Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Super Carnosine 500 mg Ingredients & Drug Interactions

by Life Extension

Super Carnosine 500 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Carnosine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Carnosine 500 mg is a dietary supplement by Life Extension with 4 active ingredients. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 89 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Carnosine, Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Carnosine 500 mg by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Carnosine 500 mg by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Carnosine 500 mg by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 4 active ingredients. Thiamine (vitamin B1) is an essential nutrient your body uses for energy and nerve function.

L-carnosine is a compound made from two amino acids, and benfotiamine is a fat-soluble form of thiamine that may absorb differently than regular thiamine. The fourth ingredient is luteolin, a plant compound we couldn't verify for interactions.

The capsule also contains several inactive ingredients — cellulose, microcrystalline cellulose, ascorbyl palmitate, and silica — which are fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Carnosine supplement for general wellness.
  • We looked for evidence on: Age-related cognitive decline, Athletic performance, Cataracts, Cognitive function, Cognitive impairment, Thiamine deficiency — and 3 related terms.
  • The strongest evidence on file: Thiamine is rated "Effective" for Thiamine deficiency (Natural Medicines).
  • Also on file: Thiamine is rated "Insufficient Reliable Evidence To Rate" for Cataracts, Cognitive function.
  • Also on file: Carnosine is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Athletic performance, Cataracts, Cognitive impairment.

Thiamine is effective for treating thiamine deficiency and Wernicke-Korsakoff syndrome, a serious brain condition. It's possibly effective for period pain (dysmenorrhea) but appears ineffective as a mosquito repellent and possibly ineffective for heart failure.

For L-carnosine and benfotiamine, the evidence we hold is much less clear. L-carnosine shows insufficient evidence for age-related cognitive decline, Alzheimer disease, athletic performance, cataracts, and cognitive impairment — meaning studies haven't been thorough enough yet to know if it works.

Benfotiamine is possibly effective for diabetic nerve damage (neuropathy) but possibly ineffective for kidney damage from diabetes. The evidence for other uses is insufficient.

The evidence, ingredient by ingredient Thiamine Carnosine Benfotiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine is generally very safe by mouth in normal amounts, though rare allergic reactions like dermatitis have been reported. Thiamine is needed during pregnancy and breastfeeding, so use it only at the doses your doctor or pharmacist recommends.

L-carnosine is generally well tolerated in short studies, but long-term safety data are sparse. It hasn't been adequately studied in pregnancy or while breastfeeding — the safety data advise against use in both.

Side effects reported include decreased appetite, dry mouth, weight changes, foot and joint pain, and rarely pneumonia. Benfotiamine is generally well tolerated; in one clinical trial, a small number of participants reported allergic skin reactions or mild stomach discomfort, but these rates matched placebo.

Pregnancy and breastfeeding safety data for benfotiamine aren't well established; talk with your doctor before use.

Side effects, ingredient by ingredient Thiamine Carnosine Benfotiamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Thiamine, Carnosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 89 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check with your pharmacist if you're on diabetes medications — carnosine may increase the risk of low blood sugar. Also check if you take trimethoprim (Proloprim), an antibiotic that can raise thiamine blood levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Super Carnosine is worth considering if you're looking to supplement thiamine or explore benfotiamine for diabetic nerve damage, but it's not proven for most other uses listed. If you take diabetes medications or trimethoprim (an antibiotic), check with your pharmacist first — the carnosine and thiamine here could affect how those drugs work.

Talk to us before starting, especially if you're pregnant, breastfeeding, or on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Carnosine 500 mg, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870202066
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328716
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Carnosine 500 mg by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
737870202066
IngredientAmount% DV
Thiamine50 mg4167%
L-Carnosine500 mg--
Benfotiamine50 mg--
Luteolin4 mg--

Other ingredients: Cellulose, Microcrystalline Cellulose, Ascorbyl Palmitate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Precautions

Read the entire label and follow the directions carefully prior to use.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule two to three times daily, or as recommended by a healthcare practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Gluten free Non GMO LE Certified

Protects muscle cell membranes

Seals/Symbols

Non GMO LE Certified

FDA Statement of Identity

Dietary Supplement

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Carnosine 500 mg by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Carnosine 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Carnosine 500 mg by Life Extension

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Thiamine

Interacts with
3 drugs
50 mg per serving Form: Thiamine Hydrochloride, Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

L-Carnosine

Interacts with
86 drugs
500 mg per serving

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is so...

L-Carnosine monograph & interactions

Benfotiamine

No known
interactions
50 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Luteolin

4 mg per serving Form: Japanese Sophora

Other (inactive) ingredients: Cellulose, Microcrystalline Cellulose, Ascorbyl Palmitate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Carnosine 500 mg by Life Extension Drug Interactions

Want to check YOUR meds against Super Carnosine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
89Drugs
86 Moderate 3 Minor

Ingredients driving the most interactions

L-Carnosine 86
Thiamine 3

Individual Drug Interactions

The ingredients in Super Carnosine 500 mg interact with 89 drugs. Click any drug to see the details.

2 of the 4 ingredients in Super Carnosine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Carnosine Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Carnosine 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D
L-Carnosine full monograph & interactions

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Carnosine 500 mg, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Super Carnosine 500 mg by Life Extension: Common Questions

Does Super Carnosine 500 mg by Life Extension interact with any medications?
Yes. Based on its ingredients, Super Carnosine 500 mg has a known interaction with 89 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Carnosine 500 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Thiamine is needed in pregnancy and while breastfeeding — the data rate it as likely safe — but only use it at doses your doctor advises. L-carnosine hasn't been adequately studied in pregnancy or breastfeeding; the safety data say to avoid it unless your doctor recommends otherwise. Benfotiamine safety data in pregnancy and breastfeeding aren't well established either. Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.
Will this help with my memory or brain fog?
The evidence for these uses is limited. L-carnosine and benfotiamine show insufficient evidence for age-related cognitive decline and Alzheimer disease — meaning we don't have enough good studies yet to say whether they work. Thiamine is effective for thiamine deficiency, which can affect brain function, but not proven for general brain health.
What side effects might I get?
Thiamine is very safe, though rare allergic reactions have been reported. L-carnosine may cause decreased appetite, dry mouth, mild weight changes, or foot and joint pain. Benfotiamine is generally well tolerated; in trials, a few people reported mild allergic skin reactions or stomach discomfort, but at the same rate as placebo. Long-term safety data for both L-carnosine and benfotiamine are limited.
Is this effective for diabetic nerve damage?
Benfotiamine, one of the ingredients, is possibly effective for diabetic neuropathy (nerve damage from diabetes). However, if you take diabetes medications, you should check with your pharmacist first — the L-carnosine in this product may lower blood sugar, raising your risk of going too low.
What exactly is each ingredient for?
Thiamine (vitamin B1) is essential for energy and nerve function. L-carnosine is a compound from amino acids — the evidence for most uses is unclear. Benfotiamine is a form of thiamine that absorbs differently, and it's being studied for diabetic nerve damage. We couldn't verify the fourth ingredient, luteolin, so we can't tell you what data support it.
Does this product have any fillers?
Yes. Besides the four active ingredients, the capsule contains cellulose, microcrystalline cellulose, ascorbyl palmitate, and silica as inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Carnosine 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Carnosine 500 mg label
Go deeper

The Full Monographs Behind Super Carnosine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph → Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph →
Sources

Sources & How We Checked

Super Carnosine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Carnosine 5 references
  1. Chengappa KN, Turkin SR, DeSanti S, et al. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res 2012;142(1-3):145-52. PubMed
  2. Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.
  3. Peng W, Mao P, Liu L, et al. Effect of carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a systematic review and meta-analysis of long-term randomized controlled trials. Complement Ther Med 2020;48:102241. PubMed
  4. Siriwattanasit N, Satirapoj B, Supasyndh O. Effect of oral carnosine supplementation on urinary TGF-ß in diabetic nephropathy: a randomized controlled trial. BMC Nephrol 2021;22(1):236. PubMed
  5. Sureshkumar K, Durairaj M, Srinivasan K, et al. Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis. Front Biosci (Landmark Ed) 2023;28(1):18. PubMed

See these in context on the Carnosine monograph →

Benfotiamine 1 reference
  1. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed

See these in context on the Benfotiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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