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Dietary supplement

Synergistic Eye Health Ingredients & Drug Interactions

by Swanson

Synergistic Eye Health label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Synergistic Eye Health against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Synergistic Eye Health is a dietary supplement by Swanson with 2 active ingredients. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are OmniXan Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Synergistic Eye Health by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Synergistic Eye Health by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Synergistic Eye Health by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: OmniXan Zeaxanthin and Lutein. Both are carotenoids — plant pigments that concentrate in the eye and are linked to eye health.

The formula also includes inactive ingredients (sunflower oil, gelatin, glycerin, purified water, and safflower oil) that help deliver these actives in softgel form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: eye health support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Zeaxanthin is possibly effective for age-related macular degeneration (AMD), a progressive eye condition that blurs central vision with age. Lutein is also possibly effective for AMD, and it's possibly effective for cataracts as well.

The evidence for both ingredients in age-related cognitive decline, Alzheimer disease, asthma, and several other conditions is insufficient — meaning the data we hold doesn't establish whether they work for those uses.

The evidence, ingredient by ingredient Zeaxanthin Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both zeaxanthin and lutein are generally well tolerated at typical supplement doses. Lutein studies have used doses up to 20 mg daily without reported adverse effects.

For pregnancy and breastfeeding, the safety data advises caution: while dietary amounts from food are fine, supplement safety in pregnancy and while breastfeeding isn't well studied. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing before starting this product.

Side effects, ingredient by ingredient Zeaxanthin Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs, double-check before using this product — zeaxanthin may theoretically increase the risk of low blood sugar. For any other prescription medications you're on, use the medication checker on this page to see if there are documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're concerned about AMD or cataracts and want to add a carotenoid supplement, this product may be worth considering — both ingredients have some evidence behind them. If you take antidiabetes medication, or any other prescription drugs, check your medications with our tool first.

Pregnant or breastfeeding? Ask your pharmacist or doctor before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Synergistic Eye Health, straight from the product label.

Brand Swanson
Barcode (UPC) 087614029863
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 204315
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Synergistic Eye Health by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
087614029863
IngredientAmount% DV
OmniXan Zeaxanthin2 mg--
Lutein20 mg--

Other ingredients: Sunflower Oil, Gelatin, Glycerin, purified Water, Safflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Made in Canada

Eye and vision health

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one softgel per day with food and water.

Brand IP Statement(s)

OnmiXan is a registered trademark of OmniActive Health Technologies, Ltd.

Precautions

Warning: For adults only.

Consult physician if you are pregnant or nursing, taking medication, or if you have a medical condition.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store in a cool, dry place. Do not refrigerate.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Lutein & Zeaxanthin

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Synergistic Eye Health by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Synergistic Eye Health label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Synergistic Eye Health by Swanson

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

OmniXan Zeaxanthin

Interacts with
86 drugs
2 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

OmniXan Zeaxanthin monograph & interactions

Lutein

No known
interactions
20 mg per serving Form: Marigold flower extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Gelatin, Glycerin, Purified Water, Safflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Synergistic Eye Health by Swanson Drug Interactions

Want to check YOUR meds against Synergistic Eye Health?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

OmniXan Zeaxanthin 86

Individual Drug Interactions

The ingredients in Synergistic Eye Health interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Synergistic Eye Health interact with drugs. Each result below shows which ingredient is responsible. OmniXan Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Synergistic Eye Health with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

OmniXan Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
OmniXan Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Synergistic Eye Health, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swanson.com
Pharmacist Counseling Corner

Synergistic Eye Health by Swanson: Common Questions

Does Synergistic Eye Health by Swanson interact with any medications?
Yes. Based on its ingredients, Synergistic Eye Health has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Synergistic Eye Health contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually work for AMD?
Both zeaxanthin and lutein are rated possibly effective for age-related macular degeneration. That means there's some evidence they help, but it's not airtight. Lutein also has possibly effective evidence for cataracts. For other eye or brain conditions, the evidence we hold is insufficient to say either way.
Can I take this if I'm pregnant or breastfeeding?
Both ingredients are rated likely safe, but the data on concentrated supplements in pregnancy and while breastfeeding isn't robust. Food sources are fine. Since supplement safety isn't well studied in these situations, talk with your doctor or pharmacist first — they can weigh the potential benefit against any individual risk factors.
What are zeaxanthin and lutein, exactly?
They're carotenoids — plant pigments that your eyes naturally concentrate in the lens and macula, the part of your retina responsible for sharp central vision. You get them from leafy greens and other colorful vegetables; these supplements deliver concentrated doses.
Are there any side effects?
Neither ingredient has reported adverse effects at typical doses. Lutein studies have used up to 20 mg daily without problems. Both are generally well tolerated.
I take diabetes medication — is this safe for me?
Zeaxanthin may theoretically increase the risk of low blood sugar when combined with antidiabetes drugs — that's a moderate concern. Run your exact medications through the checker on this page, and talk with your pharmacist or doctor before you start.
What are the inactive ingredients?
This softgel contains sunflower oil, gelatin, glycerin, purified water, and safflower oil to deliver the active carotenoids. None of those are actives — they're just the capsule and carrier.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Synergistic Eye Health label
Go deeper

The Full Monographs Behind Synergistic Eye Health’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Synergistic Eye Health's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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