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Dietary supplement

Tongkat Ali 500 mg Ingredients & Drug Interactions

by Nutricost

Tongkat Ali 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tongkat Ali 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tongkat Ali 500 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tongkat Ali 500 mg by Nutricost

Ask about any prescription or over-the-counter medication and we check it for interactions with Tongkat Ali 500 mg by Nutricost — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tongkat Ali 500 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Tongkat Ali powder (also called Eurycoma longifolia), at 500 mg per capsule. The capsule itself and the inactive ingredients — vegetable capsule material, magnesium stearate, and microcrystalline cellulose — are fillers and binders that hold it together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Male vitality and performance support.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Erectile dysfunction (ED), Male Infertility, Muscle strength, Sexual desire — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence in our data supports Tongkat Ali as possibly effective for sexual desire. For athletic performance, the evidence suggests it's possibly ineffective.

The data we hold is insufficient to rate it for back pain, osteoporosis, or diabetes — meaning there isn't enough reliable evidence yet to say whether it works for those uses.

The evidence, ingredient by ingredient Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tongkat Ali is generally well tolerated in short-term studies, but long-term safety data and product quality consistency are uncertain. One concern: the supplement may increase testosterone levels beyond the normal range, which could trigger side effects like acne, insulin resistance, and liver toxicity if levels get too high.

The safety data advises against using it during pregnancy and breastfeeding — there isn't enough information to know it's safe for either.

Side effects, ingredient by ingredient Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before starting if you take propranolol (Inderal) — Tongkat Ali can reduce its effectiveness. Also double-check any medications processed by your liver's CYP1A2, CYP2C19, or CYP2A6 enzymes, and let us know if you're on testosterone therapy.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tongkat Ali may be worth considering if you're interested in sexual function support, but it's not established for athletic performance or other uses. If you take propranolol or testosterone therapy, or rely on medications processed by your liver, talk with your pharmacist first.

Anyone pregnant or breastfeeding should skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tongkat Ali 500 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 702669936378
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 224759
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tongkat Ali 500 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
702669936378
IngredientAmount% DV
Tongkat Ali, Powder500 mg--

Other ingredients: Vegetable Capsule, Magnesium Stearate, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

(Please read the entire label before use) Recommended Use: As a dietary supplement, take 1-2 capsules up to three times daily preferably with meals or as directed by your physician.

Precautions

This product may produce a temporary flushing and/or prickly sensation of the skin which should subside within hours of use. Warning: This product is only intended to be consumed by healthy individuals 18 years of age or older. Do not exceed recommended use. Improper use will not improve results and is not advised.

Consult your physician prior to use if you are pregnant or nursing.

Keep out of reach of children.

Do not use if safety seal is broken.

Storage

Store in a cool dry place.

Formula

Eurycoma Longifolia Extract 200:1 500 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Nutricost Quality guaranteed Made in the USA

Formulation

Non GMO Gluten free product

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tongkat Ali 500 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tongkat Ali 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tongkat Ali 500 mg by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Tongkat Ali, Powder

Interacts with
248 drugs
500 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali, Powder monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Magnesium Stearate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tongkat Ali 500 mg by Nutricost Drug Interactions

Want to check YOUR meds against Tongkat Ali 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Tongkat Ali, Powder 248

Individual Drug Interactions

The ingredients in Tongkat Ali 500 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tongkat Ali 500 mg interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Tongkat Ali 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali, Powder5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tongkat Ali 500 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
7 S 1550 W #200
City
Lindon
State
UT
ZipCode
84042
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

Tongkat Ali 500 mg by Nutricost: Common Questions

Does Tongkat Ali 500 mg by Nutricost interact with any medications?
Yes. Based on its ingredients, Tongkat Ali 500 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tongkat Ali 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me with athletic performance?
The evidence we have suggests Tongkat Ali is possibly ineffective for athletic performance, so it's not a reliable choice for that goal.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it in both cases — there isn't enough reliable information to know it's safe. Talk with your doctor or pharmacist for personalized guidance.
What's the risk if this raises my testosterone too high?
If Tongkat Ali pushes your testosterone beyond the normal range, you could develop acne, insulin resistance, liver toxicity, and other testosterone-related side effects. This is a real concern, especially with long-term use.
Is this supplement safe for long-term use?
The studies show it's generally well tolerated short-term, but we don't have solid long-term safety data, and product quality can vary between manufacturers. Talk with your pharmacist about how long you're planning to take it.
Will this work for back pain?
The evidence we have is insufficient to rate Tongkat Ali for back pain — there isn't enough reliable research to say whether it works for that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tongkat Ali 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tongkat Ali 500 mg label
Go deeper

The Full Monographs Behind Tongkat Ali 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Tongkat Ali 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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