Major interaction on record — check this product against your medications before combining. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Surge 2.0 Pineapple Ingredients & Drug Interactions

by Advanced Nutrition Systems

Surge 2.0 Pineapple label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Surge 2.0 Pineapple against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Surge 2.0 Pineapple is a dietary supplement by Advanced Nutrition Systems with 5 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,429 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Surge 2.0 Pineapple by Advanced Nutrition Systems

Ask about any prescription or over-the-counter medication and we check it for interactions with Surge 2.0 Pineapple by Advanced Nutrition Systems — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Surge 2.0 Pineapple by Advanced Nutrition Systems

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 31 active ingredients.
  • “ATP Volumizing Blend” is a proprietary blend — the label gives one combined amount (3,010 mg) without saying how much of each component you get.
  • “Amino Recovery Blend” is a proprietary blend — the label gives one combined amount (10,701 mg) without saying how much of each component you get.
  • “Surge 2.0 Blend” is a proprietary blend — the label gives one combined amount (20,645 mg) without saying how much of each component you get.

Surge 2.0 Pineapple contains 31 ingredients. The active players are amino acids — L-Glutamine, L-Arginine, L-Citrulline DL Malate, L-Histidine, and branched-chain amino acids (L-Leucine, L-Isoleucine, L-Valine) — along with creatine in three forms (Creatine HCl, Creatine Monohydrate, Creatine MagnaPower) to support muscle work and recovery.

You'll also find caffeine (as Caffeine Anhydrous and Di-Caffeine Malate) for mental focus and exercise performance, plus taurine, agmatine, beta-alanine (CarnoSyn), N-Acetyl L-Tyrosine, huperzine A, and amla extract (Indian gooseberry). The rest — Maltodextrin, Waxy Maize, Sodium, Kola Nut powder, Synephrine HCl, L-Norvaline, Rutaecarpine — round out the formula.

Inactive ingredients include citric acid, natural flavors, calcium silicate, sucralose, silicon dioxide, acesulfame potassium, and yellow color.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Athletic performance and muscle strength.
  • We looked for evidence on: Athletic performance, Cognitive function, Muscle recovery, Exercise endurance, High-intensity performance.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance.
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance.

The evidence for these ingredients is mixed. Creatine (all three forms) is rated Possibly Effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss), though Possibly Ineffective for Huntington disease and bone density.

Caffeine is Likely Effective for mental alertness and athletic performance, and Effective for neonatal apnea. L-Arginine carries no effectiveness ratings in our data.

L-Citrulline is Possibly Effective for athletic performance. Beta-alanine (CarnoSyn) is Possibly Effective for athletic performance and physical performance.

Taurine is Possibly Effective for hepatitis and congestive heart failure, but Possibly Ineffective for obesity. Huperzine A is Possibly Effective for Alzheimer disease.

Amla extract is Possibly Effective for GERD and high cholesterol. Agmatine, L-Glutamine, and L-Histidine all show Insufficient Reliable Evidence — meaning the data we hold doesn't establish clear effectiveness for their claimed uses.

The evidence, ingredient by ingredient Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 15 of the 16 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 16 of 16.
  • General safety write-ups exist for 16 of 16.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses, but there are cautions. L-Glutamine may cause belching, bloating, constipation, diarrhea, nausea, and vomiting — especially at high doses.

People with kidney or liver disease should avoid it without doctor supervision, and pregnant and nursing mothers should skip supplemental doses unless advised by a clinician. Sodium in excess raises blood pressure and strains your heart; normal dietary amounts are fine, but avoid taking sodium supplements or very high amounts.

Creatine (all three forms) is well tolerated in healthy adults but demands caution if you have kidney problems; avoid it in pregnancy and while nursing because safety hasn't been established. Beta-alanine (CarnoSyn) commonly causes harmless tingling and flushing of the skin, especially on the scalp — this is normal and temporary.

L-Arginine may lower blood pressure and cause abdominal pain, bloating, nausea, or diarrhea; safety data for pregnancy and nursing are absent. Caffeine can trigger anxiety, insomnia, jitteriness, headache, and stomach upset; high doses are linked to pregnancy risks, so ask your doctor about safe limits; small amounts pass into breast milk and are usually acceptable but can affect your baby.

Taurine is well tolerated short-term in healthy adults, though long-term safety is less certain; avoid supplemental doses in pregnancy and while nursing unless your doctor advises otherwise. Huperzine A is a pharmacologically active compound that can cause dose-dependent cholinergic side effects like blurred vision, constipation, diarrhea, dizziness, dry mouth, nausea, and vomiting; avoid it in pregnancy and nursing.

Agmatine's long-term safety in humans is not well studied; avoid supplements during pregnancy and while breastfeeding. Amla extract (Indian gooseberry) is generally well tolerated as food but less studied as a supplement; avoid supplemental doses in pregnancy and while nursing.

Side effects, ingredient by ingredient Sodium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 13 of the 16 matched ingredients can interact with medications — Huperzine A, Indian Gooseberry, L-arginine, Glutamine, Cola Nut, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,430 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take ephedrine (Major-severity risk with caffeine — serious cardiovascular danger). Also double-check blood pressure medications, ACE inhibitors, ARBs, blood thinners (anticoagulants or antiplatelets including aspirin and clopidogrel), seizure medications, lithium, diabetes medications, barbiturates, clozapine, quinolone antibiotics, dipyridamole, anticholinergic drugs, or cholinergic drugs — all carry Moderate-severity interactions with one or more ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Surge 2.0 Pineapple is an amino acid and creatine blend aimed at workout performance and muscle recovery. If you take any prescription medications — especially for blood pressure, seizures, diabetes, blood thinning, lithium, or psychiatric conditions — talk to your pharmacist or doctor before adding this product; the caffeine and several amino acids carry documented risks.

Pregnant or nursing mothers should skip it unless cleared by their clinician.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 22 of 31 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Surge 2.0 Pineapple, straight from the product label.

Brand Advanced Nutrition Systems
Barcode (UPC) 814995020086
Net contents 23.1 oz.; 656 Gram(s)
Market status On market
Date entered into DSLD Aug 31, 2018
DSLD ID 180559
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Surge 2.0 Pineapple by Advanced Nutrition Systems, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
21.88 Gram(s)
Maximum serving Sizes:
21.88 Gram(s)
Servings per container
30
UPC/BARCODE
814995020086
IngredientAmount% DV
Calories40 Calorie(s)--
Total Carbohydrates10 Gram(s)3%
L-Glutamine0 NP--
Sodium5 mg1%
Creatine HCl0 NP--
Maltodextrin0 NP--
L-Leucine0 NP--
Waxy Maize0 NP--
L-Arginine0 NP--
L-Isoleucine0 NP--
Creatine Monohydrate0 NP--
Taurine0 NP--
L-Valine0 NP--
L-Histidine0 NP--
N-Acetyl L-Tyrosine0 NP--
Caffeine Anhydrous295 mg--
CarnoSyn0 NP--
L-Norvaline0 NP--
Synephrine HCl0 NP--
Agmatine Sulfate0 NP--
Di-Caffeine Malate0 NP--
L-Citrulline DL Malate0 NP--
Kola Nut powder0 NP--
Rutaecarpine0 NP--
Creatine MagnaPower0 NP--
Huperzine A0 NP--
Amla extract0 NP--
Kre-Alkalyn0 NP--
L-Arginine AKG0 NP--
Phosphatidyl Serine powder0 NP--
ATP Volumizing Blend3010 mg--
Amino Recovery Blend10701 mg--
Surge 2.0 Blend20645 mg--
L-Ornithine AKG0 NP--
Nitrovascular Blend5030 mg--
L-Arginine DL Malate0 NP--
Extreme Energy/Focus Blend1904 mg--
Mucuna pruriens extract0 NP--

Other ingredients: Citric Acid, Natural Flavors, Calcium Silicate, Sucralose, Silicon Dioxide, Acesulfame Potassium, Yellow Color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Contains: Soy

Contains caffeine.

Precautions

Contains: Soy

This product should not be taken in combination with other products containing caffeine or other stimulants. Do not take within six hours of bedtime. Please read the entire label before use.

Warning: Do not use if pregnant, nursing, or plan on becoming pregnant.

This product is intended for use by healthy adults over the age of 18 and should be avoided by those sensitive to caffeine or other ingredients that have known stimulant effects. Contains caffeine.

Do not use this product continuously for more than 8 weeks. Do not combine with alcohol. Not intended for use by those with a medical condition. Use only as directed. Do not exceed recommended daily intake.

Do not consume synephrine or caffeine from other sources, including, but not limited to, coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine. Consult a physician or licensed qualified health care professional prior to use if you are pregnant or nursing, or if you are taking medication, including, but not limited to, MAOI, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, pseudoephedrine, or other stimulants, or if you have a medical condition, including, but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma.

Discontinue 2 weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headache or shortness of breath.

Do not use if safety seal under cap is broken.

Keep out of reach of children.

Brand IP Statement(s)

CarnoSyn is a registered trademark of Natural Alternatives International, Inc. Kre-Alkalyn is a registered trademark of All American Pharmaceutical and Natural Foods Corp. Creatine MagnaPower is a registered trademark of Albion Laboratories.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults mix each serving (1 scoop) with 8 oz of water 20-30 minutes prior to workout. Do not take more than 1 scoop daily. This product should not be taken in combination with other products containing caffeine or other stimulants. Do not take within six hours of bedtime. Please read the entire label before use.

Powerful Comprehensive Pre-Workout

Premium Pre Workout

Storage

Store in a cool, dry place.

General Statements

Please recycle.

Made in the USA Proudly made in the USA with carefully selected ingredients of international and domestic origin.

Surge 2.0 was designed to deliver a multi-faceted spectrum of benefits. These benefits include: muscle-filling pumps, enhanced explosive strength and endurance, fat-melting metabolic increase, and physique-improving muscle recovery.

30 Servings

Strength Muscle Pumps Energy

Naturally flavored

General

Item ANS-109 1.1

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Surge 2.0 Pineapple by Advanced Nutrition Systems label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Surge 2.0 Pineapple label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Surge 2.0 Pineapple by Advanced Nutrition Systems

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size21.88 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
5 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Surge 2.0 Blend

20645 mg per serving
  • › ATP Volumizing Blend
  • › Amino Recovery Blend
  • › Nitrovascular Blend
  • › Extreme Energy/Focus Blend

Other (inactive) ingredients: Citric Acid, Natural Flavors, Calcium Silicate, Sucralose, Silicon Dioxide, Acesulfame Potassium, Yellow Color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Surge 2.0 Pineapple by Advanced Nutrition Systems Drug Interactions

Want to check YOUR meds against Surge 2.0 Pineapple?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,429Drugs
26 Major 1,359 Moderate 44 Minor

Ingredients driving the most interactions

Sodium 205

Individual Drug Interactions

The ingredients in Surge 2.0 Pineapple interact with 1,429 drugs. Click any drug to see the details.

1 of the 5 ingredients in Surge 2.0 Pineapple interact with drugs. Each result below shows which ingredient is responsible. Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Surge 2.0 Pineapple with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Surge 2.0 Pineapple, from the product label.

Advanced Nutrition Systems

See all Advanced Nutrition Systems products
Name
Advanced Nutrition LLC
Street Address
221 S. Cherokee St.
City
Denver
State
CO
ZipCode
80223
Web Address
www.advanced247.com
Pharmacist Counseling Corner

Surge 2.0 Pineapple by Advanced Nutrition Systems: Common Questions

Does Surge 2.0 Pineapple by Advanced Nutrition Systems interact with any medications?
Yes. Based on its ingredients, Surge 2.0 Pineapple has a known interaction with 1,429 medications, including 26 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Surge 2.0 Pineapple contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have caffeine, and how much?
Yes — it contains caffeine in two forms: Caffeine Anhydrous and Di-Caffeine Malate. The product facts don't specify the exact total dose, so check the label or ask your pharmacist how much caffeine you're getting per serving.
Is it safe to take while I'm pregnant?
The data we hold shows mixed safety. L-Glutamine and Taurine are Likely Safe; L-Histidine is Likely Safe. But Creatine (all three forms) and Beta-alanine (CarnoSyn) have no established safety in pregnancy and are best avoided. L-Arginine, L-Citrulline, Huperzine A, and Agmatine also lack pregnancy safety data. Caffeine carries pregnancy risks at high doses — ask your doctor about safe limits. Talk to your OB or pharmacist for personalized advice.
Can I take this if I'm breastfeeding?
The safety data is limited. L-Glutamine and Taurine are Likely Safe while nursing. Creatine, Beta-alanine, L-Arginine, L-Citrulline, Huperzine A, and Agmatine all lack enough safety data — best to avoid them unless your clinician advises otherwise. Caffeine passes into breast milk in small amounts and moderate intake is usually considered acceptable, but it can affect your baby's sleep and behavior. Talk with your doctor or pharmacist.
Will this cause the tingling I've heard about with pre-workout drinks?
Yes — Beta-alanine (CarnoSyn) commonly causes a harmless tingling and flushing sensation, usually starting on the scalp within 20 minutes and lasting about an hour. This is dose-dependent; higher doses cause more intense tingling. It's not dangerous, just a normal side effect some people find annoying.
What's the creatine in this product for?
Creatine helps your muscles produce energy during intense exercise and is possibly effective for building muscle strength and athletic performance, plus sarcopenia (age-related muscle loss). The product contains three creatine forms (Creatine HCl, Monohydrate, and MagnaPower). It's generally well tolerated in healthy adults but demands caution if you have kidney problems.
Is L-Arginine in here safe for someone with high blood pressure?
L-Arginine can lower blood pressure by increasing nitric oxide and widening blood vessels. If you take blood pressure medication, L-Arginine might make it work too well and drop your pressure too far — especially combined with ACE inhibitors or ARBs. You should talk to your pharmacist or doctor before using this product if you're on blood pressure drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Surge 2.0 Pineapple is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Surge 2.0 Pineapple label
Go deeper

The Full Monographs Behind Surge 2.0 Pineapple’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Surge 2.0 Pineapple's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 729 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
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Creatine 86 references
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L-arginine 66 references
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Agmatine 3 references
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Indian Gooseberry 6 references
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Cowhage 12 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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