Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Super Carnosine 500 mg Ingredients & Drug Interactions

by Life Extension

Super Carnosine 500 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Carnosine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Carnosine 500 mg is a dietary supplement by Life Extension with 4 active ingredients. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 89 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Carnosine, Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Carnosine 500 mg by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Carnosine 500 mg by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Carnosine 500 mg by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains four active ingredients. Thiamine (vitamin B1) is an essential nutrient your body uses for energy and nerve function.

Benfotiamine is a fat-soluble form of thiamine that may be absorbed more readily than standard thiamine. Carnosine is a naturally occurring compound made from two amino acids.

We could not check the fourth ingredient, luteolin, because we hold no data for it. The capsule itself is made from gelatin, microcrystalline cellulose (a plant-based binder), magnesium stearate, and silica — these are inactive ingredients that help hold the product together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Protects muscle cell membranes.
  • We looked for evidence on: Athletic performance, Muscle recovery, Muscle strength, Muscle function.
  • The closest evidence on file: Carnosine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).

Thiamine is effective for preventing and treating thiamine deficiency and Wernicke-Korsakoff syndrome, a serious brain condition. It's possibly effective for period pain (dysmenorrhea), though the evidence is mixed.

For other uses listed — heart failure and mosquito repellent — the evidence does not support it. Benfotiamine is possibly effective for diabetic nerve pain (peripheral neuropathy caused by diabetes).

For other conditions tested — diabetic kidney damage, alcohol-related disorders, Alzheimer disease, and general peripheral nerve pain — the evidence is either not strong enough to rate or suggests it doesn't help. For carnosine and luteolin, the evidence in our data is not established or insufficient to say whether they work for their proposed uses.

The evidence, ingredient by ingredient Thiamine Benfotiamine Carnosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine is generally very safe when taken by mouth in normal doses; allergic skin reactions and other hypersensitivity problems are very rare. Thiamine is needed during pregnancy and breastfeeding, but use only supplement doses advised by your doctor or pharmacist.

Benfotiamine was generally well tolerated in studies, though long-term safety isn't fully known — a small number of trial participants reported allergic skin reactions or mild stomach discomfort, but these rates matched placebo. Safety while breastfeeding hasn't been well studied.

Carnosine is generally well tolerated in short-term studies, but long-term safety data are limited; some people have reported decreased appetite, dry mouth, weight changes, foot or joint pain, and rarely pneumonia. The safety data advise against carnosine in pregnancy and breastfeeding due to insufficient information.

Side effects, ingredient by ingredient Thiamine Benfotiamine Carnosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Thiamine, Carnosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 89 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take diabetes drugs (antidiabetes medications) — carnosine may increase the risk of low blood sugar. If you're on trimethoprim (an antibiotic), let your pharmacist know before adding this product.

For luteolin, we hold no interaction data, so we cannot flag any medication concerns for that ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is most relevant if you're looking to support thiamine status or have diabetic nerve pain — though for the latter, benfotiamine's evidence is only modest. If you take diabetes medications or the antibiotic trimethoprim, or if you're pregnant or breastfeeding, talk with your pharmacist before starting.

The long-term safety of several ingredients here isn't well established, so it's worth a conversation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Carnosine 500 mg, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870128793
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2514
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Carnosine 500 mg by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
737870128793
IngredientAmount% DV
Thiamine50 mg3333%
Benfotiamine50 mg--
Carnosine500 mg--
Luteolin4 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one (1) capsule two to three times daily with or without food, or as recommended by a healthcare practitioner.

Precautions

WARNINGS: - KEEP OUT OF REACH OF CHILDREN.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

- DO NOT EXCEED RECOMMENDED DOSE.

- Do not purchase if outer seal is broken or damaged.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store tightly closed in a cool, dry place.

General

01287B Rev. 7/09

General Statements

500 mg

Protects Muscle Cell Membranes*

Read the entire label and follow the directions carefully prior to use.

Brand IP Statement(s)

For Longer Life(R)

Formulation

This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Carnosine 500 mg by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Carnosine 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Carnosine 500 mg by Life Extension

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Thiamine

Interacts with
3 drugs
50 mg per serving Form: Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Benfotiamine

No known
interactions
50 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Carnosine

Interacts with
86 drugs
500 mg per serving

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is so...

Carnosine monograph & interactions

Luteolin

4 mg per serving Form: Perilla leaf extract

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Carnosine 500 mg by Life Extension Drug Interactions

Want to check YOUR meds against Super Carnosine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
89Drugs
86 Moderate 3 Minor

Ingredients driving the most interactions

Carnosine 86
Thiamine 3

Individual Drug Interactions

The ingredients in Super Carnosine 500 mg interact with 89 drugs. Click any drug to see the details.

2 of the 4 ingredients in Super Carnosine 500 mg interact with drugs. Each result below shows which ingredient is responsible. Carnosine Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Carnosine 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D
Carnosine full monograph & interactions

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Carnosine 500 mg, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-888-280-2852
Web Address
http://www.lef.org
Pharmacist Counseling Corner

Super Carnosine 500 mg by Life Extension: Common Questions

Does Super Carnosine 500 mg by Life Extension interact with any medications?
Yes. Based on its ingredients, Super Carnosine 500 mg has a known interaction with 89 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Carnosine 500 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Thiamine is needed during pregnancy and breastfeeding and can be used at supplement doses under your doctor's guidance. Benfotiamine doesn't have enough safety data, so avoid it unless your doctor says otherwise. Carnosine — we don't have enough safety information — the data advise against use in pregnancy and while breastfeeding. Talk with your pharmacist or OB about whether this product is right for you.
Does this actually work for brain health or aging?
The evidence in our data for these uses is insufficient or not established. Thiamine is proven for deficiency and a specific brain disorder (Wernicke-Korsakoff syndrome), and possibly helpful for period pain. The other ingredients haven't shown reliable evidence for cognitive decline, Alzheimer disease, or general aging in the studies we have.
What are the most common side effects?
All three ingredients with safety data were generally well tolerated. With carnosine, some people reported decreased appetite, dry mouth, weight changes, or joint pain. Benfotiamine caused mild stomach discomfort in a few trial participants. Thiamine allergic reactions are very rare.
Why is thiamine in here if the product is called Super Carnosine?
Thiamine (vitamin B1) supports energy and nerve function, so it may complement carnosine's intended role. Benfotiamine, a special form of thiamine, is also included — it's absorbed differently than regular thiamine and is studied for diabetic nerve pain.
Is this safe if I take diabetes medication?
Carnosine in this product may increase the risk of low blood sugar (hypoglycemia) when combined with diabetes drugs. Don't start it without talking to your pharmacist or doctor first — they can assess your individual risk and monitor you if you do take it together.
What is luteolin, and does it interact with anything?
Luteolin is a plant-based compound in this product. We don't hold interaction data for it, so we can't tell you whether it affects any medications. Use the medication checker on this page to search your drugs, or ask your pharmacist to look it up.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Carnosine 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Carnosine 500 mg label
Go deeper

The Full Monographs Behind Super Carnosine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph → Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph →
Sources

Sources & How We Checked

Super Carnosine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Benfotiamine 1 reference
  1. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed

See these in context on the Benfotiamine monograph →

Carnosine 5 references
  1. Chengappa KN, Turkin SR, DeSanti S, et al. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res 2012;142(1-3):145-52. PubMed
  2. Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.
  3. Peng W, Mao P, Liu L, et al. Effect of carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a systematic review and meta-analysis of long-term randomized controlled trials. Complement Ther Med 2020;48:102241. PubMed
  4. Siriwattanasit N, Satirapoj B, Supasyndh O. Effect of oral carnosine supplementation on urinary TGF-ß in diabetic nephropathy: a randomized controlled trial. BMC Nephrol 2021;22(1):236. PubMed
  5. Sureshkumar K, Durairaj M, Srinivasan K, et al. Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis. Front Biosci (Landmark Ed) 2023;28(1):18. PubMed

See these in context on the Carnosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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