Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Super Anti-Oxidant Ingredients & Drug Interactions

by R-Garden

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Super Anti-Oxidant is a dietary supplement by R-Garden with 6 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pine bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Super Anti-Oxidant by R-Garden

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.

This supplement has six active ingredients. Protease and lipase are digestive enzymes meant to help break down protein and fat.

Cellulase breaks down plant fiber. Pine bark extract and RosaEX are plant compounds added for their antioxidant properties.

Hidrox is an olive extract. The capsule also contains rice flour as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Asthma — rated "Possibly Effective" (Maritime Pine) (Natural Medicines).
  • On file: Chronic venous insufficiency (CVI) — rated "Possibly Effective" (Maritime Pine) (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Maritime Pine) (Natural Medicines).

The evidence for most of these ingredients is thin. Lipase and Hiroox (olive) have been studied for indigestion, inflammatory bowel disease, and other conditions, but the data we hold rates them as having insufficient reliable evidence — meaning the science isn't there yet to call them effective for any condition.

We don't hold effectiveness ratings for protease, cellulase, pine bark extract, or RosaEX.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Maritime Pine Olive

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease is generally well tolerated, though it may cause digestive upset or allergic reactions in some people. Lipase is also generally well tolerated for most adults, but if you have a serious digestive condition, check with your doctor before taking it.

Both protease and lipase have limited safety data in pregnancy and breastfeeding — the safety data advises against protease in pregnancy unless your doctor prescribes it, and both warrant a conversation with your doctor or pharmacist before use during pregnancy or nursing. Hidorx (olive extract) as a food is very safe, but concentrated supplements are less studied.

The most common side effects reported are headache and stomach discomfort. We don't hold safety data for cellulase, pine bark extract, or RosaEX.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Maritime Pine Olive

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Maritime Pine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

No interactions are documented in our data for the ingredients we could check. However, we couldn't verify cellulase, pine bark extract, or RosaEX — if you take any medications, it's worth asking your pharmacist about those three.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This is a digestive-enzyme and antioxidant blend with limited effectiveness data and no documented drug interactions for the ingredients we could check. If you have a serious digestive condition or are pregnant or breastfeeding, talk to your pharmacist before starting.

If you take any regular medications, run them through the checker on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Anti-Oxidant, straight from the product label.

Brand R-Garden
Barcode (UPC) 653041000418
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 3213
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Anti-Oxidant by R-Garden, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
120
UPC/BARCODE
653041000418
IngredientAmount% DV
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Pine bark extract86 mg--
Hidrox110 mg--
RosaEX86 mg--

Other ingredients: Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take two capsules daily or as needed.

Precautions

Discontinue immediately if adverse effects occur.

Keep out of reach of children.

Do not use if tamper evident band is broken or missing.

Formulation

Vegetarian capsules

Nothing in this product is of animal origin.

General Statements

Intended for nutritional use only.

"Gratitude is the fairest blossom which springs from the soul."

Nature's finest nutritional formula

Capsule size #1

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Hidrox is a registered trademark of Creagri Inc.

See for yourself

Super Anti-Oxidant by R-Garden label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Super Anti-Oxidant by R-Garden

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Lipase

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Cellulase

0 NP per serving

Pine bark extract

Interacts with
327 drugs
86 mg per serving

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...

Pine bark extract monograph & interactions

Hidrox

No known
interactions
110 mg per serving Form: Hydroxytyrosol

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Hidrox monograph & interactions

RosaEX

86 mg per serving

Other (inactive) ingredients: Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Anti-Oxidant by R-Garden Drug Interactions

Want to check YOUR meds against Super Anti-Oxidant?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Anti-Oxidant with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pine bark extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Super Anti-Oxidant, from the product label.

R-Garden

See all R-Garden products
Name
R-Garden Inc.
City
Kettle Falls
State
WA
ZipCode
99141
Phone Number
1-800-800-1927
Pharmacist Counseling Corner

Super Anti-Oxidant by R-Garden: Common Questions

Does Super Anti-Oxidant by R-Garden interact with any medications?
Yes. Based on its ingredients, Super Anti-Oxidant has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Anti-Oxidant contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Not without talking to your doctor first. Protease safety data advises against it in pregnancy unless prescribed. Both protease and lipase have limited safety data during breastfeeding. For cellulase, pine bark extract, and RosaEX, we don't have safety information on file — so a conversation with your pharmacist or doctor is important either way.
Does protease actually help digestion?
We don't have an effectiveness rating for protease in our data. It's meant to break down protein, but the evidence backing that claim isn't on file for us.
What are the side effects I should watch for?
Protease may cause digestive upset or allergic reactions. Lipase and olive extract (Hidrox) are generally well tolerated, though digestive upset, headache, and stomach discomfort have been reported. If you have a serious digestive condition, talk to your doctor first.
Is this safe for people with digestive problems?
If you have a serious digestive condition like inflammatory bowel disease, check with your doctor before taking lipase — it should only be used under medical guidance in those cases. The same goes for protease if you have any ongoing digestive issues.
What is Hidrox?
Hidrox is an olive extract — the plant compound from olives and olive oil. As a food, olives and olive oil are very safe, but concentrated supplements are less studied.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Anti-Oxidant is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Anti-Oxidant label
Sources

Sources & How We Checked

Super Anti-Oxidant's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Maritime Pine 14 references
  1. Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  2. Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
  3. Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
  4. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
  5. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
  6. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
  7. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
  8. Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
  9. Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
  10. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
  11. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
  12. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
  13. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
  14. Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

See these in context on the Maritime Pine monograph →

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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