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Dietary supplement

Super Antioxidant Pycnogenol 30 mg Ingredients & Drug Interactions

by Nature's Bounty Optimal Solutions

Super Antioxidant Pycnogenol 30 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Antioxidant Pycnogenol 30 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Antioxidant Pycnogenol 30 mg is a dietary supplement by Nature's Bounty Optimal Solutions with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pycnogenol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Pycnogenol, a standardized extract from maritime pine bark. The capsule itself is made from vegetable cellulose and gelatin, with minimal added ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports skin and antioxidant health.
  • We looked for evidence on: Aging skin, Wrinkled skin, Chronic venous insufficiency (CVI), Varicose veins, Raynaud syndrome, oxidative stress — and 2 related terms.
  • The strongest evidence on file: Maritime Pine is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Maritime Pine is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Varicose veins, Wrinkled skin, Raynaud syndrome.

Pycnogenol shows possibly effective evidence for osteoarthritis and chronic venous insufficiency—a condition where veins in the legs struggle to return blood to the heart. It's also rated possibly effective for asthma.

For high cholesterol, the evidence suggests it's possibly ineffective, so this ingredient alone isn't a substitute for cholesterol-lowering drugs or diet.

The evidence, ingredient by ingredient Maritime Pine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pycnogenol is generally well tolerated in studies, though long-term safety data is limited. The most common side effects are gastrointestinal complaints, dizziness, and vertigo.

Headache and a single case of chest pain have been reported; the chest pain occurred in a patient with a history of heart attack, so causation is unclear. Do not use this product during pregnancy or while breastfeeding—there isn't enough safety data.

Side effects, ingredient by ingredient Maritime Pine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maritime Pine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you use blood thinners or antiplatelet drugs (like warfarin or aspirin), diabetes medications (like insulin or metformin), or immunosuppressants. These are Moderate-severity interactions with Pycnogenol.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have osteoarthritis or chronic venous insufficiency and don't take blood thinners, diabetes drugs, or immunosuppressants, this may be worth trying. If you're on any of those medication types, check with your pharmacist first.

Pregnant and breastfeeding people should skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Antioxidant Pycnogenol 30 mg, straight from the product label.

Brand Nature's Bounty Optimal Solutions
Net contents 50 Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2014
DSLD ID 29345
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Pycnogenol30 mg--

Other ingredients: Vegetable Cellulose, Gelatin, Contains <2% of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Nature’s Bounty(R) Optimal Solutions(R) Super Antioxidant Pycnogenol(R) formula is a unique natural plant extract from French maritime pine bark which supports skin and antioxidant health. Pycnogenol(R) is a patented nutrient and has been clinically studied for over a decade which makes it the perfect option to add to your supplement regimen.

(C)2013 Nature’s Bounty, Inc.

Pycnogenol(R) is a registered trademark of Horphag Research Management S.A.; Horphag Research (Luxembourg) Holding S.A. is the owner of US pat. 5,720,956; Horphag Research IP (PYC) LTD is the owner of US pat. 6,372,266.

Storage

Store at room temperature.

Precautions

Do not use if seal under cap is broken or missing.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Seals/Symbols

LABORATORY TESTED GUARANTEED QUALITY

General Statements

Laboratory tested to meet strict quality control standards for potency, purity and disintegration. 100% Quality Guaranteed.

Supports Skin & Antioxidant Health

Nutrition Questions or Comments? Call 1-800-433-2990 Mon. - Sat. 9 AM - 7 PM ET

Formula

French Maritime Pine Bark Extract

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take one (1) capsule three to four times daily, preferably with meals.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Prod. No. 53495 00A B53139 EAC

Formulation

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Antioxidant Pycnogenol 30 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Pycnogenol

Interacts with
327 drugs
30 mg per serving

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...

Pycnogenol monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Gelatin, Contains <2% of. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions Drug Interactions

Want to check YOUR meds against Super Antioxidant Pycnogenol 30 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Pycnogenol 327

Individual Drug Interactions

The ingredients in Super Antioxidant Pycnogenol 30 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Super Antioxidant Pycnogenol 30 mg interact with drugs. Each result below shows which ingredient is responsible. Pycnogenol

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Antioxidant Pycnogenol 30 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pycnogenol3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Pycnogenol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Antioxidant Pycnogenol 30 mg, from the product label.

Nature's Bounty Optimal Solutions

See all Nature's Bounty Optimal Solutions products
Web Address
www.NaturesBounty.com
Pharmacist Counseling Corner

Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions: Common Questions

Does Super Antioxidant Pycnogenol 30 mg by Nature's Bounty Optimal Solutions interact with any medications?
Yes. Based on its ingredients, Super Antioxidant Pycnogenol 30 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Antioxidant Pycnogenol 30 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin?
You should check with us first. Pycnogenol may theoretically increase your bleeding risk when combined with aspirin or other antiplatelet drugs. We can help you decide if it's right for you based on your specific dose and health situation.
Will this supplement affect my diabetes medications?
Possibly. One study shows Pycnogenol lowers blood sugar, so if you're on insulin or other diabetes drugs, you'd need to monitor your glucose closely and your doctor might need to adjust your dose. Talk to us or your doctor before starting.
What are the most common side effects?
Stomach complaints, dizziness, and vertigo are the most frequently reported. Headache has also been noted in a trial. Most people tolerate it well, but if you're prone to dizziness, start cautiously.
Is Pycnogenol safe to take while pregnant?
There isn't enough safety data to know, so it's best avoided during pregnancy. If you're pregnant and thinking about a supplement, talk with your doctor first about what's right for you.
What does Pycnogenol actually do?
It's an extract from maritime pine bark. The evidence suggests it may help with osteoarthritis and leg vein problems, and possibly asthma. For high cholesterol, though, the evidence suggests it doesn't work well.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Antioxidant Pycnogenol 30 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Antioxidant Pycnogenol 30 mg label
Go deeper

The Full Monographs Behind Super Antioxidant Pycnogenol 30 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maritime Pine

Interacts with 327 drugs

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...

Read the full Maritime Pine monograph →
Sources

Sources & How We Checked

Super Antioxidant Pycnogenol 30 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maritime Pine 14 references
  1. Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  2. Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
  3. Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
  4. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
  5. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
  6. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
  7. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
  8. Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
  9. Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
  10. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
  11. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
  12. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
  13. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
  14. Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

See these in context on the Maritime Pine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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