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Dietary supplement

Solomon's Seal Ingredients & Drug Interactions

by Hawaii Pharm

Solomon's Seal label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Solomon's Seal against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Solomon's Seal is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for joint and muscle discomfort, tendon and ligament injuries, inflammation.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Solomon's Seal Rhizome Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Solomon's Seal by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Solomon's Seal by Hawaii Pharm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Solomon's Seal by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Solomon's Seal Rhizome Extract in dried form. The liquid also includes alcohol, water, and glycerin as inactive ingredients to deliver the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Solomon's Seal product and its label doesn't state a use — see Solomon's Seal's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for Solomon's Seal in our data, so we can't tell you how well it works for any condition.

The evidence, ingredient by ingredient Solomon's Seal

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Solomon's Seal has limited safety data in people, so we recommend choosing a reputable brand and using it carefully. Long-term use has been reported to cause stomach irritation.

Large doses or overdoses may trigger nausea, diarrhea, and other digestive complaints. The safety data advises against use during pregnancy.

There isn't enough information to know whether it's safe while breastfeeding — talk with your doctor or pharmacist before using it if you're nursing.

Side effects, ingredient by ingredient Solomon's Seal

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Solomon's Seal.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood sugar medications with your pharmacist before taking this product. The moderate risk applies to antidiabetes drugs as a class, chlorpropamide, and insulin — all of which may have their effects enhanced.

If you take any of these, dosage adjustments may be needed and you'll need closer blood glucose monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Solomon's Seal may be worth considering if you're exploring traditional herbal support, but the main thing to watch is its effect on blood sugar control. If you take any diabetes medications — including insulin or chlorpropamide — talk with your pharmacist or doctor before starting this product.

Limited safety data means it's especially important to buy from a reputable maker.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Solomon's Seal, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253649935
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 332079
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Solomon's Seal by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253649935
IngredientAmount% DV
Solomon's Seal Rhizome Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications. Keep out of the reach of children!

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

USA Made in United States of America

Made in USA, Hawaii

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR code to get more info or reorder

Formula

Polygonatum biflorum

Organic Alcohol Based

Formulation

Only natural ingredients Identity and purity is laboratory verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Organic Alcohol Based

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Solomon's Seal by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Solomon's Seal label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Solomon's Seal by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Solomon's Seal Rhizome Extract, Dry

Interacts with
86 drugs
983 mg per serving Form: Polygonatum biflorum Rhizome Extract, Dry

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largel...

Solomon's Seal Rhizome Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Solomon's Seal by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Solomon's Seal?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Solomon's Seal Rhizome Extract, Dry 86

Individual Drug Interactions

The ingredients in Solomon's Seal interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Solomon's Seal interact with drugs. Each result below shows which ingredient is responsible. Solomon's Seal Rhizome Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Solomon's Seal with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Solomon's Seal Rhizome Extract, Dry3 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, concomitant use may enhance hypoglycemic drug effects and alter blood glucose control. Monitor blood glucose.

Likelihood Possible Evidence D
Chlorpropamide (Diabinese)

Concomitant use may cause additive hypoglycemic effects.

Likelihood Possible Evidence D
Insulin

Insulin dosage adjustments may be necessary, due to the possible hypoglycemic effects of Solomon's seal.

Likelihood Possible Evidence D
Solomon's Seal Rhizome Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Solomon's Seal, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St STE 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-542-9244
Web Address
Hawaiipharm.com
Pharmacist Counseling Corner

Solomon's Seal by Hawaii Pharm: Common Questions

Does Solomon's Seal by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Solomon's Seal has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Solomon's Seal contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Solomon's Seal if I'm pregnant or breastfeeding?
Safety has not been established during pregnancy, so the data advises against use. For breastfeeding, there isn't enough information to know either way — talk with your doctor or pharmacist for personalized advice before using it while nursing.
What side effects might I experience?
Long-term use has been reported to cause stomach irritation. Larger doses or overdoses may cause nausea, diarrhea, and other digestive complaints. A thorough safety evaluation hasn't been done, so we don't have a complete picture of all possible effects.
Why is this product risky for people with diabetes?
Solomon's Seal may enhance the effects of blood sugar-lowering drugs, which could drop your blood glucose too low. If you take insulin or other diabetes medications, your doctor may need to adjust your dose and you'll need to monitor your blood sugar closely.
Is this product proven to work?
We don't have effectiveness ratings for Solomon's Seal in our data, so we can't confirm how well it works for any condition.
What's in this liquid besides the active ingredient?
The formula contains alcohol, water, and glycerin to deliver the Solomon's Seal extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Solomon's Seal is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Solomon's Seal label
Go deeper

The Full Monographs Behind Solomon's Seal’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Solomon's Seal

Interacts with 86 drugs

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largely lacking. There is not enough reliable...

Read the full Solomon's Seal monograph →
Sources

Sources & How We Checked

Solomon's Seal's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Solomon's Seal 2 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Solomon's Seal monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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