Chapter: Common Questions

Does Sleep Well One Daily Multiherbal by New Chapter interact with any medications?
Yes. Based on its ingredients, Sleep Well One Daily Multiherbal has a known interaction with 1,419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep Well One Daily Multiherbal contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No—ashwagandha is likely unsafe during pregnancy due to traditional concerns about miscarriage, and passionflower is possibly unsafe because of its potential effects on the uterus and lack of safety data. Chamomile also lacks enough reliable safety information to use without your doctor's approval during pregnancy. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Is it safe to breastfeed while taking this?
The safety data for ashwagandha, chamomile, and passionflower while breastfeeding are not sufficient to recommend their use. Sour cherry is likely safe, but the other ingredients lack enough information. Check with your doctor or pharmacist for personalized advice if you're breastfeeding.
Can chamomile really lower my birth control's effectiveness?
Both chamomile extracts in this product can theoretically interfere with oral contraceptives and hormone replacement therapy at higher amounts, based on lab evidence that chamomile has antiestrogenic activity. If you're on birth control or HRT, mention this product to your doctor or pharmacist before starting.
What are the most common side effects?
With ashwagandha, diarrhea, nausea, vomiting, and gastrointestinal upset can occur, though they're not common at typical doses. Passionflower and chamomile may cause drowsiness, dizziness, and confusion. Chamomile can trigger allergic reactions in people sensitive to ragweed. Sour cherry may cause abdominal pain or loose stools in some people.
Does this product actually help with sleep?
Ashwagandha and passionflower both carry a possibly effective rating for insomnia, meaning there's preliminary evidence they may help—but stronger research is needed. Results vary from person to person, so talk with your doctor or pharmacist about whether this product makes sense for your sleep.
Why does this contain two forms of chamomile?
The product includes chamomile hydroethanolic extract and chamomile supercritical extract—two different processing methods of German chamomile that may extract or concentrate different compounds from the herb. Both are intended to contribute the herb's calming properties to the formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sleep Well One Daily Multiherbal is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep Well One Daily Multiherbal label
Go deeper

The Full Monographs Behind Sleep Well One Daily Multiherbal’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

German Chamomile

Interacts with 960 drugs

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible benefits for mild anxiety and some skin o...

Read the full German Chamomile monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Sour Cherry

Sour cherry (often sold as tart cherry or Montmorency cherry) is a fruit-based supplement rich in antioxidants that people use for muscle recovery, joint and gout symptoms, and sleep. Early...

Read the full Sour Cherry monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Sleep Well One Daily Multiherbal's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

German Chamomile 15 references
  1. Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  3. Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995;61:213-6.
  4. van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1982;8:143. PubMed
  5. van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1987;16:50-1. PubMed
  6. Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
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Ashwagandha 32 references
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Sour Cherry 4 references
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See these in context on the Sour Cherry monograph →

Passion Flower 19 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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