Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Sulforaphane+ Ingredients & Drug Interactions

by HUMANX

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sulforaphane+ is a dietary supplement by HUMANX with 3 active ingredients. Its ingredients are commonly taken for nutritional supplement, blood sugar support, cholesterol support.Based on those ingredients, 870 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Moringa oleifera Leaf Extract, BroccoRaphanin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Sulforaphane+ by HUMANX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (602 mg) without saying how much of each component you get.
  • “BroccoRaphanin” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Sulforaphane+ contains 3 active ingredients delivered in a capsule. The product includes moringa oleifera leaf extract, which is a nutrient-dense plant extract; glucoraphanin; and myrosinase, an enzyme.

These are combined with methylcellulose, an inactive binder.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cellular health, liver and cognitive function.
  • We looked for evidence on: liver health, cognitive function, cellular protection.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold on moringa oleifera leaf extract doesn't support a clear benefit for any condition. Our data rates its effectiveness for iron deficiency anemia, asthma, athletic performance, diabetes, HIV/AIDS, and high cholesterol (hyperlipidemia) all as insufficient — meaning reliable evidence to prove it works for these purposes hasn't been established.

We don't have effectiveness ratings for glucoraphanin or myrosinase in our data.

The evidence, ingredient by ingredient Moringa Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Moringa leaf appears generally well tolerated as food, though high-quality safety data are limited. The most common side effect from oral use is transient (short-lived) diarrhea; in a trial, about a quarter of people taking 8 grams daily experienced it.

Rare serious reactions including allergic reactions and Stevens-Johnson syndrome (a severe skin condition with fever and painful mouth sores) have been reported. Avoid medicinal amounts of moringa root and bark — safety data are lacking, and they may stimulate the uterus.

Moringa leaf has been traditionally used to boost milk supply, but safety hasn't been well studied, so use caution if you're breastfeeding.

Side effects, ingredient by ingredient Moringa Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Moringa.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 870 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Sulforaphane+, double-check with your doctor or pharmacist if you take CYP3A4 substrates (drugs metabolized by a major liver pathway — a Moderate concern), levothyroxine or other thyroid medications (Moderate), P-glycoprotein substrates (Moderate), blood sugar medications (Minor), or any CYP1A2 substrates or HIV drugs like nevirapine (Minor). The interaction with CYP3A4 substrates is particularly unpredictable — moringa may raise or lower their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sulforaphane+ is built around moringa leaf extract, which has potential interactions with medications metabolized by your liver (especially CYP3A4 substrates), thyroid hormone replacement, blood sugar medications, and several other drug types. If you take any prescription medications, it's essential to check them against our interaction tool before starting this supplement.

Have that conversation with your own doctor or pharmacist — they know your full medication list and can tell you whether it's a fit for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sulforaphane+, straight from the product label.

Brand HUMANX
Barcode (UPC) X002JU3KIT
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 284112
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sulforaphane+ by HUMANX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
X002JU3KIT
IngredientAmount% DV
Proprietary Blend602 mg--
Moringa oleifera Leaf Extract0 NP--
BroccoRaphanin0 NP--
Glucoraphanin30 mg--
Myrosinase0 NP--

Other ingredients: Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Sulforaphane produced from glucoraphanin supports cellular health, liver and cognitive function.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take two capsules per day with a glass of water, or as recommended by your healthcare professional.

Precautions

Caution: Keep out of reach of children and pets.

Caution: Keep out of reach of children and pets. Consult with a qualified healthcare professional prior to using this product. Do not exceed recommended daily intake. do not use if safety seal is damaged or missing.

Storage

Store at room temperature, in a dry place. Protect product from excessive heat, freezing, humidity, and light.

General Statements

100% refund guarantee Refund guarantee We offer a full refund on the purchase price of your order (minus return costs) within 30 days of purchase. Restrictions apply. Please visit shophumanx.com for full details.

602 milligrams per serving

Formulation

Supports healthy liver & cognitive function

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Sulforaphane+ by HUMANX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sulforaphane+ by HUMANX

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

602 mg per serving

Other (inactive) ingredients: Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sulforaphane+ by HUMANX Drug Interactions

Want to check YOUR meds against Sulforaphane+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
870Drugs
795 Moderate 75 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Sulforaphane+ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Moringa oleifera Leaf Extract6 drug types · 869 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Some in vitro research suggests that moringa inhibits cytochrome P450 3A4 (CYP3A4). However, other in vitro research suggests that moringa extract induces CYP3A4 enzymes. A pharmacokinetic study in patients with HIV shows no change in the pharmacokinetics of nevirapine, which is partially metabolized by CYP3A4, when administered concomitantly with moringa leaf powder 1.85 grams daily for 14 days.

Likelihood Possible Evidence D
Levothyroxine (Synthroid, Others)

Theoretically, moringa leaf can antagonize the effects of levothyroxine.
Animal research suggests that moringa aqueous leaf extract might reduce serum triiodothyronine (T3) concentrations by inhibiting the peripheral conversion of thyroxine (T4) to T3.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that moringa leaf extract inhibits renal P-glycoprotein transport activity. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, moringa might have additive effects when used with antidiabetes drugs; however, research is conflicting.
Animal research shows that moringa can lower blood glucose levels. However, research in humans has not shown consistent blood glucose lowering effects.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that moringa extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Nevirapine (Viramune)

Moringa leaf is unlikely to have a clinically significant interaction with nevirapine.
Nevirapine is partially metabolized by cytochrome P450 3A4 (CYP3A4). In vitro evidence suggests that moringa inhibits CYP3A4. However, a pharmacokinetic study in patients with HIV shows no change in nevirapine pharmacokinetics when administered concomitantly with moringa leaf powder 1.85 grams daily for 14 days.

Likelihood Unlikely Evidence B

BroccoRaphanin2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Sulforaphane+, from the product label.

HUMANX

See all HUMANX products
Name
Ilumina LLC
Street Address
302 Washington St #151
City
San Diego
State
CA
ZipCode
92103
Web Address
www.shophumanx.com
Pharmacist Counseling Corner

Sulforaphane+ by HUMANX: Common Questions

Does Sulforaphane+ by HUMANX interact with any medications?
Yes. Based on its ingredients, Sulforaphane+ has a known interaction with 870 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sulforaphane+ contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is moringa leaf safe to take long-term?
Moringa leaf appears generally well tolerated, but high-quality long-term safety data are limited. Transient diarrhea is the most common side effect. Rare serious reactions including severe allergic reactions have been reported, so stop and seek immediate care if you develop rash, swelling, or difficulty breathing.
Can I take this if I'm pregnant?
The safety data on moringa in pregnancy are mixed — it's rated both possibly safe and possibly unsafe, meaning there isn't enough consistent information. Talk with your doctor or pharmacist about whether it's appropriate for you during pregnancy.
Can I take this if I'm breastfeeding?
Moringa is rated possibly safe during breastfeeding, though evidence is limited. It's been traditionally used to support milk supply, but safety hasn't been well studied, so use caution. Discuss it with your doctor or pharmacist to decide if it's right for you.
What's the most common side effect?
Transient diarrhea is the most common side effect from moringa leaf. In a trial, about a quarter of people taking 8 grams daily experienced it, and it passed on its own.
Will this help my blood sugar or energy levels?
Our data don't establish that moringa reliably lowers blood sugar or boosts athletic performance — the evidence is rated insufficient for both. Human research has been inconsistent.
What ingredients couldn't be checked for interactions?
We don't have interaction data on file for glucoraphanin and myrosinase, the other active ingredients in this product. If you're concerned about them, ask your pharmacist to search medical literature.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sulforaphane+ is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sulforaphane+ label
Sources

Sources & How We Checked

Sulforaphane+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Moringa 23 references
  1. Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003;84:105-8. PubMed
  2. Tahiliani P, Kar A. Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats. Pharmacol Res 2000;41:319-23. PubMed
  3. Jaiswal D, Kumar Rai P, Kumar A, et al. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J Ethnopharmcol 2009;123:392-6. PubMed
  4. Bour S, Visentin V, Prevot D, et al. Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats. J Physiol Biochem 2005;61:371-9. PubMed
  5. Iffiu-Soltesz Z, Wanecq E, Lomba A, et al. Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. Pharmacol Res 2010;61:355-63. PubMed
  6. Monera TG, Wolfe AR, Maponga CC, et al. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries 2008;2:379-83.
  7. Estrella M, Mantaring J, David G, Taup M. A double blind, randomised controlled trial on the use of malunggay (Moringa oleifera) for augmentation of the volume of breastmilk among non-nursing mothers of preterm infants. Philipp J Pediatr 2000;49:3-6.
  8. Morton, J. F. The Horseradish Tree, Moringa Pterygosperma (Moringaceae) - a boon to arid lands? Economic Botany 1991;45:318-333. DOI
  9. Espinosa-Kuo CL. A Randomized Controlled Trial on the Use of Malunggay (Moringa oleifera) for Augmentation of the Volume of Breastmilk Among Mothers of Term Infants. Filipino Family Physician. 2005;43(1):26-33.
  10. King JS, Raguindin PFN, Dans LF. Moringa oleifera (Malunggay) as a Galactagogue for Breastfeeding Mothers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Philipp J Pediatr 2013;61(2):34-42.
  11. Singh D, Choudhury S, Singh TU, Garg SK. Pharmacodynamics of uterotonic effect of Moringa oleifera flowers extract. J Vet Pharmcol Toxicol 2008;7(1-2):12-15.
  12. William F, Lakshminarayanan S, Chegu H. Effect of some Indian vegetables on the glucose and insulin response in diabetic subjects. International Journal of Food Sciences and Nutrition 1993;44(3): 191-195. DOI: 10.3109/09637489309017439 DOI
  13. Monera-Penduka TG, Maponga CC, Wolfe AR, Wiesner L, Morse GD, Nhachi CF. Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study. AIDS Res Ther. 2017;14:12. doi: 10.1186/s1 PubMed
  14. Witharana EWRA, Wijetunga WMGASTB, Wijesinghe SKJ. Stevens - Johnson syndrome (SJS) following murunga leaf (Moringa oleifera) consumption. Ceylon Med J 2018;63(4):188-9.
  15. Nur R, Demak IPK, Radhiah S, Rusydi M, Mantao E, Larasati RD. The effect of moringa leaf extracton increasing hemoglobin and bodyweight in post-disaster pregnant women. Enferm Clin. 2020;30 Suppl 4:79-82. DOI
  16. Taweerutchana R, Lumlerdkij N, Vannasaeng S, Akarasereenont P, Sriwijitkamol A. Effect of Moringa oleifera Leaf Capsules on Glycemic Control in Therapy-Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study. Evid Based Complement Alternat M
  17. Sumiaty, Tahir A, Burhanuddin B, Nurhaedar J, Veni H. The effect of moringa leaves on pregnancy on growth and morbidity of 6-11 month. Enferm Clin. 2020;30 Suppl 4:104-108. DOI
  18. Ulmy MN, Tahir A, Arsunan AA, Burhanuddin B, Veni H. Effect of moringa leaves during pregnancy on growth and morbidity in 0-5 months. Enferm Clin. 2020;30 Suppl 4:61-65. DOI
  19. Amaeze O, Marques ES, Wei W, et al. Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction. Curr Drug Metab. 2021;22(14):1103-1113. PubMed
  20. Ebhohon E, Miller D. Moringa Oleifera leaf extract induced pulmonary embolism-a case report. Int J Emerg Med 2022;15(1):16. PubMed
  21. Basri H, Hadju V, Zulkifli A, Syam A, Indriasari R. Effect of Moringa oleifera supplementation during pregnancy on the prevention of stunted growth in children between the ages of 36 to 42 months. J Public Health Res 2021;10(2):2207.
  22. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  23. Amsler E, Mahevas T, Soria A, Barbaud A. Fixed food eruption to Moringa oleifera. Contact Dermatitis 2023;89(4):301-302.

See these in context on the Moringa monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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