Interactions on record — worth a quick check against your medications. Based on 5 of 9 ingredients. Check your meds →
Dietary supplement

Mood Drops to De-Stress Ingredients & Drug Interactions

by Barlean's

Mood Drops to De-Stress label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mood Drops to De-Stress against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mood Drops to De-Stress is a dietary supplement by Barlean's with 9 active ingredients. Its ingredients are commonly taken for constipation and digestive health, source of prebiotic fiber (inulin), coffee substitute.Based on those ingredients, 1,480 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha Extract, Rhodiola Root Extract, L-Theanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mood Drops to De-Stress by Barlean's

Ask about any prescription or over-the-counter medication and we check it for interactions with Mood Drops to De-Stress by Barlean's — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mood Drops to De-Stress by Barlean's

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Flower Essences Blend” is a proprietary blend — the label gives one combined amount (1,200 mg) without saying how much of each component you get.
  • “Proprietary Herbs Blend” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.

Barlean's Mood Drops to De-Stress contains 9 ingredients total, including four active herbal components: L-theanine, rhodiola root extract, ashwagandha extract, and chicory. The product also includes white chestnut and a flower essences blend (beech, gorse, mustard, oak), as well as inactive ingredients such as purified water, glycerin, xylitol, natural flavors, citric acid, and sorbic acid.

L-theanine is an amino acid; the others are plant extracts traditionally used to support calm and mood.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support emotional well-being and calm.
  • We looked for evidence on: Anxiety, Stress, Generalized anxiety disorder (GAD), Depression, Insomnia, Fatigue — and 4 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Insomnia, Stress.
  • Also on file: Rhodiola is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Chronic fatigue syndrome (CFS), Depression.

L-theanine is rated possibly effective for cognitive function, though evidence for anxiety and age-related cognitive decline is insufficient. Ashwagandha is rated possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder.

Rhodiola, chicory, and white chestnut have no established effectiveness ratings in our data for the conditions this product addresses. Overall, the evidence for using this product as a mood and stress support is mixed—some ingredients show promise for specific uses, but others lack reliable data.

The evidence, ingredient by ingredient Chicory Horse Chestnut Theanine Rhodiola Ashwagandha

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated for short-term use in healthy adults, though long-term safety is not well studied. Reported side effects include headaches, drowsiness, increased sleep duration, and increased dream activity.

Ashwagandha is generally well tolerated short-term but quality and long-term safety data are limited; gastrointestinal upset, nausea, and vomiting may occur at higher doses, and rare cases of liver problems have been reported. Rhodiola is generally well tolerated short-term; dizziness and changes in saliva production are the most common effects.

Chicory is well tolerated in food amounts but may cause gas and bloating; it can trigger allergies in people sensitive to the ragweed family. White chestnut extract is reasonably tolerated, though dizziness, upset stomach, headache, and itching have been reported.

Pregnancy: L-theanine, rhodiola, and ashwagandha lack sufficient safety data and should be avoided during pregnancy; chicory's traditional use raises concerns about uterine stimulation, so medicinal amounts are best avoided; white chestnut is unsafe in pregnancy. Breastfeeding: Safety data are insufficient for L-theanine, rhodiola, ashwagandha, and white chestnut, so these should be avoided; chicory in medicinal amounts should also be avoided.

Side effects, ingredient by ingredient Chicory Horse Chestnut Theanine Rhodiola Ashwagandha

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Chicory, Rhodiola, Ashwagandha, Theanine, Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,481 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use hepatotoxic drugs (those hard on the liver), antihypertensive medications (blood pressure drugs), CNS depressants or benzodiazepines (sedatives or anti-anxiety drugs), antidiabetes drugs, anticoagulants or antiplatelet drugs (blood thinners), immunosuppressants, thyroid hormones, or certain liver-metabolized drugs like losartan—all carry Moderate-severity interactions with one or more of these ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to people looking for herbal support for mood and stress, especially those interested in ashwagandha and L-theanine for anxiety or sleep. However, if you take blood pressure medications, blood thinners, diabetes drugs, sedatives, benzodiazepines, immunosuppressants, thyroid hormones, or any drugs that are tough on the liver, talk to your pharmacist before starting it.

Pregnant or breastfeeding? Skip this one and discuss alternatives with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mood Drops to De-Stress, straight from the product label.

Brand Barlean's
Barcode (UPC) 705875802253
Net contents 1.5 Fluid Ounce(s); 45 mL
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 337670
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mood Drops to De-Stress by Barlean's, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 mL
Maximum serving Sizes:
1.5 mL
Servings per container
30
UPC/BARCODE
705875802253
IngredientAmount% DV
L-Theanine0 NP--
Rhodiola Root Extract0 NP--
Ashwagandha Extract0 NP--
Chicory0 NP--
Flower Essences Blend1200 mg--
Beech0 NP--
Gorse0 NP--
Mustard0 NP--
Oak0 NP--
White Chestnut0 NP--
Proprietary Herbs Blend100 mg--

Other ingredients: Water, Purified, Glycerin, Xylitol, Natural Flavors, Citric Acid, Sorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Barlean's Mood Drops are crafted from a blend of premium flower essences and herbs, designed to support a range of emotional well-being needs.

Herbs and essences

Brand IP Statement(s)

Barlean's Estd 1989

Suggested/Recommended/Usage/Directions

Shake well

Directions for use: Take 1.5 droppers 30 minutes before desired effects.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

For more information, scan the QR code. Great flavor!

Formulation

Feel it in minutes Calm Peace Tranquility

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mood Drops to De-Stress by Barlean's label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mood Drops to De-Stress label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mood Drops to De-Stress by Barlean's

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Flower Essences Blend

1200 mg per serving

Proprietary Herbs Blend

100 mg per serving

Other (inactive) ingredients: Water, Purified, Glycerin, Xylitol, Natural Flavors, Citric Acid, Sorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mood Drops to De-Stress by Barlean's Drug Interactions

Want to check YOUR meds against Mood Drops to De-Stress?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,480Drugs
1,146 Moderate 334 Minor

Ingredients driving the most interactions

Ashwagandha Extract 1,372
Rhodiola Root Extract 1,271
L-Theanine 565
White Chestnut 122
Chicory 86

Individual Drug Interactions

The ingredients in Mood Drops to De-Stress interact with 1,480 drugs. Click any drug to see the details.

5 of the 9 ingredients in Mood Drops to De-Stress interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Extract Rhodiola Root Extract L-Theanine White Chestnut Chicory

Each ingredient & the kinds of drugs it affects

For each ingredient in Mood Drops to De-Stress with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ashwagandha Extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Ashwagandha Extract full monograph & interactions

Rhodiola Root Extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola Root Extract full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

White Chestnut1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
White Chestnut full monograph & interactions

Chicory1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.

Likelihood Possible Evidence D
Chicory full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mood Drops to De-Stress, from the product label.

Barlean's

See all Barlean's products
Name
Barlean's
Phone Number
1-800-445-3529
Web Address
barleans.com
Pharmacist Counseling Corner

Mood Drops to De-Stress by Barlean's: Common Questions

Does Mood Drops to De-Stress by Barlean's interact with any medications?
Yes. Based on its ingredients, Mood Drops to De-Stress has a known interaction with 1,480 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mood Drops to De-Stress contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No—the safety data aren't there. L-theanine, rhodiola, and ashwagandha all lack enough information for pregnancy, and chicory in medicinal amounts raises traditional concerns about the uterus. White chestnut is rated unsafe. Talk to your doctor about safer options.
What is L-theanine, and what does it do?
L-theanine is an amino acid found in tea. It's rated possibly effective for cognitive function, but the evidence for anxiety and other uses in this product is insufficient. It may lower blood pressure and cause drowsiness.
Does ashwagandha really help with anxiety and stress?
Ashwagandha is rated possibly effective for anxiety, stress, insomnia, and generalized anxiety disorder—so the evidence supports its use for those purposes, though it's not a guarantee. It's generally well tolerated short-term, but long-term safety data are limited.
What are the flower essences in this product for?
The product includes beech, gorse, mustard, and oak as part of a flower essences blend, which are traditional herbal ingredients. We don't have interaction data for beech, gorse, mustard, and oak, so we can't verify their safety with your medications.
What side effects might I experience?
L-theanine may cause headaches, drowsiness, or vivid dreams. Ashwagandha may cause gas, nausea, or upset stomach at higher doses. Rhodiola may cause dizziness or dry mouth. Chicory commonly causes bloating and gas. These side effects are usually mild.
Is this safe to take long-term?
The long-term safety of L-theanine, rhodiola, and ashwagandha is not well studied. Ashwagandha has been linked to rare cases of liver problems. If you're considering regular use, talk to your pharmacist about monitoring and duration.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mood Drops to De-Stress label
Go deeper

The Full Monographs Behind Mood Drops to De-Stress’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chicory

Interacts with 86 drugs

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...

Read the full Chicory monograph → Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph →
Sources

Sources & How We Checked

Mood Drops to De-Stress's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 85 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Rhodiola 13 references
  1. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
  4. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
  5. Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
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Ashwagandha 32 references
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Chicory 13 references
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Horse Chestnut 21 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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