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Dietary supplement

Solomon's Seal Ingredients & Drug Interactions

by Herbal Terra

Solomon's Seal label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Solomon's Seal against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Solomon's Seal is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for joint and muscle discomfort, tendon and ligament injuries, inflammation.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wildcrafted Solomon's Seal (Polygonatum odoratum) dried rhizome liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Solomon's Seal by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Solomon's Seal by Herbal Terra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Solomon's Seal by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a liquid extract made from the dried rhizome of Solomon's Seal (Polygonatum odoratum), harvested from wild plants. The extraction medium (menstruum) is listed as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Solomon's Seal product and its label doesn't state a use — see Solomon's Seal's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for Solomon's Seal in our data, so we can't tell you what the evidence shows about how well it works.

The evidence, ingredient by ingredient Solomon's Seal

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Limited safety data exists for Solomon's Seal in people, so use it carefully and choose a reputable product. Long-term use has been reported to cause stomach and intestinal irritation.

Large doses or overdoses may bring on nausea, diarrhea, and other digestive complaints. Safety has not been established during pregnancy, so it's best to avoid it then.

There isn't enough information to consider it safe while breastfeeding either — talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Solomon's Seal

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Solomon's Seal.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any diabetes medication — insulin, chlorpropamide (Diabinese), or other blood sugar drugs — check your exact medications with the tool below before taking this product. Solomon's Seal may enhance their effects and require dose adjustments.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Solomon's Seal may lower blood sugar, so it's mainly a concern if you take diabetes medication — especially insulin. If that's you, check with your pharmacist before starting.

For anyone else, the limited safety data means you'll want to use it carefully and buy from a reputable brand.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Solomon's Seal, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 0606595848531
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 234468
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Solomon's Seal by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
0606595848531
IngredientAmount% DV
wildcrafted Solomon's Seal (Polygonatum odoratum) dried rhizome liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: USA.

Manufactured in the USA in an FDA registered facility

Sugar free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Super concentrated liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Polygonatum odoratum

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Solomon's Seal by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Solomon's Seal label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Solomon's Seal by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Wildcrafted Solomon's Seal (Polygonatum odoratum) dried rhizome liquid extract

Interacts with
86 drugs
970 mg per serving

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largel...

Wildcrafted Solomon's Seal (Polygonatum odoratum) dried rhizome liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Solomon's Seal by Herbal Terra Drug Interactions

Want to check YOUR meds against Solomon's Seal?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

wildcrafted Solomon's Seal (Polygonatum odoratum) dried rhizome liquid extract 86

Individual Drug Interactions

The ingredients in Solomon's Seal interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Solomon's Seal interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Solomon's Seal (Polygonatum odoratum) dried rhizome liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Solomon's Seal with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Solomon's Seal (Polygonatum odoratum) dried rhizome liquid extract3 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, concomitant use may enhance hypoglycemic drug effects and alter blood glucose control. Monitor blood glucose.

Likelihood Possible Evidence D
Chlorpropamide (Diabinese)

Concomitant use may cause additive hypoglycemic effects.

Likelihood Possible Evidence D
Insulin

Insulin dosage adjustments may be necessary, due to the possible hypoglycemic effects of Solomon's seal.

Likelihood Possible Evidence D
wildcrafted Solomon's Seal (Polygonatum odoratum) dried rhizome liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Solomon's Seal, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Solomon's Seal by Herbal Terra: Common Questions

Does Solomon's Seal by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Solomon's Seal has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Solomon's Seal contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Solomon's Seal if I'm pregnant or breastfeeding?
Safety hasn't been established during pregnancy, so it's best to avoid it then. There also isn't enough information to say it's safe while breastfeeding. Talk with your doctor or pharmacist about what's right for your situation.
What side effects might I get from Solomon's Seal?
Long-term use has been reported to cause stomach and intestinal irritation. Large doses or overdoses may cause nausea, diarrhea, and other digestive complaints. A full safety review hasn't been done, so other effects are possible.
Why is there a warning about diabetes medications?
Solomon's Seal may enhance blood sugar-lowering effects. If you take insulin or other diabetes drugs, this could lower your blood glucose too much, so your dose might need adjusting and your glucose should be monitored closely.
Is Solomon's Seal proven to work?
We don't have effectiveness ratings for Solomon's Seal in our data, so we can't tell you what the evidence shows about how well it works.
Why does the label say 'limited safety data'?
Not many studies have looked at how safe Solomon's Seal is in people. That's why we recommend choosing a reputable product and using it carefully.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Solomon's Seal is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Solomon's Seal label
Go deeper

The Full Monographs Behind Solomon's Seal’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Solomon's Seal

Interacts with 86 drugs

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largely lacking. There is not enough reliable...

Read the full Solomon's Seal monograph →
Sources

Sources & How We Checked

Solomon's Seal's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Solomon's Seal 2 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Solomon's Seal monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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