Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support Ingredients & Drug Interactions

by Life Extension

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Ubiquinol CoQ10 Enhanced Mitochondrial Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for heart health, statin-related muscle aches, migraine prevention.Based on those ingredients, 284 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ubiquinol, PrimaVie Shilajit Fulvic Acid Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients. Ubiquinol is a reduced form of coenzyme Q10, a compound your cells use to make energy and defend against oxidative stress.

PrimaVie Shilajit Fulvic Acid Complex is a purified mineral-rich substance traditionally used in Ayurvedic medicine. The product is encased in a softgel made from gelatin, sunflower oil, glycerin, beeswax, sunflower lecithin, and annatto color, plus purified water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Mitochondrial support and energy.
  • We looked for evidence on: Age-related macular degeneration (AMD), Aging, Alzheimer disease, Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Angina, Anthracycline cardiotoxicity — and 4 related terms.
  • The closest evidence on file: Coenzyme Q10 is rated "Possibly Ineffective" for Alzheimer disease (Natural Medicines).
  • Also on file: Coenzyme Q10 is rated "Possibly Ineffective" for Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Chemotherapy-related fatigue.
  • Also on file: Coenzyme Q10 is rated "Likely Ineffective" for Athletic performance.

For ubiquinol, the evidence is strongest for coenzyme Q10 deficiency — that's rated Likely Effective. There's Possibly Effective evidence for fibromyalgia, migraine headache, congestive heart failure, and diabetic neuropathy, meaning small studies suggest benefit but larger or better-designed trials are needed.

For shilajit, the evidence we hold does not establish effectiveness for the uses listed — Alzheimer disease, sexual dysfunction, athletic performance, benign prostatic hyperplasia, and osteopenia all carry a rating of Insufficient Reliable Evidence To Rate. That means the research so far hasn't been robust enough to draw firm conclusions.

The evidence, ingredient by ingredient Coenzyme Q10 Shilajit

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ubiquinol is generally well tolerated when used as directed. In clinical studies, no serious side effects have been reported.

The most common are mild gastrointestinal effects — appetite suppression, diarrhea, heartburn, nausea, vomiting — occurring in less than 1% of people; dividing doses above 100 mg can help. Headache, dizziness, and insomnia have also been reported rarely.

A small number of people have reported skin itching or allergic rash. Shilajit carries caution: unpurified products may contain heavy metals or contaminants, so use only purified, tested brands.

A case of severe allergic reaction (anaphylaxis) has been reported. One case of high blood pressure related to mineral imbalance occurred in pregnancy, though a direct causal link couldn't be confirmed.

For pregnancy, the data advises against shilajit due to contamination risk and insufficient safety information. For breastfeeding, the data advises against shilajit; ubiquinol safety while breastfeeding has not been well studied, so check with your doctor.

Side effects, ingredient by ingredient Coenzyme Q10 Shilajit

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Coenzyme Q10, Shilajit.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 284 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take chemotherapy drugs (especially alkylating agents), warfarin or other blood thinners, diabetes medications, or blood pressure drugs. The ubiquinol in this product may reduce chemotherapy effectiveness and warfarin's anticoagulant effect, while shilajit may increase the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you have a documented CoQ10 deficiency or want to support heart health or migraine management, ubiquinol has reasonable evidence — but check your medications first, especially if you take warfarin, chemotherapy, or blood pressure drugs. Shilajit's benefits aren't yet established in our data, and its safety depends entirely on purity; if you choose it, buy only tested brands.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Ubiquinol CoQ10 Enhanced Mitochondrial Support, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870219835
Net contents 30 Packet(s)
Market status On market
Date entered into DSLD Aug 22, 2017
DSLD ID 74708
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
737870219835
IngredientAmount% DV
Calories5 Calorie(s)--
Calories from Fat5 Calorie(s)--
Total Fat0.5 Gram(s)1%
Ubiquinol100 mg--
PrimaVie Shilajit Fulvic Acid Complex100 mg--

Other ingredients: Sunflower Oil, Gelatin, Glycerin, purified Water, Beeswax, Sunflower Lecithin, Annatto color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Lyc-O-Mato and Tomat-O-Red are registered trademarks of Lycored LTD. SelenoExcell is a registered trademark of Cypress Systems Inc. L-OptiZinc is a registered trademark of InterHealth Nutraceuticals, Inc. LuteinPlus and MZ are registered trademarks of Nutriproducts Ltd. UK, licensed under U.S. patent 8,623,428. Crominex 3+, Capros and PrimaVie are registered trademarks of Natreon, Inc. Bio-Curcumin and BCM-95 are registered trademarks of Dolcas-Biotech, LLC. U.S Patent Nos. 7,883,728, 7,736,679 and 7,879,373. Q+, Kaneka Ubiquinol, and the quality seal are registered or pending trademarks of Kaneka Corp. Made with Quality Q Kaneka Ubiquinol

Seals/Symbols

Made with Quality Q Kaneka Ubiquinol

General Statements

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Daily supply of key nutrients in convenient packets

General

QE02198A

Formulation

Non-GMO

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one (1) packet daily with a meal, or as recommended by a healthcare practitioner.

Storage

To ensure product consistency, store tightly closed in a cool, dry place.

Precautions

Caution: Individuals consuming more than 2,000 IU/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Vitamin D supplementation is not recommended for individuals with high blood calcium levels.

If you are taking anticoagulant or antiplatelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

Do not take if you have gallbladder problems or gallstones.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Ubiquinol

Interacts with
198 drugs
100 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Ubiquinol monograph & interactions

PrimaVie Shilajit Fulvic Acid Complex

Interacts with
86 drugs
100 mg per serving

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and v...

PrimaVie Shilajit Fulvic Acid Complex monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Gelatin, Glycerin, Purified Water, Beeswax, Sunflower Lecithin, Annatto color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension Drug Interactions

Want to check YOUR meds against Super Ubiquinol CoQ10 Enhanced Mitochondrial Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
284Drugs
112 Moderate 172 Minor

Ingredients driving the most interactions

Ubiquinol 198
PrimaVie Shilajit Fulvic Acid Complex 86

Individual Drug Interactions

The ingredients in Super Ubiquinol CoQ10 Enhanced Mitochondrial Support interact with 284 drugs. Click any drug to see the details.

2 of the 2 ingredients in Super Ubiquinol CoQ10 Enhanced Mitochondrial Support interact with drugs. Each result below shows which ingredient is responsible. Ubiquinol PrimaVie Shilajit Fulvic Acid Complex

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Ubiquinol CoQ10 Enhanced Mitochondrial Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ubiquinol3 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Ubiquinol full monograph & interactions

PrimaVie Shilajit Fulvic Acid Complex1 drug type · 86 drugs

Antidiabetes Drugs

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
PrimaVie Shilajit Fulvic Acid Complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Ubiquinol CoQ10 Enhanced Mitochondrial Support, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension: Common Questions

Does Super Ubiquinol CoQ10 Enhanced Mitochondrial Support by Life Extension interact with any medications?
Yes. Based on its ingredients, Super Ubiquinol CoQ10 Enhanced Mitochondrial Support has a known interaction with 284 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Ubiquinol CoQ10 Enhanced Mitochondrial Support contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
Not without checking with your pharmacist first. Ubiquinol in this product may behave like vitamin K and reduce warfarin's blood-thinning effects — four cases of this have been reported. Your doctor or pharmacist will need to decide if it's safe for you or if your warfarin dose needs adjusting.
What are the most common side effects I might notice?
With ubiquinol, mild stomach upset — loss of appetite, diarrhea, heartburn, nausea — occurs in less than 1% of people and usually happens with doses above 100 mg split into smaller amounts. Headache, dizziness, and trouble sleeping have been reported rarely. Shilajit rarely causes headache. Skin itching or rash is uncommon but has been reported.
Can I take this supplement if I'm pregnant?
The safety data advises against shilajit during pregnancy due to contamination risk and insufficient safety information. For ubiquinol, there isn't enough data to know either way — talk with your doctor for personalized advice.
Is it safe to breastfeed while taking this?
The safety data advises against shilajit while breastfeeding. For ubiquinol, safety hasn't been well studied during breastfeeding, so check with your doctor.
What is ubiquinol used for in this product?
Ubiquinol is a reduced form of coenzyme Q10, which your cells use to generate energy and handle oxidative stress. It's included here to support heart health and mitochondrial (energy-producing cellular) function.
Only use purified shilajit — why does it matter?
Unpurified shilajit may contain heavy metals or other contaminants that pose serious health risks. Make sure any product you buy is tested and purified by the manufacturer.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Ubiquinol CoQ10 Enhanced Mitochondrial Support is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support label
Go deeper

The Full Monographs Behind Super Ubiquinol CoQ10 Enhanced Mitochondrial Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Shilajit

Interacts with 86 drugs

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and m...

Read the full Shilajit monograph →
Sources

Sources & How We Checked

Super Ubiquinol CoQ10 Enhanced Mitochondrial Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 48 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coenzyme Q10 40 references
  1. Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-51. PubMed
  2. Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;S265-72. PubMed
  3. Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;334:1372-3. PubMed
  4. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8. PubMed
  5. Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84. PubMed
  6. Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6. PubMed
  7. Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-3. PubMed
  8. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  9. Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-7.
  10. Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94. PubMed
  11. Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7. PubMed
  12. The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;57:397-404.
  13. Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42. PubMed
  14. Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003;246:75-82. DOI
  15. Porterfield LM. Why did the response to warfarin change? RN 2000;63:107.
  16. Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology 2005;64:713-5. PubMed
  17. Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87:1075-6. DOI
  18. Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004;27:295–9. PubMed
  19. Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. Arch Neurol 2007;64:938-44. DOI
  20. Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994;15 Suppl:s257-63. PubMed
  21. Yamagami T, Takagi M, Akagami H, et al. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. In: Folkers KA, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 5. Amsterdam: Elsevier Science Publications, 19
  22. Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension (review). Cochrane Database Syst Rev 2009;(4):CD007435. PubMed
  23. Rosenfeldt, F. L., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J. Y., and Watts, G. F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum.Hypertens. 2007;21(4):297-306. PubMed
  24. Stamelou, M., Reuss, A., Pilatus, U., Magerkurth, J., Niklowitz, P., Eggert, K. M., Krisp, A., Menke, T., Schade-Brittinger, C., Oertel, W. H., and Hoglinger, G. U. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, place DOI
  25. Keogh A, Fenton S, Leslie C, et al. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003;12:135-41.
  26. Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A., and Murphy, M. P. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C
  27. Lynch, D. R., Perlman, S. L., and Meier, T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67(8):941-947. PubMed
  28. Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., and George, P. M. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the me
  29. Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. Jpn.Heart J 1976;17(1):32-42. PubMed
  30. Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O'Connor, D., Sherwin, A., Karpati, G., Andermann, F., and Arnold, D. L. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993;43(5
  31. Malm, C., Svensson, M., Sjoberg, B., Ekblom, B., and Sjodin, B. Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiol Scand. 1996;157(4):511-512. PubMed
  32. Singh, R. B., Wander, G. S., Rastogi, A., Shukla, P. K., Mittal, A., Sharma, J. P., Mehrotra, S. K., Kapoor, R., and Chopra, R. K. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc. PubMed
  33. Digiesi V, Cantini F, and Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Current Therapeutic Research 1990;47(5):841-845.
  34. Parkinson Study Group QE3 Investigators, Beal MF, Oakes D, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014;71(5):543-52.
  35. Alehagen U, Johansson P, Bjornstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citi
  36. Ho MJ, Li EC, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2016 Mar 3;3:CD007435. doi: 10.1002/14651858.CD007435.pub3. PubMed
  37. Tabrizi R, Akbari M, Sharifi N, Lankarani KB, Moosazadeh M, Kolahdooz F, et al. The effects of coenzyme Q10 supplementation on blood pressures among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. PubMed
  38. Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV. Effectiveness of coenzyme Q10 supplementation for reducing fatigue: A systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 2022;13:883251. PubMed
  39. Yaghini O, Hoseini N, Ghazavi MR, et al. A comparative study on the efficacy of coenzyme Q10 and amitriptyline in the prophylactic treatment of migraine headaches in children: A randomized controlled trial. Adv Biomed Res 2022;11:43. PubMed
  40. Hansen KS, Mogensen TH, Agergaard J, et al. High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition: A randomized, phase 2, crossover trial. Lancet Reg Health Eur 2022. PubMed

See these in context on the Coenzyme Q10 monograph →

Shilajit 8 references
  1. Sadeghi SMH, Hosseini Khameneh SM, Khodadoost M, et al. Efficacy of momiai in tibia fracture repair: A randomized double-blinded placebo-controlled clinical trial. J Altern Complement Med 2020;26(6):521-528.
  2. Losa F, Deidda M, Firinu D, Martino MLD, Barca MP, Giacco SD. Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor: A case report. World J Clin Cases 2019;7(5):623-627. PubMed
  3. Biswas TK, Pandit S, Mondal S, et al. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia 2010;42(1):48-56. PubMed
  4. Stavropoulos K, Sotiriadis A, Patoulias D, et al. Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome. Gynecol Endocrinol 2018;34(12):1019-1021. PubMed
  5. Ghezelbash B, Shahrokhi N, Khaksari M, Ghaderi-Pakdel F, Asadikaram G. Hepatoprotective effects of shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats. Horm Mol Biol Clin Investig 2020;41(1):/j/hmbci. PubMed
  6. Ghezelbash B, Shahrokhi N, Khaksari M, Asadikaram G, Shahrokhi M, Shirazpour S. Protective roles of shilajit in modulating resistin, adiponectin, and cytokines in rats with non-alcoholic fatty liver disease. Chin J Integr Med 2022;28(6):531-537. PubMed
  7. Jafari M, Forootanfar H, Ameri A, et al. Antioxidant, cytotoxic and hyperalgesia-suppressing activity of a native Shilajit obtained from Bahr Aseman mountains. Pak J Pharm Sci 2019;32(5):2167-2173. DOI
  8. Trivedi NA, Mazumdar B, Bhatt JD, Hemavathi KG. Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats. Ind. J. Pharmacol. 2004; 36(6):373-376.

See these in context on the Shilajit monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team