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Dietary supplement

Thyroid Calming Ingredients & Drug Interactions

by Herb Pharm

Thyroid Calming label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Thyroid Calming against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Thyroid Calming is a dietary supplement by Herb Pharm with 4 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 273 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm aerial parts extract, Motherwort Flowering Aerial Parts Extract, Bugleweed flowering aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Thyroid Calming by Herb Pharm

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HelloPharmacist Scorecard of Thyroid Calming by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (654 mg) without saying how much of each component you get.

Thyroid Calming is a four-ingredient herbal blend in liquid form. The active components are lemon balm aerial parts extract, bugleweed flowering aerial parts extract, Cactus Grandiflorus extract, and motherwort flowering aerial parts extract — each chosen for properties traditionally associated with thyroid and nervous system function.

The product also contains cane alcohol, distilled water, and vegetable glycerin as inactive ingredients to preserve and deliver the extracts.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support normal thyroid and endocrine function.
  • We looked for evidence on: Hyperthyroidism, Anxiety, Stress, Insomnia, Heart failure, Arrhythmia — and 4 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Arrhythmia, Heart failure, Hyperthyroidism, and more.

The evidence for most of these ingredients is limited. Lemon balm is rated possibly effective for stress and depression, and possibly effective for cold sores, though the product is labeled for thyroid support.

Bugleweed, motherwort, and Cactus Grandiflorus all carry insufficient evidence ratings for their proposed uses — meaning the data we hold does not establish that they work for the conditions they're traditionally used for. If you're considering this product for thyroid concerns, talk with your doctor or pharmacist about what the evidence actually supports.

The evidence, ingredient by ingredient Lemon Balm Bugleweed Cereus Motherwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated for short-term use, though dizziness and sedation are reported; however, these occurred no more often than placebo in clinical trials. Long-term safety is not well studied.

Bugleweed may affect thyroid function and should only be used under healthcare provider guidance. Motherwort is generally tolerated orally in normal amounts, though doses above 3 grams have caused uterine bleeding; common oral side effects are diarrhea and stomach irritation.

Cactus Grandiflorus can cause mouth burning, nausea, vomiting, and diarrhea when taken orally. Pregnancy safety is a concern across all four ingredients — lemon balm has insufficient data; bugleweed and motherwort are rated likely unsafe; and Cactus Grandiflorus should be avoided.

Bugleweed may reduce milk production and should not be used while breastfeeding; motherwort and Cactus Grandiflorus also lack reliable breastfeeding safety data.

Side effects, ingredient by ingredient Lemon Balm Bugleweed Cereus Motherwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Motherwort, Bugleweed, Lemon Balm, Cereus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 273 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Thyroid Calming, double-check if you're on thyroid hormone replacement (levothyroxine and similar) — both lemon balm and bugleweed may interfere with them. Also verify any CNS depressants like benzodiazepines, sleep aids, or narcotic pain relievers; lemon balm and motherwort add to their sedating effects.

If you take digoxin (Lanoxin) for your heart, or any MAOI antidepressant, flag those too. Use the medication checker on this page to see your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient herbal blend with a long list of drug interactions — especially important to check if you take thyroid medications, CNS depressants, digoxin, or MAOIs. The evidence for its effectiveness isn't established in the data we hold.

If you're pregnant or breastfeeding, avoid it unless your doctor says otherwise. Run your medications through the checker below before starting, and talk with your pharmacist or doctor about whether this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Thyroid Calming, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700031381
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 275373
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Thyroid Calming by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
84
UPC/BARCODE
090700031381
IngredientAmount% DV
Proprietary Extract Blend654 mg--
Lemon Balm aerial parts extract0 NP--
Bugleweed flowering aerial parts extract0 NP--
Cactus Grandiflorus extract0 NP--
Motherwort Flowering Aerial Parts Extract0 NP--

Other ingredients: Cane Alcohol, distilled Water, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Shake well before using Adults: Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 4 times per day. Best taken between meals.

Precautions

Caution: Seek expert medical advice before taking during pregnancy or nursing.

Not for use in hypothyroidism or thyroid enlargement.

Use with caution in persons taking thyroid & heart medications.

Keep out of the reach of children

Storage

Store away from heat & light

Formulation

System restoration Endocrine

Gluten-free

FDA Statement of Identity

Herbal Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Thyroid Calming by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Thyroid Calming label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Thyroid Calming by Herb Pharm

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container84 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Cane Alcohol, Distilled Water, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Thyroid Calming by Herb Pharm Drug Interactions

Want to check YOUR meds against Thyroid Calming?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

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273Drugs
273 Moderate

Ingredients driving the most interactions

Lemon Balm aerial parts extract 264
Motherwort Flowering Aerial Parts Extract 248
Bugleweed flowering aerial parts extract 16
Cactus Grandiflorus extract 10

Individual Drug Interactions

The ingredients in Thyroid Calming interact with 273 drugs. Click any drug to see the details.

4 of the 4 ingredients in Thyroid Calming interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm aerial parts extract Motherwort Flowering Aerial Parts Extract Bugleweed flowering aerial parts extract Cactus Grandiflorus extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Thyroid Calming with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm aerial parts extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm aerial parts extract full monograph & interactions

Motherwort Flowering Aerial Parts Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort Flowering Aerial Parts Extract full monograph & interactions

Bugleweed flowering aerial parts extract1 drug type · 16 drugs

Thyroid Hormone

Theoretically, bugleweed may alter thyroid function.
Concomitant use of bugleweed may reduce the effects of thyroid hormones by blocking peripheral conversion of thyroxine (T4) to triiodothyronine (T3).

Likelihood Probable Evidence D
Bugleweed flowering aerial parts extract full monograph & interactions

Cactus Grandiflorus extract2 drug types · 10 drugs

Digoxin (Lanoxin)

Cereus may potentiate the actions of cardiac glycosides and may enhance the effect of other cardiac drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, excessive doses of cereus may interact with MAOIs, because of the tyramine content.

Likelihood Possible Evidence D
Cactus Grandiflorus extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Thyroid Calming, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Thyroid Calming by Herb Pharm: Common Questions

Does Thyroid Calming by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Thyroid Calming has a known interaction with 273 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Thyroid Calming contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm on thyroid medication?
Not without checking first. Both lemon balm and bugleweed in this product may interfere with thyroid hormone replacement therapy — lemon balm can block TSH activity, and bugleweed may reduce how well your body uses the hormones. Talk to your doctor or pharmacist before adding this product if you take levothyroxine or another thyroid replacement.
Can I take this with sleep aids or anxiety medication?
You'll need to check with your pharmacist. Lemon balm and motherwort both have CNS depressant effects, which means they could add to sedation from medications like benzodiazepines, sleeping pills, or prescription pain relievers. Use the drug checker below with your exact medications.
What's in this product?
Four herbal extracts: lemon balm, bugleweed, Cactus Grandiflorus, and motherwort. These are delivered in a liquid base of cane alcohol, water, and glycerin. Each extract is chosen for traditional use in supporting thyroid and nervous system function, though the evidence for effectiveness is limited.
Is lemon balm in this effective for what it's used for?
Lemon balm is rated possibly effective for stress and depression, and possibly effective for cold sores. The product itself is labeled for thyroid support, but we don't have evidence data for that use in this ingredient.
Can I take this while pregnant or breastfeeding?
No — the safety data advises against it. Bugleweed and motherwort are rated likely unsafe in pregnancy; lemon balm and Cactus Grandiflorus don't have enough data but should be avoided unless your doctor advises otherwise. Bugleweed can reduce milk production, and the others lack reliable breastfeeding data. Talk to your doctor before considering it.
Are there any common side effects?
Lemon balm and motherwort are generally well tolerated, though lemon balm can cause dizziness or sedation (no more often than placebo in trials) and motherwort may cause diarrhea or stomach irritation. Cactus Grandiflorus can cause mouth burning, nausea, and diarrhea. High doses of motherwort over 3 grams have caused uterine bleeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Thyroid Calming label
Go deeper

The Full Monographs Behind Thyroid Calming’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Bugleweed

Interacts with 16 drugs

Bugleweed is a traditional herb most often used for mild overactive thyroid symptoms and the rapid heartbeat that can come with it, but high-quality human evidence is very limited. Because i...

Read the full Bugleweed monograph → Herb & supplement monograph

Cereus

Interacts with 10 drugs

Cereus (often called night-blooming cereus) is a cactus traditionally used in folk and homeopathic medicine for heart-related complaints like palpitations. High-quality human evidence suppor...

Read the full Cereus monograph → Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph →
Sources

Sources & How We Checked

Thyroid Calming's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Bugleweed 4 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Bugleweed monograph →

Cereus 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

See these in context on the Cereus monograph →

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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