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Dietary supplement

Sustained Targeted Release Probiotics Gold 5 Billion CFUs Ingredients & Drug Interactions

by NutriGold

Sustained Targeted Release Probiotics Gold 5 Billion CFUs label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sustained Targeted Release Probiotics Gold 5 Billion CFUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sustained Targeted Release Probiotics Gold 5 Billion CFUs is a dietary supplement by NutriGold with 3 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 473 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium, Probiotic Colony Forming Units, Inulin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold

Ask about any prescription or over-the-counter medication and we check it for interactions with Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 8 active ingredients.
  • “Probiotic Colony Forming Units” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product contains 8 active ingredients: five Lactobacillus and Bifidobacterium strains (live probiotic bacteria), plus sodium and inulin. The probiotics are meant to support gut health; inulin acts as a prebiotic (food for beneficial bacteria).

The total live culture is 5 billion CFUs (colony forming units — basically a count of living cells). The tablet also contains inactive ingredients including microcrystalline cellulose, hydroxypropyl methylcellulose, pectin, rice bran extract, sodium carbonate, guar gum, and turmeric to bind and protect the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and gut microflora balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Celiac disease, Clostridioides difficile infection, Colic, Constipation — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Inulin is rated "Possibly Effective" for Constipation.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis, though the evidence is limited. It's rated possibly ineffective for atopic disease (allergic and immune conditions) and there's insufficient evidence to rate it for acute respiratory distress syndrome (ARDS).

Inulin is possibly effective for weight management, constipation, and diabetes control, but there's insufficient evidence for nonalcoholic fatty liver disease and iron deficiency anemia. We hold no effectiveness data for the other probiotic strains in this product.

The evidence, ingredient by ingredient Sodium Inulin Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though the data are limited — check with your doctor before use. The live organisms in probiotic products can theoretically cause serious infections (bacteremia, sepsis, abscesses, endocarditis) in some patients, though this is rare and usually happens in people with underlying conditions.

When taken orally with other probiotics, it may cause mild gastrointestinal side effects like stomach discomfort, bloating, gas, diarrhea, or burping; these are uncommon. Sodium is well tolerated at normal dietary levels but too much is linked to high blood pressure and heart strain — avoid sodium supplements or very high intake without talking to your doctor.

Inulin is well tolerated at food amounts but commonly causes bloating, gas, diarrhea, and cramps, especially at doses over 30 grams; anaphylaxis is rare but has occurred. This product's inactive ingredients include turmeric and other plant extracts.

Side effects, ingredient by ingredient Sodium Inulin Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lactobacillus Acidophilus, Inulin, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 473 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on blood pressure medications (antihypertensive drugs) — sodium in this product may reduce their effectiveness. Also confirm if you take antibiotics, diabetes medications, lithium, steroids (corticosteroids), didanosine, sodium phosphate products, tolvaptan, or any other sodium-containing drugs, since this product can interact with all of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may be worth considering if you have IBS, antibiotic-associated diarrhea, or bacterial vaginosis, and you're not taking antibiotics, blood pressure medications, or other sodium-sensitive drugs. If you take any prescription medication — especially antibiotics, antihypertensive drugs, diabetes medications, lithium, steroids, or didanosine — talk with your doctor or pharmacist before starting, since the interactions could affect how well your medications work.

Because probiotics contain live organisms, let your healthcare provider know if you have a weakened immune system or serious underlying illness.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sustained Targeted Release Probiotics Gold 5 Billion CFUs, straight from the product label.

Brand NutriGold
Barcode (UPC) 859447002661
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 219799
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
859447002661
IngredientAmount% DV
Lactobacillus rhamnosus0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus plantarum0 NP--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium infantis0 NP--
Lactobacillus reuteri0 NP--
Sodium5 mg1%
Inulin75 mg--
Probiotic Colony Forming Units0 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl MethylCellulose, Pectin, Rice Bran extract, Sodium Carbonate, Guar Gum, Turmeric

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Broad-spectrum complex of Lactobacillus and Bifidobacterium probiotic strains formulated using patented BIO-tract delivery system for sustained, targeted release throughout the GI tract and LiveBac tableting technology for enhanced shelf-stability at room temperature.

Precautions

Caution: Please consult a healthcare professional before taking this supplement if you are pregnant, breastfeeding, or taking any medications.

Temporary side effects (e.g. minor bloating, diarrhea, or constipation) may occur in some individuals as the probiotics in the product correct and improve gut microflora. Discontinue use immediately and seek medical attention if symptomes worsen or persist for more than 5 days.

Keep out of reach of children.

May contain traces of milk protein. Suitable for individuals on lactose-restricted or lactose-free diets.

Storage

Store in original container away from moisture and direct sunlight.

Formulation

Tested and verified non-GMO by an independent lab.

BIO-tract Delivery System

Gluten-free Soy-free

Vegetarian

Non GMO Verified

General Statements

To learn more about this product, scan QR code or visit nutrigold.com/item/266

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) tablet 1 to 3 times daily with a full glass of water, or as directed by a healthcare professional.

Brand IP Statement(s)

LiveBac and BIO-tract are registered trademarks of Probi USA Inc. in the United States (reg. in the name of Probi USA, Inc.).

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Non GMO Verified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sustained Targeted Release Probiotics Gold 5 Billion CFUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
5 mg per serving Form: Sodium Carbonate

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Inulin

Interacts with
86 drugs
75 mg per serving Form: Prebiotic Fiber

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements an...

Inulin monograph & interactions

Probiotic Colony Forming Units

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Colony Forming Units monograph & interactions
  • › Lactobacillus rhamnosus
  • › Lactobacillus acidophilus
  • › Lactobacillus plantarum
  • › Bifidobacterium animalis lactis
  • › Bifidobacterium infantis
  • › Lactobacillus reuteri

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl MethylCellulose, Pectin, Rice Bran extract, Sodium Carbonate, Guar Gum, Turmeric. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold Drug Interactions

Want to check YOUR meds against Sustained Targeted Release Probiotics Gold 5 Billion CFUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
473Drugs
387 Moderate 86 Minor

Ingredients driving the most interactions

Sodium 205
Probiotic Colony Forming Units 182
Inulin 86

Individual Drug Interactions

The ingredients in Sustained Targeted Release Probiotics Gold 5 Billion CFUs interact with 473 drugs. Click any drug to see the details.

3 of the 3 ingredients in Sustained Targeted Release Probiotics Gold 5 Billion CFUs interact with drugs. Each result below shows which ingredient is responsible. Sodium Probiotic Colony Forming Units Inulin

Each ingredient & the kinds of drugs it affects

For each ingredient in Sustained Targeted Release Probiotics Gold 5 Billion CFUs with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Probiotic Colony Forming Units1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Colony Forming Units full monograph & interactions

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sustained Targeted Release Probiotics Gold 5 Billion CFUs, from the product label.

NutriGold

Name
NutriGold Inc.
City
Orem
State
UT
ZipCode
84057
Phone Number
800-476-3542
Web Address
www.nutrigold.com
Pharmacist Counseling Corner

Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold: Common Questions

Does Sustained Targeted Release Probiotics Gold 5 Billion CFUs by NutriGold interact with any medications?
Yes. Based on its ingredients, Sustained Targeted Release Probiotics Gold 5 Billion CFUs has a known interaction with 473 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sustained Targeted Release Probiotics Gold 5 Billion CFUs contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm taking an antibiotic?
Not as well as intended. Antibiotics kill bacteria — including the live Lactobacillus acidophilus in this product — so the probiotic may lose effectiveness. Ask your doctor or pharmacist about spacing them out (taking them at different times) or waiting until after your course of antibiotics to start the probiotic.
What are the live organisms in this product supposed to do?
They're meant to restore or maintain healthy gut bacteria. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection, though the evidence is still limited.
Does this probiotic have sodium in it, and is that a problem?
Yes, it contains sodium. At normal dietary levels, sodium is fine, but if you take blood pressure medications, lithium, steroids, didanosine, or other sodium-sensitive drugs, the extra sodium here could interfere with your treatment. Check with your doctor or pharmacist first.
Will this give me bloating or gas?
Possibly. Inulin (a prebiotic ingredient) commonly causes bloating, gas, diarrhea, and stomach cramps, especially at higher doses. The probiotics themselves rarely cause these symptoms, but taken together with other probiotics, mild gastrointestinal side effects can occur.
Is this safe to take during pregnancy or while breastfeeding?
The data we have rate Lactobacillus acidophilus as possibly safe during pregnancy, and inulin as likely safe during pregnancy and lactation. However, we don't have pregnancy or breastfeeding data for the other probiotic strains in this product. Talk with your doctor or pharmacist to weigh the benefits and risks for your situation.
Can this product cause serious infections?
Serious infections from probiotics are rare and typically occur in people with weakened immune systems or serious underlying illness. If you have a compromised immune system, ask your doctor before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sustained Targeted Release Probiotics Gold 5 Billion CFUs is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sustained Targeted Release Probiotics Gold 5 Billion CFUs label
Go deeper

The Full Monographs Behind Sustained Targeted Release Probiotics Gold 5 Billion CFUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Sustained Targeted Release Probiotics Gold 5 Billion CFUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
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See these in context on the Sodium monograph →

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See these in context on the Inulin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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