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Dietary supplement

Standardized Saw Palmetto 320 mg Ingredients & Drug Interactions

by Sundown Naturalist

Standardized Saw Palmetto 320 mg label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Standardized Saw Palmetto 320 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Standardized Saw Palmetto 320 mg is a dietary supplement by Sundown Naturalist with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, urinary problems, hair loss.Based on those ingredients, 174 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saw Palmetto extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Standardized Saw Palmetto 320 mg by Sundown Naturalist

Ask about any prescription or over-the-counter medication and we check it for interactions with Standardized Saw Palmetto 320 mg by Sundown Naturalist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Standardized Saw Palmetto 320 mg by Sundown Naturalist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: saw palmetto extract at 320 mg per softgel. Saw palmetto is a plant extract from the berries of the saw palmetto palm, traditionally used for prostate and urinary symptoms.

The softgel also contains three inactive ingredients—gelatin, pure olive oil, and glycerin—which help form and deliver the extract.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Supports prostate and urinary health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Non-neurogenic lower urinary tract symptoms (LUTS), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS).
  • The closest evidence on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Saw Palmetto is rated "Insufficient Reliable Evidence To Rate" for Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Prostatitis, Non-neurogenic lower urinary tract symptoms (LUTS).

The evidence for saw palmetto's effectiveness is mixed. For benign prostatic hyperplasia (BPH), the data we hold rates it as possibly ineffective.

For transurethral resection of the prostate (TURP), it's rated possibly effective, though this is a surgical outcome and the data is limited. For chronic bronchitis, androgenic alopecia (male pattern hair loss), and non-neurogenic lower urinary tract symptoms, we don't have enough reliable evidence to say whether it works or doesn't.

If you're considering this product for any of these uses, talk it over with your doctor to see if the evidence fits your situation.

The evidence, ingredient by ingredient Saw Palmetto

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saw palmetto is generally well tolerated, with mild and reversible side effects. The most common ones reported in trials are abdominal pain, constipation, diarrhea, dizziness, fatigue, headache, nausea, decreased libido, vomiting, and rhinitis.

Rarely, skin reactions (fixed drug eruptions with blisters), changes in heart rhythm, or blood pressure changes have been reported; a few cases of serious heart issues like heart attack or severe slow heart rate have been documented, though these are uncommon. Do not use this product during pregnancy or while breastfeeding.

The safety data advises against it because of possible hormonal effects and a lack of safety information in these populations.

Side effects, ingredient by ingredient Saw Palmetto

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saw Palmetto.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 174 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sundown Naturalist's Standardized Saw Palmetto, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin)—saw palmetto may increase your bleeding risk. Also clear it if you take estrogens or birth control pills, since saw palmetto may interfere with how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Saw palmetto may be worth considering if you have prostate or urinary symptoms and want to explore a plant-based option, though the evidence is limited. You'll need to be especially careful if you take blood thinners, birth control, or estrogen therapy—check with your doctor or pharmacist before starting.

Anyone pregnant or breastfeeding should avoid it. Talk it over with your own healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Standardized Saw Palmetto 320 mg, straight from the product label.

Brand Sundown Naturalist
Barcode (UPC) 030768001278
Net contents 45 Softgel(s)
Market status On market
Date entered into DSLD Jan 25, 2017
DSLD ID 69958
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Standardized Saw Palmetto 320 mg by Sundown Naturalist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
22
UPC/BARCODE
030768001278
IngredientAmount% DV
Saw Palmetto extract320 mg--

Other ingredients: Gelatin, pure Olive Oil, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

320 mg per serving

Natural color variation is normal and does not affect the quality of the product.

WARNING: This product is intended for use by men and is not intended for use by women.

Quality Guaranteed Lab Tested Laboratory tested to meet strict quality control standards for potency, purity and disintegration. 100% Quality Guaranteed.

Actual Size

Seals/Symbols

100% Quality Assurance Laboratory Tested

Formula

Supports Prostate and Urinary Health

IMPORTANT FACTS YOU SHOULD KNOW Saw Palmetto berries contain a variety of fatty acids which have been traditionally used to help promote prostate and urinary health. Naturalist’s Saw Palmetto is provided in a standardized extract.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: FOR ADULT MEN, TAKE TWO (2) SOFTGELS TWO TIMES DAILY, PREFERABLY WITH MEALS.

Formulation

No yeast, wheat, gluten, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium.

Precautions

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

KEEP OUT OF REACH OF CHILDREN.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Prod. No. 44434 08E B12310

Brand IP Statement(s)

2016

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Standardized Saw Palmetto 320 mg by Sundown Naturalist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Standardized Saw Palmetto 320 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Standardized Saw Palmetto 320 mg by Sundown Naturalist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container22 Amounts shown are per serving.

Saw Palmetto extract

Interacts with
174 drugs
320 mg per serving Form: Sterols, total Fatty Acids

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto extract monograph & interactions

Other (inactive) ingredients: Gelatin, Pure Olive Oil, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Standardized Saw Palmetto 320 mg by Sundown Naturalist Drug Interactions

Want to check YOUR meds against Standardized Saw Palmetto 320 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
174Drugs
174 Moderate

Ingredients driving the most interactions

Saw Palmetto extract 174

Individual Drug Interactions

The ingredients in Standardized Saw Palmetto 320 mg interact with 174 drugs. Click any drug to see the details.

1 of the 1 ingredient in Standardized Saw Palmetto 320 mg interact with drugs. Each result below shows which ingredient is responsible. Saw Palmetto extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Standardized Saw Palmetto 320 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saw Palmetto extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Standardized Saw Palmetto 320 mg, from the product label.

Sundown Naturalist

See all Sundown Naturalist products
Name
Rexall Sundown, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-888-848-2435
Pharmacist Counseling Corner

Standardized Saw Palmetto 320 mg by Sundown Naturalist: Common Questions

Does Standardized Saw Palmetto 320 mg by Sundown Naturalist interact with any medications?
Yes. Based on its ingredients, Standardized Saw Palmetto 320 mg has a known interaction with 174 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Standardized Saw Palmetto 320 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take saw palmetto if I'm on birth control?
Not without checking first. Saw palmetto may have antiestrogenic effects and could interfere with how your contraceptive works. Talk to your doctor or pharmacist before adding this product to see if it's safe for you.
What are the most common side effects?
Most side effects are mild. The most often reported ones are abdominal pain, constipation, diarrhea, dizziness, fatigue, headache, nausea, and decreased libido. They're usually infrequent and go away when you stop taking it.
Is saw palmetto safe during pregnancy?
No. The safety data advises against use during pregnancy because of possible hormonal effects and lack of safety information. Avoid it while breastfeeding too.
Does saw palmetto really work for an enlarged prostate?
The evidence we hold rates it as possibly ineffective for benign prostatic hyperplasia (BPH). For other prostate-related conditions, the data is limited or insufficient. Your doctor can help you weigh whether it's worth trying in your case.
Can I take it with a blood thinner like warfarin?
You need to check with your doctor first. Saw palmetto is reported to prolong bleeding time, and combining it with blood thinners or antiplatelet drugs like warfarin or aspirin raises your bleeding risk.
What's in each capsule besides saw palmetto?
The softgel also contains gelatin, pure olive oil, and glycerin—these are inactive ingredients that form and deliver the extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Standardized Saw Palmetto 320 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Standardized Saw Palmetto 320 mg label
Go deeper

The Full Monographs Behind Standardized Saw Palmetto 320 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph →
Sources

Sources & How We Checked

Standardized Saw Palmetto 320 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saw Palmetto 22 references
  1. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
  2. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
  3. Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
  4. Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
  5. Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
  6. Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
  7. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  8. Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
  9. Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
  10. Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
  11. Agbabiaka, T. B., Pittler, M. H., Wider, B., and Ernst, E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009;32(8):637-647. PubMed
  12. Wargo, K. A., Allman, E., and Ibrahim, F. A possible case of saw palmetto-induced pancreatitis. South.Med.J. 2010;103(7):683-685. PubMed
  13. Lapi, F., Gallo, E., Giocaliere, E., Vietri, M., Baronti, R., Pieraccini, G., Tafi, A., Menniti-Ippolito, F., Mugelli, A., Firenzuoli, F., and Vannacci, A. Acute liver damage due to Serenoa repens: a case report. Br.J.Clin.Pharmacol. 2010;69(5):558-560.
  14. Mantovani, F. Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies. Minerva Urol.Nefrol. 2010;62(4):335-340.
  15. Hanaka, M., Yoshii, C., Yatera, K., Ito, C., Chojin, Y., Nagata, S., Yamasaki, K., Nishida, C., Kawanami, T., Kawanami, Y., Ishimoto, H., and Mukae, H. [A case of rhabdomyolysis caused by saw palmetto of healthy foods]. J.UOEH. 6-1-2012;34(2):193-199. PubMed
  16. Miroddi, M., Carni, A., Mannucci, C., Moleti, M., Navarra, M., and Calapai, G. Hot flashes in a young girl: a wake-up call concerning Serenoa repens use in children. Pediatrics 2012;130(5):e1374-e1376.
  17. Braeckman J. The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a multicenter open study. Current Therapeutic Research 1994;55(7):776-785. DOI
  18. Jipescu D, Patel A, Bohra H, Pientka A. Rare case of saw palmetto induced heart block. JACC 2017;69(11) supplement:2310.
  19. Morabito P, Miroddi M, Giovinazzo S, Spina E, Calapai G. Serenoa repens as an endocrine disruptor in a 10-year-Old young girl: a new case report. Pharmacology. 2015;96(1-2):41-3. doi: 10.1159/000431327.
  20. Gammoudi R, Ameur K, Ouni B, et al. Fixed drug eruption to Serenoa repens: first case report and consideration of the use of herbal medicine. Dermatol Ther 2020 Aug 29:e14247.
  21. Paulis G, Paulis A, Perletti G. Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials. Arch Ital Urol Androl 2021;93(4):475-480. PubMed
  22. Venkateswaran S, Declet-Bauzo R, Shodeinde M, Gilford P. Postoperative Retroperitoneal Hematoma: A Case of Saw Palmetto and the Importance of Primary Care Intervention. HCA Healthc J Med 2020;1(5):279-282. PubMed

See these in context on the Saw Palmetto monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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