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Dietary supplement

Tribulus 1000 mg Ingredients & Drug Interactions

by Amazing Muscle

Tribulus 1000 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus 1000 mg is a dietary supplement by Amazing Muscle with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus (Tribulus terrestris) standardized extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus 1000 mg by Amazing Muscle

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus 1000 mg by Amazing Muscle — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus 1000 mg by Amazing Muscle

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tribulus 1000 mg by Amazing Muscle contains one active ingredient: a standardized extract of tribulus (Tribulus terrestris) at 1,000 mg per tablet. The product also contains several inactive ingredients — calcium carbonate, vegetable cellulose, croscarmellose sodium, stearic acid, silica, magnesium stearate, and a vegetable coating — which are fillers and binders that help hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cardiovascular health, immune function, reproductive health.
  • We looked for evidence on: Athletic performance, Erectile dysfunction (ED), Male infertility, Premature ejaculation, Sexual dysfunction, Hypercholesterolemia — and 4 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Angina, Erectile dysfunction (ED), Hypercholesterolemia, Hypertension, and more.

The evidence on tribulus for sexual function is mixed. Clinical research suggests it may possibly help with sexual dysfunction, though the data aren't definitive.

For athletic performance, the research points to possibly ineffective — meaning the evidence doesn't support better strength or endurance. For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to rate whether it works.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term for healthy adults, but long-term safety data are limited and quality varies between products. Serious side effects are rare but have been reported — including liver and kidney injury, seizures, and persistent painful erection with impaired sexual function.

More common mild side effects can include stomach pain, cramping, nausea, vomiting, diarrhea, or constipation, though one study found these occurred at rates similar to placebo. The safety data advise against tribulus during pregnancy because it may affect hormones and safety isn't established.

Avoid it while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Tribulus 1000 mg, double-check with your doctor or pharmacist if you take blood pressure medications (Moderate interaction risk), diabetes medications (Moderate risk), or lithium (Moderate risk). These are the medication types where documented interactions exist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual function, though the evidence is still developing. If you take blood pressure medication, diabetes medication, or lithium, you need to check with your doctor or pharmacist before starting this supplement — tribulus can affect how these drugs work.

Because long-term safety data are limited, this isn't a long-term supplement to use without a reason, and it's not for pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus 1000 mg, straight from the product label.

Brand Amazing Muscle
Barcode (UPC) 819209023013
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 251211
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus 1000 mg by Amazing Muscle, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
UPC/BARCODE
819209023013
IngredientAmount% DV
Tribulus (Tribulus terrestris) standardized extract1000 mg--

Other ingredients: Calcium Carbonate, Vegetable Cellulose, Croscarmellose Sodium, Stearic Acid, Silica, Magnesium Stearate, Vegetable Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Amazing Muscle Tribulus is a standardized extract which contains 45% saponins, a compound that gives Tribulus its beneficial properties. Tribulus supports cardiovascular health, immune functions and promotes reproductive health in men. It may also help athletes gain strength and lean muscle mass.

Suggested/Recommended/Usage/Directions

As a dietary supplement, adults take one (1) tablet 1 to 2 times daily as needed prior to meals or as directed by a health care professional.

Precautions

Caution: Consult your physician before use.

This product is not intended for use by pregnant or lactating women or those with a serous medical condition.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formulation

Supports strength gain & muscle Promotes athletic performance Supports men's reproductive health

Contains No: Preservatives, sugar, starch, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or sodium.

An FDA regulated facility

Seals/Symbols

GMP Good Manufacturing Practice Quality Product

Made In USA

General Statements

Vitamin angels Proud supporter

Customer Service: 1-800-526-0177 Mon - Fri 9am - 5pm EST

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus 1000 mg by Amazing Muscle label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus 1000 mg by Amazing Muscle

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Tribulus (Tribulus terrestris) standardized extract

Interacts with
259 drugs
1000 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus (Tribulus terrestris) standardized extract monograph & interactions

Other (inactive) ingredients: Calcium Carbonate, Vegetable Cellulose, Croscarmellose Sodium, Stearic Acid, Silica, Magnesium Stearate, Vegetable Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus 1000 mg by Amazing Muscle Drug Interactions

Want to check YOUR meds against Tribulus 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus (Tribulus terrestris) standardized extract 259

Individual Drug Interactions

The ingredients in Tribulus 1000 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus (Tribulus terrestris) standardized extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus (Tribulus terrestris) standardized extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus (Tribulus terrestris) standardized extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus 1000 mg, from the product label.

Amazing Muscle

See all Amazing Muscle products
Name
Amazing Muscle
City
Jersey City
State
NJ
ZipCode
07310
Phone Number
1-800-526-0177
Web Address
www.AmazingMuscle.com
Pharmacist Counseling Corner

Tribulus 1000 mg by Amazing Muscle: Common Questions

Does Tribulus 1000 mg by Amazing Muscle interact with any medications?
Yes. Based on its ingredients, Tribulus 1000 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does tribulus really help with sexual function?
Clinical research suggests it may possibly help, though the evidence isn't conclusive enough to guarantee results. The data we hold rate it as possibly effective for sexual dysfunction, so it's worth discussing with your doctor if you're curious about trying it.
Can I take this if I'm trying to improve athletic performance?
The research on tribulus for strength or endurance points to possibly ineffective — meaning the evidence doesn't support that it will improve your athletic performance. If that's your main reason, this product probably isn't the one.
What side effects should I watch for?
Mild stomach issues like cramping, nausea, vomiting, diarrhea, or constipation can happen, though one study found these occurred at rates similar to placebo. Serious side effects are rare but have been reported — liver or kidney injury, seizures, and persistent painful erection are examples. Stop and see your doctor right away if you notice anything unusual.
Is it safe to take tribulus long-term?
Long-term safety data are limited, and product quality can vary. It's generally well tolerated in the short term for healthy adults, but we don't have enough information to say it's safe indefinitely. Talk with your doctor about how long you should take it.
Can I take this while pregnant or breastfeeding?
No — the safety data advise against tribulus in pregnancy because it may affect hormones and safety isn't established. Avoid it while breastfeeding too, due to lack of reliable safety information. Talk with your obstetrician or midwife if you have questions.
What's in this tablet besides the active ingredient?
The tablet also contains calcium carbonate, vegetable cellulose, croscarmellose sodium, stearic acid, silica, magnesium stearate, and a vegetable coating — these are inactive ingredients that bind and coat the tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus 1000 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus 1000 mg label
Go deeper

The Full Monographs Behind Tribulus 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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