Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Total Omega Vegan Swirl Pomegranate Blueberry Ingredients & Drug Interactions

by Barlean's

Liquid Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Total Omega Vegan Swirl Pomegranate Blueberry is a dietary supplement by Barlean's with 4 active ingredients. Its ingredients are commonly taken for general nutrition and energy, skin conditions like eczema, inflammation support.Based on those ingredients, 984 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Omega-3 Polyunsaturated Fat, Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Total Omega Vegan Swirl Pomegranate Blueberry by Barlean's

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • “Omega-6 Fatty Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Omega-9 Fatty Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Omega-3 Polyunsaturated Fat” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This liquid supplement contains 8 active ingredients centered on omega fatty acids and vitamin E. You're getting docosahexaenoic acid (a type of omega-3 fat), omega-3, omega-6, and omega-9 polyunsaturated and monounsaturated fats, plus linoleic acid, oleic acid, alpha-linolenic acid, gamma-linolenic acid, and vitamin E.

The remaining ingredients are inactive — water, sweetener (xylitol), glycerin, gum arabic, natural flavors, vegetable juice concentrate, citric acid, xanthan gum, guar gum, and sorbic acid (a preservative).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Complete omega-3, 6 and 9 nutrition source.
  • We looked for evidence on: Cardiovascular disease (CVD), Coronary heart disease (CHD), Atherosclerosis, Hypercholesterolemia, Hyperlipidemia, Hypertension — and 4 related terms.
  • The strongest evidence on file: Oleic Acid is rated "Possibly Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Oleic Acid is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Atherosclerosis, Atopic dermatitis (eczema).

The evidence we have covers vitamin E and oleic acid. Vitamin E is effective for treating actual vitamin E deficiency and a rare genetic condition called AVED (ataxia with vitamin E deficiency).

It's possibly effective for Alzheimer disease, beta-thalassemia, and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Oleic acid is possibly effective for high cholesterol and coronary heart disease based on preliminary research.

We don't have effectiveness ratings on file for the other omega fatty acids in this product.

The evidence, ingredient by ingredient Omega-6 Fatty Acids Oleic Acid Vitamin E Docosahexaenoic Acid (dha)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E from usual dietary amounts is generally well tolerated, but the safety notes advise caution with high-dose long-term supplements — they may raise your bleeding risk. High-dose vitamin E can also increase the risk of hemorrhagic stroke in some populations.

Rare serious side effects include bleeding, hemorrhagic stroke, and cardiovascular complications. For pregnancy and breastfeeding, usual dietary amounts and prenatal vitamins are considered appropriate, but you should avoid high-dose supplements without your doctor's direction.

Oleic acid from food amounts is considered safe, but concentrated supplements aren't well studied in pregnancy or breastfeeding.

Side effects, ingredient by ingredient Omega-6 Fatty Acids Oleic Acid Vitamin E Docosahexaenoic Acid (dha)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin E, Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 847 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use blood thinners or antiplatelet agents (anticoagulants) — vitamin E may increase bleeding risk. Similarly, if you take warfarin specifically, let your pharmacist know.

Tell your doctor or pharmacist if you're on diabetes medications, chemotherapy drugs (especially alkylating agents or antitumor antibiotics), cyclosporine, selumetinib, or niacin, since vitamin E or oleic acid may affect how these work. Finally, if you take medications metabolized by your liver's CYP3A4 system, run them through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is omega and vitamin E supplement suited for general nutritional support, especially if you're looking for a vegan liquid option. If you take blood thinners, diabetes medications, chemotherapy, or any prescription drugs metabolized by your liver, check your specific medications with the tool on this page before starting.

Talk with your pharmacist or doctor about whether this is right for you, especially if you're pregnant, breastfeeding, or have bleeding concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Total Omega Vegan Swirl Pomegranate Blueberry, straight from the product label.

Brand Barlean's
Barcode (UPC) 705875000338
Net contents 8 oz.; 227 Gram(s)
Market status On market
Date entered into DSLD Mar 24, 2016
DSLD ID 58156
Product type Fat/fatty Acid
Supplement form Liquid
Dietary claims / uses Nutrient, All Other
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Total Omega Vegan Swirl Pomegranate Blueberry by Barlean's, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tbsp
Maximum serving Sizes:
2 Tbsp
Servings per container
14
UPC/BARCODE
705875000338
IngredientAmount% DV
Calories60 {Calories}--
Total Carbohydrates5 Gram(s)2%
Calories from Fat45 {Calories}--
Docosahexaenoic Acid130 mg--
Saturated Fat1 Gram(s)5%
Polyunsaturated Fat3.5 Gram(s)--
Gamma-Linolenic Acid400 mg--
Omega-6 Fatty Acids0 NP--
Omega-9 Fatty Acids0 NP--
Total Fat5 Gram(s)8%
Vitamin E6 IU20%
Linoleic Acid1120 mg--
Oleic Acid800 mg--
Alpha-Linolenic Acid1530 mg--
Monounsaturated Fat1 Gram(s)--
Omega-3 Polyunsaturated Fat0 NP--

Other ingredients: Total Omega Vegan Oil blend, Water, Xylitol, Glycerin, Gum Arabic, Natural flavors, Vegetable Juice, Citric Acid, Xanthan Gum, Guar Gum, Sorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Total omega nutrition with the taste and texture of a delicious fruit smoothie

The Best of Barlean's

~ Delicious fruit smoothie taste & texture

Barlean's proprietary emulsification technology is designed to boost absorption and deliver significantly more nutritional value than standard supplements.

Do not give to pets.

From Our Family To Yours Freshness Dating

AMPLIFIED ABSORPTION DESIGNED TO DELIVER MORE

ESTD 1989 Barlean's Pathway To A Better Life

Smoothie Taste and Texture One Tablespoon a Day

69213-09

Product of U.S.A.

Formula

~ A complete and balanced source of Omega-3, 6 and 9 ~ Fresh pressed flaxseed and borage oil ~ 100% vegetarian plant-based DHA

Fresh pressed flaxseed oil Plant-Based DHA Pure borage oil

OK

Formulation

~ 100% vegetarian plant-based DHA

~ No artificial flavors or colors ~ No sugar: Naturally sweetened with Xylitol

~ Gluten free, Non-GMO

3.6.9 Vegan

Brand IP Statement(s)

~ Proprietary amplified absorption emulsification technology

Amplified Absorption

life's DHA is a trademark of DSM.

Suggested/Recommended/Usage/Directions

Suggested Use: 1-2 Tbsp daily. Child's dosage (4 yrs. and older): 1 Tbsp. Can be taken straight or mixed into juice, yogurt, oatmeal, cottage cheese or blended beverages.

Shake well.

Storage

Refrigerate for quality.

Precautions

Keep out of reach of children.

FDA Statement of Identity

Supplement

Seals/Symbols

life's DHA Healty Brain, Eyes, Heart

OK

See for yourself

Total Omega Vegan Swirl Pomegranate Blueberry by Barlean's label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Total Omega Vegan Swirl Pomegranate Blueberry by Barlean's

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tbsp Dosage formLiquid Servings per container14 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Omega-6 Fatty Acids

No known
interactions
0 NP per serving

Omega-6 fatty acids are essential fats your body needs but cannot make on its own, and most people get plenty from everyday foods like vegetable oils,...

Omega-6 Fatty Acids monograph & interactions
  • › Gamma-Linolenic Acid
  • › Linoleic Acid

Omega-9 Fatty Acids

0 NP per serving

Vitamin E

Interacts with
766 drugs
6 IU per serving

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Omega-3 Polyunsaturated Fat

Interacts with
375 drugs
0 NP per serving

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and gen...

Omega-3 Polyunsaturated Fat monograph & interactions
  • › Docosahexaenoic Acid
  • › Alpha-Linolenic Acid

Other (inactive) ingredients: Total Omega Vegan Oil blend, Water, Xylitol, Glycerin, Gum Arabic, Natural flavors, Vegetable Juice, Citric Acid, Xanthan Gum, Guar Gum, Sorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Total Omega Vegan Swirl Pomegranate Blueberry by Barlean's Drug Interactions

Want to check YOUR meds against Total Omega Vegan Swirl Pomegranate Blueberry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
984Drugs
983 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 766

Each ingredient & the kinds of drugs it affects

For each ingredient in Total Omega Vegan Swirl Pomegranate Blueberry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 766 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A

Omega-3 Polyunsaturated Fat3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
In people with type 2 diabetes, including those taking oral hypoglycemic medications, DHA seems to increase fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B

Oleic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Total Omega Vegan Swirl Pomegranate Blueberry, from the product label.

Barlean's

See all Barlean's products
Phone Number
800-445-3529
Web Address
barleans.com
Pharmacist Counseling Corner

Total Omega Vegan Swirl Pomegranate Blueberry by Barlean's: Common Questions

Does Total Omega Vegan Swirl Pomegranate Blueberry by Barlean's interact with any medications?
Yes. Based on its ingredients, Total Omega Vegan Swirl Pomegranate Blueberry has a known interaction with 984 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Total Omega Vegan Swirl Pomegranate Blueberry contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is vitamin E actually for?
Vitamin E is effective for treating vitamin E deficiency itself and a rare genetic condition called AVED. The evidence suggests it's possibly effective for Alzheimer disease, beta-thalassemia, and G6PD deficiency, though the research is less established for those uses.
Is this safe during pregnancy or breastfeeding?
Usual dietary amounts of vitamin E and oleic acid (the amounts you'd get from food) are fine during pregnancy and breastfeeding. However, the facts advise against high-dose supplements in pregnancy unless your doctor directs it, and to check with your doctor before taking high-dose supplements while breastfeeding. This is a liquid supplement, so it's more concentrated than typical food amounts — talk with your doctor or pharmacist.
What are the omega fatty acids in here supposed to do?
This product contains several types of omega fatty acids — omega-3, omega-6, and omega-9 — along with related polyunsaturated and monounsaturated fats. We don't have effectiveness ratings on file for those ingredients in this product, so we can't tell you what the research shows they do.
Can high-dose vitamin E cause bleeding?
Yes. High doses of vitamin E can increase bleeding risk, especially when combined with blood thinners or antiplatelet drugs. The risk appears to be dose-dependent, meaning higher doses carry more risk. If you're on any blood-thinning medication, check with your pharmacist before taking this supplement.
Does the oleic acid in this lower blood sugar?
Preliminary research suggests that oleic acid from foods like olive oil may help lower fasting blood glucose in people with type 2 diabetes. But we don't have confirmed effectiveness ratings for oleic acid in concentrated supplement form, and it may increase the effects of diabetes medications — so if you're diabetic, check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Total Omega Vegan Swirl Pomegranate Blueberry is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Total Omega Vegan Swirl Pomegranate Blueberry label
Sources

Sources & How We Checked

Total Omega Vegan Swirl Pomegranate Blueberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 134 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Omega-6 Fatty Acids 20 references
  1. Godley PA. Essential fatty acid consumption and risk of breast cancer. Breast Cancer Res Treat 1995;35:91-5. PubMed
  2. Newcomer LM, King IB, Wicklund KG, Stanford JL. The association of fatty acids with prostate cancer risk. Prostate 2001;47:262-8. DOI
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate. Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/books/03 DOI
  4. Colter, A. L., Cutler, C., and Meckling, K. A. Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study. Nutr J 2008;7:8. PubMed
  5. Yamada, T., Strong, J. P., Ishii, T., Ueno, T., Koyama, M., Wagayama, H., Shimizu, A., Sakai, T., Malcom, G. T., and Guzman, M. A. Atherosclerosis and omega-3 fatty acids in the populations of a fishing village and a farming village in Japan. Atheroscler
  6. Conklin, S. M., Manuck, S. B., Yao, J. K., Flory, J. D., Hibbeln, J. R., and Muldoon, M. F. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom.Med. 2007;69(9):932-934.
  7. Richardson, A. J., Cyhlarova, E., and Ross, M. A. Omega-3 and omega-6 fatty acid concentrations in red blood cell membranes relate to schizotypal traits in healthy adults. Prostaglandins Leukot.Essent.Fatty Acids 2003;69(6):461-466. PubMed
  8. Assies, J., Lok, A., Bockting, C. L., Weverling, G. J., Lieverse, R., Visser, I., Abeling, N. G., Duran, M., and Schene, A. H. Fatty acids and homocysteine levels in patients with recurrent depression: an explorative pilot study. Prostaglandins Leukot.Es PubMed
  9. Chiplonkar, S. A., Agte, V. V., Tarwadi, K. V., Paknikar, K. M., and Diwate, U. P. Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adults. J Am Coll.Nutr 2004;23(3):239-247. PubMed
  10. Mamalakis, G., Kiriakakis, M., Tsibinos, G., Hatzis, C., Flouri, S., Mantzoros, C., and Kafatos, A. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Pharmacol.Biochem.Behav. 2006;85(2):474-479. PubMed
  11. Okuyama, H., Ichikawa, Y., Sun, Y., Hamazaki, T., and Lands, W. E. Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. World Rev Nutr Diet. 2007;96:143-1
  12. Martinez-Ramirez, M. J., Palma, S., Martinez-Gonzalez, M. A., Delgado-Martinez, A. D., de la Fuente, C., and Delgado-Rodriguez, M. Dietary fat intake and the risk of osteoporotic fractures in the elderly. Eur.J Clin Nutr 2007;61(9):1114-1120. PubMed
  13. Sonestedt, E., Gullberg, B., and Wirfalt, E. Both food habit change in the past and obesity status may influence the association between dietary factors and postmenopausal breast cancer. Public Health Nutr 2007;10(8):769-779. PubMed
  14. Simopoulos, A. P. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac.J Clin Nutr 2008;17 Suppl 1:131-134.
  15. Harris, W. S., Mozaffarian, D., Rimm, E., Kris-Etherton, P., Rudel, L. L., Appel, L. J., Engler, M. M., Engler, M. B., and Sacks, F. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition DOI
  16. Godley, P. A., Campbell, M. K., Gallagher, P., Martinson, F. E., Mohler, J. L., and Sandler, R. S. Biomarkers of essential fatty acid consumption and risk of prostatic carcinoma. Cancer Epidemiol.Biomarkers Prev. 1996;5(11):889-895.
  17. Lee E, Kim H, Kim H, Ha EH, Chang N. Association of maternal omega-6 fatty acid intake with infant birth outcomes: Korean Mothers and Children's Environmental Health (MOCEH). Nutr J 2018;17(1):47. PubMed
  18. Pawelczyk T, Trafalska E, Pawelczyk A, Kotlicka-Antczak M. Differences in omega-3 and omega-6 polyunsaturated fatty acid consumption in people at ultra-high risk of psychosis, first-episode schizophrenia, and in healthy controls. Early Interv Psychiatry 2
  19. Gardner KG, Gebretsadik T, Hartman TJ, et al. Prenatal omega-3 and omega-6 polyunsaturated fatty acids and childhood atopic dermatitis. J Allergy Clin Immunol Pract. 2020;8(3):937-944. PubMed
  20. Luo J, Ge H, Sun J, Hao K, Yao W, Zhang D. Associations of dietary ?-3, ?-6 fatty acids consumption with sleep disorders and sleep duration among adults. Nutrients 2021;13(5):1475. PubMed

See these in context on the Omega-6 Fatty Acids monograph →

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
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Oleic Acid 1 reference
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See these in context on the Docosahexaenoic Acid (dha) monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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