Major interaction on record — check this product against your medications before combining. Based on 4 of 9 ingredients. Check your meds →
Dietary supplement

Super Pill No.4 Ingredients & Drug Interactions

by Ron Teeguarden's Dragon Herbs

Super Pill No.4 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Pill No.4 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Super Pill No.4 is a dietary supplement by Ron Teeguarden's Dragon Herbs with 9 active ingredients. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 1,149 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lycium barbarum Polysaccharide, Gynostemma pentaphyllum Extract, Powder, Pure, Astragalus membranaceus Extract, Powder, Pure. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Pill No.4 by Ron Teeguarden's Dragon Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Pill No.4 by Ron Teeguarden's Dragon Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Super Pill No.4 by Ron Teeguarden's Dragon Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Super Pill No.4 contains 9 active ingredients drawn from traditional Chinese medicine. The key ones we have data on are nicotinamide riboside (a form of vitamin B3 that supports cellular energy), two goji berry forms (lycium barbarum polysaccharide and extract), jiaogulan extract (also called Gynostemma pentaphyllum), and astragalus extract.

The product also contains astragaloside IV, tanshinone IIA, and salvia miltiorrhiza extract. Beyond the actives, the capsules include inactive ingredients like pullulan, rice powder, bamboo extract, and rice extract blend.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Advanced nutraceutical healthy aging formulation.
  • We looked for evidence on: Aging, Stress, Athletic performance, Physical performance, Quality of life, Cellular energy — and 2 related terms.
  • The closest evidence on file: Jiaogulan is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Jiaogulan is rated "Insufficient Reliable Evidence To Rate" for Stress, Aging.
  • Also on file: Goji is rated "Insufficient Reliable Evidence To Rate" for Quality of life.

The evidence for most uses in this product isn't yet established in our data. Jiaogulan is rated possibly effective for type 2 diabetes—clinical research shows it can lower blood sugar.

For everything else listed—nicotinamide riboside for age-related macular degeneration, Alzheimer's disease, athletic performance, heart failure, and nonalcoholic fatty liver disease; goji for cardiovascular disease, high blood pressure, sunburn, obesity, and quality of life; astragalus for allergic rhinitis, asthma, heart disease, and other conditions—the evidence is insufficient to rate. That doesn't mean they don't work; it means we don't yet have strong clinical data to confirm it.

The evidence, ingredient by ingredient Nicotinamide Riboside Goji Jiaogulan Astragalus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears well tolerated short-term, though long-term safety isn't fully known. Most common side effects are bloating, muscle pain, nausea, itching, sweating, and loose stools.

Jiaogulan is generally well tolerated for up to four months; mild diarrhea, nausea, dry mouth, dizziness, and insomnia have been reported. Goji berries are safe as food but concentrated supplements have less safety data; rare cases of allergic reactions ranging from mouth itching to anaphylaxis have been reported, as well as isolated cases of liver inflammation.

Astragalus is generally well tolerated in the short term but quality human data is limited. For pregnancy: nicotinamide riboside and astragalus lack enough safety data to use—talk with your doctor or pharmacist.

Jiaogulan and goji should be avoided in pregnancy due to insufficient data and traditional reports of uterine effects. For breastfeeding: there isn't enough data for jiaogulan, goji, or astragalus—discuss with your doctor or pharmacist before use.

Side effects, ingredient by ingredient Nicotinamide Riboside Goji Jiaogulan Astragalus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Jiaogulan, Astragalus, Goji, Nicotinamide Riboside.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,150 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take warfarin or other blood thinners (anticoagulants or antiplatelet drugs), antidiabetes medications, antihypertensive (blood pressure) drugs, immunosuppressant drugs, lithium, cyclophosphamide, or drugs metabolized by liver enzymes CYP2D6, CYP2C19, CYP2C9, or CYP3A4. Also check if you take flecainide.

Use the medication checker on this page with your specific drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient traditional formula with several significant medication interactions, especially with blood thinners, diabetes drugs, and immune-suppressing medications. If you take any prescription medications—particularly warfarin, heart drugs, blood pressure drugs, or diabetes or immunosuppressant medications—check your exact list with the interaction tool on this page before starting.

Talk with your pharmacist or doctor about whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Pill No.4, straight from the product label.

Brand Ron Teeguarden's Dragon Herbs
Barcode (UPC) 679372001085
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 21, 2023
DSLD ID 279252
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Pill No.4 by Ron Teeguarden's Dragon Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
20
UPC/BARCODE
679372001085
IngredientAmount% DV
Astragaloside IV112.5 mg--
Nicotinamide Riboside300 mg--
Tanshinone IIA112.5 mg--
Gypenoside180 mg--
Lycium barbarum Polysaccharide90 mg--
Salvia miltiorrhiza Extract, Powder, Pure112.5 mg--
Gynostemma pentaphyllum Extract, Powder, Pure45 mg--
Lycium barbarum Extract, Powder, Pure135 mg--
Astragalus membranaceus Extract, Powder, Pure112.5 mg--

Other ingredients: Pullulan, Natural, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Cutting edge nutraceutical Jing & Qi formulation Super Pill No.4 is a nutraceutical Jing-Qi adaptogenic formulation, composed of 5 superior quality, cutting edge nutraceutical ingredients - Nicotinamide Riboside (NR) to support NAD+ production and sirtuin functionality, Tanshinone IIA to support cardiovascular health, Astragaloside IV to support the immune system, Gypenosides to help modulate nuclear factor kappa B (NF-kB), and Lycium barbarum polysaccharides (LBP) to support healthy aging.

Pullulan caps - 100% natural, water-soluble polysaccharide from tapioca produced through a fermentation process; non-GMO; no starch, preservatives or chemical modifications; gluten free.

Precautions

Consult your physician before using this product if you are on medication for any health condition.

Keep out of the reach of children.

Formulation

Advanced nutraceutical healthy aging formulation

Pullulan caps - 100% natural, water-soluble polysaccharide from tapioca produced through a fermentation process; non-GMO; no starch, preservatives or chemical modifications; gluten free.

FDA Statement of Identity

Dietary Supplement

General Statements

Super Pill No.4 400 mg each

Designed by Ron Teeguarden

Suggested/Recommended/Usage/Directions

Directions: Take 1-3 capsules once per day or as directed by a health care professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Pill No.4 by Ron Teeguarden's Dragon Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Pill No.4 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Pill No.4 by Ron Teeguarden's Dragon Herbs

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Astragaloside IV

112.5 mg per serving

Nicotinamide Riboside

Interacts with
172 drugs
300 mg per serving

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Nicotinamide Riboside monograph & interactions

Tanshinone IIA

112.5 mg per serving

Gypenoside

180 mg per serving

Lycium barbarum Polysaccharide

Interacts with
1,000 drugs
90 mg per serving

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they...

Lycium barbarum Polysaccharide monograph & interactions

Salvia miltiorrhiza Extract, Powder, Pure

112.5 mg per serving

Gynostemma pentaphyllum Extract, Powder, Pure

Interacts with
327 drugs
45 mg per serving

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and...

Gynostemma pentaphyllum Extract, Powder, Pure monograph & interactions

Lycium barbarum Extract, Powder, Pure

Interacts with
1,000 drugs
135 mg per serving

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they...

Lycium barbarum Extract, Powder, Pure monograph & interactions

Astragalus membranaceus Extract, Powder, Pure

Interacts with
208 drugs
112.5 mg per serving

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While...

Astragalus membranaceus Extract, Powder, Pure monograph & interactions

Other (inactive) ingredients: Pullulan, Natural, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Pill No.4 by Ron Teeguarden's Dragon Herbs Drug Interactions

Want to check YOUR meds against Super Pill No.4?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,149Drugs
2 Major 1,147 Moderate

Ingredients driving the most interactions

Lycium barbarum Polysaccharide 1,000
Gynostemma pentaphyllum Extract, Powder, Pure 327
Astragalus membranaceus Extract, Powder, Pure 208
Nicotinamide Riboside 172

Individual Drug Interactions

The ingredients in Super Pill No.4 interact with 1,149 drugs. Click any drug to see the details.

4 of the 9 ingredients in Super Pill No.4 interact with drugs. Each result below shows which ingredient is responsible. Lycium barbarum Polysaccharide Gynostemma pentaphyllum Extract, Powder, Pure Astragalus membranaceus Extract, Powder, Pure Nicotinamide Riboside

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Pill No.4 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lycium barbarum Polysaccharide8 drug types · 1,000 drugs

Warfarin (Coumadin)

Goji can increase the effects of warfarin and possibly increase the risk of bleeding.
There are at least 5 case reports of increased international normalized ratio (INR) in patients stabilized on warfarin who began drinking goji juice, concentrated goji tea, or goji wine. Goji may inhibit the metabolism of warfarin by cytochrome P450 2C9 (CYP2C9).

Likelihood Probable Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Animal and in vitro research suggest that goji root bark has hypotensive effects. However, goji fruit juice does not appear to reduce systolic or diastolic blood pressure in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C19 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2C19 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C9 enzymes. Additionally, multiple case reports suggest that goji berry concentrated tea and juice inhibit the metabolism of warfarin, a CYP2C9 substrate. Concomitant use with goji may decrease metabolism and increase levels of CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
In vitro research shows that goji berry juice inhibits CYP2D6 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2D6 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Flecainide (Tambocor)

Theoretically, goji berry might increase the levels and clinical effects of flecainide.
In one case report, a 75-year-old patient stable on flecainide and warfarin presented to the emergency room with fainting and pleomorphic arrhythmia caused by flecainide toxicity. Flecainide toxicity was attributed to drinking 1-2 glasses of concentrated goji tea daily for 2 weeks. Theoretically, goji may have inhibited the cytochrome P450 2D6 (CYP2D6) metabolism of flecainide.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Animal and in vitro research show that goji root bark and fruit polysaccharides might have hypoglycemic effects. However, clinical research has only shown that taking goji fruit polysaccharides with or without antidiabetes drugs modestly reduces postprandial glucose when compared with control, with no reports of hypoglycemia.

Likelihood Possible Evidence B
Lycium barbarum Polysaccharide full monograph & interactions

Gynostemma pentaphyllum Extract, Powder, Pure3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that jiaogulan has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.
Clinical and animal studies suggest that jiaogulan can stimulate the immune system.

Likelihood Possible Evidence D
Gynostemma pentaphyllum Extract, Powder, Pure full monograph & interactions

Astragalus membranaceus Extract, Powder, Pure4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus membranaceus Extract, Powder, Pure full monograph & interactions

Nicotinamide Riboside1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Nicotinamide Riboside full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Pill No.4, from the product label.

Ron Teeguarden's Dragon Herbs

See all Ron Teeguarden's Dragon Herbs products
Name
Ron Teeguarden's Dragon Herbs
Street Address
P.O. Box 361459
City
Los Angeles
State
CA
ZipCode
90036
Phone Number
(888) 558-6642
Web Address
www.dragonherbs.com
Pharmacist Counseling Corner

Super Pill No.4 by Ron Teeguarden's Dragon Herbs: Common Questions

Does Super Pill No.4 by Ron Teeguarden's Dragon Herbs interact with any medications?
Yes. Based on its ingredients, Super Pill No.4 has a known interaction with 1,149 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Pill No.4 contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Super Pill No.4 if I'm pregnant?
Not without talking to your doctor first. Nicotinamide riboside, astragalus, jiaogulan, and goji don't have enough safety data in pregnancy—and jiaogulan and goji have traditional reports of effects on the uterus. Your doctor or pharmacist can advise you on whether the benefit outweighs the unknowns for your situation.
Can I take this while breastfeeding?
There isn't enough safety information for jiaogulan, goji, or astragalus while nursing. Nicotinamide riboside also lacks long-term safety data. Talk with your doctor or pharmacist before using this product if you're breastfeeding.
What side effects might I experience?
The most common are bloating, nausea, muscle pain or soreness, sweating, diarrhea, and changes in bowel habits from nicotinamide riboside. Jiaogulan may cause diarrhea, nausea, dry mouth, dizziness, or insomnia. Rare allergic reactions to goji—ranging from itching in the mouth to swelling and anaphylaxis—have been reported. If you notice any unusual symptoms, stop and talk to your pharmacist.
Is there good evidence this product works?
Jiaogulan is possibly effective for type 2 diabetes based on clinical research. For the other ingredients and uses claimed—nicotinamide riboside for brain health, heart function, or eye health; goji for heart health or blood pressure; astragalus for immune support—the evidence we hold is insufficient to rate. That doesn't prove they don't work, just that the clinical data isn't yet strong enough.
What is nicotinamide riboside?
It's a form of vitamin B3 that supports how cells produce energy. It's generally well tolerated, though long-term safety in supplements isn't fully understood yet.
What's the main concern with goji in this product?
If you take warfarin or other blood thinners, goji can increase their effects and your bleeding risk—there are documented case reports of this. Goji can also theoretically slow the metabolism of many other drugs. If you're on any medications, check them with your pharmacist before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Pill No.4 label
Go deeper

The Full Monographs Behind Super Pill No.4’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph → Herb & supplement monograph

Goji

Interacts with 1,000 drugs

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they are popular for eye health, immune supp...

Read the full Goji monograph → Herb & supplement monograph

Jiaogulan

Interacts with 327 drugs

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some u...

Read the full Jiaogulan monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph →
Sources

Sources & How We Checked

Super Pill No.4's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Goji 14 references
  1. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC 1999.
  2. Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium Barbarum. Ann Pharmacother 2001;35:1199-201.
  3. Leung H, Hung A, Hui AC, Chan TY. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol 2008;46:1860-2. PubMed
  4. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med 2008;14:403-12.
  5. Rivera, C. A., Ferro, C. L., Bursua, A. J., and Gerber, B. S. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy 2012;32(3):e50-e53.
  6. Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
  7. Franco, M., Monmany, J., Domingo, P., and Turbau, M. [Autoimmune hepatitis triggered by consumption of Goji berries]. Med.Clin.(Barc.) 9-22-2012;139(7):320-321.
  8. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
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Jiaogulan 8 references
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Astragalus 13 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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