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Dietary supplement

Standardized Bilberry Fruit Extract Ingredients & Drug Interactions

by Bluebonnet

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Standardized Bilberry Fruit Extract is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Standardized Bilberry Fruit Extract by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bilberry fruit extract, a concentrate from bilberry berries. The capsules themselves are made from vegetable cellulose and include vegetable magnesium stearate and silica as inactive ingredients to hold everything together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Bilberry product and its label doesn't state a use — see Bilberry's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for bilberry is mixed and often limited. For night vision, the data suggests it's probably ineffective.

For age-related cognitive decline, age-related macular degeneration (AMD), atherosclerosis, high cholesterol (hyperlipidemia), and chronic venous insufficiency (CVI)—poor circulation in the legs—we don't have enough reliable evidence to know whether it works. If you're considering this for one of those reasons, it's worth discussing with your doctor or pharmacist whether the limited evidence makes sense for your situation.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit as food is generally well tolerated. However, safety data for concentrated supplements like this one is limited, and long-term safety isn't well established—which is why the evidence advises caution with supplement doses rather than the smaller amounts you'd get from eating the fruit itself.

The most common side effects are dark-colored stools, flatulence, and stomach discomfort. Some people also notice their tongue, teeth, or stool turn dark blue or black, which is harmless but can be startling.

A small number of trial participants reported temporary digestive upset. Bilberry is rated likely safe in pregnancy and lactation, but supplement data during these times is limited, so talk with your doctor or pharmacist if you're pregnant or nursing and thinking about taking this.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this bilberry supplement, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs—the biggest concern is increased bleeding risk. Also check if you take diabetes medications, drugs processed by the liver enzyme CYP2E1, or erlotinib (Tarceva).

Your healthcare provider can tell you whether it's safe to combine them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bluebonnet's bilberry extract might interest you if you're exploring support for eye or cognitive health, though the evidence for most uses is weak or absent. If you take blood thinners, diabetes drugs, or cancer medications like erlotinib, this supplement isn't safe without checking with your doctor or pharmacist first.

Even if you don't take those, run your full medication list through the tool on this page before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Standardized Bilberry Fruit Extract, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715013131
Net contents 120 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2018
DSLD ID 179371
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Standardized Bilberry Fruit Extract by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
743715013131
IngredientAmount% DV
Bilberry fruit extract80 mg--

Other ingredients: Kosher Vegetable Capsules, Vegetable Cellulose, Vegetable Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one vegetarian capsule daily or as directed by a healthcare practitioner.

Formula

Bluebonnet’s Standardized Bilberry Fruit Extract Capsules contain Mirtoselect from Indena, a standardized extract of anthocyanins, the most researched active constituents found in bilberry fruit.

Bluebonnet’s KOF-K Certification #K-0000700

36% Anthocyanins

General Statements

A clean and gentle water-based extraction method is employed to capture and preserve bilberry’s most valuable components.

Sustainably Wildcrafted.

Formulation

Available in easy-to-swallow vegetable derived capsules for maximum assimilation/absorption and for a truly vegetarian/vegan formula.

Made with non GMO ingredients

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of corn, yeast, gluten, barley, rice, sodium and sugar.

Seals/Symbols

Sustainably wildcrafted

Made with non GMO ingredients

K Parve Gluten free Vegan

Brand IP Statement(s)

Mirtoselect is a registered trademark of Indena S.p.A.

Mirtoselect an Indiana Product

General

1313C

FDA Statement of Identity

Herbal Supplement

See for yourself

Standardized Bilberry Fruit Extract by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Standardized Bilberry Fruit Extract by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Bilberry fruit extract

Interacts with
275 drugs
80 mg per serving Form: Anthocyanins

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry fruit extract monograph & interactions

Other (inactive) ingredients: Kosher Vegetable Capsules, Vegetable Cellulose, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Standardized Bilberry Fruit Extract by Bluebonnet Drug Interactions

Want to check YOUR meds against Standardized Bilberry Fruit Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Standardized Bilberry Fruit Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry fruit extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Standardized Bilberry Fruit Extract, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
TX
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

Standardized Bilberry Fruit Extract by Bluebonnet: Common Questions

Does Standardized Bilberry Fruit Extract by Bluebonnet interact with any medications?
Yes. Based on its ingredients, Standardized Bilberry Fruit Extract has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Standardized Bilberry Fruit Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is bilberry actually good for eyesight?
For night vision specifically, the data suggests it's probably not effective. For other eye conditions like age-related macular degeneration, we don't have enough solid evidence yet to know if it helps. Talk with your eye doctor about whether this makes sense for you.
What are the most common side effects?
Most people tolerate bilberry well. The most frequent side effects are dark-colored stools, gas, and mild stomach discomfort. You might also notice your tongue, teeth, or stool turn dark blue or black—that's harmless and temporary. A small number of people in studies reported temporary digestive upset.
Can I take this while pregnant or breastfeeding?
Bilberry is rated likely safe during pregnancy and lactation based on current data. That said, safety information for supplement doses during these times is limited, so talk with your doctor or pharmacist for personalized advice before starting.
Why does the label say to avoid supplement doses?
The safety data for concentrated bilberry supplements is limited, and long-term safety isn't well established. You'd get much less product—and better-studied amounts—from eating fresh or frozen bilberries as food, which is why food amounts are considered safer.
Does this extract have any fillers?
The inactive ingredients are kosher vegetable capsules, vegetable cellulose, vegetable magnesium stearate, and silica—these are standard binders and capsule materials, not fillers in the sense of unnecessary bulk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Standardized Bilberry Fruit Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Standardized Bilberry Fruit Extract label
Go deeper

The Full Monographs Behind Standardized Bilberry Fruit Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Standardized Bilberry Fruit Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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